artificial systems for molecular recognition of mycotoxins
Structure basis for molecular recognition of folic acid by folate receptor
Ngày tải lên :
09/09/2015, 11:28
... molecular target for the development of many cancer therapeutics Despite intense research on the folate structureactivity relationship, the molecular basis for the high affinity recognition of ... primary form of folate in circulation is 5-methyl tetrahydrofolate (5-methyl THF) [7] a) b) Figure Chemical structure of folic acid and folate derivatives a) Constitution of folic acid b) Tetrahydrofolate ... expression of FRs 44 3.1.1 Screening of bacterial expression tags for FRα 44 3.1.2 Screening of FRs from different species 45 3.1.3 Purification and in vitro refolding of MBP-FRα...
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báo cáo hóa học:" Research Article Automatic Speech Recognition Systems for the Evaluation of Voice and Speech Disorders in Head and Neck Cancer" pdf
Ngày tải lên :
21/06/2014, 20:20
... of “very good normal speech.” For the four raters of the OC patients there was no need to alter the Likert scale For both databases the mean score of all perceptual evaluations was computed for ... scores of the raters and the WR even though both scales differ in their order of magnitude Comparisons of the mean values were performed using Student’s T-test The test for normal distribution of ... length of 16 milliseconds The frame rate is 100 Hz The filter bank for the Mel-spectrum consists of 25 triangular filters Delta coefficients of the 12 static features are computed over a context of time...
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Báo cáo hóa học: " Research Article Comparing Robustness of Pairwise and Multiclass Neural-Network Systems for Face Recognition" pot
Ngày tải lên :
22/06/2014, 19:20
... robustness of the face recognition systems to the data density In these experiments, we compare the performances of both recognition systems trained on the datasets containing different number of samples ... Number of neurons 0.8 150 classes 0.6 50 100 150 Number of neurons 0.4 200 (c) 50 100 150 Number of neurons 200 (d) Figure 7: Performances of the multiclass recognition systems over the number of ... out to evaluate the performance of this technique on synthetic and real face images datasets The performances of the pairwise -recognition systems are compared with those of the multiclass neural...
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Tài liệu MULTICOLOR QUANTUM DOTS FOR MOLECULAR DIAGNOSTICS OF CANCER doc
Ngày tải lên :
15/02/2014, 05:20
... well suited for monitoring biological systems for long periods of time, which is important for developing robust sensors for cancer assays and for in vivo imaging A further advantage of QDs is ... S i– OH Multicolor quantum dots for molecular diagnostics = Expert Review of Molecular Diagnostics Figure Diagram of two general strategies for phase transfer of tri-n-octylphosphine oxide (TOPO)-coated ... sections of tumor biopsies is not simple due to the high autofluorescence and the loss of antigen presentation associated with the Figure Molecular imaging of cells and tissues (A) 3D imaging of intracellular...
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Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor ppt
Ngày tải lên :
08/03/2014, 08:20
... at a flow rate of 1.5 mLÆmin)1 Retention times were 7.3 for SP, 8.6 for [Ala9]SP, 7.5 for [HGly9]SP, 7.1 for [(R)-b2-HAla9]SP and 7.7 for [(S)-b3-HAla9]SP Enzymatic assays were performed twice ... conformers of Ac-HGlyNHMe obtained with DISCOVER and AMBER forcefield Table S2 Minimum-energy conformers of Ac-b2-HAlaNHMe obtained with DISCOVER and AMBER forcefield Table S3 Minimum-energy conformers ... cannot overlap any conformation of a-amino acids In order to visualize on the potential energy surfaces the conformers of b-amino acids that fit with canonical conformations of a-amino acids, two...
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Báo cáo khoa học: A profile of the residues in the second extracellular loop that are critical for ligand recognition of human prostacyclin receptor pdf
Ngày tải lên :
23/03/2014, 07:20
... strands of the template, were extended during the temperature cycling (95 °C for 30 s, 53 °C for 30 s, and 68 °C for 13 min) for a total of 25 cycles, with an additional extension cycle of 68 °C for ... containing unit of polymerase (New England Biolabs, Beverly, MA, USA), 0.4 lm each primer, and lL of human lung cDNA, for 30 cycles of 98 °C for min, 60 °C for min, and 72 °C for The amplified ... proteins of GPCRs, the only crystal structure that has been successfully determined is that of rhodopsin [11–14], which offers a structural template for the molecular modeling of the TM domains of...
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Báo cáo khoa học: Structural basis for the recognition of complex-type biantennary oligosaccharides by Pterocarpus angolensis lectin ppt
Ngày tải lên :
23/03/2014, 11:20
... position of mannose is drawn in light green, as is the corresponding orientation of the side chain of Glu221 The second conformation of the side chain of Glu221, which also adopts two conformations ... Carbohydrate recognition by PAL L Buts et al Fig The monosaccharide binding site of PAL (A) Stereo view of the monosaccharide binding site of PAL in absence of bound carbohydrate The electron density for ... site of subunit A, but adopts an a ⁄ b mixture in the binding site of subunit B Accommodation of the b-configuration in the binding site of PAL requires a change in the rotamer conformation of Glu221...
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Báo cáo hóa học: " Probabilistic polynomial dynamical systems for reverse engineering of gene regulatory networks" docx
Ngày tải lên :
21/06/2014, 03:20
... and consists of two Gröbner cones of equal sizes (volumes) Each one of the two coordinate polynomials for f1, for instance, corresponds to of the total size of the Gröbner fan Therefore, under ... expense of having to compute the entire Gröbner fan of the ideal of points For small networks the computation of the fan is feasible but as the number of network nodes increases, the complexity of ... coefficient of in(g) in g is for each g ∈ G 2.3 Ideals of points Given a set of points, it is often necessary to find all the polynomials that vanish on it Such a set of polynomials forms an ideal...
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Báo cáo y học: "Clinical guidelines for the recognition of melanoma of the foot and nail unit." doc
Ngày tải lên :
10/08/2014, 21:24
... The prognosis for melanoma corresponds to the histological (Breslow) thickness of the excised tumour This represents a measure of depth of invasion of the tumour into the dermis For example, a ... modification of the ABCD rule developed for detection of suspicious pigmented lesions on the skin and applied it to the nail unit [39] First is A for Age, in the 5th to 7th decade of life B stands for ... worse prognosis than for other melanoma A large UK survey of regions demonstrated that NUM represented 1.4% of melanoma over a 10 year period, giving an incidence of per million of population per...
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Báo cáo y học: "The intelligence in developing systems for molecular biology" potx
Ngày tải lên :
14/08/2014, 17:22
... in the dataset RNA bioinformatics and structural informatics The importance of ncRNAs was recognized in 2006 by the award of the Nobel prize for Physiology or Medicine for work on RNA interference ... Gene-expression profiling is commonly used as a tool for identifying genes that are important for the development and maintenance of different cell types Yuan Qi (Massachusetts Institute of Technology, ... quality of talks on this topic at the meeting One theme was the detection of potential ncRNAs in genome sequences Shaujie Zhang (University of California, San Diego, USA) introduced a framework for...
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New radial basis function network based techniques for holistic recognition of facial expressions
Ngày tải lên :
16/09/2015, 17:11
... region of values in the inner cheek / nasal regions (a) for primary dataset and (b) for Half-face dataset 149 7.1 A summary of overall performance of different types of classification systems ... used for training the neural network Results obtained using the remaining 15 subjects showed recognition rates of 86.7% for Surprise, 91.7% for Fear, 92.3% for Anger, 92.9% for Sad and 84.6% for ... terms of some preconceived categories of emotions This technique is primarily intended for recording of emotions in infants and therefore is based on eight different categories of emotions often...
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Robotic systems for inspection surveillance of civil structures
Ngày tải lên :
24/02/2016, 10:27
... Accepted by the Faculty of the Graduate College, The University of Vermont, in partial fulfillment of the requirements for the degree of Master of Science specializing in Mechanical ... the thoroughness of these inspections The application of robotic systems for structural health monitoring may provide a successful means of improving the efficiency and accuracy of structural integrity ... assisting human efforts This work describes the development of an autonomous robotic system for the inspection of steel bridge girders This system serves as a mobile platform for structural health...
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A063 precast concrete pier systems for rapid construction of bridges in seimic regions
Ngày tải lên :
31/10/2016, 21:34
... 10.1: 10.2: 10.3: Comparison of Performance of Reinforced Concrete and Hybrid Frames .205 Sensitivity of Performance, Reinforced Concrete Frames 207 Sensitivity of Performance, Hybrid Frames ... Details for Complete Opening Connection for Reinforced Concrete Frames 33 Column and Cap-Beam for Complete Opening Connection for Reinforced Concrete Frames 34 Elevation of ... Reinforced Concrete Frames 24 Cap-Beam Details for Slotted Opening Connection for Reinforced Concrete Frames 29 Column and Cap-Beam for Slotted Opening Connection for Reinforced...
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Báo cáo khoa học: Molecular basis for substrate recognition and drug ˚ resistance from 1.1 to 1.6 A resolution crystal structures of HIV-1 protease mutants with substrate analogs pptx
Ngày tải lên :
30/03/2014, 20:20
... from PR–p2-NC was observed for the Fig Residues with alternate conformations The number of occurrences of alternate conformations for each residue in the A and B subunits of the eight crystal structures ... structures of HIV PR with natural cleavage substrate analogs provide new molecular details for understanding the specificity of substrate recognition and a basic framework for the design of new inhibitors ... contacts with the CB atom of Ala82 in PRV82A than observed for Val in the ˚ PR The CE atom of P3¢ Arg moved 1.2 A and formed closer interactions with the CB atom of Ala82 All of these observed structural...
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Báo cáo hóa học: "Mechanical tuning of molecular machines for nucleotide recognition at the air-water interface" pot
Ngày tải lên :
21/06/2014, 04:20
... = mN · m-1) Therefore, conditions suitable for discrimination of the nucleotides and for most efficient binding of a single nucleotide component can be selected The molecular recognition system ... 4A, the binding constants of the nucleotides to the monolayer of gradually decreased as the surface pressure increased This is because expansion of the molecular area of by binding to the nucleotides ... pressures Complexation of Li+ ion by the triazacyclononane ring causes two variations in the characteristics of the recognition system The presence of Li+ ion at the core of ensures strong electrostatic...
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Dendritic cells respond differently to live and killed bacteria molecular mechanisms of pathogen recognition by dendritic cells and implications for vaccine development
Ngày tải lên :
14/09/2015, 08:24
... Figure 1.3 Role of TLRs in the control of adaptive immunity TLRs sense the presence of infection through recognition of PAMPs (pathogen-associated molecular patterns) Recognition of PAMPs by Toll-like ... induction of adaptive ve immunity as differentiation of these cells into Th1 or Th2 cells, determine the nature of adaptive immune response (116) T cell activation requires not only recognition of foreign-peptide-MHC ... vaccination, a further understanding of the mechanism of adjuvant recognition and structural characteristic of TLRs in immature DCs could be beneficial for the evaluation of possible advantageous effects...
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Báo cáo y học: "The Diels-Alder-Reaction with inverse-Electron-Demand, a very efficient versatile Click-Reaction Concept for proper Ligation of variable molecular Partners"
Ngày tải lên :
26/10/2012, 09:39
... subsequently for the transport into subcellular components like the cell nucleus for imaging of molecular processes at the transcriptional level Therefore rapid and selective ligation of pharmacologically ... wide range of dienophilic compounds is available for DARinv In order to obtain reaction times in the range of minutes for the DARinv, the reactivity of the dienophile is decisive for the rapid ... inside of the cyclobutene ring The presence of a further double bond inside of the cyclohexene ring is not of relevance due to the inactivity of this double bond in the DARinv The anhydride ring of...
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Diffusion of photovoltaic systems for rural electrification in Thailand
Ngày tải lên :
05/09/2013, 16:10
... three main formats according to the informants One format of the interview guide is for officers from eight governmental agencies who are the subjects of the overall case The second format aims ... Office of the Basic Education Commission (OBEC); iv Office of the Non-formal and Informal Education (ONIE); v Vocational Education Commission (VEC); NSTDA (2008) Memorandum of understanding for ... is that the transformation to sustainable forms of energy in rural areas of developing countries may take time and need a lot of efforts Even if the energy is provided for free of charge, there...
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Molecular Biology of Secondary Metabolism - Case Study for Glycyrrhiza Plants
Ngày tải lên :
25/10/2013, 05:20
... shows the contribution of this strategy to the development of plants with biofarming potential in the frame of a high demand of natural and ecologically accepted sources of renewable compounds ... the aglycone of glycyrrhizin, into seven biotransformation products, but formation of glycyrrhizin was not detected among the biotransformation products To elucidate the regulation of the triterpene ... well as the pattern of chemical conversion of intermediate metabolites showed that hydroxylation of C-24 methyl group of glycyrrhetinic acid occurs at the first step of biotransformation, which is...
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22 global optimization for parameter estimation of dynamic systems lin chinese 2005
Ngày tải lên :
12/01/2014, 22:03
... can be used to estimate the parameters of dynamic systems • A validated solver for parametric ODEs is used to construct bounds on the states of dynamic systems • An efficient constraint propagation ... Construct Taylor models of the states using a new validated solver for parametric ODEs (VSPODE) (Lin and Stadtherr, 2005) – Compute the Taylor model Tφ of the objective function – Perform constraint ... where, S is the interval bound of other terms by direct evaluation Taylor Models - Constraint Propagation • Goal – to reduce part of domain not satisfying c(x) ≤ • For some i = 1, · · · , m bi...
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