assessment of her 2 status
Báo cáo khoa học: "Comparison of immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) assessment for Her-2 status in breast cancer" ppsx
Ngày tải lên :
09/08/2014, 04:21
... FISH for 2Her- 2 gene amplification FISH for Her- 2 gene amplification Figure (A) Negative amplification of human epidermal growth factor receptor -2/ neu (Her- 2) gene case with the ratio of Her- 2 (red ... amplification of human epidermal growth factor receptor -2/ neu (Her- 2) gene case with the ratio of Her- 2 (red signals) to CEP 17 (green signals) is obviously larger than 2. 2 or 1+ but Her- 2 FISH positive ... cases with Her- 2 status of IHC 3+ or FISH positive are proposed to be treated with herceptin 10 11 12 Parkin DM, Bray F, Ferlay J: Global cancer statistics, 20 02 CA Cancer J Clin 20 05, 55 (2) :74-108...
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Báo cáo sinh học: " Tumor escape and progression of HER-2/neu negative breast cancer under immune pressure" potx
Ngày tải lên :
18/06/2014, 19:20
... levels of HER- 2/ neu-specific IFN-g production (HER- 2/ neu positive or HER- 2/ neu negative tumors) showed weak and scattered Figure HER- 2/ neu-specific T cell responses in patients with HER- 2/ neu ... accruing 12 breast cancer patients with HER- 2/ neu negative tumors (HER- 2/ neu status: FISH negative) and three breast cancer patients with HER- 2/ neu positive tumors (FISH positive) We detected HER- 2/ neu-specific ... overexpression of HER- 2/ neu in DCIS lesions predicts the presence of invasive foci in patients with DCIS [15] Others also have suggested that the low frequency of HER- 2/ neu expression (20 -25 %) in invasive...
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báo cáo hóa học:" Tumor escape and progression of HER-2/neu negative breast cancer under immune pressure" pdf
Ngày tải lên :
20/06/2014, 03:20
... levels of HER- 2/ neu-specific IFN-g production (HER- 2/ neu positive or HER- 2/ neu negative tumors) showed weak and scattered Figure HER- 2/ neu-specific T cell responses in patients with HER- 2/ neu ... accruing 12 breast cancer patients with HER- 2/ neu negative tumors (HER- 2/ neu status: FISH negative) and three breast cancer patients with HER- 2/ neu positive tumors (FISH positive) We detected HER- 2/ neu-specific ... overexpression of HER- 2/ neu in DCIS lesions predicts the presence of invasive foci in patients with DCIS [15] Others also have suggested that the low frequency of HER- 2/ neu expression (20 -25 %) in invasive...
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Báo cáo y học: "Flow cytometric assessment of the signaling status of human B lymphocytes from normal and autoimmune individuals" doc
Ngày tải lên :
09/08/2014, 01:23
... cytometry Clin Immunol 20 01, 100 :27 0 -27 6 11 Chow S, Patel H, Hedley DW Measurement of MAP kinase activation by flow cytometry using phospho-specific antibod- 22 23 24 25 26 27 28 29 30 ies to MEK and ... Natl Acad Sci U S A 1999, 96 :22 21 -22 26 Schwarz UR, Geiger J, Walter U, Eigenthaler M: Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory ... Arthritis Rheum 20 02, 46:1417-1 429 Peng SL, Gerth AJ, Ranger AM, Glimcher LH: NFATc1 and NFATc2 together control both T and B cell activation and differentiation Immunity 20 01, 14:13 -20 Ranger AM,...
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Báo cáo khoa học: "Correlation of HER-2 over-expression with clinico-pathological parameters in Tunisian breast carcinoma" ppsx
Ngày tải lên :
09/08/2014, 07:21
... (10%) (0%) 0(0%) 1 (2. 6%) 4(3.45) N+ HER- 2 Total 30 14 39 90 Negative (35%) (16.7%) (77.8%) 25 (86 ,2% ) 40 ( 62. 5) Positive 13 (65%) (83.3%) (22 .2% ) (13,8%) 24 (37.5) Total 20 29 64 N0: without lymph ... breast carcinomas: correlation Page of (page number not for citation purposes) World Journal of Surgical Oncology 20 08, 6:1 12 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 with patient ... 0.88 (4,4) 24 (36.9) 53 (58.9) 39 (60) 0.0 72 0.66 46 (51.1) 35 (54.7) 0.000 17 (14.8) 11 (27 .5) p 83 ( 72. 2) (22 .5) 0.000 70 (61.4) 11 (27 .5) HER- 2: Human epidermal growth factor receptor 2; ER: Estrogen...
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An assessment of factors affecting quality customer care services in telkom kenya 2
Ngày tải lên :
07/06/2014, 18:09
... handling of customers and development of good public relations REFERENCES [1] Aburoub et al, "An empirical assessment of the SERVQUAL scale", Journal of Business Research, Vol 24 , pp 25 3-68 ,20 11 [2] ... Journal of Bank Marketing, Vol 12 No pp.10-18, 20 04 [3] Babakus, E and Boiler, G.W"An empirical assessment of the SERVQUAL scale", Journal of Business Research, Vol 24 , pp 25 3-68, 19 92 [4] Beardwelland ... perception of quality", Journal of Retailing, Vol 64 No 1, pp 123 7 109 IJSTR 20 13 www.ijstr.org INTERNATIONAL JOURNAL OF SCIENTIFIC & TECHNOLOGY RESEARCH VOLUME 2, ISSUE 10, OCTOBER 20 13 ISSN 22 77-8616...
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Báo cáo hóa học: " Vaccination with a plasmid DNA encoding HER-2/ neu together with low doses of GM-CSF and IL-2 in patients with metastatic breast carcinoma: a pilot clinical trial" pptx
Ngày tải lên :
18/06/2014, 16:20
... Her2 derived epitopes at long term follow-up, while there was a transient decrease in Her2 -specific immunity immediately after three cycles of Her2 -pDNA plus GM-CSF and IL -2 Evaluation of Her2 -specific ... HER2 -specific T Lymphocytes Against HER2 -overexpressing Tumor Cells Cancer Res 20 02, 62: 224 4 -22 47 Donnelly JJ, Ulmer JB, Liu MA: DNA vaccines Life Sci 1997, 60:163-1 72 Corr M, Lee DJ, Carson DA, Tighe ... with HER- 2/ neu peptide-based vaccines J Clin Oncol 20 02, 20 :26 24 -26 32 37 Leyland-Jones B, Gelmon K, Ayoub JP, Arnold A, Verma S, Dias R, Ghahramani P: Pharmacokinetics, safety, and efficacy of...
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Integrated Assessment of Health and Sustainability of Agroecosystems - Chapter 2 potx
Ngày tải lên :
18/06/2014, 19:20
... 0.5 Tigoni 22 9 22 4 40 188 41 83 2. 3 ± 0.17 2. 1 ± 0. 12 2.7 ± 0.34 3.5 ± 0.14 1.8 ± 0 .21 1.9 ± 0.19 23 19 15 304 29 6 41 23 0 62 147 22 .7% 18.8% 30.0% 17.0% 43.9% 27 .7% 31.9% 46.4% 50.0% 32. 4% 53.7% ... Other Improvements No Improvements 81 .2 7.5 6.9 30.1 22 .8 12. 2 35 .2 59.0 45.0 50.5 55.4 64.3 63.4 57.6 59.8 50.0 35.6 36.1 34.4 29 .3 42. 6 71.6 40.0 34.0 20 .5 58.9 41 .2 50.9 4.8 2. 5 12. 2 ... 67.5% 29 .8% 36.6% 57.8% 5.6 ± 0 .25 6.1 ± 0 .22 7.8 ± 0.6 8.0 ± 0.35 7.3 ± 1.0 7.0 ± 0.36 0.3 ± 0.06 0.8 ± 0.10 2. 5 ± 0.4 0.6 ± 0.09 1.4 ± 0.35 1.5 ± 0 .20 2. 3 ± 0. 12 2.7+0.15 1.7 ± 0 .28 2. 8 ± 0.15 2. 24...
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báo cáo hóa học:" Can subjective global assessment of nutritional status predict survival in ovarian cancer?" pptx
Ngày tải lên :
20/06/2014, 07:20
... Oncol 20 07, 107 :26 0 -26 5 Montazeri A, McEwen J, Gillis CR: Quality of life in patients with ovarian cancer: current state of research Support Care Cancer 1996, 4:169-179 20 21 22 23 24 25 26 27 von ... global assessment of nutritional status? JPEN J Parenter Enteral Nutr 1987, 11:8-13 Page of (page number not for citation purposes) Journal of Ovarian Research 20 08, 1:5 28 29 30 31 32 33 34 ... P-value 19.3 (14.1 to 24 .5) 15.5 (5.8 to 25 .1) 6.7 (4.1 to 9.3) 15.9 0.0003 23 .9 (7.7 to 40.3) 15.5 (10.0 to 20 .9) 3.3 0.07 43.1 (18.1 to 68.1) 12. 1 (7 .2 to 17.1) 13.5 0.00 02 N = 1 32 for stage at diagnosis...
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Báo cáo y học: "Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years" ppt
Ngày tải lên :
09/08/2014, 14:22
... 6 .2 ± 1.7 < 0.001 BASFI, 0-10 158 3.1 ± 2. 4 307 5.3 ± 2. 1 < 0.001 166 3.5 ± 2. 4 307 6.7 ± 1.9 < 0.001 167 3.4 ± 2. 6 307 6.7 ± 2. 0 < 0.001 165 3.7 ± 2. 7 306 6.4 ± 2. 0 < 0.001 160 1.5 ± 1.9 3 02 ... spondylitis? A comparison of the available methods based on the Outcome Measures in Rheumatology Clinical Trials filter Arthritis Rheum 20 04, 50 :26 22- 26 32 Creemers MC, Franssen MJ, van't Hof MA, Gribnau ... baseline to year 2b Between-cohort P value Etanercept [2] 25 7 10 ± 8.5 16 ± 18.3 0.9 ± 2. 5 0.996 OASIS 175 11 ± 8.5 14 ± 17.6 1.0 ± 3 .2 Infliximab [3] 156 10 .2 ± 8.7 17.7 ± 17.9 0.9 ± 2. 6 OASIS 165...
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báo cáo khoa học: "SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status" pptx
Ngày tải lên :
10/08/2014, 22:20
... significance of BCL -2 expression and http://www.jhoonline.org/content /2/ 1/8 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 bcl -2 major breakpoint region rearrangement in diffuse large cell ... 800 nM 20 0 nM 0 12 24 36 48 60 72 0 0 0 75 50 25 50 50 25 50 50 25 75 50 25 75 50 25 75 50 25 40 30 750 50 25 0 Time (hr) Figure Structure of small molecule inhibitor TW-37 Structure of small ... http://www.jhoonline.org/content /2/ 1/8 48 hr 25 0 500 B) 24 hr Con.(nM) 25 0 500 750 48 hr 72 hr 25 0 500 750 25 0 500 750 Bcl -2 Bcl -2 Bcl-XL Bcl-XL Mcl-1 Mcl-1 Bax Bax Bim Bim β -actin C) Con.(nM) 0 750 β -actin 25 0 24 hr...
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Báo cáo y học: "hytol-based novel adjuvants in vaccine formulation: 2. assessment of efficacy in the induction of protective immune responses to lethal bacterial infections in mice" ppsx
Ngày tải lên :
11/08/2014, 10:23
... 1PHYTOL 2N/A 2N/A 2N/A 2N/A 0 0 3 .2 ± 1.1 × 104 1.8 ± 0.5 × 104 0 4.4 ± 1 .2 × 105 6.0 ± 1.6 × 104 0 2N/A 2N/A 2N/A 2N/A 1.1 ± 0.1 × 104 2. 1 ± 0.5 × 104 0 fluid samples from all groups of mice ... 0 .20 × 108 2N/A 0 0 4. 92 ± 0.94 × 105 2. 35 ± 1. 12 × 105 3.64 ± 1.44 × 105 4.0 ± 0 .25 × 103 1.54 ± 0.94 × 106 1 .23 ± 1.14 × 106 1.13 ± 2. 31 × 106 3.16 ± 1.94 × 106 1.80 ± 0 .22 × 106 8.90 ± 3 .20 ... coli after 36 hr (Table 1) IgG1 IgG2a IgG2b IgG3 IgM 1 .2 O.D @ 490nm 1.0 0.8 0.6 0.4 0 .2 0.0 PBS PHYTANOL PHYTOL B IgG1 and IgG2a profile of anti-E coli Ab 3.0 2. 5 2. 0 1.5 1.0 0.5 0.0 PBS IFA PHYTANOL...
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Handbook of Ecological Indicators for Assessment of Ecosystem Health - Chapter 2 ppsx
Ngày tải lên :
11/08/2014, 13:22
... High status: >4 bits/individual Good status: 4À3 bits/individual Moderate status: 3 2 bits/individual Poor status: 2 1 bits/individual Bad status: 1À0 bits/individual Detractors of Shannon ... Coefficient of Pollution 124 Calculation of the index is based on several integrated equations These equations are: S0 ¼ s þ t=ð5 þ 0:2sÞ i0 ¼ ðÀ0:0187s þ 2: 63s À 4Þ 2: 20 À 0:0166hÞ g0 ¼ I=ð0:0 124 i þ ... Pi,a 2: 6aÞ ði ! 2; covers inorganic compounds and detritus) and Pi,a ¼ 20 À700g 2: 6bÞ ½À where g is the number of genes Equation 2. 4 is reformulated to: cieq % Pieq  c0eq ½Moles LÀ3 2: 7Þ...
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báo cáo khoa học:" Validation of the "World Health Organization Disability Assessment Schedule, WHODAS-2" in patients with chronic diseases" ppt
Ngày tải lên :
12/08/2014, 01:21
... (10.3) 15.9 (16.4) 18.6 (20 .1) 25 .0 (30.1) 22 .0 (16.1) Severe (31) 27 .6 (22 .2) * 31.1 ( 32. 2)* 22 .7 (24 .4)* 31.1 (25 .3)* 36.6 (34.0)* 61 .2 ( 42. 2)* 39.4 (24 .0)* ES = 0.89 ES = 1 .21 ES = 1.09 ES = 0.44 ... (20 .6) 5.0 (8.7) 9.5 (11.4) 30.0 (22 .4) 33.0 ( 32. 8) 21 .8 (13.8) 9.4 (9 .2) 20 .5 (20 .6) 16.3 (19.5) 12. 0 ( 12. 7) 18.8 (22 .1) 21 .4 (19.9) 22 .4 (15 .2) 19.8 (19.4)* 42. 5 (33.0)* 31.9 (30.6)* 20 .7 (23 .8) ... ES = 1 .27 Eutimic (78) 21 .4 (19.6) 9.0 ( 12. 3) 4.1 (8.5) 19.8 (20 .5) 20 .1 (24 .8) 15.8 (22 .2) 15.3 (15.4) No eutimic (36) 44.0 (26 .5)* 20 .7 (24 .4)* 23 .3 (20 .4)* 38.9 (26 .1)* 34.7 (28 .8)* 72. 9 (40.0)*...
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Báo cáo y học: "The trauma of ongoing conflict and displacement in Chechnya: quantitative assessment of living conditions, and psychosocial and general health status among war displaced in Chechnya and Ingushetia" pptx
Ngày tải lên :
13/08/2014, 13:21
... 68.6% 72. 5% 59.7% 44 .2% 41.3% 136 144 58 14 181 53.1% 56 .2% 22 .7% 5.4% 0.8% 71.1% 137 126 68 16 20 4 48.4% 44.5% 24 .1% 5.6% 2. 5% 72. 1% 66 25 18 15 25 .8% 9.8% 7% 5.8% 2. 7% 0.4% 58 27 21 23 11 20 .5% ... 2. 0% 83.1% 86.3% 27 2 104 154 25 11 160 24 3 96.1% 36.8% 54.4% 8.8% 3.9% 56.6% 85.9% 25 0 97.7% 2. 3% 25 3 30 89.4% 10.6% 20 0 25 31 78.4% 9.8% 12. % 129 139 15 45.6% 49.1% 5.3% 66 60 40 28 22 10 (26 ) ... 71 149 126 22 .3% 27 .7% 58 .2% 49 .2% 54 65 118 108 19.1% 23 .0% 41.7 38 .2 249 25 4 97.3% 99 .2% 25 0 26 8 88.3% 94.7% Page of 13 (page number not for citation purposes) Conflict and Health 20 07, 1:4...
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Báo cáo y học: "Acute fluid shifts influence the assessment of serum vitamin D status in critically ill patients" pps
Ngày tải lên :
14/08/2014, 07:21
... elevated 1a ,25 (OH)2D3 levels through extra renal production of 1a ,25 (OH)2D3 [19] Alterations in VDBP are known to influence monocyte responses to 25 (OH)2D3 and 1a ,25 (OH)2D3 [20 ] Whether it played ... 14:R216 http://ccforum.com/content/14/6/R216 Page of Table Changes in serum total and ionised calcium, magnesium and phosphate T1 T2 T3 T4 T5 Total calcium (mmol/L) 2. 2 ± 0.1 1.9 ± 0.1* 2. 1 ± 0 .2* ... normal blood volume of L, this prime would increase the blood volume by an additional 40% Therefore, reductions of 25 (OH)D3, and 1a ,25 (OH)2D3 of 35% and 45% respectively at T2 would be consistent...
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The assessment of public knowledge on diabetes mellitus and patient reported outcomes measurement among patients with type 2 diabetes in thailand
Ngày tải lên :
11/09/2015, 09:56
... 30 28 27 24 21 20 18 17 20 12 10 10 10 -2 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40 42 44 46 48 50 overall score According to the grading criteria established, 26 .9%, 58.8% and 14.3% of ... 4 12 (41 .2) 73 (7.3) 515 (51.5) 23 3 (23 .3) 747 (74.7) 133 (13.3) 89 (8.9) 6 32 (63 .2) 164 (16.4) 494 (49.4) 25 5 (25 .5) 24 8 (24 .8) 25 5 (25 .5) 1 92 (19 .2) 5 52 (55 .2) 584 (58.4) 21 (2. 1) 395 (39.5) 22 3 ... obese† 767 (76.7) 125 ( 12. 5) 107 (10.7) constant thirst† 416 (41.6) 121 ( 12. 1) 4 62 (46 .2) frequent urination 650 (65.0) 67 (6.7) 28 3 (28 .3) unexplained weight loss 22 9 (22 .9) 421 ( 42. 1) 350 (35.0)...
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Heregulin enhanced tyrosine phosphorylation in breast cancer cells role of PP2A in HER 2 eu oncogenic signalling
Ngày tải lên :
11/09/2015, 10:06
... 44 2. 1 2. 1.1 2. 1 .2 2.1.3 2. 1.4 Materials Ligand and inhibitors Antibodies Cell-lines Fresh frozen clinical specimens 44 44 44 45 45 2. 2 2. 2.1 2. 2 .2 2 .2. 3 2. 2.4 2. 2.5 2. 2.6 2. 2.7 2. 2.8 2. 2.9 2. 2.10 ... cancer 1 1 .2 1 .2. 1 1 .2. 2 1 .2. 3 1 .2. 4 1 .2. 5 1 .2. 6 HER- 2/ neu-positive breast cancer Definition Clinical significance of HER- 2/ neu as a prognostic indicator in breast cancer Diagnosis of HER- 2/ neu-positive ... arrays 65 3 .2. 5 Validation of antibody array results 71 3.3 Discussion 73 CHAPTER REGULATION OF PP2A BY HER- 2/ neu 77 4.1 77 Overview 4 .2 4 .2. 1 4 .2. 2 4 .2. 3 4 .2. 4 Results 80 Inhibition of HER- 2/ neu signalling...
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Assessment of nutritional status among primary schoolchildren in krong bong district, daklak province
Ngày tải lên :
16/10/2015, 17:53
... 21 ,6 17 ,2 6,8 7 .2 7 .2 7,0 20 10 20 11 20 12 27 25 .6 24 .6 23 .8 22 .9 22 .1 2. 8 2. 4 2. 2 0.4 0.3 0.3 36.9 35.5 34.5 22 .6 21 .5 21 14.3 14 13.5 8 .2 7.9 7.8 WHz < -2 WHz +2 WHz >+3 Moderate Severe 20 05 34.3 28 .3 5.9 0.1 41.6 24 .1 17.5 6.9 20 06 20 07 20 08 20 09 32, 8 30.4 29 .1 28 ,4 27 ,4 25 .7 5,3 4.6 0,1 0.1 23 ,4 23 .5 17,0 17.7 25 ,5 2, 8 0,1 40,4 41 .2 39.5 38,8 21 ,6 ... 80 (26 .4%) 20 0 (66%) 23 (7.6%) Operating (n=18) (27 .8%) (50%) (22 .2% ) Total (n= 321 ) 85 (26 .5%) 20 9 (65.1%) 27 (8.4%) Health clinic (n =29 8) 79 (26 .5%) 199 (66.8%) 20 (6.7%) At Home (n =23 ) (26 .1%)...
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ASSESSMENT OF STATUS MEDICAL WASTE MANAGEMENT AND TREATMENTIN TUYEN QUANG GENERAL HOSPITAL
Ngày tải lên :
19/12/2015, 19:26
... total of solid hazardous medical waste (kg) Month 20 13 20 14 January 26 82 2741.5 February 24 31.5 23 60 March 24 87 22 36.5 April 26 73.5 27 43.5 May 27 94 27 16 June 26 93.5 26 63.5 July 26 19 27 82 August 27 56.5 ... August 27 56.5 26 48 September 27 23.5 26 87.5 October 3031 28 47 November 29 48 30 82 December 29 70.5 31 62 ( Tuyen Quang General Hospital, 20 13 & 20 14) 33 3500 3000 25 00 20 00 20 13 1500 20 14 1000 500 ... base of the study 2. 2 Theoretical base of the study 2. 2.1 Classification of the medical waste 2. 2 .2 Harmful effects of medical waste 11 2. 3 Current status of medical...
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