animal models of behçet s disease

... ~8 weeks, ~10 weeks, ~12 weeks, and ~13 weeks Discussion Gait disturbances are characteristic of Parkinson 's disease, Huntington 's disease, and amyotrophic lateral sclerosis Gait reflects several ... image analyses The treadmill belt was wiped clean between studies if necessary Statistics Data are presented as means ± SE ANOVA was used to test for statistical differences among saline-treated, ... aspects of pathogenesis and pathology of motor dysfunction, we also studied gait dynamics in the SOD1 G93A transgenic mouse model of ALS [39] to compare gait variability in mouse models of basal...

Ngày tải lên: 19/06/2014, 10:20

... increased levels of cytokines in the brains of Alzheimer 's disease patients, and in transgenic mouse models of Alzheimer 's disease [10-12] However, all these reports have focused on a small number ... expressed in picograms per milligram of protein P < 0.05 was considered statistically significant Table 1: Quantification of Aβ levels in TgAPPsw and PS1/APPsw mouse brain slices Data expressed as ... GM-CSF Figure Cytokine production by brain slices from transgenic mouse models of AD at 15 months of age Cytokine production by brain slices from transgenic mouse models of AD at 15 months of...

Ngày tải lên: 19/06/2014, 22:20

... 38:426-433 Suzuki N, Nara K, Suzuki T: Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet s disease Clin Med Res 2006, ... and diseasespecific features of BD is the occurrence of a positive skin pathergy reaction (SPR), which is observed in 30% to 75% of all BD patients [2,4] Neutrophils and subsequently lymphohistiocytic ... inflammatory cells On the other hand, those micro-organisms are also capable of stimulating an immune response in BD Most tissue studies of the pathophysiology of BD are conducted in skin One of the unique...

Ngày tải lên: 09/08/2014, 14:20

... Katsuyama Y, Pivetti-Pezzi P, Ohno S, Inoko H: Significant associations of HLA-B*5101 and B*5108, and lack of association of class II alleles with Behçet s disease in Italian patients Tissue ... patients with Behçet disease: a metaanalysis Arch Med Res 2010, 41:142-146 Lee EB, Kim JY, Zhao J, Park MH, Song YW: Haplotype association of IL-8 gene with Behcet s disease Tissue Antigens 2007, ... diagnosis of Behçet s disease International Study Group for Behçet s Disease Lancet 1990, 335:1078-1080 Lee EB, Yoo JE, Lee YJ, Choi YJ, Park KS, Song YW: Tumor necrosis factor receptor polymorphism...

Ngày tải lên: 12/08/2014, 15:22

... Authors Journal compilation ª 2010 FEBS 1391 Animal models of Alzheimer s disease O Philipson et al Transgenic animal models Models devoid of any disease- causing APP mutations Animal models expressing ... increased resistance of Ab40 to proteolysis In aged animals there was an extensive accumulation of CAA in leptomeningeal and cortical vessels with few diffuse plaques, severe loss of SMCs, weakening ... relevance of cross-breeding experiments is strengthened if expression and deletion of the gene (s) results in the opposite outcome, or if the results are substantiated by in vitro studies or analyses of...

Ngày tải lên: 16/02/2014, 09:20

... expression libraries using BD sera was used since this approach has been successfully employed in the characterization of many clinically relevant antigens in systemic rheumatic diseases such as SS-A/Ro ... diseases such as SLE, SjS, rheumatoid arthritis etc., as well as those diseases not easily differentiated from BD, such as recurrent aphthous oral ulcer, Reiter 's syndrome, inflammatory bowel diseases ... any other disease (Group II, defined as 'probable BD' in this study) Disease controls included 10 patients with SLE and 10 with SjS, all satisfying corresponding international classification...

Ngày tải lên: 09/08/2014, 07:20

... distinct autoimmune diseases characterized by the presence of serum anti-endothelial cell antibodies such as BD, systemic lupus erythematosus (SLE), systemic sclerosis (SSc), various forms of ... patients and healthy subjects Anti-carsubjects boxy-terminal subunit of Sip1 (anti-Sip1 C-ter) antibodies in patients with Behçet' s disease (BD), systemic lupus erythematosus (SLE), systemic sclerosis ... donors Serum samples Number of total samples Anti-Sip1 C-ter antibody response, number of positive samples (%) IgG IgM IgA Behçet' s disease 56 11 (20) 23 (41) (17) Systemic lupus erythematosus 32...

Ngày tải lên: 09/08/2014, 08:22

... years) who presented at disease relapse while not receiving corticosteroid treatment were studied prospectively Subsequent to their clinical assessment, these patients underwent vascular studies ... days Clinical assessment and vascular studies were repeated on day The present study was conducted, using both case-controlled cross-sectional and prospective interventional approaches, to dissect ... presence of corticosteroid treatment, and their respective control subgroups Numbers of patients and significant differences between subgroups (t-test) are shown Values are expressed as mean ± standard...

Ngày tải lên: 09/08/2014, 10:21

... studies [24-26] have demonstrated substantial pathologic roles of HO-1 in rheumatic diseases Abundant expression of HO-1 was identified in synovial tissues of patients with RA, in the absence of ... by using Scion image analysis and image processing software (NIH Image Engineering, Bethesda, MD, USA) Statistical analysis Mann-Whitney U-test, Kruskal-Wallis test with post-hoc Scheffe 's test, ... Hirose S, Matsuda H, Wakisaka A, Aizawa M: Close association of HLA-Bw51 with Behcet 's disease Arch Ophthalmol 1982, 100:1455-1458 Sezer FN: The isolation of a virus as the cause of Behcet 's diseases...

Ngày tải lên: 09/08/2014, 10:22

... vascular disease present 2.90 rs9513584 Both eye and vascular disease present 1.13 rs4936742 Vascular disease absent 1.81 rs317711 Vascular disease present G rs2061634 Eye disease absent rs11206377 ... the susceptibility to develop Behçet' s disease in a cohort of Turkish Behçet' s disease patients and controls Materials and methods Patients and controls We studied a cohort of Behçet' s disease ... ethnic groups The pathogenesis of Behçet' s disease remains incompletely understood We have performed a genome-wide genetic association study using a cohort of Turkish Behçet' s disease patients and...

Ngày tải lên: 09/08/2014, 14:20

... chromosomal breakpoints impact the level of LMO2 expression in T-ALL Blood 2007, 110:388-392 Yazici H, Fresko I, Yurdakul S: Behçet s syndrome: disease manifestations, management, and advances in treatment ... Missotten T, van Daele PL, Jamnitski A, Baarsma GS, van Hagen PM: Adalimumab: a new modality for Behçet s disease? Ann Rheum Dis 2007, 66:565-566 Page of (page number not for citation purposes) ... interests References Cañete JD, Celis R, Noordenbos T, Moll C, Gómez-Puerta JA, Pizcueta P, Palacin A, Tak PP, Sanmartí R, Baeten D: Distinct synovial immunopathology in Behçet disease and psoriatic...

Ngày tải lên: 09/08/2014, 14:22

... both, is a rare and serious complication of Behçet s disease, these authors from a University Hospital in Turkey presented 30 cases of Budd-Chiari syndrome, of whom patients with Behçet s disease ... oral ulcers, she had recurrent genital ulceration, skin lesions and a positive skin pathergy test Evidence in countries where Behçet s disease is prevalent suggests that this disease should be ... diagnostic possibilities in cases of Budd-Chiari syndrome because the third most common cause from a total of 75 patients diagnosed with Budd-Chiari syndrome was Behçet s disease [14] Thus, although...

Ngày tải lên: 11/08/2014, 00:22

... ulcers, genital ulcers, skin ulcers, eye symptoms, gastrointestinal ulcers, arthritis, and neural involvement, as well as skin crusting The frequency of these symptoms is similar to that of patients ... consisted of typical mucocutaneous symptoms in mice without ocular symptoms, while those of BD eye mice consisted of ocular symptoms with mucocutaneous symptoms After FACS staining, lymphocytes ... mouse model JAS conducted the experiments on the NK cells KSP and ESL participated in the design of the study and discussion of data analysis SS conceived of the study, participated in its design...

Ngày tải lên: 11/08/2014, 03:20

... cultures Statistical analysis Results were expressed as the mean standard deviation Statistical differences were assessed using one-way ANOVA with posthoc test of the means according to Tukeys method ... the disease such as, the genetic susceptibility, environmental factors, anomalies in the inflammatory responses and immune system dysfunction [1, 2] In response to antigens, mediators such as cytokines ... method In single mean comparisons, Students t-test was used to test the data and considered statistically significant for P values

Ngày tải lên: 11/08/2014, 03:20

... hepatitis, and cirrhosis [1] Animal models of Wilson 's disease The LEC rat [36] and the toxic milk mouse are the only known valid animal models of Wilson 's disease [11,37] Animal models of Wilson 's disease ... Wilson 's disease patients [66] Animal models of Wilson 's disease – Toxic milk mice Toxic milk is an autosomal recessive mutation which alters copper homeostasis in mice [37] Offspring of mutant ... toxicosis has generated much interest as a possible animal model for Wilson 's disease However, it has been proven that Wilson 's disease and Bedlington Terrier copper toxicosis not share the same...

Ngày tải lên: 13/08/2014, 13:20

... these positive symptoms of PD ANIMAL MODELS OF PARKINSON S DISEASE AND PARKINSONISM Early animal models of PD were based on lesions of midbrain areas in monkeys (Poirier et al., 1975) These anatomical ... robust model of parkinsonism Proceedings of the National Academy of Sciences, of the United States of America, 102, 2174 2179 1: THE ETIOPATHOGENESIS OF PARKINSON S DISEASE: BASIC MECHANISMS OF ... which slows or stops disease progression ACKNOWLEDGEMENT This study was supported by grants from the NIH/NINDS (1 RO1 NS045999-01), the Bendheim Parkinson s Disease Center, and the Morris and...

Ngày tải lên: 14/02/2014, 17:20

... a-syn, proteins that displayed increased (›) or decreased (fl) expression as a consequence of a-synuclein overexpression; complex, proteins that displayed altered levels as a result of the association ... silver-stained gel images revealed 28 spots whose intensity was significantly different in at least one of the four groups considered (Fig 2) Two groups of spots showing remarkable changes in the isoform ... present study could represent a valuable starting-point for focused investigations aiming to better understand the key issues of PD pathogenesis Materials and methods Cells Human neuroblastoma SH-SY5Y...

Ngày tải lên: 15/02/2014, 01:20

... of their parents.[1] Scrofula, which is another disease closely allied to consumption, is hereditary also; and hip disease, disease of the spine, abscesses, and enlarged glands in any members ... Afterwards may be studied the diseases of the head, the chest, and the bowels; next constitutional diseases, such as consumption and scrofula; and lastly, the various fevers, as typhoid, or, as it is ... great causes of mortality in infancy, and of sickliness in later life The statistics of Foundling Hospitals bear sad testimony to the fact of its dangers, and the researches of physicians show that...

Ngày tải lên: 17/02/2014, 23:20