and toxic epidermal necrolysis

... CDO was an effective cytotoxic drug in HCT116 and GEO cells (300 nM and Ó FEBS 2004 CRE-decoys in colorectal cancer cells (Eur J Biochem 271) 2779 Fig Effect of CDO and cytotoxic agents on SA-b-gal ... cytotoxic agents in general, CDO had no effect on cell proliferation at equi-molar concentrations (cells per mL and percentage viability with 1.6 lM CDO: 1.1 · 106 and 89.7% vs 1.7 · 106 and ... alone and into cells treated with VP16 alone was summed, and compared to the extent of BrdU incorporation into cells treated with both CDO and VP16 together Each column represents the mean and...

Ngày tải lên: 07/03/2014, 15:20

... Mean, standard deviation, and maximum and minimum nicotine values measured in different indoor environments with smoking occupancy 3-23 Mean, standard deviation, and maximum ... Tables B-13 and B-16 and corrected elements B-13 Notation for distribution of reported female lung cancer cases and controls by husband's smoking ... PASSIVE SMOKING AND RESPIRATORY SYMPTOMS AND LUNG FUNCTION IN ADULTS 7.9.1 Recent Studies on Passive Smoking and Adult Respiratory Symptoms and Lung Function...

Ngày tải lên: 15/03/2014, 01:20

... usual practice (standard of care) and followed over time using standardized methods and forms to make possible a valid and reliable description of case-mix, pattern of care and outcomes Subjects ... objective to assess the epidemiology and quality of different and alternatives analgesic strategies (such as oral morphine, fentanyl and buprenorphine patches, etc) and their effect on patient-reportedoutcomes ... (pharmacological and non-pharmacological treatments) and relevant efficacy (analgesic and other patient-reported outcomes (PRO) outcomes such satisfaction, quality of life measures) and safety outcomes...

Ngày tải lên: 20/06/2014, 15:20

... tumorigenesis including cell proliferation and apoptosis [7], and also angiogenesis [8] were assessed in gastric tumors after drug treatment Materials and methods Chemicals and reagents CKBM-A01 (Batch no.: ... proliferation and promotion of apoptosis in this model Dietary supplement containing Schisandra chinensis has been shown to reduce prostate cancer cell growth and induce apoptosis by inhibiting androgen ... company He had been the founding Editor and Editor-in-Chief of Biological Signals and Biological Signals and Receptors, Adjunct Professor of University of Toronto and is Honorary or Visiting Professor...

Ngày tải lên: 08/08/2014, 18:20

... contributions KLC and AH treated the patient and conceived the idea JW performed the literature search and wrote the manuscript KLC reviewed and revised manuscript All authors have read and approved ... neuropathy and myositis Endocrine treatment not only led to tumour regression but also to an improvement in the biochemical markers (CK and IgG) and clinical symptoms The severity of her symptoms and ... affect most organs and tissues with cancer cachexia and hypercalcaemia being common examples [1] This patient had a neurological syndrome experiencing papillitis, myositis and sensory peripheral...

Ngày tải lên: 09/08/2014, 07:22

... a radiation dose of Gy and Gy, respectively At h and 48 h after irradiation, cells were processed for RNA and protein extraction, clonogenic assays (1 h) and migration and apoptosis assays (48 ... the data and drafted the manuscript HW, MKa, HT and DV aided in study design, analyzed the data and reviewed the manuscript MKo performed experimental procedures, analyzed the data and reviewed ... markers of tumour hypoxia and angiogenesis in localised prostate cancer and outcome of radical treatment: a retrospective analysis of two randomised radiotherapy trials and one surgical cohort...

Ngày tải lên: 09/08/2014, 09:20

... eagle medium (Gibco, Grand Island, NY) containing 10% (v/v) heat-inactivated fetal bovine serum (Gibco, Grand Island, NY), penicillin (100 U/mL) and streptomycin (100 mg/mL), and they were maintained ... the expression of b1- and b2-ARs was determined at both the mRNA and protein level in SGC-7901 and BGC-823 cells by RT-PCR and western blot Our results showed that b1- and b2-adrenergic receptors ... the data and plotting of the figures were performed with the aid of software (Origin Version 7.5 and SPSS Version 13.0) Results Expression of b1- and b2-adrenergic receptors in SGC7901 and BGC-823...

Ngày tải lên: 09/08/2014, 09:20

... cancer and overcoming resistance to standard genotoxic chemo- and radiotherapy Importantly, Akt is embedded into a highly complex network of upstream regulators and downstream effector proteins and ... performed conception and design of the study and substantially contributed to interpretation of data, drafting and critical revision of the manuscript and final approval All authors read and approved ... Cell lines and cell culture The prostate cancer cell lines LNCaP (p53 wild type, androgen-dependent, highly differentiated), PC3 (p53-/-, androgen-independent, poorly differentiated), and DU145...

Ngày tải lên: 09/08/2014, 09:20

... the associations between tTATI and s-TATI concentrations, before and after RT, and clinicopathological parameters, including s-CEA and s-creatinine Classification and regression tree (CRT) analysis ... shown) Association between TATI in tissue and serum and clinicopathological characteristics Figure TATI expression in tumour tissue and normal mucosa before and after radiotherapy Box plots showing ... Angenete E, Oresland T, Falk P, Breimer M, Hultborn R, Ivarsson ML: Preoperative radiotherapy and extracellular matrix remodeling in rectal mucosa and tumour matrix metalloproteinases and plasminogen...

Ngày tải lên: 09/08/2014, 09:21

... DVH and DSH in Fig 1a) 3D-CRT and in Fig 1b) IMRT treatment planning statistically significant between DVH and all other dose parameters, between DWH and DSH but not between DWH and DWH3 and ... DVH, DWH and DSH in 3D-CRT and IMRT treatment planning for prostate cancer A literature review of the association of these dose parameters with late rectal toxicity was conducted Materials and methods ... anatomical anal canal and rectum as the most superior and inferior parts were not included into the OAR Anal canal and rectum were not delineated as different OARs to make the analysis and presentation...

Ngày tải lên: 09/08/2014, 10:21

... differential expression between ER- and ER+ samples (b) Expression levels of Ago1, Ago2, Dicer, and TRBP in ER+ (red) and ER- (green) samples The mean and the standard deviation of the expression ... PicTar algorithm (b) miRanda algorithm (c) Intersection of miRanda and PITA (d-f) TargetScan algorithm where the site is conserved (d), the site context score is above -0.20 (e), and all potential ... breast cancer plete results based on three TargetScan predictions, miRanda, PicTar, and the intersection of PITA and miRanda can be found in Additional data file Use of alternative methods to...

Ngày tải lên: 09/08/2014, 20:20

... and Octreotide-induced expression of XAF1 mRNA and protein in PC3 cell line Cells were stimulated with nM somatostatin (a and b) and nM Octreotide (c and d) for the time periods indicated a and ... Time-dependent somatostatin and Octreotide-induced expression of XAF1 mRNA and protein in DU145 cell line Cells were stimulated with nM somatostatin (a and b) and nM Octreotide (c and d) for the time ... Time-dependent somatostatin and Octreotide-induced expression of XAF1 mRNA and protein in LNCaP cell line Cells were stimulated with nM somatostatin (a and b) and nM Octreotide (c and d) for the time...

Ngày tải lên: 10/08/2014, 10:20

... (HA) and laminin, and mediates cell-cell and cell-matrix adhesion [12,13] The present study aimed to determine the impact of a1, 2-FT gene transfection on the expression of CD44 on cells and the ... expression of CD44 in RMG-I and RMG-I-H cells detected by immunocytochemistry (×400) Panels and are negative controls; panels and are Lewis y antibody-untreated cells; panels and are Lewis y antibody-treated ... cellular functions and related to some malignant cell behaviors, including adhesion, recognition, and signal transduction, and that the increased fucosylated antigens benefit the invasion and migration...

Ngày tải lên: 10/08/2014, 10:21

... Leiden, The Netherlands Page of Authors’ contributions Data were extracted by CvH and CCD and analyzed by FD and NPMS CCD and AWW contributed substantially to data acquisition and analysis The ... with EPD treatment of normal fibroblasts, OVCAR3 and SKOV3 cancer cells (average (AV) and standard deviation (SD)) % cell viability: average and standard deviation EPD Conc 24 hours 48 hours 72 ... Merck, Germany) and by H-NMR spectroscopy Structures of purified compounds were determined by mass spectrometry and H-NMR and 13C-NMR spectroscopy Graphs and Statistics Graphing and statistical...

Ngày tải lên: 10/08/2014, 10:21

... It has anti-tumor metastasis and protective effects on patients accepted radiotherapy and chemotherapy and been widely used to treat acute pancreatitis and shock and to improve surgical outcome ... Effects of ulinastatin and docetaxel on uPA, uPAR and phosphorylated ERK1/2 (p-ERK1/2) proteins Levels of uPA, uPAR and p-ERK1/2 in MDA-MB-231 cells treated with ulinastatin and docetaxel are shown ... other hand, although docetaxel enhanced the expression of uPA, uPAR and ERK1/2, its cell toxicity still plays a dominant role, so when treated with docetaxel alone, the proliferation and tumor...

Ngày tải lên: 10/08/2014, 10:21

... gene was targeted All single shRNA strands were synthesized at Sangon Biotechnology Co., Ltd (Shanghai, China), and were annealed and ligated into the BglII and HindIII sites of linearized psuper-EGFP ... Met and p-MEK1/2 and p-ERK1/2 expression were observed in OVCAR-3-s3 cells However, none obvious changes were detected on levels of total MEK1/2, total ERK1/2, total Akt and p-Akt (Figure 13 and ... studies, drafted manuscript and performed statistical analysis SH participated in design of the study and reviewed manuscript CZ, RF and HH carried out immunohistochemistry and participated in statistical...

Ngày tải lên: 10/08/2014, 10:21

... contributions BX-L and MC-Z carried out experiments and drafted the manuscript CL-L and P-Y participated in study design and helped to draft the manuscript HL, HM-X, HF-X, YW-S and AM-X participated ... demethylated H3K9me3 and facilitated transcription of ER responsive oncogenes including MYB, MYC and CCND1, and knockdown of JMJD2B severely impaired estrogen induced cell proliferation and the tumor ... on the transfection Further, FCM and MTT assay results showed cell cycle changes and proliferation inhibition existed in MDA-MB-231 cell line, and migration and invasion in vitro were both suppressed...

Ngày tải lên: 10/08/2014, 10:21

... at 59°C for 35 s and extension at 72°C for min, and followed by the final extension at 72°C for 10 The primers were shown in Table and Table Materials and methods Cell culture and transfection ... demethylation Hela and Siha cells were transfected with siRNA and treated with 1.0 μM 5az-dC (Sigma) respectively, and harvested at 72 h after incubation Genomic DNA was extracted and randomly sheared ... SFRP4, TSLC1 and CHFR in Hela cells and CCNA1, PTEN, SFRP4 and TSLC1 in Siha cells were analyzed Surprisingly, transfection did not affect the methylation status and mRNA expression of FHIT and PTEN...

Ngày tải lên: 10/08/2014, 10:21

... here the literature and our experience on the in vitro and in vivo animal biological studies of β-glucans, particularly on their immune and anti-cancer mechanisms Physical and chemical properties ... intestine rapidly and are captured by the macrophages after oral administration The βglucans are then internalized and fragmented into smaller sized β-glucans and are carried to the marrow and endothelial ... essential if we want to understand and compare the results on how β-glucans act on our immune system and exerting anti-cancer effects A possibly well-defined β-glucan standard is urgently needed in...

Ngày tải lên: 10/08/2014, 22:20