antibodies to proteus in rheumatoid arthritis patients from southern japan
Báo cáo y học: "Circulating tumour necrosis factor-α bioactivity in rheumatoid arthritis patients treated with infliximab: link to clinical respone" pot
Ngày tải lên :
09/08/2014, 06:22
... according to the revised criteria of the American College of Rheumatology (ACR) [7], were enrolled Rheumatoid factor was present in 31 of the patients All received infliximab according to the ... tumour and healthy individuals Pattern of plasma patients necrosis factor (TNF) bioactivity in rheumatoid arthritis (RA) patients and healthy individuals Using the ability of TNF-α to stimulate RA ... all patients (ACR 50; R152 Figure clinical response Link between circulating tumour necrosis factor (TNF)-α bioactivity and clinical response Using the ability of TNF-α to stimulate rheumatoid arthritis...
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Báo cáo y học: "DAS28 best reflects the physician''''s clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment" potx
Ngày tải lên :
09/08/2014, 06:23
... and patients stopped for protocol violation Of the remaining 474 patients, 102 (22%) patients, who were not optimally responding to treatment according to the treating rheumatologist's opinion, ... analyses was to evaluate which single or composite variables, combined in a model, could discriminate the treating rheumatologist's decision to give a dose increase of infliximab to RA patients not ... of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials The Committee on Outcome Measures in Rheumatoid Arthritis Clinical Trials Arthritis...
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Báo cáo y học: " Impact of concomitant DMARD therapy on adherence to treatment with etanercept and infliximab in rheumatoid arthritis. Results from a six-year observational study in southern Sweden" docx
Ngày tải lên :
09/08/2014, 08:23
... Maslinski W: Laboratory changes on anti-tumor necrosis factor treatment in rheumatoid arthritis Curr Opin Rheumatol 2003, 15:267-273 21 Lugering A, Schmidt M, Lugering N: Infliximab induces apoptosis ... TNF-blocking drugs in combination with MTX or as monotherapy is shown in Table The number of patients initiated on TNF-blocking agents in combination with other DMARDs was too small to allow meaningful subgroup ... at treatment termination in disease activity, measured by DAS28, between patients terminating treatment because of failure in the infliximab groups (DAS28 Patients withdrawing from treatment because...
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Báo cáo y học: "Determining a low disease activity threshold for decision to maintain disease-modifying antirheumatic drug treatment unchanged in rheumatoid arthritis patients" docx
Ngày tải lên :
09/08/2014, 14:22
... Bergman M, Toloza S, Pincus T, Questionnaires in Standard Monitoring of Patients With Rheumatoid Arthritis Group: Remission and rheumatoid arthritis: data on patients receiving usual care in twenty-four ... and to develop recommendations for clinicians to use the DAS28 in clinical practice in the area of uncertainty (DAS28 of to 3.2), in order to guide the decision to maintain unchanged or to not ... Utrecht Rheumatoid Arthritis Cohort study group: Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission Computer Assisted Management in Early Rheumatoid Arthritis...
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báo cáo hóa học:" Do visual analogue scale (VAS) derived standard gamble (SG) utilities agree with Health Utilities Index utilities? A comparison of patient and community preferences for health status in rheumatoid arthritis patients" pptx
Ngày tải lên :
20/06/2014, 15:20
... directly obtained patient preferences in a sample of rheumatoid arthritis patients Methods Study sample A sample of patients with a rheumatologist-confirmed diagnosis of rheumatoid arthritis (RA) ... 0.49 to 0.64 0.46 to 0.62 0.45 to 0.61 0.45 to 0.61 0.42 to 0.59 0.41 to 0.58 0.48 to 0.63 0.45 to 0.61 60% 58% 58% 57% 56% 55% 62% 61% 0.60 0.56 0.55 0.54 0.52 0.50 0.58 0.54 0.52 to 0.66 0.47 to ... 0.47 to 0.62 0.42 to 0.59 0.42 to 0.58 0.41 to 0.58 0.38 to 0.56 0.36 to 0.54 0.47 to 0.62 0.44 to 0.60 58% 55% 55% 55% 53% 52% 60% 60% 0.57 0.52 0.51 0.50 0.47 0.45 0.56 0.53 0.49 to 0.64 0.43 to...
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Báo cáo y học: "Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept" pot
Ngày tải lên :
09/08/2014, 01:21
... rheumatoid arthritis Arthritis Rheum 2001, 44:2009-2017 van den Berg WB: Uncoupling of inflammatory and destructive mechanisms in arthritis Semin Arthritis Rheum 2001, 30:7-16 Feldmann M, Maini ... D: A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: radiologic progression ... Breedveld F, Weisman M, Weinblatt M, Rau R, Lipsky P: How to report radiographic data in randomized clinical trials in rheumatoid arthritis: guidelines from a roundtable discussion Arthritis Rheum 2002,...
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Báo cáo y học: "Differentiation of naive CD4+ T cells towards T helper 2 cells is not impaired in rheumatoid arthritis patients" pps
Ngày tải lên :
09/08/2014, 01:23
... production of proinflammatory cytokines and immunoglobulins by interleukin-4 in an ex vivo model of rheumatoid synovitis Arthritis Rheum 1992, 35:874883 Isomaki P, Luukkainen R, Toivanen P, Punnonen ... Punnonen J: The presence of interleukin-13 in rheumatoid synovium and its antiinflammatory effects on synovial fluid macrophages from patients with rheumatoid arthritis Arthritis Rheum 1996, 39:1693-1702 ... activity of interleukin-4 and interleukin-10 in suppression of inflammation and joint destruction in rheumatoid arthritis Arthritis Rheum 2001, 44:3-12 Horsfall AC, Butler DM, Marinova L, Warden...
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Báo cáo y học: "Balance between survivin, a key member of the apoptosis inhibitor family, and its specific antibodies determines erosivity in rheumatoid arthritis" ppt
Ngày tải lên :
09/08/2014, 06:22
... azathioprine The inhibitors of TNF-α were used in 47 patients (42 patients in combination with MTX, three patients in combination with azathioprine, one patient in combination with cyklosporine, ... regulatory role of survivin in the pathogenesis of arthritis Studying the variability of survivin levels in patients with RA, we observed that in most cases survivin levels were inclined to decrease ... disease arthritis levels in plasma and increased in of case of erosive joint Survivin (RA) are significantly synovial fluid thepatients with rheumatoid arthritis (RA) are significantly increased in...
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Báo cáo y học: "Survival of TNF antagonists in spondylarthritis is better than in rheumatoid arthritis. Data from the Spanish registry BIOBADASER" docx
Ngày tải lên :
09/08/2014, 08:22
... failed to respond to two NSAIDs and two disease-modifying antirheumatic drugs (DMARDs) In Spain, infliximab was available for clinical use in August 1999, etanercept in April 2003, and adalimumab in ... In the present study, we have analysed the survival of TNF antagonists in patients with SpA in clinical practice in comparison with RA patients in a registry We have found that, due in part to ... in patients with spondylarthritis and rheumatoid arthritis treated with biologics Spondylarthritis Biologic and total exposure Type of adverse event Rheumatoid arthritis Infliximab 1,915 Etanercept...
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Báo cáo y học: "Four-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-standing refractory disease: attrition and long-term evolution of disease activity" pot
Ngày tải lên :
09/08/2014, 08:22
... treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial Arthritis Rheum 2003, 48:35-45 Maini SR: Infliximab treatment of rheumatoid arthritis Rheum Dis Clin North ... Our findings also indicate that the decision to continue infliximab therapy is best made using the DAS28 score Competing interests The study was supported by a grant from Centocor BV and Schering-Plough ... reflects the physician's clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment Arthritis Res Ther...
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Báo cáo y học: "Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients – a prospective clinical study" ppt
Ngày tải lên :
09/08/2014, 10:23
... Denmark) for 15 minutes and with an Avidin/Biotin blocking kit (SP-2001, Vector Laboratories, Burlingame, CA USA) according to the manufacturer's instructions Saponin (0.1% w/v in HEPES pH 7.2) ... chromosomal protein plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine Arthritis Rheum 2003, 48:971-981 Andersson U, Tracey KJ: HMGB1 as a mediator of necrosisinduced inflammation ... activity [27] In addition, intra-articular injections of HMGB1 trigger destructive arthritis in naive mice [5] Different modes of HMGB1-blocking therapy, including neutralising antibodies, antagonistic...
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Báo cáo y học: " Myeloid dendritic cells correlate with clinical response whereas plasmacytoid dendritic cells impact autoantibody development in rheumatoid arthritis patients treated with infliximab" pdf
Ngày tải lên :
09/08/2014, 14:22
... Maini RN: Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor alpha: findings ... Plasmacytoid dendritic cell number, blood IFNα and anti-nuclear antibody positivity in infliximab-treated rheumatoid arthritis patients body positivity in infliximab-treated rheumatoid arthritis patients ... Bienvenu J, Fabien N: Infliximab therapy in rheumatoid arthritis and ankylosing spondylitis-induced specific antinuclear and antiphospholipid autoantibodies without autoimmune clinical manifestations:...
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Báo cáo y học: "Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect? A cross sectional study" pptx
Ngày tải lên :
09/08/2014, 14:22
... ApoB Insulin resistance was evaluated from fasting glucose and insulin using the Homeostasis Model Assessment of Insulin Resistance (HOMA IR) [37] and the Quantitative Insulin Sensitivity Check Index ... homocysteine levels and hyperinsulinaemia Eur J Endocrinol 2004, 151:483-489 54 Dessein JH, Joffe BI, Stanwix AE: Should we evaluate insulin sensitivity in rheumatoid arthritis? Semin Arthritis Rheum 2005, ... the WHO definition This phenomenon may be explained by differences in the components and cut-off values used in the definitions The WHO is the only definition to include albumin/creatinine ratio...
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Báo cáo y học: "Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients" pdf
Ngày tải lên :
11/08/2014, 08:21
... Weiner DB: Tyrosine kinase signal transduction in rheumatoid synovitis Semin Arthritis Rheum 1992, 21:317-329 Takeuchi T, Abe T: Tyrosine phosphorylated proteins in synovial cells of rheumatoid ... Coexpression of phosphotyrosine-containing proteins, platelet-derived growth factor-B, and fibroblast growth factor-1 in situ in synovial tissues of patients with rheumatoid arthritis and Lewis rats ... AREG stimulates RA-FLS to produce proinflammatory cytokines, including angiogenic factors IL-8 has been reported to be an angiogenic factor as well as a chemoattractant factor [38,39] Although...
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báo cáo khoa học: " Oral bisphosphonate-related osteonecrosis of the jaws in rheumatoid arthritis patients: a critical discussion and two case reports" potx
Ngày tải lên :
11/08/2014, 20:20
... Bisphosphonate therapy in rheumatoid arthritis Joint Bone Spine 2006, 73:349-54 19 Joffe I, Epstein S: Osteoporosis associated with rheumatoid arthritis: Pathogenesis and management Seminars in Arthritis ... the inflammatory process in RA [20] Considering that this disease is characterized by persistent high levels of proinflammatory cytokines [21] and accumulation of inflammatory cells [20], a link ... any signs of inflammatory or infectious processes (Figure 5) Case A 68-year-old woman was admitted to a private dental clinic in October 2009, complaining about cold tooth sensation in the region...
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Báo cáo y học: "Maintenance of cytomegalovirus-specific CD4pos T-cell response in rheumatoid arthritis patients receiving anti-tumor necrosis factor treatments" potx
Ngày tải lên :
12/08/2014, 14:22
... important in the control of CMV in vitro [25] and in vivo [21], we tested the intracellular production of IFN-γ in CD4pos T cells in response to total CMV Ags in patients with RA, before and after initiation ... in patients with rheumatoid arthritis J Clin Invest 1994, 94:749-760 30 Romagnoli P, Strahan D, Pelosi M, Cantagrel A, van Meerwijk JP: A potential role for protein tyrosine kinase p56(lck) in ... similar to those in previous studies in normal blood donors regarding proliferation [18] and cytokine production by flow cytometry in transplant recipients [37] and HIV patients [36] Contrary to the...
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Báo cáo y học: " Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients" potx
Ngày tải lên :
12/08/2014, 15:22
... Material from RA patients T lymphocytes were isolated from the peripheral blood of 73 RA patients (cross-sectional-study: 58 patients, longitudinal study: 20 patients, included in both studies: patients) ... anti-CD20 treatment (rituximab) Patients receiving interleukin (IL)-6 receptor blocking antibodies (tocilizumab) were excluded from the primary analysis because of its direct influence on CRP and ESR ... individual patients In an additional set of experiments, nine patients with a therapeutic switch to tocilizumab were followed up for six months as well (Figure 4) By interfering with IL-6 signaling, tocilizumab...
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Báo cáo y học: "Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins" pot
Ngày tải lên :
12/08/2014, 14:22
... detected Fibβ in IC These results indicate that citrullinated antigens (mainly vimentin) present in IC of SF from RA patients can only be found in CCP+ patients and not in CCPpatients or SpA patients ... of patients with rheumatoid arthritis induce apoptosis in cytokine-activated chondrocytes Rheumatol Int 2007, 27:901-909 11 Mathsson L, Lampa J, Mullazehi M, Ronnelid J: Immune complexes from rheumatoid ... citrullinated proteins were detected in the flow-through This indicates that Fibβ could be present in a citrullinated form in IC in SF of RA patients In RA serum, however, no citrullinated proteins...
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Báo cáo y học: "4th meeting of the EU research network EUROME: From the identification of genes and cellular networks in murine models of arthritis to novel therapeutic intervention strategies in rheumatoid arthritis, London, UK, 9 March 2004" pot
Ngày tải lên :
09/08/2014, 01:23
... FcgRIII-mediated cell activation resulting in innate cell mediator activation and the production of inflammatory cytokine interleukin-1 and TNF-α, leading to joint destruction In recent studies, mice depleted ... murine pristaneinduced arthritis, where a systemic granulomatous disease, including arthritis, occurs after repeated injections of pristane intraperitoneally To identify the genes controlling ... complement inhibitor factor H (and in some cases, also the factor H-like protein 1) to its surface Binding is mediated by two types of plasmidencoded protein, class I (20 kDa proteins) and class...
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Báo cáo y học: "VLA-4-dependent and -independent pathways in cell contactinduced proinflammatory cytokine production by synovial nurselike cells from rheumatoid arthritis patients" potx
Ngày tải lên :
09/08/2014, 06:22
... with rheumatoid arthritis and other inflammatory arthritides Arthritis Rheum 1988, 31:784-788 Arend WP, Dayer JM: Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis Arthritis ... nurse-like stromal cells from bone marrow of patients with rheumatoid arthritis: indication of characteristic bone marrow microenvironment in patients with rheumatoid arthritis Rheumatology 1999, 38:854-863 ... human T-cell line (Molt-17) was a kind gift from Dr J Minowada (Fujisaki Cell Center, Okayama, Japan) The B-cell and T-cell lines were maintained in RPMI 1640 medium (Gibco BRL) containing the same...
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