and their role in cancer and in chronic diseases

... on-going evolution of the understanding of the non-physical aspects of pain has been applied to the areas of screening for, intervening in and predicting those at risk of developing into a chronic ... respondent pain may eventually evolve into operant and persisting pain if the environment offers pain contingent reinforcement Pain behaviour may also be learned by observing "pain models" i.e., individuals ... cognitive capacity In the acute pain situation, "avoidance" behaviours, such as resting, are effective in allowing the healing process to occur [24] In chronic pain patients, the pain and disability...

Ngày tải lên: 13/08/2014, 13:22

... to consider their role in cancer and inflammation S100 proteins are a family of over 20 proteins expressed in vertebrates exclusively and characterized by two calcium binding EF-hand motifs connected ... upregulation of inflammation in this setting [181] Another RAGE ligand, AGE-CML, is present in endoneurial and epineurial mononuclear cells in chronic inflammatory demyelinating polyneuropathy and vasculitic ... that have distinct and often unapparent RAGEactivating properties S100 Proteins as RAGE ligands and their role in Inflammation A recent review on S100 proteins has been published, and provides...

Ngày tải lên: 18/06/2014, 15:20

... been fully investigated in ovarian cancer In the present study, we examined the relationship between the expression of Ets-1 and its targets Ang-2 and maspin in ovarian cancer and their clinical ... maspin in ovarian carcinoma Clin Cancer Res 2002, 8:2924-2932 doi:10.1186/1756-9966-30-31 Cite this article as: Lin et al.: Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role ... different roles in angiogenesis: Ang-1 and Ang-4 are agonist ligands for Tie2 and induce tyrosin phosphorylation of Tie2, while Ang-2 and Ang-3 are antagonist ligands They bind to Tie2 without inducing...

Ngày tải lên: 10/08/2014, 10:21

... case in point, formation of huntingtin-containing inclusion bodies in Huntington’s disease encourages cell survival, whereas monomers and small inclusion bodies of huntingtin, a protein possessing ... opaque with age and contain many inclusion bodies reactive with antibody to aB-crystallin, but not to b- and c-crystallin, suggesting an important role for aA-crystallin in maintaining lens transparency ... aAcrystallin requires this domain [66] Attachment of R116C aA-crystallin to Hsp27 and aB-crystallin increases in comparison to wild type, while binding to cC-crystallin and bB2-crystallin decreases...

Ngày tải lên: 19/02/2014, 18:20

... and 20 and in Recycling (code 370) over 1996-2000 in county 19 For the corresponding years, there are no enterprises registered in the corresponding industries and counties, and submitting financial ... 20 Fernandez , Martinez and Saurina (2000) study cyclical behaviour of bank loans, loan losses and loan loss provisions in Spain and show that housing prices, asset prices and lending margins have ... are found in the following industries: Agriculture and forestry (code 111) in 1990-1992, Raising of fish (code 051) in 1988-1993, Fishery (code 052) in 1988-1993, Publishing, printing and reproduction...

Ngày tải lên: 22/03/2014, 20:21

... also contain a carboxy-terminal extension containing T-box and A-box motifs [124] In each zinc finger, four invariant cysteine residues coordinate tetrahedrically to a zinc ion, and both zinc fingers ... overlapping ligand-binding pockets The difference of the binding pocket is easy to understand by looking at the superimposition between PonA and BYI06830 shown in Fig Ligand-binding affinity Typically, ... for retaining the ligand-binding activity They found two high-affinity binding sites (Kd1 = 0.24 nm and Kd2 = 3.9 nm) The removal of GST had no effect on PonA binding, but altered DNA binding The...

Ngày tải lên: 23/03/2014, 04:20

... DNA-degradation in cancer Isothiocyanates and the indole-3-carbinols interfere categorically in the metabolism of carcinogens thus causing inhibition of procarcinogen activation, and thereby inducing the ... of saponins and these include: steroid saponins and triterpene saponins Saponins are soluble in water and insoluble in ether, and like glycosides on hydrolysis, they give aglycones Saponins are ... hydrolysable tannins include theaflavins (from tea), daidezein, genistein and glycitein (Fig 5) Tanninrich medicinal plants are used as healing agents in a number of diseases In Ayurveda, formulations...

Ngày tải lên: 28/06/2014, 11:20

... diabetic laboratory animals and in humans The above findings indicate that differences in the cellular availability of zinc in both insulin producing b-cells and in insulin target cells are associated ... on insulin signaling and coronary heart disease Insulin and zinc ions have potent stimulatory effects on lipogenesis and glucose uptake Zinc-deficient animals are less sensitive to insulin Zinc ... zinc The other is MT 1A, a member of a protein family that links zinc and redox metabolism Changes in the availability of zinc ions modulate insulin signaling and redox processes Both zinc and...

Ngày tải lên: 09/08/2014, 01:24

... staining pattern in mouse knee joint was influenced by disease severity Mild inflammation (Figure 5a) was associated with discrete BMP7 staining in the lining layer of synovium (Figure 5b) and in ... morphogenetic protein signaling in joint homeostasis and disease Cytokine Growth Factor Rev 2005, 16:287-298 Sancho E, Batlle E, Clevers H: Signaling pathways in intestinal development and cancer Annu ... BMP7 stainings Arrows indicate BMP7-positive cells in synovium, and arrowheads indicate BMP7-positive cells in articular cartilage Asterisk indicates gradual clearing of the synovial lining layer...

Ngày tải lên: 09/08/2014, 13:22

... hyroxymethyl cytosine or that they glycosylate their DNA In addition all of the r genes in T4 that are known to be involved in superinfection and lysis inhibition [45] are missing in cyanophage genomes, ... in S-PM2, P-SSM4 and S-RMS4 speD encodes S-adenosylmethionine decarboxylase a key enzyme in the synthesis of the polyamines spermidine and spermine With polyamines implicated in the stabilising ... factor in T4 and is involved in the transcription of structural proteins [45] Homologues of the T4-genes g33 and g45 which are also involved in late transcription in T4 are all found in Clokie...

Ngày tải lên: 12/08/2014, 02:20

... recombination of the masculinizing and feminizing factors by chromosomal linkage and inversion The result is the establishment of sex determining superloci that allow for segregation of male and ... position -30 in the 5'UTR, (ACAAAAAAGG) position 1083 in the second intron, and (TCAAAAAAGG) position 3052 in intron We detected a single potential LEAFY binding site (CCATTGT) in the second intron ... genes in their native context SpAGAMOUS retains floral organ identity and meristem determinacy functions in spinach A single C class gene has been previously described in Spinacia oleracea and...

Ngày tải lên: 12/08/2014, 03:21

... HIF-1 Hexokinase-1 HIF-1 Hexokinase-2 HIF-1 Insulin-like growth factor-2 (IGF-2) HIF-1 IGF-binding protein-1 HIF-1 IGF-binding protein-2 HIF-1 IGF-binding protein-3 HIF-1 Interleukin-6 NF-IL6 ... rats with hypoxia-induced pulmonary hypertension J Clin Invest 1995, 96:1823–1833 23 Morrell NW, Morris KG, Stenmark KR: Role of angiotensin-converting enzyme and angiotensin II in development of ... subunits in pulmonary artery smooth muscle cells J Clin Invest 1997, 100:2347–2353 Author’s affiliation: Institute of Genetic Medicine and Departments of Pediatrics and Medicine, The Johns Hopkins...

Ngày tải lên: 12/08/2014, 18:20

... This expanding IL-1R1-like family includes murine and human proteins, Drosophila (fruit fly) proteins, and a plant (tobacco) protein [7,8] In Drosophila, Toll is involved in the rapid and transient ... sections) Understanding the regulation of TLR expression will provide further insight into their tissue distribution and their role in combating infection There has been an initial report of ... (see Fig 3) Further evidence for the role of TRAF6 and NF-κB-inducing kinase in TLR4 signaling came from the study of TRAF6 and NF-κB-inducing kinase dominant-negative (DN) variants, which could...

Ngày tải lên: 12/08/2014, 18:21

... Nectar-producing species in highland forests 10 Nectar-producing species in wooded grassland (savannah) 11 Nectar-producing species in arid and semi-arid land 12 Nectar-producing species in coastal plains ... trees In spite of this, the bees perhaps play a minor role as pollinators in the rain forest compared to their role in temperate forests, monsoon forests and savannah woodland In tropical rain forests, ... national and international networks, to find out about sources of training, markets, research findings, and raises their awareness of the industry and available opportunities Concerning financial...

Ngày tải lên: 03/06/2015, 08:41

... protein containing the RNA-binding motif reduces the strength of the interaction The NS3-NS3 interaction was also confirmed by co-expressing myc-tagged and flag-tagged NS3 in COS-7 cells and showing ... implicating its involvement in oncogenesis Taken together, most of the viral proteins interact and may affect the activities of host proteins in the long-term The understanding of the interplay ... activity (Levin and Patel, 1999), helicase mutants defective in self-interaction may be inactive for their unwinding activity because of their inability to from dimers or oligomers To investigate...

Ngày tải lên: 16/09/2015, 17:12

... display a remarkable affinity to heparin and are also called heparin binding growth factors (HBGF) FGF-2 is an 18Kd protein consisting of 155 amino acids, and an isoelectric point of 9.6, without ... that growth factors, cytokines, integrins, antigens and G protein coupled receptors also utilise tyrosine kinase pathways to transduce intracellular signals (Zachary and Rozengurt 1992, Aoki et ... specific ligands and activate second transduction pathways Intracellular signals are transmitted by coupling of receptors to cytoplasmic guanine nucleotide-binding regulatory 15 proteins (G proteins)...

Ngày tải lên: 17/09/2015, 17:20

... produced dark brown stain in apoptic nuclei) B Atropine 0.1 µM C Atropine µM D Atropine 10 µM E Atropine 100 µM Fig10A Immumocytochemistry of mAchR subtypes in human SF in culture Subtype selective ... corresponding to mAchR subtypes m1,m2,m4, and m5 identified in mouse sclera by immunoblotting Subtype selective antibodies bound to specific protein bands in mouse sclera extract Sepcific bands did ... Fig 8A Effect of atropine inhibiting SF cell proliferation in culture Chick SF were incubated with atropine Phase contrast photomicrographs were taken after 24...

Ngày tải lên: 17/09/2015, 17:20

... potential benefits of statin therapy on inflammatory airway disease After priming and intra-nasal ovalbumin challenge, reductions in inflammatory cell infiltrate and eosinophilia in bronchoalveolar ... Kwak and colleagues first showed that statins inhibit interferon-γ (IFN-γ)-inducible MHC-II expression in various cell types including endothelial cells and macrophages, thereby inhibiting MHC-II-mediated ... both oral and intraperitoneal administration of simvastatin [36] Continuing studies are addressing the local cell-specific pathways subserving these in vivo observations Finally, statins have...

Ngày tải lên: 09/08/2014, 06:22

... http://www.implementationscience.com/content/3/1/35 Interpreting CPGs Variability in client needs In interpreting clinical practice guidelines and translating these into a skill and competency input required for individual management, ... the prevention and management of chronic diseases in the primary care setting This includes allied health disciplines, community nursing and medical, covering both current and emerging occupational ... surplus) This can inform the work of planners in defining possible strategies to meet skill needs, in the short, medium, and long term, including implications for education and training Tasks eight:...

Ngày tải lên: 11/08/2014, 05:21

... http://www.implementationscience.com/content/3/1/35 Interpreting CPGs Variability in client needs In interpreting clinical practice guidelines and translating these into a skill and competency input required for individual management, ... the prevention and management of chronic diseases in the primary care setting This includes allied health disciplines, community nursing and medical, covering both current and emerging occupational ... surplus) This can inform the work of planners in defining possible strategies to meet skill needs, in the short, medium, and long term, including implications for education and training Tasks eight:...

Ngày tải lên: 11/08/2014, 16:21