applications of high throughput sequencing

... coverage of the Drosophila libraries [17] miRTRAP performs better when more sequencing data are available However, this is not a concern given the rapid advances of high- throughput sequencing ... identification of microRNAs using high- throughput sequencing reads is to compute a set of quantities for each candidate locus, and by using thresholds for each quantity we define a space of values ... consider pertain to the structure of the hairpin and positions of reads The distance between a miR and moR on the same arm of the hairpin, the offset of the 5' positions of products that overlap at...

Ngày tải lên: 09/08/2014, 20:21

... high- throughput sequencing: preparation, immobilization, and sequencing Preparation of the sample for highthroughput sequencing involves random fragmentation of the genomic DNA and addition of ... some cases, sequencing has replaced traditional Introduction approaches such as microarrays, furthermore offering finer outcomes A review of each of the applications of high- throughput sequencing ... construction of the high- throughput sequencing instruments Commercial high- throughput sequencing platforms share three critical steps: DNA sample preparation, immobilization, and sequencing (Fig...

Ngày tải lên: 29/05/2014, 14:33

... develop new applications of HTS The objective of this chapter is to give an overview of the most important applications of HTS We shall discuss actual applications of HTS as well as possible applications ... here a great number of research on actual applications of HTS as well as possible future applications of HTS Depending on the strength of the applied magnetic field, applications of HTS may be divided ... Applications of High- Tc Superconductivity The fabrication of HTS cables and coils are essential for all types of applications of HTS Thus, in Section 2, we describe the state -of- the-art of the technology...

Ngày tải lên: 19/06/2014, 19:20

... solutions for the use of superconducting devices in superconducting electronics Overview of Possible Applications of High Tc Superconductors 11 The future of applications of HTS is very exciting ... tests of the heart activity The magnetic activity of other regions of the human body may also be detected using SQUIDs A study about the state -of- the-art and future developments of applications of ... 10 Applications of High- Tc Superconductivity Possible applications of HTS in medicine The ultimate objective of science and technology is human welfare...

Ngày tải lên: 19/06/2014, 19:20

... 30 Applications of High- Tc Superconductivity (=22) states and three qubits in any superposition of (=23) states etc While, for the classical computer one of these states has the probability of ... operating time of qubit is in the order of nano seconds The coherence times need some improvement On the other hand, some high temperature superconductors such as Bi- 32 Applications of High- Tc Superconductivity ... the basis of the working principle of the flux qubit (Mooij et al., 1999) Some Contemporary and Prospective Applications of High Temperature Superconductors 33 Fig 12 The configuration of flux...

Ngày tải lên: 19/06/2014, 19:20

... protect quench of HTS conductor 56 Applications of High- Tc Superconductivity In CD type HTS cable, most of fault currents are transferred from HTS conductor to former conductor because of superconductor ... 200 115 500 300 Table Comparison of ratings between WD and CD HTS power cable HTS(CD) 200 115 1000 200 52 Applications of High- Tc Superconductivity The capacity of WD HTS cable is about 2.5[kA] ... sheath of cable Qc represents heat capacity of conductor and sheath Heat capacity of dielectrics are calculated Fig 13 Equivalent heat transfer circuit of HTS cable T1 : Total heat resistance of...

Ngày tải lên: 19/06/2014, 19:20

... (a)~(c) points of Fig 29 Point (a) is to limit fault current of distribution feeder SFCL at (b) point reduces fault 72 Applications of High- Tc Superconductivity current impact of adjacent transformer ... temperature of YBCO CC, Ic=700 A is critical currents of two YBCO CC in 4.2 K and T 82 Applications of High- Tc Superconductivity Neglecting magnetic field effect, the dependence of resistivity ... n value of NbTi Comparing with IL, the rate of increase or decrease of IH is lower since Bi2223 has a lower n value 3.2 Stability of the hybrid conductor 3.2.1 Stability of hybrid made of NbTi/Cu...

Ngày tải lên: 19/06/2014, 19:20

... Voltage profiles with impulse duration of 59 ms and amplitude of 0.1 A 94 Applications of High- Tc Superconductivity 12 T1 T2 T(K) 10 430 440 450 460 470 480 490 500 t(s) Fig 20 Temperature profiles ... 90 Applications of High- Tc Superconductivity one order of magnitude higher than the NbTi Therefore, the stability of the hybrid conductor is improved greatly ... majority of studies dealing with applications of HTS also paid little attention to the problem of creep In this chapter we describe the methods of influence on the relaxation rate both of local...

Ngày tải lên: 19/06/2014, 19:20

... right angle to the plane of the disk The distribution density of these domains in the disk plane 114 Applications of High- Tc Superconductivity corresponds to the distribution of the local induction ... Rossel, C.; Hofer, J.; Keller, H.; Erb, A & Walker, E (1998) Strong shift of the irreversibility line in high- Tc superconductors upon vortex shaking with an 118 Applications of High- Tc Superconductivity ... 2004; 120 Applications of High- Tc Superconductivity Gou, et al.,2007a; Gou, et al.,2007b) using these methods was to calculate the levitation force of a bulk high- Tc superconductor by aid of the...

Ngày tải lên: 19/06/2014, 19:20

... combination of properties, which are especially important for, e.g., biomagnetic applications Biomagnetic 148 Applications of High- Tc Superconductivity applications demand a very challenging tasks of ... Rail_A and 138 Applications of High- Tc Superconductivity Rail_B shown in Fig 12, are the ratio between the width of two different magnetized magnets, the width of and the height of the magnetic ... especially for the case at a 140 Applications of High- Tc Superconductivity Fig 16 The changing curve of the levitation force on the high- Tc superconductors at positions of 5, 10, 15 and 20 mm above...

Ngày tải lên: 19/06/2014, 19:20

... and fluctuations of superconducting current at the grain boundaries often act 156 Applications of High- Tc Superconductivity as sources of flicker noise in the SQUIDs Patterning of bottom layers ... improvement of the operation parameters of the high- Tc DC SQUID magnetometers and gradiometers Fig 12 Schematics of the dual-SQUID flip-chip magnetometer with control electronics 168 Applications of High- Tc ... presence of oxygen plasma also leads to recrystallization of the surface of edges of the etched film, which partially recovers its microstructural and electron transport properties A high quality of...

Ngày tải lên: 19/06/2014, 19:20

... conductor The phonon–phonon 186 Applications of High- Tc Superconductivity Fig Absolute thermoelectric power of copper as a function of temperature Fig Thermoelectric power of the sample with composition ... in turn, supported the further development of high- Tc sensors: more than 20 types of high- Tc DC SQUID magnetometers and gradiometers prepared by the high oxygen pressure sputtering technique are ... 2002) The diversity of the applications of the multilayer high- Tc SQUID sensors is astonishing They have already proved that it is worthwhile to further develop the technology of these sensors Other...

Ngày tải lên: 19/06/2014, 19:20

... 1.1 30 Table List of chemical solution deposited oxide buffer layers with Jc of the high temperature superconducting YBCO films deposited on such buffers 196 Applications of High- Tc Superconductivity ... (HRTEM), high resolution powder neutron diffraction and electron energy loss spectroscopy Up to now, large number of experimental and theoretical of works has been studied because of its high Tc of ... grinding and were put into Fe 206 Applications of High- Tc Superconductivity tubes with a length of 140 mm, an outer diameter (O.D) of 10 mm, and an inner diameter (I.D) of mm The packing process was...

Ngày tải lên: 19/06/2014, 19:20

... et al (2009) Growth of graphene on Ir(111) New J Phys., Vol 11, pp 023006-22 ISSN 1367-2630 218 Applications of High- Tc Superconductivity Hur, J M et al (2008) Fabrication of high- performance MgB2 ... earlier 212 Applications of High- Tc Superconductivity in MgB2 and attributed to phonon density of states (PDOS) due to disorder The EPC strength in MgB2 depends greatly on the characteristic of E2g ... microstructure revealed by high resolution transmission electron microscope (TEM) observations show that G037 sample has grain size of 100-200 nm which is consistent with 214 Applications of High- Tc Superconductivity...

Ngày tải lên: 19/06/2014, 19:20

... creation of composite diamond superconductors was suggested by one of the authors of the present 238 Applications of High- Tc Superconductivity article, G Dubitsky, who used sintering of diamond ... given for reference 242 Applications of High- Tc Superconductivity such microdomains is high apparently due to the effect of the of diamond crystallites, which have much higher hardness (100 – ... size of – µm were used as the initial materials consisting of 60 wt % of diamond and 40 wt % of molybdenum A compact material was obtained by holding at a pressure of 7.7 GPa and a temperature of...

Ngày tải lên: 19/06/2014, 19:20

... 250 Applications of High- Tc Superconductivity 4.3 Superconductivity of heterofullerides Recently a method has been developed for synthesizing superconducting heterofullerides of the Fe ... Obtained by High- Pressure -High- Temperature Sintering 251 the heterofullerides studied is smaller than that of K3C60 , apparently because substitution of the potassium ion by an ion of smaller ... 1.445 nm) Such appreciable increase of the parameter a of face-centred cubic lattice is quite naturally and also is one more proof of intercalation of atoms of bigger sizes in fulleride structure...

Ngày tải lên: 19/06/2014, 19:20

... handling of reads >32 bp The length and abundance of ChIP fragments were modeled from sequencing reads using Model-Based Analysis of ChIP-Seq (MACS) with model fold at 100 and P-value cutoff at ... phospho-p53ser15 and phospho-p53ser20 (Cell Signaling), as previously described [15] ChIP-Seq High- throughput sequencing of the sequential-ChIP fragments from human hearts was performed using Illumina Genome ... genome-wide chromatin marks of transcription start sites and transcriptional elongation, promoters of human miRNAs were recently identified [5], but the diverse expression profiles of miRNAs indicate...

Ngày tải lên: 11/08/2014, 12:20

... http://genomemedicine.com/content/3/5/31 (a) Page of 12 (b) Scarce clinical samples (c) Circulating tumour cells Rare chemo resistant cells Figure Medical applications of single-cell sequencing (a) Profiling of rare tumor cells ... reducing the cost and time of sequencing Fortunately, the cost of DNA sequencing is falling precipitously as a direct result of industry competition and technological innovation Sequencing has an additional ... application of single-cell sequencing will be in the genomic profiling of copy number or sequence mutations in CTCs and disseminated tumor cells (DTCs) (Figure 1b) Although whole genome sequencing of...

Ngày tải lên: 11/08/2014, 12:21

... terminology of graphs Undirected graphs An undirected graph consists of a set of nodes V and a set of edges E and is denoted as G = (V,E) Each element of the edge set E is an unordered pair (u,v) of nodes, ... types of nodes, and edges only connect a node of one type to a node of the other For example, the proteins of a biological system could be the nodes of one type, its functional modules that of the ... use this as an indication of systematic error affecting at least part of the data for that protein An application of this criterion to the subgraph GBP of the data of Krogan et al [11] is shown...

Ngày tải lên: 14/08/2014, 08:20