antipurines in childhood acute lymphoblastic leukemia

... Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors Jade England1, Simon Drouin1, Patrick Beaulieu1, Pascal St-Onge1, Maja Krajinovic1, ... Maja Krajinovic1, Caroline Laverdière1,2, Emile Levy1,3, Valérie Marcil1,3 and Daniel Sinnett1,2* Abstract Background: While cure rates for childhood acute lymphoblastic leukemia (cALL) now exceed ... examined the cardiometabolic profile and performed whole-exome sequencing in 209 cALL survivors from the PETALE cohort Variants associated with cardiometabolic outcomes were identified using PLINK

Ngày tải lên: 06/08/2020, 04:38

... frequently investigated gene for instance in drug-related toxicities, in therapy-response, resistance against various drugs, in carcinogenesis and in the outcomes of osteosarcoma and leukemia [64–70] ... marker against ACT, its minor allele (A) found more often in controls than in patient cases [37, 82] This SNP was recommended for clinical use in pharmacogenetic testing before using doxorubicin or ... ABCC1: ATP Binding Cassette Subfamily C Member 1; ABCC2: ATP Binding Cassette Subfamily C Member 2; ACT: anthracycline-induced cardiotoxicity; ALL BFM: Berlin– Frankfurt–Münster; ALL: acute lymphoblastic

Ngày tải lên: 24/07/2020, 01:53

... Background Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer, accounting for 27.3% of pediatric cases [1] Treatment for ALL, divided into the stages of induction therapy, intensive ... concerned children’s feelings of fear and pain in having their blood sampled or having needles inserted in them A previous Canadian study conducted among 260 children with ALL receiving treatment [22] ... quality of life during induction therapy in pediatric acute lymphoblastic leukemia Support Care Cancer 2014;22(12):3235–42 Kobayashi K, Kamibeppu K Measuring quality of life in Japanese children:

Ngày tải lên: 21/09/2020, 13:50

... as “Plai” in Thailand and “Bonglai” in Malaysia It has long been used in traditional medicine in Thailand, being the prime ingredient in massage oil to relieve muscle pain In Northeast India, oral ... of caspase 9) into the cytoplasm Interestingly, there was significant decline in the level of XIAP (apoptosis inhibitor protein) suggesting possible inhibition of this protein by increased level ... cell line, leading to the programmed cell death via intrinsic mitochondrial pathway of apoptosis induction Introduction Plants, in particular have been used by mankind as a source of medicine since

Ngày tải lên: 02/11/2022, 09:29

... potential of HDACis in acute leukemia is quite modest In phase I clinical studies of Vorinostat and Tefinostat in patients with advanced leukemia or myelodysplastic syndrome, only a minority (o20%) ... effects of HDACis in a complex leukemia model We investigated antileukemia effects of Givinostat (ITF 2357), a pan-HDACi used in numerous phase II clinical trials, including for relapsed leukemias, ... in Figures 4b and c This observation was in line with increased levels of acetylated tubulin in vivo (Figure 1c) and increased levels of acetylated histone (lysine 9) in T-ALL cells treated in

Ngày tải lên: 19/11/2022, 11:49

... aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo ... genetic event implicated in relapsed ALL, and an in- depth investigation of the efficacy of cell cycle inhibitors (e.g CDK inhibitors, and aurora kinases inhibitors) in eliminating relapsed leukemic ... sequential therapy of acute myelogenous leukemia in adults: a phase II study of retinoids in combination with the sequential administration of cytosine arabinoside, idarubicin and etoposide Leuk

Ngày tải lên: 20/09/2020, 01:23

... role in the long-term wellbeing in childhood cancer survivors but the impact of these changes in subsequent health perturbations in these survivors remain unexplored Keywords: Childhood acute lymphoblastic ... microbiome composition predicts infection risk during chemotherapy in children with acute lymphoblastic leukemia Clin Infect Dis 2018;67(4):541–8 21 Yeoh AEJ, Lu Y, Chin WHN, Chiew EKH, Lim EH, Li ... Access Temporal changes in gut microbiota profile in children with acute lymphoblastic leukemia prior to commencement-, during-, and post-cessation of chemotherapy Ling Ling Chua1,2, Reena Rajasuriar3,4,

Ngày tải lên: 17/06/2020, 03:22

... in TP53 DNA-binding domain may also inactivate TP53 by affecting its DNA-binding ability [29] We also found different mutations in PTEN (the tumor suppressor phosphatase and tensin homolog) in ... predominant in childhood ALL, especially in the high-hyperdiploid subtype in our research Keywords: Acute lymphoblastic leukemia, Genomics, Molecular pathogenesis, Pediatrics, KMT2D Background Acute ... therapeutic interventions in the clinic, especially kinaseactivating alterations in BCR-ABL1-positive or Philadelphia chromosome-like ALL patients who are amenable to tyrosine kinase inhibitors

Ngày tải lên: 17/06/2020, 11:17

... monitoring to inform patient outcomes and treatment choice is discussed in clinical practice guidelines for several indications [4, 10–18] The widespread adoption of MRD monitoring in everyday clinical ... is mainly driven by the number of malignant cells being evaluated while being independent of the total amount of input DNA This finding illustrates the value of providing large amounts of input ... childhood acute lymphoblastic leukemia: a clinical evidence review Ont Health Technol Assess Ser 2016;16(7):1–52 Landgren O, Rustad EH Meeting report: advances in minimal residual disease testing in

Ngày tải lên: 06/08/2020, 05:20

... Asparaginase By reducing protein C levels may exaggerate the effects of FVL even in heterozygous subjects Protein C, S and AT deficiency Asparaginase By inhibiting protein synthesis results in reduction ... not very well studied in children with ALL In a multicenter, prospective Prophylactic Antithrombin Replacement in Kids with Acute Lymphoblastic Leukemia Treated with Asparaginase (PARKAA) study, ... inhibitors of fibrinolysis [4] Thus, an increase in the levels of procoagulant factors combined with reduction in natural anticoagulants or fibrinolytic potential may result in predisposition

Ngày tải lên: 06/08/2020, 07:57

... leading cause of death Keywords: Childhood cancer survivors, Acute lymphoblastic leukemia and lymphoma, Metabolic syndrome, Adipokines, Insulin resistance, Obesity Background The increase in the ... including leptin and adiponectin, which are known to affect insulin sensitivity and vascular functionality, thereby, increasing the risk of MS [5] In fact, low adiponectin and high leptin concentrations ... adiponectin concentrations, the leptin/adiponectin ratio, insulin resistance, and adiposity, in a sample of child survivors of lymphoma and leukemia in Mexico City Methods: Fifty two children (leukemia

Ngày tải lên: 20/09/2020, 01:21

... of bufalin on multidrug resistance in K562/VCR vincristine-resistant leukemia cell line J Tradit Chin Med Chung Tsa Chih Ying Wen Pan Spons -China Assoc Tradit Chin Med Acad Tradit Chin Med 2014;34:678–83 ... survival of B-lineage acute lymphoblastic leukemia cells is accompanied by overexpression of bcl-2 protein Blood 1993;81:1025–31 Qinghong S, Shen G, Lina S, Yueming Z, Xiaoou L, Jianlin W, et al ... could play a role in the induction of chemotherapy resistance in leukemia [44] Testa group explain that in acute myeloid leukemia (AML) the alteration of apoptotic pathway with an induction of anti-apoptotic

Ngày tải lên: 20/09/2020, 18:03

... cells and diminished expression of Mcl-1 and X-linked inhibitor of apoptosis protein (XIAP) in such cells Furthermore, inhibition of SIRT1 by Tenovin-6 inhibited the Wnt/β-catenin signaling pathway ... efficacy in ALL patients Keywords: Acute lymphoblastic leukemia, Targeted therapy, Epigenetics, SIRT1 inhibitor, Tenovin-6, Apoptosis, p53, β-catenin, Stem/progenitor cells Background Acute lymphoblastic ... Jin et al BMC Cancer (2015) 15:226 DOI 10.1186/s12885-015-1282-1 RESEARCH ARTICLE Open Access Tenovin-6-mediated inhibition of SIRT1/2 induces apoptosis in acute lymphoblastic leukemia

Ngày tải lên: 29/09/2020, 15:54

... the database inception to March 2016, using the following text and/or medical subject heading terms: (1) ? ?acute lymphoblastic leukemia? ?? or ? ?acute lymphoblastic leukaemia”; (2) “minimal residual ... 95%−CI Adding Spinelli,2007 (k=1) Adding Lankester,2010 (k=2) Adding Elorza,2010 (k=3) Adding Doney,2011 (k=4) Adding Ruggeri,2012 (k=5) Adding Bachanova,2012 (k=6) Adding Mizuta,2012 (k=7) Adding ... Adding Spinelli,2007 (k=1) Adding Bachanova,2012 (k=2) Adding Ruggeri,2012 (k=3) Adding Mizuta,2012 (k=4) Adding Sanchez−Garcia,2013 (k=5) Adding Gandmer,2014 (k=6) Adding Bar,2014 (k=7) Adding

Ngày tải lên: 03/07/2020, 01:19

... found in pediatric T-cell acute lymphoblastic leukemia (T-ALL) This chromosomal region includes the mitogen-activated protein kinase kinase kinase (MAP3K7) gene which has a crucial role in innate ... threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase (TAK1) in a signaling complex containing TAK1-binding ... and pelleted for staining with an Annexin V-R-Phycoerythrin (PE) conjugate (BD Biosciences) Cells were washed twice in Annexin V binding buffer and then incubated with Annexin V-PE for 15 at room

Ngày tải lên: 24/07/2020, 01:20

... BCR-ABL1 in chronic mylogenous leukemia (CML) [13], fusions involving nucleopins 98 and 124 and MLL gene fusions in acute myelogenous leukemia (AML) [2, 14, 15], and TEL-AML1 and TCF3-PBX1 in acute lymphoblastic ... mutations in patients with childhood acute lymphoblastic leukemia (ALL) Med Oncol 2013;30:1–3 34 Serinsöz E et al Aberrant expression of β-catenin discriminates acute myeloid leukaemia from acute lymphoblastic ... and K562 expressing Dll4 cells, they were grown and maintained in RPMI 1640 supplemented with 15 % FBS and antibiotics T-ALL cell lines were grown and maintained in RMPI containing 10–20 % FBS

Ngày tải lên: 21/09/2020, 01:29

... supporting the finding of a direct role of either of the cannabinoid receptors in induction of apoptosis in acute leukemia models To confirm rescue from induction of apoptosis on the protein level, ... patient, as well as independent acute myeloid leukemia cell lines (MV4-11, M0-7e, HL60), the core binding factor cell line Kasumi1 and the acute blast crisis CML cell line K562 All cell lines were treated ... preferentially seen in leukemia cells of the lymphatic lineage or in acute myeloid leukemia cells expressing lymphatic markers Results THC inhibits cellular proliferation in lymphatic and myeloid leukemia

Ngày tải lên: 21/09/2020, 10:20

... cell lines To determine if growth inhibition induced by curcumin was a result of apoptosis, the pro-apoptotic effect was examined using Wright-Giemsa, Hoechst 33342 and Annexin-V/PI staining Both ... to that seen in curcumin-treated cells, suggesting an important role for Bcl-2 in curcumin-induced apoptosis in these CD34+AML cell lines Accumulating evidence has shown that curcumin potentiates ... S, Khanin M, Studzinski GP, Danilenko M: Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid, and silibinin on proliferation and apoptosis in acute myeloid leukemia

Ngày tải lên: 18/06/2014, 19:20

... assessing the sub-G1 population (Figure 4B). In addition, apoptotic cells were also detected by both Annexin V/PI staining and immunofluorescent staining with Hoechst 33342. Annexin V/PI staining ... Li 2,4 , Dong-Jun Lin 3,4 and Quentin Liu 1,3,4* Abstract Background: Aurora kinase ensures accurate chromosome segregation during cell cycle, maintaining genetic integrity in cell division. VX-680, ... activation of Aur-A and induces monopolar spindle in NB4-R2 cells. (A) VX-680 inhibited phosphorylation of Aur- A at Thr288 in NB4-R2 cell line. Cells were incubated with increasing doses of VX-680

Ngày tải lên: 18/06/2014, 19:20

... assessing the sub-G1 population (Figure 4B). In addition, apoptotic cells were also detected by both Annexin V/PI staining and immunofluorescent staining with Hoechst 33342. Annexin V/PI staining ... Li 2,4 , Dong-Jun Lin 3,4 and Quentin Liu 1,3,4* Abstract Background: Aurora kinase ensures accurate chromosome segregation during cell cycle, maintaining genetic integrity in cell division. VX-680, ... activation of Aur-A and induces monopolar spindle in NB4-R2 cells. (A) VX-680 inhibited phosphorylation of Aur- A at Thr288 in NB4-R2 cell line. Cells were incubated with increasing doses of VX-680

Ngày tải lên: 20/06/2014, 03:20