anticoagulation in the older surgical patient

... hrs following the post-dialysis dose There is a case report in which lithium levels were maintained in the therapeutic range by intraperitoneal administration of lithium during continuous peritoneal ... gabapentin in patients with HCV [55] These findings suggest that valproate can be used for some patients with HCV without adversely affecting ALT levels Obtaining pretreatment baseline ALT levels in ... shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution in patients...

Ngày tải lên: 25/10/2012, 10:51

... cytokines, including IL-1b, TNF-a and IFN-c (B) Chemokines expressed in the joint recruit leukocytes into the joints In addition to functioning in cell trafficking, several chemokines have other biological ... concentrations of several chemokines Chemokines in the joints of patients Table Chemokines and chemokine receptors expressed in the joint of RA patients Systemic name CC chemokines CCL2 CCL3 CCL5 CCL13 ... subclasses include the CC chemokines (where the cysteines are neighboring) and the CXC chemokines (where the cysteines are separated by one amino acid) The CXC chemokines mainly act on neutrophils...

Ngày tải lên: 18/02/2014, 18:20

... is therefore recommended For anticoagulation in the therapeutic range, dabigatran etexilate was compared to warfarin in the RE-LY study including AF patients and in the RE-COVER study including ... impact on the quality of anticoagulation, frequently assessed by the percentage of INR values in the therapeutic interval and expressed as the “time in the therapeutic range” (TTR) Even in clinical ... years), the only item independently associated with the likelihood of not receiving VKAs in the multivariate analysis was increasing age No other single factor, including the presence of contraindications...

Ngày tải lên: 14/03/2014, 20:20

... translation Pre-testing of the checklist and the schedule were done in the gynecology out -patient clinic of the same hospital before starting of the study on 10 patients and accordingly necessary ... (9.2) (0.4) Figures in the parentheses indicate percentages *Multiple responses; @includes bleeding during examination and sexual intercourse; #include dysfunctional uterine bleeding, fibroid uterus, ... micturition, pain in urination, difficulty in urination, haematuria, true incontinence of urine Out of these 29 patients who had miscellaneous symptoms, 17 patients (58.6%) had ovarian cancer and patients...

Ngày tải lên: 28/03/2014, 14:20

... cardiac output However, in the absence of bleeding, the increase in hemoglobin concentration could very well be offset by a decrease in cardiac output because of the increase in blood viscosity associated ... really happen in clinical practice? It is obvious that RBC transfusions can be lifesaving in situations of acute severe anemia or in bleeding patients in whom RBC administration can increase both ... hemoglobin or hematocrit trigger, and for the same level of hemoglobin, some patients will well, whereas others will not Thus, the decision to transfuse a patient should be individualized, taking into...

Ngày tải lên: 20/06/2014, 23:20

... treatment of allergic rhinitis The first-generation or "older" antihistamines (e.g., chlorpheniramine, diphenhydramine) are effective in reducing sneezing, itching, and rhinorrhea They have untoward ... approach Before going into specific treatment options, I would like to emphasize the main goal of treatment in most older patients; namely moistening the nasal mucosa The nose of the elderly is ... obstruction Anti-inflammatory nasal sprays These agents may be useful in reducing sneezing, itching, congestion, and rhinorrhea and are extremely safe in the elderly They can be divided into nonsteroidal...

Ngày tải lên: 08/08/2014, 21:20

... all patient types encountered in real-world settings Furthermore, the findings reported here should also be interpreted within the context of the open-label study design Additional limitations include ... aripiprazole to their previous medication(s), as assessed using the preference of medication scale scores during the switching treatment phase This finding, coupled with the improvement in QOL ratings, ... enrolled in the study, 106 patients (69.2%) were compliant with treatment During the 12-week switching period, no patients received diphenhydramine and five patients received lorazepam for the treatment...

Ngày tải lên: 09/08/2014, 01:21

... illustration of the anatomy and detection of inflammation in the bone marrow The entire lumbar spine including the zygapophyseal joints and, if available, the thoracic spine was analyzed for increased ... systematic histological study of zygapophyseal joints in patients with AS [10] In the present study, we first examined whether inflammation in the spine of patients with AS, as detected by histopathology, ... detected by histopathology in the zygapophyseal joints of the lumbar spine was found by MRI in three of eight patients with AS (Table 1) Most interestingly, in these patients a good correlation...

Ngày tải lên: 09/08/2014, 08:22

... was the principal investigator of the OASIS study and is the principal investigator who assisted in designing the ATLAS study WPM is the principal investigator and assisted in designing the Canadian ... Goldstein N, Braun J, Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy Study Group: Radiographic findings following two years of infliximab therapy in patients ... radiographs of the lateral cervical and lumbar spine in patients in the OASIS and the adalimumab cohorts were scored using the mSASSS scoring method [17,18] Radiographs from the OASIS cohort and the adalimumab...

Ngày tải lên: 09/08/2014, 14:22

... improvement in 6MWT distance, which is useful in the serial evaluation of patient status The most clinically relevant finding was the increase in exercise capacity as indicated by the increase in 6MWT ... cost-acceptable in the low-income nations The aim of this study is to evaluate the safety and feasibility of intraoperative device closure of ASD in the older patients with transthoracic minimal invasion The ... significantly, indicating the reduction in the leftto-right shunting through the ASD, showing a trend toward a reduction in the pulmonary, right atrial, and right ventricular pressures Then those patients...

Ngày tải lên: 10/08/2014, 09:22

... Clustering: Average density in the local neighborhoods of individuals rather than in the total network Here it is defined as the density in the networks of others connected to an individual (leaving ... person was involved in professional contacts so far Knowing each other was defined in the questionnaire as ‘knowing the face, having talked to each with other, or having heard of.’ Having professional ... respect to their prominence and influence in the network The aim of this study was to examine the connectedness in a newly established regional ParkinsonNet of health professionals involved in the treatment...

Ngày tải lên: 10/08/2014, 11:20

... this is sustained The findings further indicate that the use of US imaging of the foot would be more beneficial than clinical examination alone in the refinement of diagnosis and the implementation ... monitoring of biologic therapy [14-16] The aim of this study was to evaluate by means of US, the effects of antiTNF therapy in RA patients with specific focus on the forefoot using the hypothesis ... regress within the forefeet In previous work, within the MCP joints of the hands a reduction in sonographically detectable synovial hypertrophy was noted at eighteen weeks following infliximab therapy,...

Ngày tải lên: 10/08/2014, 21:24

... was involved in the interpretation of data AD participated in the coordination of the study PM commented on drafts of paper AP was involved in the conception of the study RH was involved in the ... missing values in at least one EQ-5D item Excluding participants with missing data in the EQ-5D index or in the covariates reduced the final sample size from 4,565 to 4,412 The 153 (3.35%) individuals ... of the study and assisted in writing the manuscript All authors have read and approved the final version of the manuscript Competing interests The authors declare that they have no competing interests...

Ngày tải lên: 12/08/2014, 00:20

... determined from the kinetic rate constants (ka and kd) The binding curves were processed by double referencing and were globally fitted to a 1:1 binding model The stoichiometry of binding was ... of BLyS The molecular mass of the heterotrimers was confirmed by SEC-MALS mass distribution LS/UV/RI 3-detector analysis Binding kinetics and affinity studies The binding affinities and kinetics ... cells The interaction with TRAFs induces the nuclear factor (NF)-B signaling pathway, which plays a pivotal role in regulating diverse aspects of immune function, including mediating inflammatory...

Ngày tải lên: 12/08/2014, 12:20

... Finally, intensivists are strongly motivated by the ‘rule of rescue’ Intensivists feel obliged to offer some therapy, any therapy, to a patient in imminent danger of dying [16] As is often the ... life-saving therapy from a patient with ARDS by deciding not to put the patient in the prone position Clinicians who choose ventilation in the prone position are applying experimental therapy and must ... ventilator-induced lung injury [8] Clinical experience Prone positioning has improved arterial oxygenation in all studies in patients with ARDS that have examined the question, especially in the early phase...

Ngày tải lên: 12/08/2014, 18:21

... of septic shock Katherine G Craig and Keith R Walley The debate surrounding the use of corticosteroids in septic patients has continued for over 30 years Two metaanalyses in the mid-1990s seemed ... controlled trials is confined to the most severely ill [12–15] This does not fit with the patient described in the aforementioned scenario Clinical case In view of conflicting older, yet strong, evidence ... and newer, yet preliminary, The patient described in the present scenario is improving in all aspects of organ failure, but remains catecholamine dependent A thorough examination and review of...

Ngày tải lên: 12/08/2014, 18:21

... used intravenous and enteral antibiotics (including amphotericin) to achieve decontamination of the gastrointestinal tract for the purpose of possibly decreasing bacterial inoculation of the necrotic ... there is no definitive, level one, data supporting the use of intravenous antibiotics in the treatment of patients with severe pancreatitis, even in the setting of pancreatic necrosis The few prospective ... undergoing the antibiotic regimen Other large trials utilizing gastrointestinal decontamination in groups of critically ill patients have failed to demonstrate a decrease in mortality or intensive...

Ngày tải lên: 12/08/2014, 19:22

... discussed there is a paucity of clinical information describing how any of these preoperative risk assessments has either influenced the management of individual patients or of patient groups in the ... http://ccforum.com/content/9/4/390 patients in different ways with a benefit in patient outcome, however that is to be defined In our opinion the two most useful scoring systems in surgical risk assessment remain the ASA ... Anaesthetist Likelihood of surviving 30 days Likelihood of surviving the anaesthetic Intensivist Likelihood of leaving the intensive care unit Prolonged stay on the intensive care unit Administrator...

Ngày tải lên: 12/08/2014, 22:21

... Bordoni V, Cardona X, Inguaggiato P, Pilotto L, d’Intini V, Bellomo R: Interpreting the mechanisms of continuous renal replacement therapy in sepsis: the peak concentration hypothesis Artif Organs ... lot remains to be done For sure, the progress of technology in critical care nephrology has been enormous and more will come in the near future Competing interests The author declares that they ... Figure The technological evolution from continuous arteriovenous hemofiltration (CAVH) to the last generation of continuous renal replacement therapy machines (a) CAVH machine; (b) the BSM32 machine;...

Ngày tải lên: 12/08/2014, 23:22

... carried out in the operating room and the intensive care unit (ICU) (24 beds) of a tertiary hospital The informed consent to take part in the study was obtained from the patient or from their closest ... to the dobutamine group received the first fluid cycle during 60–90 minutes followed by increasing doses of dobutamine, beginning with µg/kg/minute, until the goal was reached The patient should ... Fifty patients completed the study: 25 in the volume group and 25 in the dobutamine group The demographic data of the patients are presented in Table The therapeutic interventions and perfusion...

Ngày tải lên: 12/08/2014, 23:23