application to the study of the crouzon mouse model

... Another way of examining cross-hybridization of the mouse liver mRNA would be to apply the mouse mRNA to the microarray in the absence of human mRNA However, the purpose of this study was to ... promoter [4-7] Expression of the uPA transgene in the mouse liver causes a gradual depletion of the mouse hepatocytes Transplantation of normal human hepatocytes into these SCID-beige/AlbuPA mice ... genes substantially The presence of the ML RNA increased the number of upregulated genes (2-fold) to either 1142 or 1132 (Table 1), indicating that the mouse RNA was hybridizing to the human oligonucleotide...

Ngày tải lên: 20/06/2014, 01:20

... contributed to the conception and the design of the study, analyzed the data and drafted the manuscript UR contributed to the conception and the design of the study TB acquired the data IK contributed to ... or the choice of the number of samples, when no a priori knowledge of the inherent periods of the data is available To derive a more robust version of the statistical test use the rank of the ... different nycthemeral rhythms, one describing crime rates on d6 and d7, the other on d1 to d5, see Figure for a plot of these two rhythms Now the “whiteness“ of the residuals of the fit of d1 to d5...

Ngày tải lên: 10/08/2014, 09:20

... energy ∆Eo to the v v electrons of the solid The projection of q upon the surface kx determines the plasmon wave vector and, together with the dispersion relation, the energy loss of the scattered ... Figure 12 A schematic sketch of the cavity system considered in this chapter The distance of the center of the cavity to the surface is h The major and minor axis of the cavity are denoted ˆ as ... specifically, the Maxwell equation for the considered cavity system was solved The solution shows the effect of the aspect ratio of the cavity on the field structure and spectral response of the system...

Ngày tải lên: 14/09/2015, 14:01

... chapter The distance of the center of the cavity to the surface is h The major and minor axis of the cavity are ˆ denoted as a and b respectively a y -axis is pointing perpendicularly out of the ... which leads to the catalyzed hydrolysis of triglycerides (2) Such a unique property of lipase may lead to the use of the enzyme in the detergent industry as a facilitator for the removal of fat stains ... project Both the results of the fabrication and characterization of the cavity systems are evaluated In addition, the prospective developments of the systems as well as their contributions to the understanding...

Ngày tải lên: 14/09/2015, 14:02

... collected data, due to the general nature of these tools and availability of sources, which can provide help in these respects 2.4 Outline of the report An overview of the sections of the report is ... organisation of repair and maintenance of tools and their final disposal at the end of their life For the example of the tool library, the following attributes could be suggested in the above context ... structuring the research and specifically for identifying the main steps of car-sharing adoption The purpose of the study was to test the feasibility of the eco-efficient services with regards to acceptance...

Ngày tải lên: 04/11/2013, 10:15

... structures of the b-amino acids that best fit are shown in Fig They all correspond to gauche(+) values of the h angle The methyl group of b2-HAla occupies a position close to that of CH2b of Pro or the ... response of these agonists could be explained by the number of receptors to be occupied by these agonists to get activation of the second messenger cascade as reported [40] Enzymatic degradation of ... of a-amino acids) has recently been applied to the syntheses of linear tetrapeptides of somatostatin [20] and of cyclic tetrapeptide and pentapeptide analogues of the RGD sequence [19] With the...

Ngày tải lên: 08/03/2014, 08:20

... calculated when more than the half of the items of the scale were available ("half item rule”); the score of the scale was the sum of the item scores further normalized to range from to 100, with higher ... regression models [20] were constructed to identify the type and determinants of missingness for each item of the SF-36 (except for HT) In these models, the dependent variable was binary: the item ... SF-36 were the number of items of the questionnaire missing (in addition to the item analyzed) and the eight subscale scores, including the score for the scale to which the missing item belongs...

Ngày tải lên: 18/06/2014, 19:20

... on, the CM of the modelled portion of the body involved in the movement are needed as model inputs The outputs of the TIPs are the kinematic and kinetic variables associated with the actuators ... overview of the KDD process are reported Methods A MMIM applied to the STS task – The TIP model A MMIM is a model of a portion of the musculoskeletal system that includes the invariant aspects of both ... kinetic variables of the main actuator are strongly related to each other and their timing Given a value of one of them, a limited range of values is to be expected for the others Moreover, 'average'...

Ngày tải lên: 19/06/2014, 10:20

... implementation of the Leslie horn simulator is shown in Figure The sound produced by the horn is composed of the sum of the direct sound source and the five image sources (the back wall of the horn part of ... available in the literature [31] The same procedure was used for the woofer simulator As in the real Leslie cabinet, crossover filtering of the input signal gives the input to both the woofer and the horn ... from the detectors triggers the onset of sounds Depending on the parameters of the particles detected, various types of sounds are generated These parameters and the rate of occurrence of the...

Ngày tải lên: 22/06/2014, 00:20

... δ, 4.2 10 Journal of Inequalities and Applications By virtue of the expression of the P C-mild solution of the Cauchy problem 2.7 , we can introduce the P C-mild solution of the Cauchy problem ... P and give the e relation between T0 -periodic P C-mild solution and the fixed point of P After showing the compactness of the Poincar´ operator P and obtaining the boundedness of the fixed point ... x s x ∈ X In order to obtain the local existence of mild solution for system 4.14 , we only need to set up the framework for use of the contraction mapping theorem Consider the ball given by B...

Ngày tải lên: 22/06/2014, 03:20

... introduced in the model Finally, to illustrate one of the potential uses of the model, we present the study of branch carbon balance, to analyse the links between branch death and branch carbon autonomy ... perpendicular to and in the direction of their woody axes are presented for two different shoots: (a) at the bottom of the crown and (b) at the top of the crown their maximal length: the assimilating ... foliage area of the shoot then begins to reduce as a consequence of needle fall The evolution of the internal geometry of the shoot coincides with a modification of the general orientation of the shoot...

Ngày tải lên: 08/08/2014, 14:22

Ngày tải lên: 08/08/2014, 21:20

... Figure The GSH/GSSG ratio of the prototype and expanded models The GSH/GSSG ratio of the prototype and expanded models The prototype model (A) and the expanded model (B) Page of 11 (page number not ... map of the prototype RBC model Metabolic map of the prototype RBC model The circles are metabolic intermediates and ions These molecular species are defined as "Substance" in the E-Cell system The ... Our prototype model of the RBC was developed on the basis of the whole-cell model of Joshi and Palsson [8-11] with slight modifications (Figure 1) We modified the model to represent the oxidantinduced...

Ngày tải lên: 13/08/2014, 22:22

... in the scope of study in this thesis In the three hybrid PSTD methods developed in this thesis, only the application of PSTD-FDTD method is extended to the 3D problems The applications of the ... this thesis improve the accuracy of the traditional PSTD method and preserve the efficiency of the PSTD algorithm They help to extend the application scope of the PSTD method to some practical large ... condition The other option is to analyze FZP problems using the full-wave numerical methods However, due to the large size of the FZP diffraction problem, the memory requirement of the traditional...

Ngày tải lên: 11/09/2015, 09:00

... like the theory of psychology of activities of A.N.Leonchiep, theory of formation of period-based intellectual actions of P.Ia.Galperin, theory of learning via the circle of experience is one of ... proposed by the topic are applied, they will contribute to improving the efficiency of the VT of civil electricity for the rural labor force STUDY TASKS To study theories and practice of TFEL in VT ... sectors of interest focus, especially in the matter of raising the quality and effectiveness of training The quality of the training is closely related to many factors, including the application of...

Ngày tải lên: 15/09/2015, 15:17

... transformed into ellipses in the video The ellipses we want to detect in this thesis are the projections of the central circle of the soccer field Most of these ellipses are only partial (due to the camera ... position and the lengths of the major and minor axes, i.e the paper assumed that the ellipse is horizontal The particle filter uses the contour and the histogram of the objects to differentiate the ball ... of candidate ball-like objects Then, in the second step, we use information of the path trajectories of these candidate objects over a short sequence of frames to obtain the ball (and prune off...

Ngày tải lên: 15/09/2015, 21:56

... considered that the increased renal Gb3 of the Fabry mouse might extend to the glomerulus to provide a model of the human disease In the cortex of wild-type kidney, subpopulations of renal tubules ... order to begin to address this potential, we determined the effect of CsA on Gb3 synthesis in the Fabry mouse model Our studies have further delineated the abnormal Gb3 synthesis in this model ... disease, the primary pathology is in the kidney [1], the major site of Gb3 synthesis in man [11], and in the heart, possibly due to the association of Gb3 synthesis with the microvasculature GSL synthesis...

Ngày tải lên: 19/02/2014, 07:20

... as the roots of the DAG As a starting point, only the roots of the DAG are displayed to the user Figure shows the five roots for the ‘asthma’ query Exploration process The user selects one of the ... Fragment of the entailment graph for ‘asthma’ (top), and its conversion to a DAG (bottom) Figure 4: The roots of the entailment graph for the ‘asthma’ query 3.2 Exploration Scheme The objective of the ... refinements of the query that can lead to more focused sets of documents Each facet corresponds to a clustering of the current result set, focused on a more specific topic than the current query The user...

Ngày tải lên: 07/03/2014, 18:20

... University at the airport at the control tower at the mouth of the river at the hospital at the farmhouse WHITE at the point at the surface of the earth at the top of a mountain at the level of the sea ... (motion) towards come to the edge went to them bring water to dry fields come up to the falls by boat turn to the right or left swings to the right forces the tail to the left plane banks to the right ... to the settlers TO 7: to * with talk to the pilots TO 8: to * in honor of a monument to freedom a toast to the married couple to *—— to everyone’s surprise to my amazement to...

Ngày tải lên: 30/03/2014, 17:20

... Russia and to compare the results to the outcomes of the other approaches used to model deposits in the banking sector In Chapter we investigate bank failures The financial crisis of 1998 and ... 33% of all loans to the non-financial sector and owns about one third of the total number of bank branches in the country (1,009, see Table 1.6.), while the total number of Sberbank operating offices ... the possibility of substitution between deposits and other borrowed funds on the input side The second objective of this study is to illustrate the new substitution model for the banking sector...

Ngày tải lên: 03/06/2014, 02:06