assessment methodology for systemic importance of g sibs

Báo cáo khoa học: Identiﬁcation of the structural determinant responsible for the phosphorylation of G-protein activated potassium channel 1 by cAMP-dependent protein kinase pdf

Ngày tải lên : 07/03/2014, 00:20

... using the catalytic subunit of PKA (PKA-cs) and [32P]ATP[cP] Autoradiograms of subsequent SDS gels revealed GIRK1 migrating in two bands, indicating a glycosylated and a nonglycosylated form, ... currents originating from the triple-mutated GIRK1F137S*** protein (C) Statistics of the effects of cAMP on basal currents of heterooligomeric GIRK1 ⁄ GIRK4, homooligomeric GIRK1 and homooligomeric, ... Langeberg LK & Scott JD (2006) AKAP signaling complexes: getting to the heart of the matter Trends Mol Med 12, 317–323 Rusinova R, Shen Y-MA, Dolios G, Padovan J, Yang H, Kirchberger M, Wang R...

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Selling Financial Products - A proven methodology for increasing sales of banking and financial services doc

Ngày tải lên : 23/03/2014, 11:20

... Overview of our Training in “Selling Financial Products” Marketing Strategy ■ Positioning of banking products ■ Analysing the product range ■ Launching new financial offerings ■ Marketing channels ... during the training But selling is one thing, selling profitably is quite another DC Gardner Training has developed best-practice negotiation skills training which, through practical negotiation games ... Handling client resistance ■ Objection-handling ■ Appropriate closing techniques Negotiating in the Financial Sector ■ Negotiating basis points ■ Negotiating fees and rates ■ Key rules of negotiation...

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báo cáo hóa học:" A decade of modelling research yields considerable evidence for the importance of concurrency: a response to Sawers and Stillwaggon" potx

Ngày tải lên : 20/06/2014, 08:20

... Sawers and Stillwaggon, I end with a call to leave open all promising areas Page of of research in trying to solve one of the world’s greatest public health crises Acknowledgements The author ... release of a public programming package for cross-sectional versions of these models that has been widely used in a variety of fields http://www.statnetproject.org However, additional modelling questions ... opening the door for a much broader array of dynamic network modelling investigations The first applied HIV epidemiology paper using this approach was recently published [26], appearing well before...

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Báo cáo y học: "An alternative methodology for the prediction of adherence to anti HIV treatment" ppt

Ngày tải lên : 10/08/2014, 05:21

... EuResist modelling work, this magnitude of change is suggested as it would give a large enough change to avoid inclusion of insignificant fluctuations in VL [38] These pairs of time points can then be ... adherence/non-adherence' groupings based upon the rate of change of VL and the presence of mutation Testing the hypothesis The preliminary work relating to testing this hypothesis requires longitudinal data ... produce pairs of VL measurements relating to the start and end points of an increase in log10 (VL) of greater than log – In keeping with the clinical practice underlying the EuResist modelling work,...

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báo cáo khoa học: "The efficacy of computer reminders on external quality assessment for point-of-care testing in Danish general practice: rationale and methodology for two randomized trials" pot

Ngày tải lên : 10/08/2014, 11:20

... Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark 2Section of General Practice and Research Unit for General ... would like to thank all participating GPs, the Capital Region and Copenhagen General Practice laboratory for providing data, Niels Hornum for programming the algorithm which were used to produce ... (92) 47 (52) INR* HGB/GLU** 0.35 (0.55) 1.07 (1.36) GP and practice characteristics Gender Mean number of patients per GP (SD) Practice organization Single Handed Group Point of Care Tests at baseline...

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Systemic risks of genetically modified crops the need for new approaches to risk assessment

Ngày tải lên : 17/02/2016, 11:38

... citizen groups It also lacked the strong focus on emerging commercial prospects of genetic engineering While the model of the NIH guidelines was adopted by many European governments, the emerging public ... Developing American and British regulatory policy for genetic engineering, 1972 - 1982 Chicago: The University of Chicago Press; 1994 NRC: Risk assessment in the federal government: managing the ... decisionmaking procedures cannot guarantee an appropriate reflection of these findings A way forward in integrating the concept of systemic risks” in GMO decision making could be the application of internationally...

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A methodology for validation of integrated systems models with an application to coastal-zone management in south-west sulawesi

Ngày tải lên : 06/11/2012, 10:35

... 1985): formulating the problem; identifying, designing, and screening the possible alternatives; forecasting future contexts or states of the world; building and using models for predicting the ... five different types of integration within the framework of Integrated Assessment Modelling (IAM) These are integrations of disciplines, of models, of scales, of issues, and of stakeholders Scrase ... University of Utrecht University of Utrecht ISBN 90-365-2227-7 Printed by: PrintPartners Ipskamp, Enschede Copyright © 2005 Tien Giang Nguyen All rights reserved A METHODOLOGY FOR VALIDATION OF INTEGRATED...

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Sanitation in Urban Poor Settlement and the Importance of Education for the Reduction of the Diffused Pollution - A Case Study of Bauniabad, Bangladesh

Ngày tải lên : 05/09/2013, 09:08

... bear 100% of the cost of the cleaning of the connection system such as pipes and connection pits in the case of blockage At this stage, the regular maintenance and cleaning of the biogas plant ... production of biogas for cooking as byproduct A survey concerning the willingness to pay for the installation, operation and maintenance of various options for water and sanitation was conducted before ... floating-drum type digester In most of the cases, the input is cow dung (Lichtman, 1987) Also in Bangladesh, there are some programs to promote the biogas technology lead by Bangladesh Council for...

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Tài liệu THE IMPORTANCE OF SOLITUDE FOR A BALANCED LIFE ppt

Ngày tải lên : 21/01/2014, 18:20

... advantages of solitude THE IMPORTANCE OF SOLITUDE FOR A BALANCED LIFE PUT YOUR LIFE IN PERSPECTIVE Being in your own company gives you the chance to see where you’re heading in terms of your ... both of which are essential for achieving spiritual THE IMPORTANCE OF SOLITUDE FOR A BALANCED LIFE peace The Buddha attained enlightenment after long and intense meditation on the challenges posed ... YOU LIKE One of the greatest advantages of solitude is freedom to what you desire You can read for as long as you want, watch that TV documentary about space without having to fight for the remote...

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Tài liệu The importance of interest rates for forecasting the exchange rate doc

Ngày tải lên : 15/02/2014, 05:20

... an out -of- sample forecasting exercise The forecasting performance of an alternative structural model that identifies a long run relationship based on pure PPP, thereby ignoring any long run link ... are: The log of the nominal exchange rate in Norway relative to its trading partners, log of home and foreign consumer prices and home and foreign interest rates, (see Appendix A for a further ... compared using levels on the left hand side, so that it is the forecast of (the log of) the actual exchange rate (and not its change) that are compared Following Meese and Rogoff (1983), we perform an...

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Tài liệu Báo cáo Y học: Importance of the amino-acid composition of the shutter region of plasminogen activator inhibitor-1 for its transitions to latent and substrate forms pdf

Ngày tải lên : 22/02/2014, 07:20

... Q334A/K335A Q334H Q334H/K335A Q334S S53A/Q334H G5 6A/Q334S G5 6S/Q334H G5 6S/Q334H/K335A S /G/ Q S /G/ Q A /G/ Q A /G/ Q S/A/Q S/S/Q S/S/Q S /G/ A S /G/ A S /G/ H S /G/ H S /G/ S A /G/ H S/A/S S/S/H S/S/H 87.1 ^ 22.2 (20) ... shutter region affect the rate of latency transition by affecting the rate of passage of the RCL through the gate region Based on the aminoacid sequence of the RCL and b strand 5A being directly ... by changing the local conformation of these residues, including their hydrogen bonds As there is no P1 –P10 cleavage during latency transition, strand insertion must imply the passage of the...

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Mechanisms for delayed density-dependent reproductive traits in ﬁeld voles, Microtus agrestis: the importance of inherited environmental effects doc

Ngày tải lên : 05/03/2014, 17:20

... 0.3-ha live-trapping grid was established, consisting of 100 Ugglan Special Mousetraps in a 10×10 conﬁguration with 5-m spacing The trapping regime followed the ‘robust design’ (Pollock 1982) ... Hence, the sum of weightings of animals of a particular characteristic divided by the total sum of weightings for all animals will be the same among the survivors as in the original sample (where ... weightings used to test for differences between samples of females 95% conﬁdence intervals of the parameters are given in brackets Models were selected according to the lowest AIC Weightings for...

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The importance of project management in small- and medium-sized enterprises (SMEs) for the development of new products through E-collaboration docx

Ngày tải lên : 07/03/2014, 00:20

... strategy for managing organizational change in contemporary organizations, with corporations, government, academia and other organizations recognizing the value of common project approaches and of ... Afr J Bus Manage Figure Trend of project management (source: Web of Science ® 2010) Figure Trend of SMEs (source: Web of Science ® 2010) Figure Trend of new product (source: Web of Science ® 2010) ... (2009).The role of monitoring and shirking in information systems project management J Project Manage (In Press) Mezgár I, Kovács GL, Paganelli P (2000).Co-operative production planning for small-...

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Báo cáo khoa học: The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts doc

Ngày tải lên : 07/03/2014, 05:20

... VIIIG 0 ct % Cell distribution (HT29) VIG Late Cell stage B OWG ct Early IVG VG VIG OWG IVG ct VIIIG VG VIG OWG IVG ct VIIIG VG VIG OWG IVG ct * * * VIIIG * 10 ct * VG * VIG 10 * OWG * * 15 IVG ... extracts 60 VG OWG VIG IVG VIIIG ct VG OWG VIG IVG VIIIG ct VG OWG VIG IVG VIIIG ct 70 * * * * * * * 10 20 % Cell distribution (HT29) ** 60 70 IVP S G1 G2 ct VIIIG ct VIIIG ct S Cell cycle stages S ... VIG IVG VIIIG ct VG OWG VIG IVG VIIIG ct * Cell cycle stages ** * * * 10 20 30 40 50 S * G1 S G2 Cell cycle at IC50 (Grape fractions) G1 Cell cycle stages Antiproliferative properties of natural...

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Báo cáo khoa học: Pressure and heat inactivation of recombinant human acetylcholinesterase Importance of residue E202 for enzyme stability pdf

Ngày tải lên : 08/03/2014, 10:20

... numerous negative charges located at the rim of the gorge did not participate to the entrance of substrate or ligand in the gorge [20], we tentatively suggest that this cluster of charges could ... 269) 4305 gorge is thought to be lower for wild-type enzyme than for D74N and E202Q, allowing ﬂexibility of the gorge for entrance and binding of substrates or inhibitors and exit of reaction ... that ANS binding is also favored by the overall electric charge of proteins [38,39] As observed for ANS binding to BSA, binding of ANS is thought to induce a conformational tightening of the protein...

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Methodology for Integral Water Pollution Assessment within Agricultural Area docx

Ngày tải lên : 15/03/2014, 23:20

... mgD/L mg/L mgO2/L mgO2/L μgN/L μgN/L μgN/L μgP/L μgP/L μgA/L mgD/L cfu/100 ml mgCaCO3/L gD/m2 mgC/L μgN/L μgP/L μgN/L mgD/L mgO2/L mgA/m2 μgN/L mgO2/L - Note distance in km conductivity inorganic ... COND_(UMHO ISS_(MGD/L DO(MGO2/L) CBODS_(MGO CBODF_(MGO NO(UGN/L) NH4(UGN/L) NO3(UGN/L) PO_(UGP/L) INORG_P_(U PHYTO_(UGA DETRITUS_( PATHOGEN ALK PH BOT_ALG_ (G TOC TN TP TKN TSS CBODU Bot Algae NH3 DO_SAT ... The methodology (figure 1) consists of three steps: • Application of GIS technologies GIS basis could be used to help in building cadastre of polluters It requires spatial geo-positioning of polluters,...

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Process-Based Self-Assessment Tool for the Organic Chemical l Industry: EPA Office of Compliance Chemical Industry Branch pptx

Ngày tải lên : 22/03/2014, 14:20

... acknowledge the support of the following individuals: George Jett Daniel Fort Conrad Simon Robert Kramer Gerald Fontenot Ken Garing Gene Lubieniecki David Mahler Hugh Finklea U.S EPA Office of Water ... include defining the objectives and scope of the assessment, identifying the assessment team, compiling and evaluating background information, and preparing the assessment plan or strategy Sample ... TSCA Regulatory Requirements G- 1 G- 3 G- 3 G- 4 G- 5 G- 6 G- 6 G- 7 G- 7 G- 8 G- 9 Appendix H References ...

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Báo cáo khoa học: Engineering of monomeric FK506-binding protein 22 with peptidyl prolyl cis-trans isomerase Importance of a V-shaped dimeric structure for binding to protein substrate docx

Ngày tải lên : 30/03/2014, 01:20

... follows: 5¢-AGAGAGAATTCATATGTCAGATT TGTTCAG-3¢ for primer 1; 5¢-TTCCATACCACCACCT GCAACTTGAAGCTC-3¢ for primer 2; 5¢-GTTGCAGGT GGTGGTATGGAACAGCATGCT-3¢ for primer 3; and 5¢-GGCCACTGGATCCAACTACAGCAATTCTCA-3¢ ... protein substrate of PPIase for binding to the trigger factor [26] and E coli FkpA [27], suggesting that RCM a-lactalbumin and a protein substrate of PPIase share a common binding site of FKBP family ... Technology Research Grant Program from the New Energy and Industrial Technology Development Organization (NEDO) of Japan References Lang K, Schmid FX & Fischer G (1987) Catalysis of protein folding...

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báo cáo hóa học:" Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors" docx

Ngày tải lên : 18/06/2014, 15:20

... limit of pore size in the BBTB of small RG-2 gliomas RG-2 glioma volumes (mm3): Gd -G1 , 27; Gd -G2 , 28; Gd -G3 , 19; LC Gd -G4 , 24; Gd -G4 , 17; Gd -G5 , 18; Gd -G6 , 22; Gd -G7 , 24; Gd -G8 , 107 Respective Gd-dendrimer ... (LC) Gd -G4 , 162; Gd -G4 , 200; Gd -G5 , 230; Gd -G6 , 201; Gd -G7 , 170; Gd -G8 , 289 B) Small RG-2 gliomas Gd -G1 thorough Gd -G6 dendrimers extravasate across the BBTB of the microvasculature of small RG-2 ... since Gd -G8 dendrimers are larger than the physiologic upper limit of pore size in the BBTB of large RG-2 gliomas RG-2 glioma volumes (mm3): Gd -G1 , 104; Gd -G2 , 94; Gd -G3 , 94; lowly conjugated...

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Báo cáo sinh học: " A critical assessment for the value of markers to gate-out undesired events in HLA-peptide multimer staining protocols" pot

Ngày tải lên : 18/06/2014, 22:20

... staining, in collaboration with the CIC executive office and the steering committee of the CIC Immunoassay working group The authors of this group acknowledge the concept of the Minimal Information ... using different gating strategies, the Wilcoxon signed rank test for paired comparisons was used To compare the percentage of MULTIMER+ CD8+ cells between labs that used different gating strategies, ... staining conditions Influence of gating styles and role of MULTIMER binding to CD8-negative cells A well-known critical factor in determining the amount of antigen specific cells is the placement of...

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