art science and innovation in the treatment of early trauma

... tissue and gastrointestinal tract, as well as other sites, are known to reach the CNS to effect changes in feeding behavior and energy expenditure Thus, insulin, leptin and ghrelin, as well as other ... closely and rapidly with reciprocal changes in the levels of the orexigenic and anorectic Signaling mediators in the treatment of obesity neuropeptide expression in the hypothalamus [22] Thus an increase ... explored further Other areas of the brain have also been shown to regulate feeding via AMPK [35,36] Of interest is the extensive use of fructose as a sweetener in the human diet [37] Glucose and fructose...

Ngày tải lên: 14/02/2014, 22:20

... at each phase of the cell cycle by various complexes of cell-cycle-related molecules, including cyclins, cyclin-dependent kinases, their inhibitors and the retinoblastoma protein (RB), as well ... calorie intake induces expression of RMI1 and E2Fs in adipocytes, and these changes in expression are expected to increase a positive interaction between the molecules The increased expression of ... recruitment of preadipocytes [12], suggesting that these cyclin-dependent kinase inhibitors are important in the regulation of adipocyte number The S-phase kinase-associated protein (Skp)1–CullinF-box...

Ngày tải lên: 06/03/2014, 01:20

... effective in the treatment of psychotic major depression, and the switch to sertraline worsened the psychotic symptoms in the patient The mechanisms underlying the opposite effects of these two ... fluvoxamine binds to sigma-1 receptors in the intact human brain at therapeutic doses [25], suggesting that sigma-1 receptors are involved in the active mechanisms of fluvoxamine [19] Interestingly, ... that activation of the dopaminergic system by the inhibition of dopamine transporter may be involved in the mechanism of unwanted effects (deterioration of psychosis) of sertarline in this case,...

Ngày tải lên: 08/08/2014, 23:21

... approved the final manuscript Competing interests The funding source had no influence on study design, in the collection, analysis, and interpretation of the data, in the writing of the manuscript, ... telbivudine are more widely used in treatment of CHB In this systematic review, we focus on the comparison of the efficay of lamivudine and telbivudine in the Figure Effect of telbivudine vs lamivudine ... of the healthcare system is not satisfactory There are limitations in the reimbursement of anti-HBV therapy, either in the selection of agent or the duration of dosing Therefore, lamivudine and...

Ngày tải lên: 12/08/2014, 01:21

... further investigations in controlled, randomized and probably multicentre trials to evaluate the clinical value and the appropriate dosage of L-carnitine in each of these conditions Competing interests ... pathophysiology and significance of VPA-induced carnitine deficiency and evaluated the literature pertaining to carnitine supplementation during VPA therapy in children Despite the lack of prospective, randomized ... [38] Administration of exogenous carnitine is thought to decrease ammonia levels by binding to VPA, thereby enhancing the β-oxidation process and production of acetyl-CoA, and relieving the inhibition...

Ngày tải lên: 12/08/2014, 22:22

... pressures and short-term survival, in comparison to the single use of epinephrine This study adds some evidence to the existing literature of the epinephrine-vasopressin combination benefits and further ... vasoconstrictive Page of (page number not for citation purposes) effect of the combination of the two drugs in comparison to epinephrine alone in the first minute of CPR with an increase of CPP This increase ... interpretation of the clinical outcome in vasopressin studies The authors recognize several limitations in the interpretation of the present findings The study was conducted on apparently healthy pigs and...

Ngày tải lên: 13/08/2014, 08:21

... [16] and the possibility of costs minimization [8, 14] The disadvantage of lacking inspections of the sponges can be compensated by daily controlling of the canister fluid and monitoring of the inflammation ... of an endoprosthesis involving the local tissue and causing an immune reaction [15] The most common problem hereby is the draining sinus, prolongating and preventing wound healing The pathophysiological ... haemodynamics, the surrounding tissue is decompressed and local microcirculation is re-established The increase of the oxygen gradient facilitates the transportation of toxins and inhibitors inducing thereby...

Ngày tải lên: 26/10/2012, 09:53

... approximately 15 minutes, the physicist then loaded the corresponding radiation plan onto the controller unit contaminating the field The catheter end was passed through a hole in the drape and a FlexiShield™ ... Results The radiation oncologist then broke scrub, attached the XB controller to the catheter, and inserted the radiation source into the balloon The radiation therapy was then Figure and no evidence ... cc was found to be the proper size, a × cm XB balloon catheter kit was then opened by the OR staff The CED was then deflated and removed and a XB was then inserted in place of the CED If a 40 cc...

Ngày tải lên: 09/08/2014, 04:21

... developed the design of the randomised clinical trial and participated in writing the article MSLY is the principal investigator and writer of this manuscript DDN, MSLY, JPF, NLMV, JBN, NMV and PM ... placebo in reducing the severity of the three symptom clusters of PTSD, as well as alleviating the symptoms of depression, and in improving the quality of life measures The current evidence base of ... Although there are limited clinical studies with topiramate in the treatment of PTSD, the findings of prior topiramate studies suggest that this anticonvulsant may be promising in the management of...

Ngày tải lên: 11/08/2014, 17:20

... 2004, of portacaval shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution ... syndrome), including carbamazepine, phenytoin, phenobarbital, and lamotrigine The triad of hypersensitivity includes fever, rash and internal organ involvement with onset of symptoms within to weeks of ... pre-dialysis and 2–3 hrs following the post-dialysis dose There is a case report in which lithium levels were maintained in the therapeutic range by intraperitoneal administration of lithium during continuous...

Ngày tải lên: 25/10/2012, 10:51

... arthritis or other types of pain) or is unwilling to stop taking other medications for the treatment of OA Any other condition that, in the opinion of the investigator, would adversely affect the subject's ... one month prior to study and during the study, other than multivitamin and mineral supplements containing vitamins and minerals as the sole medicinal ingredients Use of concomitant prohibited ... Subjects in the UC-II group were instructed to take two “sugar pills” in the morning to protect blinding and two UC-II capsules in the evening accounting for a daily dose of 40 mg UC-II containing...

Ngày tải lên: 26/10/2012, 09:48

... medical treatment in 1998 This was partly because of confusion in the field about pupil age, and partly because in the early stages of the program several of the Kenya Ministry of Health nurses administered ... charts, and the training of teachers in each treatment school on worm prevention Health education stressed the importance of hand washing to avoid ingesting roundworm and whipworm larvae, wearing ... base their conclusions suffer from several shortcomings First, existing studies randomize the provision of deworming treatment within schools to treatment and placebo groups, and then examine the...

Ngày tải lên: 22/03/2014, 15:20

... the quantum theory The only uncertainty, according to Einstein, lay in our inability or lack of ingenuity in measuring the objective properties of such systems When Bohr and Einstein met at the ... totally independent of the state of the observer This is the deeper meaning of Einstein’s great discovery Behind all phenomena are laws of nature, and the form of these laws, their most elegant mathematical ... live within the heart of the material world We are all participators in the world, and the entrance fee we pay is living with a measure of uncertainty Uncertainty also exists in another and even...

Ngày tải lên: 09/04/2014, 16:38

... existing node The links would show up as a numbered list at the bottom of each page, and the only way of finding information was by browsing the links, starting from the start page The links between ... existing resources The space of innovation exists in the periphery and on the margin, in under-specified, undetermined and unused spaces Innovation can, however, also exist in interstices of current ... At the level of ecology of communities of practice, the speed of recombination has therefore increased The space of recombination has become an increasingly dominant space for innovation The...

Ngày tải lên: 01/06/2014, 10:08

... screening including erythrocyte sedimenta- Page of tion rate and C-reactive protein was normal Plain radiographs revealed areas of periprosthetic osteolysis in the femur and the tibia, and a ... image of the left knee showing the introducing cannula and simultaneous venting of the medial tibial condylar cyst Discussion When dealing with massive periprosthetic osteolysis the aims of surgery ... Orthop Scand 2002, 73(2):157-64 Yetkinler DN, Ladd AL, Poser RD, Constantz BR, Carter D: Biomechanical evaluation of fixation of intra-articular fractures of the distal part of the radius in cadavera:...

Ngày tải lên: 20/06/2014, 04:20

... caspase-3 and cleaved PARP proteins in mice Increase in the expression of caspase-3 and cleaved PARP proteins noticed in the mice treated in vivo with GnRH-Ag also showed increase in the number of atretic ... receptors, and steroidogenic and apoptotic factors in the ovary was investigated following in vivo and in vitro administration of GnRH agonist in the intact cyclic mice Methods Animals All the experiments ... planned and executed the experiments, responsible for data interpretation and writing of the manuscript, AK helped in planning and supervised the work, participated in data analysis and interpretation...

Ngày tải lên: 20/06/2014, 07:20

... Journal of the International AIDS Society 2004, 6:56 http://www.jiasociety.org/content/6/3/56 sharing, and education that must attend expanding global HIV/AIDS care initiatives Authors and Disclosures ... grants for clinical research and/ or honoraria for educational and/ or advisory activities from Bristol-Myers Squibb, Boehringer Ingelheim, Gilead Sciences, GlaxoSmithKline, Idenix, Merck, and Roche ... Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical researc h in our lifetime."...

Ngày tải lên: 20/06/2014, 08:20

... Annals of General Psychiatry 2009, 8:16 the treatment of acute mania, the approval of quetiapine and the olanzapine-fluoxetine combination against acute bipolar depression and the approval of olanzapine, ... reliability and validity of psychiatric diagnosis perplexes the problem and makes the gathering of scientific data difficult, because the diagnosis of BD in particular is often made retrospectively and ... dose at the end of the study was 15.5 mg daily The results suggest that in weeks to and then again at week there is a significant reduction in the MADRS scores in the aripiprazole group in comparison...

Ngày tải lên: 08/08/2014, 23:21

... concerning radiotherapy and followed up the patient at his out-patient clinic AK was the radiologist performing the preoperative and postoperative CT and MRI scans and wrote the part of the paper ... contributions All of the authors have been involved in drafting this paper and have read and approved the final manuscript KG conceived the idea of the paper, reported the case, performed the literature ... radiotherapy and conventional fractionation while minimising the risks of RT-inducing brain injury like radiation necrosis and cognitive decline The optimal radiation dose has not yet been defined We...

Ngày tải lên: 09/08/2014, 09:20