anoxic brain damage in a near drowning

... cephalosporins (cefazolin, cefotaxime, and cefepime), the fluoroquinolones (ciprofloxacin, levofloxacin), the aminoglycosides (amikacin, gentamicin, and tobramycin), meropenem, pipercillin/tazobactam ... pipercillin/tazobactam and trimethoprim/sulfa At this point, the patient was started on meropenem The initial CT scan of the brain done on arrival to Mount Sinai was negative However, follow-up CT of the brain ... stability On day eight, he was airlifted to Mount Sinai Medical Center, a tertiary care facility in Miami Beach, Florida, for further management Upon arrival, he was afebrile (T 98.0°F), bradycardic...

Ngày tải lên: 26/10/2012, 09:53

... 30:552-558 Castellanos M, Castillo J, Garcia MM, Leira R, Serena J, Chamorro A, Davalos A: Inflammation-mediated damage in progressing lacunar infarctions: A potential therapeutic target Stroke ... glutamate was selected as a biomarker of excitotoxic damage, ICAM-1 and IL-6 as inflammatory biomarkers, and MMP-9 as well as cFn as blood brain barrier disruption biomarkers We did not find any ... previously [6,9,10] Each sample was assayed in duplicate and intra-assay coefficients of variation sample values were always

Ngày tải lên: 18/06/2014, 19:20

... 30:552-558 Castellanos M, Castillo J, Garcia MM, Leira R, Serena J, Chamorro A, Davalos A: Inflammation-mediated damage in progressing lacunar infarctions: A potential therapeutic target Stroke ... glutamate was selected as a biomarker of excitotoxic damage, ICAM-1 and IL-6 as inflammatory biomarkers, and MMP-9 as well as cFn as blood brain barrier disruption biomarkers We did not find any ... previously [6,9,10] Each sample was assayed in duplicate and intra-assay coefficients of variation sample values were always

Ngày tải lên: 20/06/2014, 03:20

... probes placed in the hemisphere contralateral to an intracerebral hematoma may dramatically underestimate ICP and render apparently Page of normal values even in the case of transtentorial brain herniation ... to a large intracerebral hemorrhage may grossly underestimate ICP around the hematoma This can be particularly devastating when hemorrhage occurs in deep brain structures such as the basal ganglia ... Yano M, Ikeda Y, Kobayashi S, Otsuka T: Intracranial pressure in headinjured patients with various intracranial lesions is identical throughout the supratentorial intracranial compartment Neurosurgery...

Ngày tải lên: 11/08/2014, 02:21

... was altered, indicating minor brain damage After the vitreous hemorrhage had cleared, a retinal break was found superiorly where the intraretinal hemorrhage had been located, and the break was ... Karadayi A: The nonsurgical management of a penetrating orbitocranial injury reaching the brain stem: case report J Trauma 1994, 36:116-118 Matsuyama T, Okuchi K, Nogami K, Hata M, Murao Y: Transorbital ... resonance imaging Dry wood can be isodense with air and orbital fat by computed tomography Surv Ophthalmol 1992, 36:341-344 Agrawal A, Pratap A, Agrawal CS, Kumar A, Rupakheti S: Transorbital orbitocranial...

Ngày tải lên: 11/08/2014, 14:21

... preparation NF was involved in animal experimentation, tissue sample preparation and toxin quantification RV participated in animal experimentation AA was involved in histopathological studies and ... image analysis FV participated in coordination of experiments and manuscript preparation KF was involved in sample preparation and quantification LAP participated in the design and coordination ... tissues during pneumococcal pneumonia was performed by in situ-TUNEL assay and by specific immunostaining of active caspase-9 TUNELand caspase-9-staining were located in alveolar macrophages at 12...

Ngày tải lên: 12/08/2014, 16:20

... leads to the formation of brain edema in septic rats Magnesium administration attenuated the increased BBB permeability and caused a reduction in brain edema formation in our rat model of intraperitoneal ... Effects of magnesium administration on brain edema and blood brain barrier breakdown after experimental traumatic brain injury in rats J Neurosurg Anesthesiol 2003, 15:119-125 Heath DL, Vink R: Neuroprotective ... infusion of bacteria in a chronic porcine model Anesthesiology 2000, 93:793-804 18 van den Brink WA, Marmarou A, Avezaat CJ: Brain edema in experimental closed head injury in the rat Acta Neurochir...

Ngày tải lên: 12/08/2014, 20:20

... Journal compilation ª 2008 FEBS D E Pellegrini-Giampietro et al The endocannabinoid system in cerebral ischemia Glutamatergic terminal GABAergic terminal CB1 CB1 GA B A Glutamate Soma AEA 2-AG Spine ... 2006 Hayakawa K, Mishima K, Abe K, Hasebe N, Takamatsu F, Yasuda H, Ikeda T, Inui K, Egashira N, Iwasaki K et al (2004) Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism ... 15–27 38 Zani A, Braida D, Capurro V & Sala M (2007) D9-tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid...

Ngày tải lên: 07/03/2014, 03:20

... and gamma, are known to prevent ischemic brain damage [51–57] By contrast, nuclear factorkappaB, activating transcription factor-3, CCAATenhancer binding protein-beta, interferon regulatory factor-1, ... ischemic brain damage [125], and both intracerebroventricular and systemic administration of IL-1 receptor antagonist (IL-1ra) markedly reduces brain damage induced by focal stroke, further implicating ... result of peri-infarct spreading depression and molecular injury pathways that are activated in the cellular and extracellular compartments At this stage, cellular damage is mainly triggered...

Ngày tải lên: 07/03/2014, 03:20

... Kitagawa-Sakakida S, Nishimura M, Morishita R, Kaneda Y, Kohmura E, Yoshimine T & Matsuda H (2001) Nuclear factor-kappa B decoy attenuates neuronal damage after global brain ischemia: a future strategy ... Bim noxa Fig NF-jB signaling in ischemia, In brain ischemia, NF-jB becomes rapidly activated in response to diverse extracellular signals (including glutamate and TWEAK) and to intracellular events ... JH, Park SW, Kapadia R & Vemuganti R (2007) Role of transcription factors in mediating post-ischemic cerebral in ammation and brain damage Neurochem Int 50, 1014–1027 Schwaninger M, Inta I &...

Ngày tải lên: 07/03/2014, 03:20

... neurodegeneration seems to occur mainly in specific types of brain ischemia, including the global type of brain ischemia Also, activation of the apoptotic program typically occurs in a delayed manner in brain ... clinically relevant tool to limit postischemic brain damage because of its ability to inhibit microglia activation Minocycline is indeed able to reduce brain infarct volumes in preclinical models ... observations suggest that NMDA receptor channel openings, ROS formation, DNA damage and PARP activation are sequential crucial steps in the process leading to neuronal death They also indicate that...

Ngày tải lên: 07/03/2014, 03:20

... [7], are cytoskeletal components, such as ankyrin and bands 4.1 and 4.2, as well as the integral membrane protein band (AE1; the anion transporter) [6] In this respect, asparaginyl deamidation has ... number of abnormal aspartate residues, spontaneously arising from L-asparaginyl deamidation and/or L-aspartyl isomerization reactions [7] In addition it has been reported that isoaspartate residues, ... glycosylation of haemoglobin (glycation) has been shown to increase in the course of mismanaged hyperglycaemia in diabetes [27] Haemoglobin is a useful protein marker of this kind of damage, although...

Ngày tải lên: 08/03/2014, 22:20

... University Hamilton, Ontario, Canada DESIGN OF A NEAR INFRARED SPECTROPHOTOMETRY BRAIN IMAGING SYSTEM BY SUKNEET BASUTA Electrical and Biomedical Engineering Faculty Advisor: Prof Doyle Electrical and ... Basuta Abstract Measuring brain activity is at task generally left for EEG or fMRI However, there is a lesser known imaging technique known as near infrared spectrophotometry, in which near infrared ... that is able to measure brain activity The results show that not able is the system able to measure changes in brain activity relating to motor movement, visual stimulation, and intense thinking,...

Ngày tải lên: 16/04/2014, 01:56

... Yoshinaga M, Ohkawara S, Nariuchi H, McCracken Jr, G.H.: Tumor necrosis factor alpha / cachectin and interleukin beta initiate meningeal inflammation J Exp Med 1990, 172:497-507 Saukkonen K, Sande ... impairment in young people in industrialized countries [1,2] The neuropathological sequelae of brain injury are mediated in large part by a profound host-mediated intracranial inflammatory response ... demonstrated significantly elevated intracranial IL-18 levels after brain injury, both in humans as well as in experimental model systems [8,9] With regard to TNF, the mean levels in individual serial...

Ngày tải lên: 19/06/2014, 22:20

... were always assayed at the same time and in the same way All samples were always determined in triplicate and in a blind fashion Immunoblot analysis An aliquot of brain homogenates was electrophoresed ... this AD-like brain A amyloidosis model Previously, we have shown that a full dose of indomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain ... outlined anatomical area in the image, as previously described [9,16,17] Analyses were always performed in a coded fashion Statistical analysis Data are expressed as mean ± standard error of mean...

Ngày tải lên: 19/06/2014, 22:20

... Justicia C, Camins A, Planas AM: Activation of nuclear factor-kappaB in the rat brain after transient focal ischemia Brain Res Mol Brain Res 1999, 65:61-69 Zhang W, Potrovita I, Tarabin V, Herrmann ... M: NF-kappaB is activated and promotes cell death in focal cerebral ischemia Nat Med 1999, 5:554-559 Rothwarf DM, Karin M: The NF-kappa B activation pathway: a paradigm in information transfer ... Discussion Brain damage caused by IR is due, in part, to secondary injury from inflammation [32] The degree of inflammation is exacerbated by increased lipid peroxidation which increases neuronal death...

Ngày tải lên: 19/06/2014, 22:20

... pathway activity after traumatic brain injury (TBI) Functional Functional assessment of mAb 1379 on alternative complement pathway activity after traumatic brain injury (TBI) Relative alternative ... complement-mediated neuroinflammatory response after head injury Background Traumatic brain injury (TBI) represents a neuroinflammatory disease which is in large part mediated by an early activation of ... controls: (1) A significant attenuation of complement pathway activity at the level of the alternative pathway (zymosan assay) and overall at the level of anaphylatoxin formation (C 5a ELISA) Page 10...

Ngày tải lên: 19/06/2014, 22:20

... in cerebral vasculature by anandamide provides a new mechanism that may explain the therapeutic action of increased anandamide tone in neuroinflammatory diseases like MS Additional material Additional ... A, Bari M, Granata F, Gasperi V, De Stefano ME, FinazziAgrò A, Strom R: Regulation by cannabinoid receptors of anandamide transport across the blood -brain barrier and through other endothelial ... lipase), and degradation enzymes (FAAH, MAGL) and proteins involved in their transport, and intracellular trafficking [9] Increasing evidence suggests the involvement of the ECS in both the inflammatory...

Ngày tải lên: 19/06/2014, 22:20

... different readout modes such as progressive scan and interlaced scan Assume the size of the raw Bayer data is ∗ 4, take the progressive scan as an example, the raw Bayer image data are read out as shown ... parameter Image format Low-pass transformation filter Raw Bayer data JPEG-LS encoding Compressed data (a) Quality control factor ROI parameter Restored Bayer data Image format transformation JPEG-LS ... compressed image data, and a dual port block memory is used as two line buffer for image format transformation 8 EURASIP Journal on Advances in Signal Processing Buf for variable N Buf for variable C...

Ngày tải lên: 22/06/2014, 23:20