application to sunitinib in patients with gastrointestinal stromal tumors

... metal-protein complexes interacting with lymphocytes can lead to the production of factors, which act in both an autocrine and paracrine fashion to contribute to either increased bone resorption ... released from macrophages to synergize with IFN-gamma in an autocrine fashion to induce a variety of macrophage activation genes including nitric oxide synthase, also implicated in aseptic osteolysis ... clinical significance of these findings is unknown, in part, because it is not currently feasible to compare implant performance in prospective groups with and without metal reactivity Continued...

Ngày tải lên: 20/06/2014, 01:20

... associated to refractoriness to agomelatine within months of 50 mg/day therapy This appears to be consistent with evidence in the current literature pointing out a lack of response to antidepressants ... Altamura AC: Switching from serotonin reuptake inhibitors to duloxetine in patients with resistant obsessive compulsive disorder: a case series J Psychopharmacol 2008, 22:210-213 Centorrino F, Hennen ... trends within months of administration of agomelatine 50 mg/day in serotonin reuptake inhibitor (SRI)-refractory obsessive-compulsive disorders (OCDs) When remission occurred, it was substantial In...

Ngày tải lên: 09/08/2014, 01:21

... recent studies indicate that the CPT provokes increases in cortisol and norepinepherine as well as producing increases in pro-inflammatory cytokine production [16,17] In the present protocol, participants ... capacity to determine the causal links between RA disease processes and cytokine reactivity to pain It is possible, for example, that pre-existing individual differences in pro-inflammatory cytokine ... example, in contrast to pain as a stressor, exercise stress does not induce cortisol increases in either RA patients or controls [48] However, an insulin tolerance stress test resulted in a finding...

Ngày tải lên: 09/08/2014, 14:20

... preservation [1-3] Recently, sitagliptin, the first DPP-4 inhibitor launched on the market, has been approved for use in combination with insulin Sitagliptin combined with insulin significantly reduces blood ... period following the meal test Serum C-peptide and insulin levels were found to significantly increase over the four-hour period following the meal with sitagliptin in comparison to that in patients ... addition of sitagliptin to the ongoing insulin therapy was considerably effective in the patients whose insulin secretory capacity (residual b-cell function) was severely diminished Page of 8.1%...

Ngày tải lên: 11/08/2014, 00:23

... responses for bronchodilators in patients with COPD [8-12] In Phase II dose-ranging studies in COPD, indacaterol consistently demonstrated bronchodilator efficacy that was superior to placebo, regardless ... from 7476 patients enrolled in 11 placebo-controlled studies in which indacaterol was administered to patients with COPD at doses of 18.75 to 600 μg once daily (Table 1) The analysis involved ... study, for both indacaterol (lefthand panel) and comparators (right-hand panel) Visual inspection of the indacaterol data points indicated that with increasing dose the response asymptotically approached...

Ngày tải lên: 12/08/2014, 13:22

... as factors involved in matrix remodeling, that is insulin growth factor-1 (IGF-1), transforming growth factor-β (TGFβ), MMP-13 and tissue inhibitors of metalloproteinase (TIMPs), or in inflammation, ... expression of leptin in cartilage compared with lean patients, indicating that local hyperleptinemia may be found in the joint Interestingly, obesity is characterized by a systemic hyperleptinemia whereas ... degenerative changes in obese mice with impaired leptin signalling compared with lean wild-type mice, indicating that leptin is required to increase the incidence of OA due to extreme adiposity...

Ngày tải lên: 12/08/2014, 14:22

... finding in patients with isolated TBI and suggested that alcohol intoxication is associated with a lower incidence of coagulopathy as compared to non-intoxicated patients [28] Early hemostatic monitoring, ... monitoring, including point-of-care thromboelastography or thromboelastometry, may contribute to early diagnosis of coagulation disorders in patients with isolated head injury Although data regarding ... INR: international normalized ratio; IQR: interquartile range; ISS: injury severity score; PAI-1: plasminogen activator inhibitor; OR: odds ratio; PT: prothrombin time; TBI: traumatic brain injury...

Ngày tải lên: 14/08/2014, 07:21

... lymphohistiocytosis (HLH), VAHS is associated with massive cytokine release ("cytokine storm”), elevated plasma levels of soluble interleukin receptor (sIL-2R) and other inflammatory mediators and ... population Patients with VAHS were intended to be treated according to the recommendations of the Histiocyte Society with a modified HLH-94 protocol which consisted of intravenous etoposide (100 to 150 ... (IQR, 14 to 26 days) In patients without VAHS, the median viral shedding time was 15 days (IQR, 12 to 22 days) as opposed to a median of 21 days (IQR, 14 to 26 days) (P = 0.13) in patients with VAHS...

Ngày tải lên: 14/08/2014, 07:21

... treatments according to the planned protocol In all patients the response to therapy was excellent with complete response in patients and a partial remission in the remaining three patients A brief ... using a 0–3 scale resulting in a total staining score Abnormal staining (fluorescein and rose bengal) was classified as greater than or equal to a score of [9] Rose bengal staining of the conjunctiva ... treatment with RT or CT-RT combined with amifostine, where included in this study None of the patients had a history of dry eye, sarcoidosis, or thyroid associated eye disease Treatment According to...

Ngày tải lên: 09/08/2014, 09:22

... scoring index to predict the outcomes of patients with HCAP, a type of pneumonia that occurs prior to hospital admission in patients with specific risk factors following contact or exposure to ... possible factors (for example, incorrect dosing, interval of administration, pharmacokinetic/pharmacodynamic features, hypoalbuminemia in critically ill patients) which were not investigated in this ... (47.6 to 65.3) 41.9 (31.8 to 52.6) 82.9 (78.2 to 86.9) 74.9 (70.1 to 79.4) 57.5 (48.4 to 66.2) 30.7 (22.8 to 39.5) 82.3 (77.7 to 86.4) 83.0 (78.4 to 86.9) 0.697 (0.652 to 0.740) 0.584 (0.537 to...

Ngày tải lên: 14/08/2014, 07:21

... view, in this thesis, we are trying to find the role of GIT transit using bran scan in IBS patients with bloating (See later chapter) 1.3 The role of Serotonin in IBS Serotonin (5-hydroxytryptamine, ... with an intestinal prokinetic agent, tegaserod, on bloating and intestinal transit The aims of this study are to determine: 1) To investigate the baseline gastrointestinal & bowel symptoms and ... symptom-based criteria to help researchers and physicians in identifying patients with IBS In 1978 Manning et al were the first to describe six key abdominal/intestinal symptoms, now referred to...

Ngày tải lên: 26/09/2015, 10:05

... endoscopy in outpatients with iron deficiency anemia The aim of our study was to investigate the incidence of GI pathological findings in symptomatic and asymptomatic patients with IDA and to identify ... submitted to gastrointestinal (GI) evaluation Iron deficiency anemia results from chronic occult gastrointestinal bleeding Endoscopic evaluation of the gastrointestinal tract is commonly performed to ... Most of patients with iron deficiency in, whom gastrointestinal or systemic signs or symptoms are absent have an underlying gastrointestinal lesion [24] Idiopathic iron-deficiency anemia in adults...

Ngày tải lên: 25/10/2012, 11:18

... rh-HGF administration (day 14) and the observation period (day 28) to evaluate renal involvement, including serum creatinine and histological findings A phase I/II clinical trial for patients with ... during rh-HGF infusion and renal toxicity induced by repeated rh-HGF dosing, including an increase in urinary excretion of albumin, were potential adverse events in a human study In the phase ... administration (min) 30 Time after rh-HGF administration (min) Figure Blood pressure decreased during infusion of rh-HGF in patients with FH or LOHF BP and HR were monitored during rh-HGF infusion...

Ngày tải lên: 18/06/2014, 19:20

... multidimensional pain inventory profile differences in predicting treatment outcome in a heterogeneous cohort of patients with chronic pain Clin J Pain 2002, 18(3):139-143 Rudy TE, Turk DC, Kubinski JA, ... treatment of patients with long-term pain using multidisciplinary collaboration and approaches The patients in this study are identical to those contributing to a companion study[7] in which life ... Special interest was focused on the relation of reported pain severity to the different LiSat-11 domains We used the median value from the MPI scale "pain severity" to dichotomize the patients into...

Ngày tải lên: 18/06/2014, 19:20

... observed in patients with moderate to severe psoriasis The difference in MCS scores between the REVEAL and the MEPS samples were 3.1 to 3.4 points, which exceeded the MCID of 3.0 points This finding ... baseline to endpoint improvements (range of trial durations: 10 to 16 weeks) were seen in the Bodily Pain and Social Function scales These findings are also consistent with those reported for infliximab ... life with infliximab induction and maintenance therapy in patients with moderate -to- severe psoriasis: a randomized controlled trial Br J Dermatol 2006, 154(6):1161-1168 Krueger GG, Langley RG, Finlay...

Ngày tải lên: 18/06/2014, 19:20

... multitargeted tyrosine kinase inhibitor with antiangiogenic activity in vivo, has been investigated in advanced HCC within several phase II trials [13-15], and a phase III trial comparing sunitinib with sorafenib ... (95% CI) Endpoint, soluble protein, and time point Median ratio to baseline Median time to event, weeks Patients with ≤ median ratio to baseline† Patients with > median ratio to baseline† TTP VEGF-A ... points in patients with high VEGF-C concentrations at baseline, with little change in patients with low baseline VEGF-C This finding is consistent with the positive associations between clinical...

Ngày tải lên: 18/06/2014, 22:20

... implementation into TBI rehabilitation may solve this problem To date numerous custom-made VR applications have been tested and shown to be effective in restoring sensorimotor abilities in patients with ... how to control her body and was no longer afraid of instability Indeed, training the patients in how to gain control, rather than in how to stabilize posture, was an ultimate goal of the gaming ... short-term practice with trunk restraint results in greater reach -to- grasp improvements in patients with chronic stroke than practice without trunk compensatory involvement [43] The same finding is true...

Ngày tải lên: 19/06/2014, 08:20

... impingement following whiplash injuries to the neck [6,12] Gorski [7] described asymptomatic impingement syndrome: where patients with neck pain alone responded to subacromial injections with ... complaining of generalised shoulder pain following their neck injury Pain radiating from the neck to the shoulder after whiplash injuries is common and difficult to treat In contrast impingement ... taken to rule out any bony injury Further imaging (as part of the medicolegal assessment) was not, however, routinely obtained A total of 56/220 patients (26%) had shoulder pain following the injury,...

Ngày tải lên: 20/06/2014, 01:20

... multitargeted tyrosine kinase inhibitor with antiangiogenic activity in vivo, has been investigated in advanced HCC within several phase II trials [13-15], and a phase III trial comparing sunitinib with sorafenib ... (95% CI) Endpoint, soluble protein, and time point Median ratio to baseline Median time to event, weeks Patients with ≤ median ratio to baseline† Patients with > median ratio to baseline† TTP VEGF-A ... points in patients with high VEGF-C concentrations at baseline, with little change in patients with low baseline VEGF-C This finding is consistent with the positive associations between clinical...

Ngày tải lên: 20/06/2014, 04:20