applications in basic research and translational medicine

... receptor NLRP3 (NOD-, LRRand pyrin domain-containing 3) and the PYHIN (pyrin and HIN200 domain-containing) family protein AIM2 (absent in melanoma 2) are two PRRs that survilliance intracelluar DAMPs ... future  research.   The  book  is  targeted  at  researchers  and clinicians  who  are  interested  in learning  about  new  advances  in the  understanding and treatment of AMD, and insights into future research of AMD.  ... (Martinon et al., 2009) NLRs contain a central nucleotide-binding oligomerization domain (NACHT), an N-terminal effector domain (pyrin domain, caspase-recruitment domain or BIR domain) and C-terminal...

Ngày tải lên: 27/06/2014, 15:20

... DATA HANDLING IN SCIENCE AND TECHNOLOGY -VOLUME Advanced scientific computing in BASIC with applications in chemistry, biology and pharmacology DATA HANDLING IN SCIENCE AND TECHNOLOGY ... PRonSsING Classical mthods Interpolation Smmthing Differentiation Integratim Spline functions in signal prccessing Interpolating splines Smmthing splines Fourier transform spectral methods Continuous ... coefficients and interpolated valws Local cubic interpolation 5-pint cubic smoothing by Savitzky and Golay Determination of interpolating cubic spline Function value, derivatives and definite integral...

Ngày tải lên: 22/03/2014, 23:20

... Tissue Engineering Applications 33 3.1 Introduction As explained in chapter 1, inadequate vascularization is a major bottleneck limiting widespread clinical applications of tissue engineering, and ... bonds, and evaluated its efficacy in stimulating angiogenic signaling and vascular infiltration This study is described in detail in the following chapter 32 Chapter Incorporation of a PHI into ... in the late 1980s, its clinical applications remain limited mainly to thin or avascular tissues, such as skin, cartilage, and the cornea, due to difficulties in inducing adequate vascularization...

Ngày tải lên: 09/09/2015, 11:11

... This protein does not contain much hydroxyproline or lysine, but is rich in glycine and proline It has a large content of valine and contains desmosine and isodesmonine, which form crosslinks between ... Järvinen, MD Department of Medicine, Tampere University, FIN-33101 Tampere, Finland Pekka Kannus, MD Accident and Trauma Research Center and Tampere Research Center of Sports Medicine, UKK Institute, ... extrinsic, of these injuries The main intrinsic and extrinsic factors relating to tendon injuries are illustrated in Table 5-1 [11] Table 5-1 Factors associated with overuse tendon injuries Intrinsic...

Ngày tải lên: 15/03/2014, 09:20

... (2000: 176) research, who said: 'You cannot sit here and see the patients for ten-minute intervals doing Western medicine and then switch for two minutes into Chinese medicine' Dr Deakin does manage ... around her and so are developed in interaction with those other people and their own established ways of behaving, thinking and feeling These are in turn linked to general cultural ideas and practices ... Jeffrey and A Lyon 1989 Labour Pains and Labour Power: Women and Childbearing in India London: Zed Books Jeffery, P.M., R Jeffery and A Lyon 2002 'Contaminating States: Midwifery, Childbearing and...

Ngày tải lên: 22/03/2014, 20:21

... 'Pluralism and Integration in the Indian and Chinese Medical Systems', in A Kleinman (ed.) Medicine in Chinese Cultures Washington D.C.: U S Government Printing Office, 401-417 1976 'Introduction', in ... within biomedicine and in late-capitalist production, and as a dominant organising principle in various forms of praxis in Western culture In spite of limitations in studies of elective affinity ... in China; and biomedicine, Ayurvedic medicine and Un ani medicine in India; and to the fact that all of these traditions include major medical texts, educational institutions, and professionalised...

Ngày tải lên: 22/03/2014, 20:21

... working in the area of women’s and children’s health, with a focus on adolescent sexual and reproductive health and increasing investment in family planning in the Pacific • Research interest in ... understanding & interpretation of common accounting reports, budgeting & financial analysis An introduction to basic economic theory relevant to clinicians & clinical managers, including funding ... issues in clinical research; sampling & inference; selecting items, reducing items & creating aggregate scores; inter-rater & intro-rater reliability & interval consistency of responses; assessing...

Ngày tải lên: 23/03/2014, 06:20

... molecules and cells, tissues and organs, individuals, and populations) The crossing of translational barriers (T1, T2, and T3) can be enabled using translational bioinformatics and clinical research informatics ... biomedical informaticians in translational medicine teams Biomedical Informatics Biomedical informatics is an over-arching discipline that includes sub-disciplines such as bioinformatics, imaging informatics, ... organizing and sharing data associated with clinical research[ 112,126], including those from HL7 and the Clinical Data Standards Interchange Consortium (CDISC) Within public health, the International...

Ngày tải lên: 18/06/2014, 16:20

... guitar tones using a combination of physical modelling and warped linear predictive coding is outlined in Section Section analyzes the results from simulated coding scenarios using the recorded ... sequencing program using only virtual instruments and software effects, the file size (including simple instrument and effect model algorithms) is on the order of 500 kB For WLP in Physical Modelling ... this real-time parameterization and coding problem for string modelling in the marriage of two common techniques, the basic plucked string physical model and warped linear prediction (WLP) [12] The...

Ngày tải lên: 23/06/2014, 01:20

... Advances in Wavelet Theory and Their Applications in Engineering, Physics and Technology (a) (b) Fig The original license plate candidate image is shown in (a) and prominent edges in the LP candidate ... image (a) and image (b) shows prominent edges (a) (b) Fig The original license plate candidate image is shown in (a) and prominent edges in the LP candidate are shown in (b) using single level ... divided into four parts These are input image normalization, edges enhancement using filters, edges finding and linking to rectangles using connected component analysis (CCA) and plate candidate finding...

Ngày tải lên: 27/06/2014, 00:20

... fingerprints only for improving the fingerprint retrieval efficiency 2.2 Exclusive fingerprint classification Exclusive fingerprint classification groups fingerprint images into some predefined ... patterns, mouse movements, and online behaviors Detailed examples and intriguing descriptions of biometric data-mining and its implications are presented in this chapter Continuing in the theme of privacy ... fingerprint configuration, as less than 5% of all fingerprints is arches Plain Arch is defined as a type of fingerprint in which ridges enter one side and 26 Biometrics - Unique and Diverse Applications...

Ngày tải lên: 27/06/2014, 06:20

... CT, and MRI scans are today usually 28 Brain Damage – Bridging Between Basic Research and Clinics done at defined intervals after birth in order to evaluate the timing and evolution of brain injury ... monitoring and intervention that underlie good obstetric care and underpin optimal fetal outcome including the lowest chance of brain injury occurring for any reason In the context of intrapartum ... slowing of fetal somatic and brain growth (intrauterine growth retardation) and increasing risk of acute placental insufficiency leading to fetal distress, again with the likelihood of hypoxia and...

Ngày tải lên: 28/06/2014, 12:20

... These include endotoxins and polysaccharide binding proteins, cytokines, leukotrienes, clotting factors, C-reactive protein, histamine, uric acid, catecholamines, and procalcetonin, to name but a ... tissue ischemic injury in patients presenting in shock and attempts to rescue patients in shock following the development of the ischemic insult Finally, applying protocolized care in the management ... electrocardiogram and, echocardiography, end-tidal CO2, and urine flow together with measurements of sublingual PCO2 and metabolic measurements in blood, including lactate Invasive measurements, including...

Ngày tải lên: 10/08/2014, 18:21

... mucosa and serosa This decrease was accompanied by an increase in the intestinal PCO2 gap Administering fluids alone or together with SIN-1 increased flow and mucosal µPO2 to baseline levels SIN-1 ... prostacyclin when no further increase in DO2 could be obtained by volume resuscitation and dobutamine infusion Gastric intramucosal pH (pHi) improved after starting prostacyclin, suggesting an increase ... aggressive therapy to maintain brain perfusion has a major impact on secondary brain ischemia in brain trauma patients Maintaining adequate brain perfusion allows the brain lesion to the limited...

Ngày tải lên: 10/08/2014, 18:21

... the increased oxygen demand due to the dobutamine, suggesting both an inadequacy of hemodynamics and/ or an inadequacy of mitochondrial function In fact, considering the dobutamine test as an ‘increased ... (1993) Effects of norepinephrine, epinephrine, and dopamine infusions on oxygen consumption in volunteers Crit Care Med 21:1502–1508 54 Uusaro A, Hartikainen J, Parviainen M, Takala J (1995) ... frequently measured variables in medicine and is obviously of great importance in detecting patients with clinical hypertension and monitoring their subsequent treatment However, in critically ill unstable...

Ngày tải lên: 10/08/2014, 18:21

... during 170 A B J Groeneveld and J Verheij ALI/ARDS, caused by indirect injury, including sepsis, than caused by direct/inhalational injury, in man Indeed, Holm et al observed no EVLW elevation in ... therapeutic studies utilizing the fiberoptic technique, aimed at preventing or ameliorating an increase in EVLW and subsequent morbidity and mortality, thereby confirming and extending the Mitchell et ... volume and cardiac output continuously Integrating such a monitoring tool into the existing and accepted concepts such as pressureand volume-monitoring seems to be a promising way for new, physiology-directed...

Ngày tải lên: 10/08/2014, 18:21

... Messmer K, Fink MP (eds) Update in Intensive Care and Emergency Medicine Vol 33: Tissue Oxygenation in Acute Medicine Springer-Verlag, Berlin, pp 128–137 56 VanderMeer TJ, Wang H, Fink MP (1995) ... flow Interestingly, these alterations are more severe in septic than in other insults [12,13] Endotoxin administration induces severe microcirculatory alterations, including severe arteriolar and ... PEEP and hepatic metabolic performance in septic shock Intensive Care Med 22:1274–1275 23 De Backer D, Creteur J, Silva E, Vincent JL (2003) Effects of dopamine, norepinephrine and epinephrine...

Ngày tải lên: 10/08/2014, 18:21

... flow using pulsed Doppler and analyzing tricuspid annulus movement using Doppler tissue imaging (DTI) More interestingly, in spontaneously breathing patients, the collapsibility index, defined ... than cm in normovolemia and may be more than 1.5 cm in hypovolemia In spontaneously breathing patients, the interatrial septum moves during inspiratory and expiratory phases During the inspiratory ... value in predicting an increase in cardiac output in response to fluid infusion in patients with cardiovascular instability [1] In patients with sepsis-induced hypotension, responders and non-responders...

Ngày tải lên: 10/08/2014, 18:21

... Biosciences), which absorb and emit in higher wavelength light (ex/em, 774/789 nm), and investigated their applicability in cell labeling and in vivo imaging Results and discussions Preparation ... biodistribution is independent of the routes of administration, such as intravenous injection [13-15,18,53,75,78,79], intraperitoneal injection [26], intratracheally instillation [77], and inhalation ... Model Animal Research Center of Nanjing, Nanjing University (Nanjing, China) The streptavidinIRDye 800CW was purchased from Li-Cor Biosciences (Lincoln, NE, USA) The main chemicals, including EDC,...

Ngày tải lên: 11/08/2014, 00:22

... Distance and URLs in Pre-, During-, and Post-event Window (Hashtag Level) 133 4.3 Interaction Plot on Distance and URLs in Pre-, During-, and Post-event Window (Dyad ... maintaining diversity (91% inter-list diversity) in the recommendation list in a scalable fashion The second essay examines information propagation using the retweet feature on Twitter where information ... are spent for advertising products, political campaigning, and marketing in these social media Particularly, in product advertising and campaigning through social media, brands or companies seek...

Ngày tải lên: 09/09/2015, 08:12