anti vascular endothelial growth factor monoclonal antibody bevacizumab

... the vascular endothelial growth factor promoter causes motor neuron degeneration Nat Genet 28, 131–138 19 Sun Y, Jin K, Childs JT, Xie L, Mao XO & Greenberg DA (2006) Vascular endothelial growth ... of antisense vascular endothelial growth factor sequence Cancer Res 5, 393–401 Zhang Y, Zhang N, Dai B, Liu M, Sawaya R, Xie K & Huang S (2008) FoxM1B transcriptionally regulates vascular endothelial ... VEGF–Trap, anti- VEGFR neutralizing IgG and immunotherapy against VEGFRs are undergoing clinical trials Table Activities of vascular endothelial growth factor (VEGF) family members PlGF, placenta growth...

Ngày tải lên: 18/02/2014, 11:20

... Cytoplasmic extracts were preincubated with an anti- PTB monoclonal antibody (PTB), with a control anti- GM-CSF monoclonal antibody (GM), or without antibody (–) Labeled V1 RNA probe was then added ... Antibodies The anti- CSD antibody is a rabbit polyclonal Ig raised against a peptide conserved in dbpA and dbpB/YB-1 CSD proteins across species [49,51] The anti- PTB Ig is a mouse monoclonal antibody ... Post-transcriptional regulation of vascular endothelial growth factor by hypoxia J Biol Chem 271, 2746–2753 17 Shih, S.-C & Claffey, K.P (1999) Regulation of human vascular endothelial growth factor mRNA stability...

Ngày tải lên: 19/02/2014, 12:20

... for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation J Biol Chem 275, 5096–5103 32 Kroll, J & Waltenberger, J (1997) The vascular endothelial ... cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation J Cell Biochem ... King, G.L (1996) Characterization of vascular endothelial growth factor s effect on the activation of protein kinase C, its isoforms, and endothelial cell growth J Clin Invest 98, 2018–2026 29...

Ngày tải lên: 19/02/2014, 16:20

... viral vascular endothelial growth factor Virus Res 124, 50–58 14 Ueda N, Wise LM, Stacker SA, Fleming SB & Mercer AA (2003) Pseudocowpox virus encodes a homolog of vascular endothelial growth factor ... of vascular endothelial growth factor- E J Biol Chem 281, 19578–19587 23 Keyt B, Nguyen H, Berleau L, Duarte C, Park J, Chen H & Ferrara N (1996) Identification of vascular endothelial growth factor ... & Carmeliet P (2003) Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition...

Ngày tải lên: 23/03/2014, 07:20

... angiogenesis and vascular endothelial growth factor secretion in human melanoma Br J Cancer 1998, 77:897-902 37 Straume O, Akslen LA: Expression of vascular endothelial growth factor, its receptors ... μg/ml murine anti- VEGF monoclonal antibody 30 prior to BM conditioned media Once treatments were finished, a B16M adhesion assay to BMSCs was performed In other experiments, anti- VCAM-1 antibody ... μg goat anti- mouse agarose-conjugated VCAM-1 polyclonal antibody (Santa Cruz Biotechnology, Santa Cruz, CA) and blots were blocked and incubated with rat anti- mouse VCAM-1 monoclonal antibody...

Ngày tải lên: 18/06/2014, 22:20

Ngày tải lên: 19/06/2014, 22:20

... expression of endogenous control b-actin ALS, amyotrophic lateral sclerosis; VEGF-A, vascular endothelial growth factor- A; CCL2, chemokine ligand-2; PBMCs, peripheral blood mononuclear cells levels ... is represented by x-axis in part “A” ALS, amyotrophic lateral sclerosis; VEGF-A, vascular endothelial growth factor- A; CCL2, chemokine ligand-2; PBMCs, peripheral blood mononuclear cells and ... is represented by x-axis in part “A” ALS, amyotrophic lateral sclerosis; VEGF-A, vascular endothelial growth factor- A; CCL2, chemokine ligand-2; PBMCs, peripheral blood mononuclear cells Conclusion...

Ngày tải lên: 19/06/2014, 22:20

... overnight with a rabbit polyclonal anti- phospho-Akt C antibody (1:1,000; Cell Signaling), anti- BAX antibody (1:1,000; Cell Signaling), and mouse monoclonal anti- α-tubulin antibody (1:10,000; Sigma-Aldrich), ... protocols leading to better prognosis List of abbreviations VEGF, vascular endothelial growth factor; VEGFR1, vascular endothelial growth 16 factor receptor 1; PI3K, Phosphoinositide 3-kinase; AMD, age-related ... yoko-o@sc.itc.keio.ac.jp Abstract Background: Anti- vascular endothelial growth factor (VEGF) drugs and/or photodynamic therapy (PDT) constitute current treatments targeting pathological vascular tissues in tumors...

Ngày tải lên: 19/06/2014, 22:20

... proteins vascular endothelial growth factor, basic fibroblast growth factor, insulin-like growth factor- 1, platelet derived growth factor, placenta growth factor and tumor necrosis factor alpha ... VEGF: neutralising monoclonal antibody to vascular endothelial growth factor isotype 165 (0.3 ug/mL), VEGF: vascular endothelial growth factor, PlGF: placental like growth factor Data illustrates ... like growth factor -1, VEGF 165: vascular endothelial growth factor isotype 165, PlGF: placental like growth factor, bFGF: basic fibroblast growth factor, PDGF: platelet derived growth factor...

Ngày tải lên: 20/06/2014, 01:20

... from mature, monomeric VEGF), but not human placenta-derived growth factor, platelet-derived growth factor, or transforming growth factor Inter- and intra-assay variances for VEGF, sVEGFR-1, and ... ventricular ejection fraction (%) (mean ± SD%) 62 ± Antinuclear antibodies ≥1/160 38 (92) Anti- topoisomerase I antibodies /anti- centromere antibodies 12/7 Creatininaemia (µmol) (mean ± SD) 79 ... serum creatinine concentration, and antinuclear, anticentromere (indirect immunofluorescence on HEp2 cells), and antitopoisomerase I (counterimmunoelectrophoresis) antibody levels Pulmonary involvement...

Ngày tải lên: 09/08/2014, 01:23

... 1/43 1/9 Antinuclear antibody- positive 39/43 9/9 Anti- Scl-70 autoantibody-positive 13/43 0/9 Anticentromere antibody- positive 11/43 7/9 No autoantibodies 4/43 0/9 70 (26–144) – Antinuclear antibodies ... 0.32) Serum levels of vascular endothelial growth factor (VEGF) analyzed according to the presence of anti- Scl-70 autoantibodies Patients with anti- topoisomerase I (Scl-70) autoantibodies (Scl-70 ... endostatin and the presence of anti- Scl-70 autoantibodies, anticentromere antibodies or antinuclear antibodies Similarly, there was no association of bFGF with any of the autoantibodies Page of 10 (page...

Ngày tải lên: 09/08/2014, 06:22

... tumor necrosis factor- α, vascular endothelial growth factor1 65 and SU1498 on ADAM15 expression (a) Effect of tumor necrosis factor expression (TNF)-α and vascular endothelial growth factor (VEGF)165 ... rabbit anti- VEGFR-2 antibody (Flk-1; µg/ml; Santa Cruz Biotechnology, Santa Cruz, CA, USA), rabbit antivon Willebrand factor (vWF; 15 µg/ml; DakoCytomation Norden A/S) or mouse anti- CD31 antibody ... immunoblotted with anti- FLAG antibody (lanes and 2) or anti- ADAM15 antibody (240-2C7) (lanes 36) as described in Materials and methods The absorption study was carried out by incubation of the antibody...

Ngày tải lên: 09/08/2014, 07:20

... Role of vascular endothelial growth factor in the regulation of angiogenesis Kidney Int 1999, 56:794-814 Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z: Vascular endothelial growth factor (VEGF) ... Stringer SE: The splice variants of vascular endothelial growth factor (VEGF) and their receptors J Cell Sci 2001, 114:853-865 Thomas KA: Vascular endothelial growth factor, a potent and selective ... peptide vascular endothelial growth factor are expressed in osteoarthritic cartilage Arthritis Rheum 2001, 44:1082-1088 Pufe T, Harde V, Petersen W, Goldring MB, Tillmann B, Mentlein R: Vascular endothelial...

Ngày tải lên: 09/08/2014, 08:23

... SigmaAldrich Co., Ltd (St Louis, MO, USA) An antibody against human COX-2 was obtained from Invitrogen Biotechnology (catalog number COX 229, Camarillo, CA, USA), antibody against human VEGF was obtained ... washed twice with permeabilization buffer and the supernatant was removed Mouse anti- human VEGF antibody (1 μL) and human anti- rabbit IgG (1 μL) was added to experimental and control tubes, respectively, ... of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells PNAS 2001, 98(12):6905-10 Petersen...

Ngày tải lên: 10/08/2014, 10:20

... neuronal vascular endothelial growth factor (VEGF) in the central nervous system J Biol Chem 2002, 277:11410-11415 Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, Ferrara N: Vascular endothelial ... N, Tohyama M: Vascular endothelial growth factor rescues hippocampal neurons from glutamateinduced toxicity: signal transduction cascades FASEB J 2001, 15:1218-1220 Ogunshola OO, Antic A, Donoghue ... incubated with anti- Flt-1 (sc-316), anti- Flk-1 (sc-504) or anti- Neuropilin (sc-5541) antibodies (2 µg/ml, Santa Cruz Biotechnology) in blocking buffer at 4°C o/n Unbound primary antibodies were...

Ngày tải lên: 11/08/2014, 08:20

... growth factor and vascular endothelial growth factor in sera of cancer patients Br J Cancer 1997, 76:238-43 27 Kondo S, Asano M, Suzuki H: Significance of vascular endothelial growth factor /vascular ... which are vascular endothelial growth factor (VEGF) and basic growth factor (bFGF) In angiogenesis, a number of growth factors (for example Angiopoietin-1, Platelet derived growth factor, Hypoxia ... for vascular endothelial growth factor J Biol Chem 1994, 269:26988-95 20 Dietz A, Rudat V, Vanselow B, Conradt C, Möhler T: [Predictive value of serum levels of basic fibroblast growth factor, vascular...

Ngày tải lên: 11/08/2014, 20:20

... Gene Symbol Assay ID Vascular endothelial growth factor A Vascular endothelial growth factor B Vegfa Vegfb Placenta growth factor Pgf Rn00585926_m1 Vascular endothelial growth factor receptor Vegfr1 ... and cell survival functions of vascular endothelial growth factor (VEGF) J Cell Mol Med 2005, 9(4):777-94 Wirzenius M, et al: Distinct vascular endothelial growth factor signals for lymphatic vessel ... characterization of a naturally occurring vascular endothelial growth factor. placenta growth factor heterodimer J Biol Chem 1995, 270(13):7717-23 Eriksson A, et al: Placenta growth factor- 1 antagonizes VEGF-induced...

Ngày tải lên: 12/08/2014, 13:22

... specific monoclonal antibody was coated onto a microplate Standards and samples were added and a polyclonal detection antibody added The resultant colour developed in proportion to the amount of growth ... of vascular endothelial growth factor in human pulmonary epithelial cells Am J Physiol Lung Cell Mol Physiol 2000, 279(2):L371-L378 Thickett DR, Armstrong L, Christie SJ, Millar AB: Vascular endothelial ... DR, Maeda H: Real-time RT-PCR quantitative assays and postmortem degradation profiles of erythropoietin, vascular endothelial growth factor and hypoxia-inducible factor alpha mRNA transcripts in...

Ngày tải lên: 12/08/2014, 14:20

... CD, Lynch DA, Flores SC, Voelkel NF: Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor in emphysema Am J Respir ... of pulmonary vascular remodeling in smokers and patients with mild COPD Eur Respir J 2002, 19:632-8 Kanazawa H, Hirata k, Yoshikawa J: Imbalance between vascular endothelial growth factor and endostatin ... PAP : pulmonary arterial pressure • PVR : pulmonary vascular resistance • PWP : pulmonary wedge pressure • VEGF : vascular endothelial growth factor Competing interests The author(s) declare that...

Ngày tải lên: 12/08/2014, 15:20