animal models of periodontitis associated systemic disease

... Animal models of Wilson's disease The LEC rat [36] and the toxic milk mouse are the only known valid animal models of Wilson's disease [11,37] Animal models of Wilson's disease – LEC rat The LEC ... contribute to the knowledge of the pathogenesis of copper -associated diseases This re- view demonstrates that there are numerous spontaneous animal models of copper -associated liver diseases Based on the ... an interesting feature of this particular animal model because hepatocellular carcinoma is rarely diagnosed in Wilson's disease patients [66] Animal models of Wilson's disease – Toxic milk mice...

Ngày tải lên: 13/08/2014, 13:20

... end of both inflammatory models, a panel of cytokines was analyzed in blood At sacrifice whole blood was collected from the heart of the animals and plasma was obtained by centrifugation 25 μl of ... article as: Patrignani et al., Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation Journal of Inflammation 2010, 7:16 ... right paws were used as reaction index for the individual animal A cut-off of 25 seconds was used to avoid tissue damage in case of absence of response Automated Von Frey test Mechanical allodynia...

Ngày tải lên: 11/08/2014, 03:20

... 1391 Animal models of Alzheimer’s disease O Philipson et al Transgenic animal models Models devoid of any disease- causing APP mutations Animal models expressing wild-type (wt) human APP are of ... revolutionized our ability to develop animal models of AD, and also contributed significantly to the understanding of molecular pathogenesis Today a wide range of animal models are available for mechanistic, ... in Alzheimer’s disease pathogenesis Familial forms of AD, with an autosomal dominant mode of inheritance, account for < 2% of all AD cases Onset is most often before 65 years of age, and the...

Ngày tải lên: 16/02/2014, 09:20

... not considered in the category of animal models of disease, one can view the field of human genetics as probing a vast natural mutagenesis screen involving billions of individual organisms As in ... to developing animal models of CCM disease Classically, a CCM consists of a cluster of dilated blood vessels [12,13] Each vessel in the cluster is grossly dilated, earning the name of a cavern; ... CCM animal models A C Chan et al quency [26,31–34] Although disappointing, this lack of faithful disease modeling has generally been the case for most mouse genotype equivalents of human disease...

Ngày tải lên: 15/03/2014, 10:20

... by the use of germ line p53 inactivation alters immune system function in a number of significant ways in these animals, limiting the use of these models for evaluating the effect of anti-tumor ... the systemic effects of EGF-R overexpression on immune function However the dependence of EGF-R models on the use of cross breeding with germ line mutants, likely introduces its own set of immunobiological ... critical immunologic functions Specific to the current discussion of the immune system, Table 1: A summary of existing animal models of brain tumors Tumorigenesis Method Implantation Genetic Technique...

Ngày tải lên: 18/06/2014, 15:20

... experimental animal models through the expression of herpes simplex virus thymidine kinase (HSV-Tk) in cells of animals and then injecting the animals with 2′-fluoro-2′-deoxy-1-beta-Darabinofuranosyl-5-iodo-uracil ... of formation of the immunological synapse, a specific supramolecular pattern of receptors involved in immune cell communication, in vivo [42,43] Two-photon microscopy One of the limitations of ... high-resolution images of small animals) It was found that the anti-glucose-6-phosphate isomerase antibody was rapidly concentrated in distal joints (the targets of the disease) , while control...

Ngày tải lên: 09/08/2014, 01:22

... investigation in animal models of arthritis This review focuses on the gene therapeutic strategies of restoring the cytokine balance and genetic synovectomy in animal models of RA, as summarized ... Loo et al disease, and cessation of treatment results in a relapse of disease in RA patients Second, repeated systemic delivery is necessary to achieve steady and efficacious levels of the agent ... independently in animal models of arthritis Recent human trials of IL-1Ra revealed moderate efficacy, probably because of poor pharmacokinetics and the 100- to 1000-fold excess of this molecule...

Ngày tải lên: 09/08/2014, 01:24

... varying patterns of expression [14] Extracellular domains of FGFRs consist of three immunoglobulin-like loops (loop I, loop II, and loop III) Alternative mRNA splicing of loop III of FGFR1 to FGFR3 ... and progression of OA The purpose of the present study was to examine whether FGF8 is involved in the destruction of cartilage in OA models Initially, a rabbit meniscectomy model of OA, in which ... FGF8f specifically out of the four human FGF8 isoforms, and showed little binding to other members of the FGF family Neutralizing activity of KM1334 was shown by the blocking of FGF8b binding to...

Ngày tải lên: 09/08/2014, 10:23

... to determine expression patterns of a panel of relevant genes in a large number of distinct colonies of the susceptible mouse strain BALB/c Although induction of disease by the usual immunisation ... genetics of rheumatoid arthritis point to subclassification into distinct disease subsets Arthritis Res Ther 2008, 10:205 Holmdahl R: Dissection of the genetic complexity of arthritis using animal models ... sub-lines of BALB/c mice showed modest but significant differences in immune parameters such as cytokine and antibody responses and clinical scores when disease was induced with suboptimal doses of...

Ngày tải lên: 09/08/2014, 14:20

... likely that IC models mimic part of the RA pathology There is growing interest in the use of passive IC models, together with a range of transgenic knockouts, to identify Page of 10 (page number ... interests References Conclusion Models are tools that mimic aspects of human disease It is clear that animal models have contributed considerably to further our understanding of arthritic processes and ... 14 The Scientific Basis of Rheumatology: A Decade of Progress This article is part of a special collection of reviews, The Scientific Basis of Rheumatology: A Decade of Progress, published to...

Ngày tải lên: 09/08/2014, 14:22

... activation of the complement system and cellPage of (page number not for citation purposes) mediated immunity in order to eliminate the germ-inducing perpetuation of the inflammation The ability of the ... related to the natural course of the disease and not to the efficacy of the antibiotic therapy Thus, randomized placebo control studies are needed to document the effects of antibiotic therapy Further ... antibiotic therapy Further trials are needed to create a model of SAPHO disease using P acnes transfer to healthy animals Mechanisms of ineffective host responses for neutralizing and eliminating...

Ngày tải lên: 09/08/2014, 14:22

... userfriendly to the experimentalist Animal models that may be of great benefit to the study of the mechanisms involved in the development of COPD were described The importance of animal and strain selection ... induction of emphysema were also described It was evident from the meeting that much more needs to be done in this field and that the importance of having robust animal models of the disease that ... antielastase and lack of sensitivity to oxidants) Conclusion It was evident from this meeting that a great deal of effort is going on worldwide to produce animal models of COPD Page of (page number...

Ngày tải lên: 12/08/2014, 18:20

... different animal models of COPD which have been established so far, it is crucial to reflect that within COPD, different disease stages exist and that only some of them may be mimicked in animal models ... heterogeneous disease and different possible outcomes may occur at each of the stages Experimental modeling of each stage of severity may be a way of providing an answer to this issue Animal models ... laboratory animal models but provides an advantage for developing models in larger animals such as the pig or sheep Part of the problem of analyzing small airways is also due to the lack of sophistication...

Ngày tải lên: 12/08/2014, 18:21

... al., 2001) 1.4 Animal models of asthma Animal models of asthma have contributed abundantly to the understanding of the pathophysiological mechanisms of asthma Accordingly, they are of great value ... levels, the number of IgE receptors expressed on the surface of basophils, the clinical severity of asthma, the 23 frequency of exacerbations, and the corticosteroids requirements of patients with ... have broad utility in the treatment of pulmonary disease However, full knowledge of the therapeutic value of this novel compound class awaits the outcome of long-term clinical trials (Torphy...

Ngày tải lên: 15/09/2015, 22:09

... studies on the effects of the intervention of these signaling pathways in animal models of asthma The purpose of my thesis was to investigate the antiinflammatory effects of genistein, a broad-spectrum ... TABLE OF CONTENTS iii LIST OF FIGURES viii LIST OF TABLE xii LIST OF ABBREVIATIONS xiii LIST OF PUBLICATIONS AND CONFERENCE PAPERS xv SUMMARY xvii INTRODUCTION 1.1 Asthma 1.1.1 Pathophysiology of ... Effects of U0126 on cytokine levels in BAL fluid 97 5.1.4 Effects of U0126 on serum immunoglobulin levels 97 5.1.5 Effects of U0126 on the expression of VCAM-1 in lung tissues 103 5.1.6 Effects of...

Ngày tải lên: 16/09/2015, 17:11

... a greater understanding of the role of this process in the development of AD-type pathology Unfortunately, knowledge of the extent of complement activation in animal models is lacking This paper ... criteria for an optimal animal model to study this issue, (b) present knowledge about complement activation in animal models of AD, and (c) additional animal models which offer alternatives for ... optimal animal model of AD should be associated with SPs and, in those models in which neurofibrillary pathology occurs, with NFTs Initiation of complement activation early in development of pathology...

Ngày tải lên: 19/06/2014, 22:20

... number of available animal models for RA that all mimic various aspects of the disease, possibly reflecting disease pathways that operate in different subgroups of RA patients Thus, all of these models ... understand these genetic regions Animal models and their relevance to rheumatoid arthritis The value of mapping in animals is dependent on there being good models of human diseases In this review we ... modifications of animals With emerging knowledge of the major genes that underlie human disease and improved animal models, it seems straightforward to investigate the in vivo function of these genes...

Ngày tải lên: 09/08/2014, 01:22

... coverage of structural assignments to the N-terminus of Ab Moreover, the procedures described here are also suitable for expression and purification of mutant versions of Alzheimer’s disease -associated ... high-resolution structural analysis of Ab monomer and its assemblies has been hampered because of the lack of an affordable source of Ab peptides Chemical synthesis of various Ab peptides is now routine ... C-terminus, is particularly associated with disease [12] Through biochemical and animal modeling studies, researchers have built up a detailed picture of the natural economy of brain Ab Like all proteins,...

Ngày tải lên: 18/02/2014, 13:20

... professor of the University of Texas, whose comments and suggestions were of inestimable value for our study using GC-A knockout mice, to Professor Misono of the University of Nevada School of ... regulation of blood pressure Overall, these results show the significance of the endogenous natriuretic peptide system in the maintenance of normal blood pressure Regulation of blood volume Infusion of ... phenotype Not reported No signs of systemic hypertension Heart Systemic overexpression Systemic disruption Average 5.2 mmHg below normal in F1 mice carrying three copies of the GC-A gene Normal blood...

Ngày tải lên: 14/03/2014, 23:20

... that a matrix of gait dynamic markers could be useful in characterizing different diseases of motor control [36] Comparable analyses of gait and stride variability in mouse models of PD and HD ... of motor dysfunction, we also studied gait dynamics in the SOD1 G93A transgenic mouse model of ALS [39] to compare gait variability in mouse models of basal ganglia disease to a mouse model of ... variability of the hind limbs was affected after the 2nd administration of 3NP (cumulative dose of 50 mg/kg) After the 3rd administration of 3NP (cumulative dose of 75 mg/kg), half of the 3NP-treated...

Ngày tải lên: 19/06/2014, 10:20