antioxidant properties of nitric oxide

... delivery and distribution of TS in each cell line Recently, we found that TS-induced apoptosis of VSMC was caused by the stimulation of superoxide production due to the activation of NADPH oxidase [32] ... Regulation of inducible nitric oxide synthase gene expression in vascular smooth muscle cells Gen Pharmacol 32, 9–16 19 Kim, S.-J., Bang, O.-S., Lee, Y.-S & Kang, S.-S (1998) Production of inducible nitric ... VSMC As shown in Fig 2A, approximately 20 lM of NO was produced by 10 lgÆmL)1 of LPS and 100 UÆmL)1 of IFN Under these conditions, detectable induction of iNOS protein was observed by Western blotting...

Ngày tải lên: 22/02/2014, 04:20

... suppression of the expression and activity of inducible nitric oxide synthase (iNOS) by zinc [32,33], released from MT under the influence of nitric oxide (NO), and the scavenging of NO through ... and CD spectra of metallothioneins devoid of any aromatic residues that Fig Wavelength and time scans of the CD of MT2 in the presence and absence of NO and GSH/GSSG CD spectra of 100 lM Cd5Zn2MT2 ... interactions of nitric oxide Cell 78, 931–936 Stamler, J.S., Simon, D.I., Osborne, J.A., Mullins, M.E., Jaraki, O., Michel, T., Singel, D.J & Loscalzo, J (1992) S-nitrosylation of proteins with nitric oxide: ...

Ngày tải lên: 07/03/2014, 15:20

... In the presence of Ca2+, the addition of an equimolar ratio of CaM to either of the peptides resulted in a significant increase in a-helical content The addition of equal amounts of either iNOS ... formation of aggresomes [35] This may provide a rapid means of clearing the cells of iNOS that would be detrimental to the cell because of its prolonged production of large amounts of •NO Our ... presence of excess wild-type CaM The addition of the excess native CaM appears to prevent the apparent aggregation of the protein This is likely to occur because of a change in the interaction of nCaM...

Ngày tải lên: 16/03/2014, 13:20

... Role of interferon regulatory factor in induction of nitric oxide synthase J Exp Med 180, 977–984 15 Weisz, A., Cicatiello, L & Esumi, H (1996) Regulation of the mouse inducible-type nitric oxide ... signals of LPS for the production of these mediators are transduced through CD14 Stimulatory effect of IFN-c and IL-12 + IL-18 on NO production by PEC of C3H/HeN and C3H/HeJ mice The role of IFN-c, ... production of IFN-c by nonadherent cells occurs independently of LPS, as neither adherent cells nor nonadherent cells of HeJ mice respond to LPS Effect of LPS stimulation on the activation of IRF-1...

Ngày tải lên: 17/03/2014, 10:20

... image of an MWCNTs-doped SnO2 sol (c); FE-SEM image of an MWCNTs-doped SnO2 (d) Please cite this article in press as: N Van Hieu, et al., Gas-sensing properties of tin oxide doped with metal oxides ... member of Physics Society of Vietnam and the Vietnamese Materials Research Society Please cite this article in press as: N Van Hieu, et al., Gas-sensing properties of tin oxide doped with metal oxides ... Yu, Gas sensing properties of tin dioxide coated carbon nanotubes, Thin Solid Films 497 (2006) 355–360 [9] L Zhao, L Gao, Filling of multi-walled carbon nanotubes with tin(IV) oxide, Letters to...

Ngày tải lên: 19/03/2014, 16:48

... images of tungsten oxide nanostructures synthesized at WCl6 concentration of 0.01 M, 0.015 M and 0.02 M, respectively, after annealing at 300 ◦ C for h (b) TEM image of the annealed tungsten oxide ... supersaturation of tungsten source, promoting the growth of tungsten oxide nanowires [23] At higher concentration, the highly saturated WCl6 could prohibit the growth of tungsten oxide nanowires ... New Teacher Foundation of Ministry of Education (No 200800561109) of China References [1] G Eranna, B.C Joshi, D.P Runthala, R.P Gupta, Oxide materials for development of integrated gas sensors-a...

Ngày tải lên: 20/03/2014, 13:04

... temperature of 400 1C, the former morphology of sample C changed rimous and rough Such surface mophology of sample D could be due to the agglomerated growth of grains and the formation of good crystallinity ... image of XPS was conducted to determine the surface oxidation states of the tungsten oxide thin film sample Fig 5a shows survey scans spectra recorded within a range of and 1000 eV at a takeoff ... result of WO3 ðtransparencyÞþ xMþ þ xeÀ 2Mx WO3 ðblueÞ The studies of cyclic voltammograms and spectrophotometric methods have shown the effects of mesoporous nanostructure on The properties of tungsten...

Ngày tải lên: 20/03/2014, 13:08

... hydrolysis of a very limited number of peptide bonds; specifically, in the case of nNOS, degradation can occur with the cleavage of two peptide bonds and, in the case of eNOS, with the cleavage of a ... Degradation of NOS isozymes by calpain 44 Araujo IM, Ambrosio AF, Leal EC, Santos PF, Carvalho AP & Carvalho CM (2003) Neuronal nitric oxide synthase proteolysis limits the involvement of nitric oxide ... aliquots of each incubation (50 lL) as described in the Experimental procedures and is reported as a percentage of NOS activity assayed in the absence of calpain The amount of native band of HSP90...

Ngày tải lên: 23/03/2014, 07:20

... that of Ca2+-CaM [10,11,25,26], and therefore adversely affects binding of CaM to the Ca2+-CaM-binding domain of nNOS CaM is not only essential for the operation of nNOS and the other NOS isoforms, ... when it binds to the CaM-binding domain of endothelial nitric oxide synthase (eNOS) [33] The second example is when the C-terminal lobe of Ca2+-CaM binds part of the target peptide This is shown ... al Fig 15N HSQC spectra of CaM in the absence of cupiennin 1a (red), and with the addition of cupiennin 1a in a : molar ratio (purple) chiometry and providing evidence of slow exchange binding...

Ngày tải lên: 23/03/2014, 09:21

... University of Genoa References Kone BC, Kuncewicz T, Zhang W & Yu Z (2003) Protein interaction with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide ... degradation of nitric oxide synthase: effect of inhibitors and role of HSP90-based chaperones J Pharmacol Exp Ther 304, 493–497 13 Govers R, de Bree P & Rabelink TJ (2003) Involvement of the proteasome ... HSP90 and NOS degradation of the administration to the HSD-treated NMS animals of C.I.1 (Fig 5) In the brain of hypertensive rats, in spite of a preexisting condition of altered Ca2+ homeostasis,...

Ngày tải lên: 30/03/2014, 04:20

... with the result of XRD 3.2 Gas sensing properties A lot of studies on the fabrication of metal oxide sensors for many gases have been reported in the literature However, most of studies focused ... All of the chemical reagents used in the experiment were of analytical grade A typical synthesis process for the preparation of WO3 nanorods was as follows: 1.5 g of Na2WO4Á2H2O and 2.5 g of Na2SO4 ... stoichiometric proportion of WO3 Fig Powder XRD pattern of WO3 nanorods prepared by microwave hydrothermal process Fig EDX spectrum of WO3 nanorods The morphology and microstructure of the products are...

Ngày tải lên: 05/05/2014, 15:27

... iNOS, inducible nitric oxide synthase; MAPK, mitogen activated protein kinase; NF-κB, nuclear factor kappa B; NGF, nerve growth factor; NO, nitric oxide; nNOS, neuronal nitric oxide synthase; ... Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: Involvement of glutamate induced nitric oxide in motor neuron toxicity and nonmotor neuron protection Annals of ... nitric oxide and dementia of the Alzheimer's type Brain Res Brain Res Rev 2001, 35:73-96 de la Monte SM, Lu BX, Sohn YK, Etienne D, Kraft J, Ganju N, Wands JR: Aberrant expression of nitric oxide...

Ngày tải lên: 19/06/2014, 22:20

... Fujimura, H and Yanagihara, T Nitric oxide via an inducible isoform of nitric oxide synthase is a possible factor to eliminate inflammatory cells from the central nervous system of mice with experimental ... Dijkstra, C D and Van der Valk, P Immunocytochemical characterization of the expression of inducible and constitutive isoforms of nitric oxide synthase in demyelinating multiple sclerosis J Neuropathol ... expression of constitutive and inducible forms of nitric oxide synthase in autoimmune encephalomelitis 27 28 29 30 31 32 33 34 35 36 37 38 Induction of nitric oxide synthase activity in human astrocytes...

Ngày tải lên: 07/08/2014, 14:22

... present time The aim of this work is first to compare three different methods of measuring antioxidant capacity: inhibition of methyl linoleate autoxidation, rate constant of reaction of DPPH with wood ... Investigation of plant extracts for the protection of processed foods against lipid oxidation Comparison of antioxidant assays based on radical scavenging, lipid oxidation and analysis of the principal antioxidant ... stability of wood, we have measured, for the woods the extracts of which have been studied above, colour evolution during exposure of a solid wood sample to a solar-type light Variation of colour of...

Ngày tải lên: 07/08/2014, 16:20

... Immunohistochemical localization of neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) isoforms of nitric oxide synthase (NOS) in the ovaries of pigs The intensity of staining is indicated by ... Dubey RK Role of nitric oxide in the biology, physiology and pathophysiology of reproduction Hum Reprod Update 1998, 4, 3-24 10 Shukovski L, Tsafriri A The involvement of nitric oxide in the ovulatory ... T Enhanced expression of constitutive and inducible forms of nitric oxide synthase in autoimmune encephalomyelitis J Vet Sci 2000, 1, 11-17 Knowles RG, Moncada S Nitric oxide synthases in mammals...

Ngày tải lên: 07/08/2014, 18:21

... FY: Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients J Exp Med 1996, 184:1519-1524 42 Stefanovic-Racic M, Stadler J, Evans CH: Nitric oxide and arthritis ... which are composed solely of the total fraction of unsaponifiables of avocado and soybean oils in proportions of one-third to two-thirds, respectively ASU are a member of what are called 'slow-acting ... effect of ASU on clinical symptoms of knee and hip OA, with a carryover effect that persists after termination of treatment [10-12] The primary aim of the present study was to explore the effects of...

Ngày tải lên: 09/08/2014, 14:20

... support of nitric oxide (NO) involvement in the cyclic release of prolactin and LH surges Brain Res 1994, 660:175-179 Gonzalez MC, Linares JD, Santos M, Llorente E: Effects of nitric oxide donors ... Nitric oxide inhibits the release of norepinephrine and dopamine from the medial basal hypothalamus of the rat Proc Nat Acad Sci USA 1995, 92:11299-11302 McCann SM: The nitric oxide hypothesis of ... Daspartate, nitric oxide and serotonin in the control of prolactin secretion in prepubertal male rats Eur J Endocrinol 1997, 13:99-106 Chiodera P, Volpi R, Coiro V: Involvement of nitric oxide in...

Ngày tải lên: 10/08/2014, 09:20

... the inhibition of TGF-beta signaling in lung fibroblasts Respir Res 2006, 7:16-29 13 Tayler BS, Geller DA: Regulation of the inducible nitric oxide synthase (iNOS) gene In Nitric oxide and inflammation ... amounts of superoxide, which is responsible for the formation of the most toxic molecules, hydrogen radicals [21] Furthermore, down-regulation of iNOS expression suppresses the production of inflammatory ... least part of the therapeutic mode of action of the agent on chronic airway inflammatory diseases It is also suggested that M-4 will be a good candidate for the Page 11 of 12 treatment of chronic...

Ngày tải lên: 11/08/2014, 03:20

... the inhibition of TGF-beta signaling in lung fibroblasts Respir Res 2006, 7:16-29 13 Tayler BS, Geller DA: Regulation of the inducible nitric oxide synthase (iNOS) gene In Nitric oxide and inflammation ... amounts of superoxide, which is responsible for the formation of the most toxic molecules, hydrogen radicals [21] Furthermore, down-regulation of iNOS expression suppresses the production of inflammatory ... least part of the therapeutic mode of action of the agent on chronic airway inflammatory diseases It is also suggested that M-4 will be a good candidate for the Page 11 of 12 treatment of chronic...

Ngày tải lên: 11/08/2014, 06:22

... effects of NO on the cardiovascular system are dependent upon the amount of NO produced, the local environment, and redox state of NO While low levels of NO are necessary for the integrity of the ... GAPDH (Qiagen) primer assay Quantitation of TNF-α and Nitric Oxide HMEC-1 cells were grown to confluency and infected with PIC at an MOI of Supernatants of HMEC-1 cell cultures were collected at ... cytoplasm of infected cells (Fig 1A) This is the first report to our knowledge of PIC infection of human endothelial cells Effects of PIC infection on HMEC-1 permeability To investigate the effect of...

Ngày tải lên: 12/08/2014, 04:20