and superoxide dismutase sod provides important cellular protection however
Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf
Ngày tải lên :
14/02/2014, 22:20
... iron-containing
SOD (Fe -SOD) , manganese-containing SOD (Mn-
SOD) and nickel-containing SOD (Ni -SOD) . These
four types of SOD are divided into three groups based
on amino acid sequence homology; Fe- and Mn-SODs
are ... (MI:0407)bymolecular sieving (MI:0071)
Abbreviations
ApeSOD, superoxide dismutase from Aeropyrum pernix; SOD, superoxide dismutase; TthSOD, superoxide dismutase from
Thermus thermophilus.
598 FEBS Journal ... (uniprotkb:Q9Y8H8) and Superoxide dismutase
(uniprotkb:
Q9Y8H8) bind (MI:0407)byx-ray crystallography (MI:0114)
l
MINT-8075678: Superoxide dismutase (uniprotkb:Q9Y8H8) and Superoxide dismutase
(uniprotkb:
Q9Y8H8)...
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Báo cáo khoa học: Engineering and characterization of human manganese superoxide dismutase mutants with high activity and low product inhibition potx
Ngày tải lên :
07/03/2014, 11:20
... encoded within its genome its own
native MnSOD and iron superoxide dismutase
(FeSOD). However, an E. coli strain incapable of pro-
ducing its own MnSOD and FeSOD, the QC774 strain,
has been developed ... hMnSOD and N73S–Q143A
hMnSOD mutants obtained by directed evolution, the
N73S–C140S–Q143A hMnSOD mutant created by
site-directed mutagenesis, and the parent Q143A hMn-
SOD and wild-type hMnSOD, ... applications, and our kinetic and
structural studies also provide new insights into the structure–function rela-
tionships of human manganese superoxide dismutase.
Abbreviations
FeSOD, iron superoxide dismutase; ...
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- 0
Robot Mechanisms and Mechanical Devices Illustrateds on bone fracture repair - identifying important cellular characteristics ppt
Ngày tải lên :
09/03/2014, 00:20
... repair
- identifying important cellular characteristics
Summary
Fracture repair is a complex and multifactorial process, which involves a well-programmed
series of cellular and molecular events ... focused on the left hand side, and the experiments required (right
hand side) were adopted from other studies that were performed at the AO Research Institute.
ix
Mechanical and mechanobiological ... connective tissues, and via cartilage to bone. However, the process can fail and
this results in delayed healing or non-union, which occur in 5-10% of all cases. A better
understanding of this process...
- 179
- 409
- 0
báo cáo hóa học: " Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene" ppt
Ngày tải lên :
19/06/2014, 22:20
... Becher MW, Lee MK, Anderson KL, Jenkins NA, Copeland
NG, Sisodia SS, Rothstein JD, Borchelt DR, Price DL, Cleveland DW:
ALS-linked SOD1 mutant G85R mediates damage to astro-
cytes and promotes rapidly ... mimic human disease [1,2,5], and these
have provided important leads towards understanding the
molecular pathology of ALS. Since SOD1 is critically
involved in eliminating superoxide, an undesirable
byproduct ... histopathological studies and drafted
the manuscript. QX participated in analysis of histopatho-
logical findings and design of figures and schematics. WS
conceived and directed the study, and completed...
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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
Ngày tải lên :
15/02/2014, 01:20
... each sample and data were
processed using CellQuest software (Becton-Dickinson).
Fluorescent emission of propidium iodide and Annexin
V-FITC were collected through a 575 and a 530 ⁄ 30 band-
pass ... putative
kinase 1 mutations. Mitochondrial and proteasome
dysfunction and oxidative stress could account for the
selective degeneration of dopaminergic SNpc neurons
and their specific vulnerability [1–6].
Single ... linear gradient to 8000 V and 2 h
and 30 min at 8000 V. IPG strips were then equilibrated for
2 · 30 min in 50 mm Tris-HCl (pH 8.8), 6 m urea, 30% glyc-
erol, 2% SDS and traces of bromophenol...
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- 0
Tài liệu Báo cáo khoa học: The solution structure of reduced dimeric copper zinc superoxide dismutase doc
Ngày tải lên :
21/02/2014, 03:20
... bertini@cerm.unifi.it
Abbreviations: SOD, superoxide dismutase; Q133M 2SOD, F50E/
G51E/E133Q monomeric mutant superoxide dismutase; FALS,
familial amyotrophis lateral sclerosis; M 4SOD, F50E/G51E/V148K/
I151K monomeric mutant superoxide ... Nd1of His46, and zinc to
Nd1 of His63, His71, and His80 and to Od1 of Asp83.
Lower and upper distance limits of 1.8 and 2.3 A
˚
,
respectively, were imposed between t he metal i ons and
the donor ... Conte and Maria Silvia Viezzoli
Department of Chemistry and Centro Risonanze Magnetiche, University of Florence, Italy
The solution structure of homodimeric Cu
2
Zn
2
superoxide
dismutase (SOD) ...
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Báo cáo khoa học: A superoxide dismutase–human hemoglobin fusion protein showing enhanced antioxidative properties pptx
Ngày tải lên :
07/03/2014, 00:20
... reactive oxygen species, such as the superoxide anion. Superoxide
is intrinsically toxic, and superoxide dismutase (SOD) provides important
cellular protection. However, if the Hb molecule is located ... to eliminate
the superoxide. Chang [2], Alagic [4] and Tarasov [5]
have characterized Hb chemically conjugated to SOD
alone or SOD combined with catalase, i.e. Hb SOD
and polyHb SOD catalase, respectively. ... bottom): the high molecular
mass complex, an SOD Hb dimer, and finally
an SOD Hb monomer.
A
B
Fig. 3. Reduced SOD Hb and Hb were bubbled with O
2
(A) or CO
(B). SOD Hb shows the absorption spectrum characteristics...
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- 389
- 0
Government size and business cycle volatility; How important are credit constraints? pot
Ngày tải lên :
15/03/2014, 07:20
... Urban
it
, and the fraction of left-wing parties in
parliament, Left
it
. Bootstrapped standard errors in brackets.
∗∗∗
,
∗∗
, and
∗
denote statistical significance at the 1-percent, 5-percent, and 10-percent ... ega-
litarianism, altruism, spite and parochialism in childhood and adolescence
2011-06 Octavio Fern´andez-Amador, Martin G
¨
achter, Martin Larch, Georg
Peter: Monetary policy and its impact on stock ... Urban
it
, and the fraction of left-wing parties in
parliament, Left
it
. Bootstrapped standard errors are in brackets.
∗∗∗
,
∗∗
, and
∗
denote statistical significance at the 1-percent, 5-percent, and...
- 32
- 335
- 0
Báo cáo khoa học: Betulinic acid-mediated inhibitory effect on hepatitis B virus by suppression of manganese superoxide dismutase expression pot
Ngày tải lên :
16/03/2014, 01:20
... units)
SOD2 –1500
SOD2 –1500/ – 1335 (T)
*
*
0
120
A
B
C
100
80
60
40
20
SOD2 –2000
SOD2 –1500
SOD2 –1200
SOD2 –1000
SOD2 –500
SOD2 –200
SOD2 –100
SOD2 –0
SOD2 transcriptional activity
(Arbitrary units)
CTL
Bet A
*
*
*
#
#
*
*
*
0
BERC
cuL
TCT
G
CAGT
T
CTGCAGT
TCTGTA
G
T
BERC
0
c
u
L
BERC
0
cuL
0
50
100
150
CTL ... 6G), and HBx protein
expression (Fig. 6H), whereas a combination of BetA
and SOD2 overexpression totally abolished the BetA-
mediated HBV-inhibitory effect. On the other hand,
SOD2 knockdown (siSOD2) ... levels for CREB, pCREB and SOD2 were measured by western blotting
from liver tissue and quantitated. (D) Enzyme activities for caspase-3 and SOD2 from liver tissue were measured and expressed as arbitrary
units....
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- 0
Báo cáo khóa học: Assembly of the silk fibroin elementary unit in endoplasmic reticulum and a role of L-chain for protection of a1,2-mannose residues in N-linked oligosaccharide chains of fibrohexamerin/P25 ppt
Ngày tải lên :
16/03/2014, 16:20
... Nd-s
D
mutant
and two transgenic lines. Proteins from cocoon shells of a normal breed
C108 (C; lanes 1 and 5), Nd-s
D
(N
D
; lanes 2 and 6), L6 · 7(L6;lanes3
and 7), or L7-4 (L7; lanes 4 and 8) were ... lanes
1and5 ),Nd-s
D
(200 lg; Fig. 5, lanes 2 and 6) and two
transgenic lines [L6 · 7(5lg; Fig. 5, lanes 3 and 7) and
L7-4 (200 lg; Fig. 5, lanes 4 and 8)] were subjected to
Western blotting with ... transgenic lines (L6 · 7 and L7-4), fhx/P25
was detected as two bands of 30 and 27 kDa (Fig. 5C, lanes
3, 7 and 4, 8) like in the normal breed C108 (Fig. 5C, lanes 1
and 5). The slight decrease...
- 11
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- 0
Báo cáo khoa học: Apolipoproteins A-I and A-II are potentially important effectors of innate immunity in the teleost fish Cyprinus carpio pot
Ngày tải lên :
16/03/2014, 18:20
... ApoA-I and apoA-II in innate immunity of the carp (Eur. J. Biochem. 271) 2989
Fig. 4 B, t he inta ct a poA-I (b and a), an intermedia ry
fragment (band b) and a more stable third band (band c)
were ... T he positive c ontrol contained
bacteria and diluent only. P. citreus , Y. ruckeri and Pseudo-
monas sp. were incubated at 2 0 °CandE. coli at 37 °Cand
the attenuance (D) was read at 570 nm ... procedure
involving affinity and gel filtration chromatography and
were shown to display bactericidal and/ or bacteriostatic
activity in the micromolar range against Gram-positive
and Gram-negative bacteria,...
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- 0
Báo cáo khoa học: Increased amylosucrase activity and specificity, and identification of regions important for activity, specificity and stability through molecular evolution doc
Ngày tải lên :
23/03/2014, 11:20
... resulting in a high affinity and low V
max
at
low sucrose concentrations (V
max1
and Km
1
) and low
affinity and high(er) V
max
at high sucrose concentra-
tions (V
max2
and Km
2
) [13]. In Table ... the enzyme
that are clearly important for amylosucrase activity, as
b strand 7, connecting to the important Asp393 resi-
due, and the region close to the salt bridge and the
secondary sucrose-binding ... substrate and products
[10,11] have indicated the presence of various import-
ant regions inside and outside the active site pocket
characterized by sucrose and oligosaccharide-binding
sites (SB and...
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- 0
Báo cáo hóa học: " Heavily glycosylated, highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent cellular responses but delayed neutralizing antibody responses" pdf
Ngày tải lên :
20/06/2014, 01:20
...
Gary Landucci
4
, Jason T Kimata
5
and Julie Overbaugh*
1,3
Address:
1
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,
2
Program in Molecular and Cellular ... position 120 was a K in
SIVMneCL8 and an R in SIVMne170, and reverted to a K
in animal J94233 (19/27 sequences). Position 137 was a
T in SIVMneCL8 and an I in SIVMne170, and reverted to
a T in most ... helped design and oversee that ADCVI assays
and provided comments on the manuscript. GL per-
formed ADCVI assays. JTK helped direct the initial infec-
tion studies and provided input and comments...
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- 0
- zn-superoxide dismutase
- dna methylation affects important developmental processes in both plants and animals the process of methylation of cytosines at c5 is catalysed by dna methyltransferases mtases
- the normal protection systems involving sod and catalase are no longer closely associated with it
- exposing hb and its cellular surround
- in this series of four minireviews the field of scaffold proteins and proteins of similar molecular⁄cellular functions is overviewed by binding and bringing into proximity two or more signaling proteins
- this book provides information on the clinical relevance of blood groups and on the importance of blood group antibodies in transfusion medicine in particular
- radians and an important limit
- lightning protection and trees
- protection schemes and methods to do thesis
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