antithrombotic therapy and suvival in cancer patients

... strategies, and called for a prospective program of research aimed at making available to treating physicians, patients and families valid information about pain management in cancer Two main lines ... endpoint is the reduction in Adequacy of analgesic-drug therapy: Patient Management index (PMI), categorized in a binary variable according to negative (indicating inadequate analgesic care) and ... Cherny N: The management of cancer pain Cancer J Clin 2000, 50:70-116 Hearn J, Higginson IJ: Cancer pain epidemiology: a systematic review In Cancer Pain, Assessment and Management Edited by: Bruera...

Ngày tải lên: 20/06/2014, 15:20

... circulating IL-6 and midkine, independently of the patients weight status, and with Il-1, Il-8 and VEGF in cachectic cancer patients TNF-a, IL-1 and IL-6 are key cytokines involved in cancer- related ... [23] Ghrelin participates directly in hypothalamic regulation of nutrition, it causes weight gain by reducing food utilization, increasing food intake, and inhibiting leptininduced feeding reduction ... cachexia in gastrointestinalcancer Dig Dis 2003, 21:198-213 Chamberlain JS: Cachexia in cancer- zeroing in onmyosin N Engl J Med 2004, 351:2124-2125 Rubin H: Cancer cachexia: its correlations andcauses...

Ngày tải lên: 09/08/2014, 03:22

... and other major complications indicates that US guidance should be mandatory for CVC insertion in patients with cancer Background Central venous access is essential in patients with cancer, and ... catheter in the internal jugular vein [19] In addition, a report in the United States also showed that

Ngày tải lên: 09/08/2014, 03:22

... cardiac insufficiency in patients with solid tumours, and more patients with AIDS in patients with haematological cancer Corticosteroids and chemotherapy were more commonly used in patients with cancer ... of infection in all three groups, both at admission and during the ICU stay, was the lung (Table 2) Abdominal infections occurred more frequently in patients with solid cancer compared with patients ... stay than patients without cancer As expected, leucopenia was more common in patients with solid tumours and in patients with haematological cancer (Table 3) Patients with haematological cancer...

Ngày tải lên: 13/08/2014, 15:21

... adsorption or combination), timing of initiation and dose of treatment The relationship between patient outcome and treatment dose was first introduced in a landmark study where patients randomised to ... assessment (SOFA) and serum creatinine at CRRT initiation and CRRT downtime (hours); for IRRT the covariates included were age (10-years increments), sex and RIFLE class at IRRT initiation In addition ... Ronco C: Beginning and Ending Supportive Therapy for the Kidney (B.E.S.T Kidney) Investigators Writing Committee Patient and kidney survival by dialysis modality in critically ill patients with...

Ngày tải lên: 13/08/2014, 16:20

... C, Kellum JA, Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators: Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe ... would have (probably) fulfilled the urine criteria for AKI stage III The remaining 583 patients had RRT without a 300% change in creatinine or a creatinine of 354 μmol/L or more (as per AKI stage ... creatinine criteria for AKI stage III (serum creatinine ≥ 354 μmol/L (≥ 4.0 mg/dL) or a rise in serum creatinine by more than 300% from baseline) had a significantly lower ICU mortality than patients...

Ngày tải lên: 13/08/2014, 19:20

... years) Patients were divided into two groups according to the median arousal value and patients characteristics and laboratory findings were demonstrated in Table LP-PLA2, total cholesterol and ... triglyceride levels were increased in patients above median arousal and TAC was reduced in these subjects Other demographic and laboratory findings were comparable in two groups According to the arousal ... arousal index was associated with increased LP-PLA2 level The elevated levels of circulating LP-PLA2 may explain prone to sudden death due stroke and AMI in patients with OSA and increased arousal index...

Ngày tải lên: 25/10/2012, 11:00

... ATP binding site serves as a docking site for specific binding of cytoplasmic signaling proteins containing Src homology-2 (SH2) and protein tyrosine binding (PTB) domains These proteins in turn ... tyrosine kinase inhibitors Inhibiting the activity of tyrosine kinases by low molecular weight compounds capable of interfering with either ligand binding (in the case of receptor tyrosine kinases) ... carcinoma Bladder cancer Glioblastoma multiforme Autocrine-paracrine loop Glioma Autocrine-paracrine loop PDGFR and PDGF IGFR and IGF I and II Breast cancer Table Protein kinase inhibitors in clinical...

Ngày tải lên: 03/11/2012, 09:57

... excluded patients after randomization, introducing bias Forty patients were each initially randomized to intervention and control conditions In the intervention group, patient was excluded owing to ... discussions of coping with cancer and encouragement to express feelings Content included redefining life priorities and detoxifying death, building bonds, management of physical problems and side effects ... Medicine’s Evidence-Based Medicine Working Group, there are specialized bodies of knowledge needed for conducting, reporting, and interpreting randomized clinical trials This knowledge cannot be inferred...

Ngày tải lên: 15/02/2014, 05:20

... 1-6 main chains and 1-4 branchings, and the more common 1-3 main chains and 1-6 branchings.18 This fraction also is highly active in vitro and in animal models of cancer, although activity in these ... predict anticancer efficacy in humans Maitake D-Fraction has been used in a few exploratory studies in cancer patients. 17 In 1994, a group from China published in abstract form their findings from ... cells could infiltrate cancerous stomach lesions in their patients. 34 Further examinastomach cancer patients up to five years, intion of biopsy material revealed that patients cluding some patients...

Ngày tải lên: 06/03/2014, 02:21

... understanding of this repeating immune cycle might be able to assist the clinician by pinpointing recurring opportunities to selectively enhance Teffectors and/ or deplete or inhibit T-reg cells, in ... S, Lawlor DA: Associations of circulating Creactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis Cancer Causes Control 2009, 20(1):15-26 ... hypothesis further by examining the timing of chemotherapy doses with respect to the LCRP immune oscillatory cycle, in patients with advanced melanoma, while examining the clinical responses The current...

Ngày tải lên: 18/06/2014, 15:20

... life during chemotherapy for advanced breast cancer between patients receiving intermittent and continuous treatment strategies The findings indicated that changes in the quality of life index, ... in many instances when one includes both physical functioning and performance status in the regression models, the likelihood of finding inconsistent results can be expected In other words, in ... distress in newly diagnosed ambulatory cancer patients and as a predictor of survival in lung cancer J Pain Symptom Manage 1995, 10:423-431 Ringdal GI, Götestam KG, Kaasa S, Kvinnsland S, Ringdal...

Ngày tải lên: 18/06/2014, 19:20

... Saulino M, Scott M: Methods for a randomized trial of weight-supported treadmill training versus conventional training for walking during inpatient rehabilitation after incomplete traumatic spinal ... Wingendorf I, Hoölig G, Koch R, Hesse S: Repetitive locomotor training and physiotherapy improve walking and basic activities of daily living in subacute, nonambulatory stroke patients: a single-blind, ... the training of stair climbing Subjectively, he rated the locomotor training positive but demanding, particularly during the simulated stair climbing He noticed a constant improvement in his...

Ngày tải lên: 19/06/2014, 08:20

... Casciani CU: Distribution in Th1 and Th2 subsets of CD4+T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression Cancer Immunol Immunother ... suggesting that the elevation of IL-4 production during an ongoing immune response to tumor can down-regulate Th1 cytokine production Therefore, in gastrointestinal cancer patients, the initial ... adding an equal volume of 4% formaldehyde fixative After washing and incubating with PBS/BSA/saponin for 10 min, cells were incubated with for 30 min, respectively Results were analyzed using...

Ngày tải lên: 09/08/2014, 04:21

... compared UFH and LMWH in cancer patients (Table 1) [39-45] The Enoxaparin and Cancer (ENOXACAN) study compared the LMWH enoxaparin and UFH in 1,115 patients undergoing abdominal or pelvic cancer surgery ... excluded from clinical trials, the patients included in clinical trials are typically in better health than cancer patients seen in clinical practice Conclusion Cancer patients are at increased risk ... over warfarin in cancer patients in terms of practicality of use as well as in efficacy Cost comparisons The costs involved in managing VTE in general are considerable In the US managing DVT alone...

Ngày tải lên: 10/08/2014, 22:20

... in oncology and/ or R195 intensive care, and take part in regular training of oncology and intensive care nurses The nurse/patient ratio ranges from 1.2 to 1.7 Routine clinical rounds, including ... life-sustaining therapy in ICU patients independently predict hospital death Intensive Care Med 2003, 29:1895-1901 Moreno R, Matos R: Outcome prediction in intensive care Solving the paradox Intensive ... out, especially in a single centre Decisions to forgo life-sustaining therapy were demonstrated to independently predict hospital death in ICU patients [37] Our ICU policies, including decisions...

Ngày tải lên: 12/08/2014, 20:20

... reported with many anti -cancer agents, including gemcitabine, bleomycin, cisplatin, CCNU, cytosine arabinoside, daunorubicin, deoxycoformycin, 5-FU, azathioprine and interferon α [25] Lastly, ... cytoreductive therapy and develops in 20% to 40% of BMT recipients [47] Amphotericin during conditioning Acyclovir during conditioning Vancomycin during conditioning The main site of liver damage in this ... level monitoring, is crucial to prevent extrarenal methotrexate toxicity During methotrexate infusion and elimination, fluids should be given to maintain a high urinary output and urinary alkalisation...

Ngày tải lên: 12/08/2014, 23:23

... al Figure Figure Luminal concentrations of L-lactate (a) and D-lactate (b) in non-surviving and surviving septic patients and healthy subjects and surviving septic patients and healthy subjects ... VLJ and AP were involved in design, data collection and analysis, drafting of manuscript, and revisions NR was involved in data collection and analysis All authors read and approved the final ... L-lactate in the rectal lumen in septic patients, in whom dynamic assessment during treatment may be possible [29] Conclusion Luminal concentrations of L- and D-lactate in the rectum are increased in...

Ngày tải lên: 13/08/2014, 03:20

... December 2004 and 16 December 2005 After receiving approval from our institutional ethics committee and obtaining the informed consent of the patients or next of kin, we performed the study in 51 consecutive ... were routinely administered in our patients presenting septic shock Hemodynamic exploration, using echocardiography or a Swan-Ganz catheter, was routinely performed in all patients presenting septic ... mortality of patients with septic shock In the survivors and during the first three days of ICU course, NT-proBNP levels were similar in patients previously treated with anthracyclines and in patients...

Ngày tải lên: 13/08/2014, 03:20

... the initial clinical experience with head and neck RapidArc patients, in terms of dosimetric analysis and acute toxicity results Methods and materials Patients selection This is a single-Institute ... contoured by the planner and included as follow: spinal cord, brain stem, left and right parotids; larynx and uninvolved oral cavity were outlined whenever not heavily included in the target Whenever ... radiathion therapy in head and neck cancers: an update Head and Neck 2007, 29:387-400 Popovtzer A, Eisbruch A: Advances in radiation therapy of head and neck cancer Expert Rev Anticancer Ther...

Ngày tải lên: 09/08/2014, 09:20