anticoagulation coagulopathies blood transfusion and conservation

... data and procedures Hb [mmol/l] HK [%] HbS [%] Measure 2.0 0.09 32.3 Transfusion of units of red blood cells 4.8 0.25 5.3 0.24 Transfusion of units of red blood cells 5.0 0.24 Start dialysis, transfusion ... blood cells 6.9 0.31 5.6 0.27 5.5 0.26 4.6 0.22 Sequestrectomy femur, transfusion of unit of red blood cell 4.9 0.22 Transfusion of units of red blood cells 6.6 0.31 Sequestrectomy humerus, transfusion ... red blood cell 5.6 0.27 5.0 0.23 5.4 0.26 4.5 0.23 Debridement humerus, transfusion of unit of red blood cell 3.7 0.18 Transfusion of units of red blood cells 5.3 0.25 Debridement humerus, transfusion...

Ngày tải lên: 11/08/2014, 12:20

... (Anemia and Blood Transfusion in Critical Care) Investigators: Anemia and blood transfusion in critically ill patients JAMA 2002, 288:1499-1507 Marik PE, Corwin HL: Efficacy of red blood cell transfusion ... EC, Blajchman MA: Transfusion- related immunomodulation (TRIM): an update Blood Rev 2007, 21:327-348 Page of Vamvakas EC: White -blood- cell-containing allogeneic blood transfusion and postoperatieve ... 108:31-39 doi:10.1186/cc9191 Cite this article as: Müller MCA, Juffermans NP: Anemia and blood transfusion and outcome on the intensive care unit Critical Care 2010, 14:438 ...

Ngày tải lên: 13/08/2014, 21:21

... Critical Care Focus 8: Blood and Blood Transfusion EDITOR DR HELEN F GALLEY Senior Lecturer in Anaesthesia and Intensive Care University of Aberdeen EDITORIAL BOARD ... Anaesthesia and Intensive Care University of Aberdeen DR PAUL G P LAWLER Clinical Director of Intensive Care South Cleveland Hospital DR NEIL SONI Consultant in Anaesthesia and Intensive Care Chelsea and ... behalf of the Canadian Critical Care Trials Group and the Transfusion Requirements in Critical Care Investigations) Bioactive substances in blood for transfusion 13 HANS J NIELS E N Haemostatic problems...

Ngày tải lên: 10/08/2014, 08:21

... CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION care units, less than 50% of blood transfusions are given for physiological reasons such as haemodynamic ... Transfusion may cause immunosuppression and increase infection rates • The risks of transfusion may outweigh the benefits TRANSFUSION REQUIREMENTS IN CRITICAL CARE as critical care anaemia) and ... of the physicians wanted CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION 100 Haemoglobin (g/l) 95 90 85 80 75 70 Institution number Figure 1.1 Mean transfusion thresholds by institution number...

Ngày tải lên: 10/08/2014, 08:21

... for transfusion and no infection are the same as no transfusion and no infection However patients who receive blood transfusion and subsequently develop post-operative 15 CRITICAL CARE FOCUS: BLOOD ... substances in blood for transfusion HANS J NIELSEN Introduction Transfusion associated acute reactions to allogeneic blood transfusions are frequent In the surgical setting, peri-operative blood transfusion ... complications and cancer recurrence and/ or survival rates in patients receiving autologous blood donated before operation and in those receiving allogeneic blood 20 BIOACTIVE SUBSTANCES IN BLOOD FOR TRANSFUSION...

Ngày tải lên: 10/08/2014, 08:21

... have entered human trials Safety and efficacy, however, must be demonstrated in preclinical and Phase I–III clinical trials, 27 CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION before these novel ... spleen, a similar situation will exist Transfusion of platelets may not necessarily restore platelet function (Box 3.2) 25 CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION Box 3.2 Causes of refractoriness ... Von Willebrand factor and P-selectin Platelet count In Chapter haemoglobin levels as triggers for transfusion were discussed, and in this chapter some triggers of platelet counting and the problems...

Ngày tải lên: 10/08/2014, 08:21

... the blood Since the endothelial cell surface area per unit of blood volume is much greater within the 39 CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION microcirculation than in larger blood ... after meeting the inclusion criteria Patients were randomly assigned through a centralised randomisation 41 CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION centre to receive either activated protein ... FOCUS: BLOOD AND BLOOD TRANSFUSION 10 11 12 13 14 15 16 17 18 19 20 36 Souter PJ, Thomas S, Hubbard AR, Poole S, Romisch J, Gray E Antithrombin inhibits lipopolysaccharide-induced tissue factor and...

Ngày tải lên: 10/08/2014, 08:21

... CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION Clinical manifestations TRALI is characterised clinically by symptoms and signs of dyspnoea, cyanosis, hypotension, fever and chills and pulmonary oedema ... kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF alpha) production in the THP-1 monocytic cell line Br J Haematol 2000;110:130–4 47 CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION 15 Boehme ... manifestations, possible causes and similarity to other lung conditions of transfusion related lung injury and suggests future research strategies What is transfusion- related lung injury? Transfusion- related...

Ngày tải lên: 10/08/2014, 08:21

... colloid preparations (albumin and others), and blood products Some of these solutions may be differentially distributed between the intraand extra-vascular, and intra- and extra-cellular compartments, ... compared 57 CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION with electrolytes Plasma proteins, especially albumin are thus largely confined to the intravascular fluid and contribute to the colloid ... treatment of shock and other conditions where restoration of blood volume is urgent, and also in patients with burns and hypoproteinaemia Plasma, albumin, synthetic colloids and crystalloids may...

Ngày tải lên: 10/08/2014, 08:21

... ferric (met) haemoglobin and superoxide radical (Figure 7.2) 69 CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION Fe2+ + O2 Fe2+ – O2 • Fe3+ + O2 – H2 O2 Figure 7.2 Haemoglobin and myoglobin redox ... haemoglobins to hydrogen peroxide in terms of ferryl iron formation (Figure 7.8A) and free 75 CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION A 100 DBBF-Hb 80 Hb 60 40 20 PHB-Hb 0 10 12 Time (minutes) ... (catalase), defence (myeloperoxidase) and biosynthesis (prostaglandin H synthase) Haemoglobin and myoglobin redox states The normal redox state of haemoglobin and myoglobin is ferrous iron (Fe2ϩ),...

Ngày tải lên: 10/08/2014, 08:21

... INDEX colorectal cancer leucocyte-depleted blood transfusion 17 post-operative infections and transfusion 14–15 tumour recurrence and transfusion 15–16 VEGF and metastases 16–17 complement activation ... immunosuppression, transfusion- induced 2, allogeneic v autologous blood 16 leucocyte-depleted blood 17 infections DIC 28 post-operative 13–14 blood transfusion and 14–15 leucofiltration and 20 see also ... interventions recruitment 6–7 results 6–10 study design trauma transfusion and infection after 14 transfusion thresholds 3, TRICC trial see Transfusion Requirements in Critical Care (TRICC) trial tumour...

Ngày tải lên: 10/08/2014, 08:21

... observational [1-3] and interventional studies [9,10], the impact of blood transfusions given before and after the ICU stay on outcome was not evaluated and the indication for blood transfusion was ... (Anemia and Blood Transfusion in Critical Care) Investigators: Anemia and blood transfusion in critically ill patients JAMA 2002, 288:1499-1507 Vincent JL, Sakr Y, Sprung C, Harboe S, Damas P: Are blood ... the first week in the ICU Blood transfusion A total of 1,833 patients (30.9%) received a blood transfusion in the ICU within a median of (IQR to 2) days The initial blood transfusion was given on...

Ngày tải lên: 13/08/2014, 20:22

... and TNFa were clearly below (0.22 and 0.15, respectively) Effect of blood transfusion on pulmonary and systemic coagulation and fibrinolysis Multiple blood transfusions were associated with activation ... lung injury after blood transfusion in mechanically ventilated patients Transfusion 2004, 44:1468-1474 48 Vamvakas EC: White -blood- cell-containing allogeneic blood transfusion and postoperative ... units and one unit of platelets of five donors (n = 10); and a control group receiving no transfusions (n = 17) The definition of multiple transfusions included transfusion of different blood...

Ngày tải lên: 14/08/2014, 07:21

... blood and blood products should be offered to recipients in need for blood transfusion; however, safe blood transfusion remains a problem in developing countries where resources are limited and ... HEPATITIS B AND BLOOD TRANSFUSION Recently there has been much concern about “Occult Hepatitis B infection (OBI)” in blood transfusion settings OBI is characterized as the presence of HBV DNA in blood ... type 1a and 1b [127] Genotypes 1, 2, and of the Hepatitis C virus (HCV) are widely distributed throughout Western countries and the Far East (Japan, China, Taiwan, and Thailand) Types and are...

Ngày tải lên: 03/03/2015, 21:05

... in heart rate, and systolic and diastolic blood pressures for up to five hours Of interest is the fact that Min et al [18] used this same product in a similarly designed study and saw no effect ... used in weight loss and weight management products in combination with caffeine, polyphenolics, and other constituents [4-7] These products are designed to promote thermogenesis and increase metabolism, ... thermogenesis and increase metabolism, suppress appetite, and/ or slow the absorption of fats and carbohydrates [5] In spite of their widespread use and the lack of credible reports regarding adverse...

Ngày tải lên: 25/10/2012, 11:10

... energy and vice versa Frictional and drag forces on the other hand are called “non-conservative” for reasons that are explained below Consider a system that consists of a block of mass m and the ... back and forth between kinetic energy K of the bob and potential energy U of the bob-earth system We assume that U is zero at the lowest point of the pendulum orbit K is maximum in frame a, and ... example at x2 , x3 and x4 the slope of the U(x) vs x curve is zero, thus F = The slope dU/dx between x3 and x4 is negative; Thus F > for the this interval The slope dU/dx between x2 and x3 is positive;...

Ngày tải lên: 23/12/2013, 00:16

... Reproductive Strategy and Ungulate Population Dynamics 191 12 Management and Conservation of Mountain Goats 204 13 Long-Term Monitoring of Marked Individuals and Advances in Ecology and Conservation 219 ... Ecological Questions, Conservation Challenges, and Long-Term Research The Study Area and the Goat Population 17 Caw Ridge Study Methods and Limitations 36 Home Ranges, Forage Availability, and Habitat ... chapter Ecological Questions, Conservation Challenges, and Long-Term Research The conservation of biodiversity and the management of wildlife require an understanding of the basic ecology of...

Ngày tải lên: 17/02/2014, 17:20

... Ecology and Conservation OUP CORRECTED PROOF FINAL, 6/12/2011, SPi Techniques in Ecology and Conservation Series Series Editor: William J Sutherland Bird Ecology and Conservation: A Handbook ... J Sutherland, Ian Newton, and Rhys E Green Conservation Education and Outreach Techniques Susan K Jacobson, Mallory D McDuff, and Martha C Monroe Forest Ecology and Conservation: A Handbook of ... for Conservation: A Handbook of Techniques Malcolm Ausden Conservation and Sustainable Use: A Handbook of Techniques E.J Milner-Gulland and J Marcus Rowcliffe Invasive Species Management: A Handbook...

Ngày tải lên: 17/02/2014, 17:20

... amount of blood in cases of blood transfusion for therapeutic purposes From the number of red blood corpuscles of the patient before and after blood transfusion, the amount of blood transfused and ... THE BLOOD the Blood, by Paul Ehrlich and Adolf Lazarus The quantity of the blood Number of red corpuscles Size of red corpuscles 12 Amount of hổmoglobin in the blood 13 Specific gravity of the blood ... the Blood, by Paul Ehrlich and Adolf Lazarus HISTOLOGY OF THE BLOOD NORMAL AND PATHOLOGICAL London: C J CLAY AND SONS, CAMBRIDGE UNIVERSITY PRESS WAREHOUSE, AVE MARIA LANE, AND H K LEWIS,...

Ngày tải lên: 17/02/2014, 22:20

... these cells Mesenteric BECs and LECs (Fig 5A,B) were also obtained by the same strategy as illustrated in Figs and 4, and were treated with VEGF-A or VEGF-C (Fig 5C) MAPK and Akt phosphorylation ... with 500 lL MACS buffer and applied onto MACS columns Magnetically selected positive cells and depleted cells were cultured independently as lymphatic endothelial cells and blood vascular endothelial ... I.) and the Ministry of Education, Culture, Sports, Science and Technology, Japan (to T Y., T I., N Y and H I.) References Adams RH & Alitalo K (2007) Molecular regulation of angiogenesis and...

Ngày tải lên: 18/02/2014, 17:20