applying nature s principles to personal design
A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 1 ppsx
Ngày tải lên :
14/08/2014, 07:20
... agents in the same class of drug/device In some instances, for example, when you want to demonstrate that your treatment is as efficacious as the standard but has fewer, less severe side effects, ... need to spend far more time on planning, less on the repairs My pessimism stems, in part, from my having spent the last twenty-five years as a consultant to drug and device firms As a consultant, ... nondiabetics) and to assess the effects of concurrent medications and various risk factors on the ultimate outcome The longer time period provides for an assessment of the effects of chronic usage...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 2 pps
Ngày tải lên :
14/08/2014, 07:20
... investigators for the study The medical monitors will answer all questions from investigators as to the procedures to be followed and will investigate possible protocol violations A statistician—preferably ... disaster Track Progress With the assignment of personnel to the team, begin to establish milestones and track progress If multiple projects are underway, progress should be tracked across as ... others, encourage differing points of view yet obtain consensus, assign and organize tasks, and make, not defer, decisions He or she is responsible for establishing milestones, making personnel asignments,...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 3 pps
Ngày tải lên :
14/08/2014, 07:20
... discussion, it is easy to see that baseline measurements offer two opportunities for reducing person -to- person variation First, some components of the baseline measurements such as demographics ... results for each years Exclude all those with diastolic vessel separately? blood pressure over 105 mmHg as • Report the results on a patientby-patient basis, choosing measured on two occasions ... and risk factors can be used for forming subgroups or strata for analysis Second, obtaining a baseline measurement allows us to use each individual as his own control Without a baseline measurement,...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 4 potx
Ngày tải lên :
14/08/2014, 07:20
... and to ask questions I hereby consent to take part in this study Signature of Participant Date Signature of Investigator Date Signature of Witness Date PROCEDURES MANUALS The design process is ... adverse events or that the events are affecting only a single subgroup such as those with specific risk factors or the most preexisting complications In such an instance, you may wish to stop enrolling ... deviations, excessive numbers of adverse events, or evidence of fraud can be traced to a few specific sites, then the first obvious step is a visit to the site by the clinical research monitor In most...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 5 potx
Ngày tải lên :
14/08/2014, 07:20
... here to see a list of patients with missing treatment assignments • Click here to view program logic • Click here to view SAS programs 100 PART II DO Binary residual stenosis based on an analysis ... has been extensive research in the area, no single set of demographic factors has proved to be consistent predictors of success (See, for example, some of the articles in Haynes, Taylor, and Sackett, ... here to see a list of patients with missing film data • Click here to view program logic • Click here to view SAS programs Postprocedural residual stenosis based on reports from 670 patients was...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 6 pdf
Ngày tải lên :
14/08/2014, 07:20
... information, risk factors, medical history, physical assessment, current medications, and baseline laboratory values For the reasons outlined in Chapter 7, these screens should already be tested and ... user should not be able to advance to the next screen of a series without filling in answers to all the questions on the screen she is currently viewing The second purpose of testing is to ensure ... sequence is to conduct training on a trial basis at one or two sites, then to give one or two group training sessions, and then to follow up with individual sessions for those sites who missed the...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 7 pot
Ngày tải lên :
14/08/2014, 07:20
... remind investigators of their responsibilities as necessary, and with the assistance of the CRMs reward investigators for successful execution of their responsibilities The CRM is responsible for ... Proposal Physician s manual Informed consent form Laboratory manuals Patient instructions INVESTIGATORS Investigators have been recruited Your staff has visited the sites of all investigators and ... expenses at the investigator s site are excessive The CRM s responsibility is to document all the expenses involved and be in a position to compare them with expenses at other sites If it is the...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 8 pot
Ngày tải lên :
14/08/2014, 07:20
... ADVERSE EVENTS Excessive numbers of serious adverse events can result in decisions to modify, terminate, or extend trials in progress Comments from investigators along with ongoing monitoring ... problems related to these committees have to with the dissemination of observations to committee members, the collection of results, and the entry of results into the computer Today, digital dissemination ... 13 Control Drug Responded 2 10 2 11 1 N 32 18 15 19 10 17 15 27 18 11 19 11 48 48 13 13 Thus the first steps in our analysis must be to address these issues Consider the results summarized in Table...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 9 doc
Ngày tải lên :
14/08/2014, 07:20
... with a statistical analysis of the set of adverse events as a whole as well as supplementary analyses of classes of adverse events that are known from past studies to be treatment or disease specific ... as seminars at Are the assumptions for the test local universities and think tanks are satisfied? musts If the only texts your statisti• Samples randomly selected cian has at her desk are those ... is too sick to come into the physician s office Noncompliant patients are also likely to skip visits You need to analyze the data to ensure that the proportions of missing observations are the same...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 10 potx
Ngày tải lên :
14/08/2014, 07:20
... SAS Campus Drive, Cary, NC 27513 (Windows, MVS, CMS, VMS, Unix) www.sas.com SPSS The poor man s SAS, offers ease of use along with a large number of statistics A bootstrap subcommand provides ... Human Subjects (CPHS) Critical value, 222 Critical terms, 49 CRMs See Clinical research monitors (CRMs) CROs See Contract research organizations (CROs) Crossover design, 70 Crossovers, 205 Cross ... has been used in APPENDIX SOFTWARE 243 dozens of submissions Versions for Windows or Unix Also available as an add-on module for both SAS and SPSS Cytel Software Corporation, 675 Massachusetts...
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Applying cooperative learning principles to the teaching of English speaking skills in large classes = Ứng dụng các nguyên lý học hợp tác vào việc dạy kỹ năng n
Ngày tải lên :
28/03/2015, 09:07
... and discussion Besides, they were asked not to discuss too loudly so as not to affect other groups as well as to control the noise of the whole large class The assessment was also made known to ... used variety of tools which are class observation, informal interviews, questionnaires and students’ journals and speaking test scores, the discussion in the previous chapters has made it possible ... students helped the weaker to fulfill the common tasks 3.2.7 Less time-consuming: it saves a great amount of time as many students speak at the same time Besides, the teachers s assessment is given...
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focal press tradigital blender, a cg animator's guide to applying the classic principles of animation (2011)
Ngày tải lên :
03/04/2014, 13:11
... before it stops, it slows down, unless it does something disastrous like smashing into a concrete wall, in which case it stops almost immediately and probably exhibits some extreme squash and stretch ... 2.17 Setting the control s value to 1.0 uses the full IK solution At 0.0, it uses the FK position Values in between show a blend of the two different possible poses Sometimes these blended poses ... from to 11, two frames less Thus, the motion happens more quickly, resulting in fewer ghosts (less frames), which are further apart (because distance shows velocity) This was just a demonstration...
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the book of css3 - a developer's guide to the future of web design - by peter gasston
Ngày tải lên :
20/09/2013, 09:09
... discuss DOM selectors CSS3 provides three new attribute selectors and one new combinator—that is, a selector that joins other selectors together, such as the child combinator (>) from CSS2 These ... CSS3 Is and How It Came to Be First, I want to discuss what CSS3 is—and isn’t—and the form it takes The W3C s approach to CSS3 is quite different from its approach to CSS2, so this overview should ... Recommendation status As long as you make provisions for Internet Explorer s lack of support, you can start using CSS3 selectors right away—many sites already Attribute Selectors Attribute selectors were...
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Tài liệu The Web Designer’s Guide to iOS Apps: Create iPhone, iPod touch, and iPad Apps with Web Standards (HTML5, CSS3, and JavaScript) pdf
Ngày tải lên :
12/02/2014, 20:20
... easy-touse device for listening to music, news, information, and audio books, and seeing photos or even watching movies and TV shows This isn’t business content This is life content Interestingly, ... THE WEB DESIGNER S GUIDE TO IOS APPS In order to design iOS applications, you need to establish what I call your app design studio This studio will be the place in which you design, test, and ... United States and other countries Many of the designations used by manufacturers and sellers to distinguish their products are claimed as trademarks Where those designations appear in this book,...
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Tài liệu Nature’s Numbers Expanding the National Economic Accounts to Include the Environment doc
Ngày tải lên :
13/02/2014, 23:20
... mineral reserves This effort reflects a serious and professional attempt to value subsoil mineral assets and assess their contribution to the U .S economy BEA s methods are widely accepted and used ... picture is therefore missing if natural assets are omitted in creating the national balance sheet Likewise, consuming stocks of valuable subsoil assets such as fossil fuels or water or cutting first-growth ... inputs and outputs often include the free goods and services provided by environmental assets such as air, water, forests, and complex ecosystems Many of these assets—such as recreational sites...
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Tài liệu User-Centered Design: A Developer''''s Guide to Building User-Friendly Applications ppt
Ngày tải lên :
21/02/2014, 10:20
... Addison-Wesley Pro‐ fessional, Microsoft Press, Sams, Que, Peachpit Press, Focal Press, Cisco Press, John Wiley & Sons, Syngress, Morgan Kaufmann, IBM Redbooks, Packt, Adobe Press, FT Press, Apress, ... www.it-ebooks.info Design principles Fortunately for us, many principles exist to guide us towards proven designs that work We’ll discuss some of the most popular design principles you can apply to your ... employ to solve user-experience concerns Usability studies Observing users while they use your applications is one of the most important processes in usability research We’ll discuss the various tools...
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DNA-Templated Organic Synthesis: Natures Strategy for Controlling Chemical ReactivityApplied to Synthetic Molecules** doc
Ngày tải lên :
05/03/2014, 21:20
... organic solvents While in some respects an aqueous solvent is a constraint that prevents the use of strongly basic or strongly acidic reactants, the above analysis suggests that water is also a ... DNA-Templated Synthesis Figure 10 Three linker strategies for DNA-templated synthesis.[47] Cleavage of a “useful scar linker” generates a functional group that serves as a substrate in subsequent steps A ... addition to its sequence, can be transferred to the products of a templated synthesis In theory, stereoselective DTS could also be used to alter the distribution of stereoisomeric products arising...
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A Designer''''s Guide to Adobe InDesign and XML: Harness the Power of XML to Automate your Print and Web Workflows pptx
Ngày tải lên :
14/03/2014, 23:20
... SGML that stresses content over design XSD XSD stands for XML Schema Definition (see Schema, earlier in this list) XSL Means eXtensible Stylesheet Language This is a language used to style XML ... coolest tricks of XML, you can use entities to insert names, special typesetting characters or symbols, or long passages of text and data stored in separate files Some entities are standard (those ... display in Web browsers W hat I s X M L? : X M L R u l e s 11 XSLT This is short for eXtensible Stylesheet Language Transformation XSLT is a method that combines the use of a style sheet (XSL)...
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Báo cáo khoa học: Solution structure of 2¢,5¢ d(G4C4) Relevance to topological restrictions and nature’s choice of phosphodiester links docx
Ngày tải lên :
16/03/2014, 18:20
... duplex was seen to be 30 °C Tables and show the chemical shift values for all the assigned sugar and base protons The stereospecific assignments involving the 3¢ and 3¢¢ protons were based on ... possess nearly the same slide ˚ ()1.7 A) Thus, the base stacking pattern in iso d(G4C4) is like that in ADNA, except at the GC step where a large slide causes adjacent bases to move away, resulting ... d(CGGCGCCG) [10] suggest that even 2¢,5¢ DNAs are prone to sequence effects, as evidenced by some differences seen in structures of the two sequences The former sequence assumes a hybrid structure of...
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The Web Designer’s Guide to iOS Apps: Create iPhone, iPod touch, and iPad Apps with Web Standards docx
Ngày tải lên :
22/03/2014, 20:20
... easy-touse device for listening to music, news, information, and audio books, and seeing photos or even watching movies and TV shows This isn’t business content This is life content Interestingly, ... THE WEB DESIGNER S GUIDE TO IOS APPS In order to design iOS applications, you need to establish what I call your app design studio This studio will be the place in which you design, test, and ... United States and other countries Many of the designations used by manufacturers and sellers to distinguish their products are claimed as trademarks Where those designations appear in this book,...
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