antioxidant roles of nitric oxide and cytoprotection

... Jonas M, Oduro A, Borland C, Higenbottam T: Safety guidelines for use of nitric oxide Lancet 1992, 339:1615–1616 Sydow M, Bristow F, Zinserling J, Allen SJ: Variation of nitric oxide concentration ... Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn Lancet 1992, 340:819–820 Roberts JD, Polander DM, Lang P, Zapol WM: Inhaled nitric oxide in persistent pulmonary ... Anesthesiology 1993, 78:577–580 Austin AT: The chemistry of the higher oxides of nitrogen as related to the manufacture, storage and administration of nitrous oxide Br J Anaesth 1967, 39:345–350 Gaston B,...

Ngày tải lên: 12/08/2014, 18:20

... Nuclear factor-kappa B NO Nitric oxide NOF (HCT-1026) Nitroflurbiprofen NOS Nitric oxide synthase nNOS (NOS I) Neuronal nitric oxide synthase NOx Nitrate/nitrite NO-NSAID Nitric oxide- releasing non-steroidal ... Effect of flurbiprofen or nitroflurbiprofen on NF-κB activation in the liver of rats at h after LPS injection Figure 6-7 Effect of flurbiprofen or nitroflurbiprofen on the proteolytic activity of ... LPS pre-treatment VII List of Figures with either equivalent volume of vehicle, flurbiprofen or nitroflurbiprofen Figure 6-2 Effect of flurbiprofen or nitroflurbiprofen on MPO activity Figure...

Ngày tải lên: 14/09/2015, 14:16

... consisted of mL of hypnorm (Jansen Pharmaceutica, Beerse, Belgica), which contained 0.315 mg of fentanyl and 10 mg of fluanisone, and mL of midazolam (Roche, Basel, Switzerland) which contained mg of ... shock model: The role of NO and PGE2 and the therapeutics effects of conservative fluids, NOS and COX-2 inhibitors 45 4.1 Introduction The up-regulation of nitric oxide (NO) and cyclooxgenase-2 ... implicated in the induction of inducible nitric oxide synthase that leads to increase production of nitric oxide (NO) We investigated the effects of NO in two rat models of hemorrhagic shock The...

Ngày tải lên: 16/09/2015, 15:54

... Pathophysiology of prolonged hemorrhagic shock Role of nitric oxide (NO) in prolonged hemorrhagic shocked rats and therapeutic effects of conservative fluids, NO donor and NOS inhibitors Role of nitric oxide ... analysis of major organ injury of different 22 groups of rats Table 2.2 Creatinine and GOT levels in different groups of rats 22 Table 3.1 Semi-quantitative analysis of major organ injury of different ... groups of rats Figure 4.3F Plasma GOT levels at 24, 48 and 72 hours in different 60 groups of rats Figure 4.4.1 Hemotoxylin and eosin stain of Kidneys 62 Figure 4.4.2 Hemotoxylin and eosin stain of...

Ngày tải lên: 16/09/2015, 15:54

... induction Effects of a-T and its derivatives on the enhancement by TS of LPS/IFN-induced NO production We compared the effects of a-T and its derivatives TA and TN with that of TS on LPS/IFN-induced ... production with Ro31-2880 and GF109203X were approximately 70 and 30%, respectively Effects of TS on the amount of PKCa We further examined the effects of TS on the amounts of PKCa and PKCb by Western ... upregulation of PKCa DISCUSSION Fig Effects of PKA inhibitors (KT-5720 and H8) and PKC inhibitors (Ro31-8220 and GF109203X) on the enhancement by TS of LPS/IFNinduced NO production in VSMC (A), and Western...

Ngày tải lên: 22/02/2014, 04:20

... isoforms of NOS with CaM-TnC chimeras demonstrated that the roles of the four EF hands in the binding and activation of the cNOS and iNOS enzymes are distinct [13] Replacement of any CaM EF hand ... of the target peptide with EF hand in closest contact with the reductase domains The central helix is composed of the C-terminal and N-terminal helices of EF hand units and 3, respectively, and ... importance of EF hand of CaM in binding and activating the iNOS enzyme in the presence and absence of Ca2+ [13] It is noteworthy that iNOS coexpressed with CaMCC produces •NO at 50% of the rate of iNOS...

Ngày tải lên: 16/03/2014, 13:20

... homeostasis A B Fig Levels of NOS isozymes and HSP90 in brain and aorta of NMS rats treated with HSD and C.I.1 Aliquots of brain soluble material (20 lg protein) and of aorta total lysate (50 ... place, and the right amount of nitric oxide Am J Physiol Renal Physiol 285, 178–190 In vivo degradation of NOS and HSP90 by calpain Kone BC (2000) Protein–protein interactions controlling nitric oxide ... brain and aorta The level of HSP90 and the type of NOS isoform present in rat brain and aorta were determined by immunoblotting (Fig 1) In brain, nNOS was the most preferentially expressed isoform,...

Ngày tải lên: 30/03/2014, 04:20

... temporal profiles of morphological change and release of cytokines and nitric oxide Neurosci Res 1999, 35:95-100 Feinstein DL, Galea E, Reis DJ: Norepinephrine suppresses inducible nitric oxide synthase ... dichlorofluorescin Nitric Oxide 1997, 1:359-369 Stasiolek M, Gavrilyuk V, Sharp A, Horvath P, Selmaj K, Feinstein DL: Inhibitory and stimulatory effects of lactacystin on expression of nitric oxide ... Ricciardi-Castagnoli P: Inducible nitric oxide synthase activity of cloned murine microglial cells Glia 1993, 7:255-262 Boje KM, Arora PK: Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal...

Ngày tải lên: 19/06/2014, 22:20

... W and Brosnan, C F Enhanced expression of constitutive and inducible forms of nitric oxide synthase in autoimmune encephalomelitis 27 28 29 30 31 32 33 34 35 36 37 38 Induction of nitric oxide ... R., Theeuwes, J W., Dijkstra, C D and Van der Valk, P Immunocytochemical characterization of the expression of inducible and constitutive isoforms of nitric oxide synthase in demyelinating multiple ... magnification: x200 4A and 4D: rabbit anti-nNOS, 4B and 4E: rabbit antieNOS, 4C and 4F: rabbit anti-iNOS antisera Enhanced expression of constitutive and inducible forms of nitric oxide synthase in...

Ngày tải lên: 07/08/2014, 14:22

... Society: ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide Am J Respir Crit Care Med 2005, ... 0.35) and 0.7%/log mg/dL (-1.3 to 2.6, P = 0.50) after and 12 months of treatment, respectively Exhaled nitric oxide In both groups, changes from baseline in ENO values after and 12 months of treatment ... outcomes of the study were the BRI to AMP and ENO concentration On the basis of previous data[43], this study had 80% power to detect a Page of 11 difference of 1.5%/log mg/dL in the BRI to AMP and...

Ngày tải lên: 08/08/2014, 21:20

... Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients J Exp Med 1996, 184:1519-1524 42 Stefanovic-Racic M, Stadler J, Evans CH: Nitric oxide and arthritis ... design CB, JC and JPP participated in the acquisition of data CB, JMP, JC and JPP participated in the analysis and interpretation of data CB, JM-P and JPP prepared the manuscript CB, JM-P and JC participated ... superficial zone of cartilage corresponds to the superficial and the upper intermediate layers, and the deep zone to the lower intermediate and deep layers The total number of chondrocytes and those...

Ngày tải lên: 09/08/2014, 14:20

... 47(6):655-9 ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 Am J Respir Crit Care Med ... number with percent age (%) of three domains of asthma severity: level of current prescribed treatment, level of current baseline control of asthma and immediate past burden of asthma exacerbations, ... proximal and distal airway nitric oxide categories Respir Res 2010, 11:47 doi:10.1186/1465-9921-12-65 Cite this article as: Mahut et al.: Exhaled nitric oxide and clinical phenotypes of childhood...

Ngày tải lên: 12/08/2014, 13:22

... References Brown-CG: Nitric oxide and mitochondrial respiration Biochem Biophys Acta 1999, 1411:351-369 Beltran B, Mathur A, Duchen MR, Erusalimsky JD and Moncada S: The effect of nitric oxide on cell ... Textbook of Rheumatology 7th edn Elsevier, Saunders; 2005 van’t Hof RJ, Ralston SH: Nitric oxide and bone Immunology 2001, 103:255-261 Nagy G, Clark JM, Buzás EI, Gorman CL, Cope AP: Nitric oxide, ... Endogenous nitrice oxide synthesis: biological functions and pathophysiology Free Radic Res 1999, 31:577-596 Chung HT, Pae HO, Choi BM, Billiar TR, Kim YM: Nitric oxide as a bioregulator of apoptosis...

Ngày tải lên: 12/08/2014, 14:22

... neuroprotective and neurodestructive effects of nitric oxide and related nitrosocompounds Nature 1993, 364:626-632 11 Hesse AK, Dorger M, Kupatt C, Krombach F: Proinflammatory role of inducible nitric oxide ... Expression of inducible nitric oxide in human lung epithelial cells Biochem Biophys Res Commun 1994, 203:209-218 Ricciardolo FL, Sterk PJ, Gaston B, Folkerts G: Nitric oxide in health and disease of ... Standardized Offline Collection of Exhaled Nitric Oxide Chest 1999, 116:754-759 25 Ohuchi Y, Ichinose M, Miura M, Kageyama N, Tomaki M, Endoh N, Mashito Y, Sugiura H, Shirato K: Induction of nitric oxide...

Ngày tải lên: 13/08/2014, 10:20

... 21 Handa O, Stephen J, Cepinskas G: Role of endothelial nitric oxide synthase-derived nitric oxide in activation and dysfunction of cerebrovascular endothelial cells during early onsets of sepsis ... to over-expression of NOS, but also to enhanced activity of constitutively expressed enzymes Therefore, to profoundly understand the roles of different NOS isoforms in ALI and sepsis, we measured ... http://ccforum.com/content/14/4/R129 Page of 10 Materials and methods This study was approved by the Animal Care and Use Committee of the University of Texas Medical Branch and conducted in compliance with the guidelines of the...

Ngày tải lên: 13/08/2014, 21:20

... dysfunction SH3 and SH2 domain dysfunction Deletion of N-terminal, SH3 and SH2 domain of active n-Src Deletion of N-terminal, SH3 and SH2 domain of kinase-dead n-Src of PP3, the inactive form of PP2, ... ligands of the SH3 and SH2 domains, respectively, both intra- and intermolecularly, and thereby disrupt the overall functions of Src kinase [3,18–21] After PP2 application, peak amplitudes of ... Institutes of Health (R01 NS053567) to X.-M.Y Plasmids of v-Src, and n-Src and its mutants were kindly provided by Dr T Pawson (Department of Molecular Genetics, University of Toronto, Canada) and Dr...

Ngày tải lên: 06/03/2014, 01:20

... suppression of the expression and activity of inducible nitric oxide synthase (iNOS) by zinc [32,33], released from MT under the influence of nitric oxide (NO), and the scavenging of NO through ... nm in UV and CD spectra of metallothioneins devoid of any aromatic residues that Fig Wavelength and time scans of the CD of MT2 in the presence and absence of NO and GSH/GSSG CD spectra of 100 ... traces and online element-selective detection of the SEC–ICPMS characterization of pure 20 lM Cd5Zn2-MT2 and mixtures of MT2 + NO (1 +11) and MT2 + GSH + NO (1 +25 +10) The amount of zinc and cadmium...

Ngày tải lên: 07/03/2014, 15:20

... activation of the various intermediates in DIM and PGL biosynthesis has not been analyzed This study was undertaken to dissect the roles of FadD22, FadD26 and FadD29 in the biosynthesis of DIMs and ... knowledge of the biosynthesis of DIMs and PGLs, the in vivo functions of these FadD proteins in this pathway remain to be established and ⁄ or completed For instance, the involvement of FadD26 ... Schematic representation of the roles of the FadD proteins encoded by the DIM + PGL locus in the biosynthesis of DIMs and related compounds in Mycobacterium tuberculosis The role of the activation enzymes...

Ngày tải lên: 15/03/2014, 11:20

... nature and behavior of the financial At the core of this issue are questions about the type of financing need and receive at various stages of their growth, the nature of the private equity and ... alternative of small business finance is a growing of small business finance For example, the impact of the U.S of the early 1990s and the effect of the consolidation of the banking industry on the of ... questions trade credit, and other sources of funds These data allow for tests of research regarding the cost and availability of different types of external finance and how the cost and availability...

Ngày tải lên: 15/03/2014, 21:20

... chemotherapeutics adriamycin, etoposide and cisplatin), the levels of Itch become reduced and allow the accumulation of p73 [53] p73 displays functions in apoptosis induction, and many of its pro-apoptotic target ... Bernardi R & Pandolfi PP (2007) Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies Nat Rev Mol Cell Biol 8, 1006–1016 Krieghoff-Henning E & Hofmann TG (2008) Role of nuclear ... kinases ATM and ATR ATR and ATM in turn phosphorylation-dependently activate the downstream checkpoint kinases Chk1 and Chk2, respectively, and the tumour suppressor p53 Furthermore, ATM and ATR...

Ngày tải lên: 16/03/2014, 00:20