and bar polymorphisms in human heart failure
báo cáo khoa học: " High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-κB-complex-dependent gene expression in human heart failure" pps
... transactivation domain of RELA because a purified recombinant GST fusion protein of the RELA carboxy-terminal domain, but not the amino terminus DNA binding domain, was sufficient to interact with ... benefit of inhibiting mir-21 has previously been shown [23] and our work adds to the understanding of how mir-21 is upregulated in heart failure On a wider level, our findings add to an emerging paradigm ... in a multi-protein complex may control gene expression program in heart failure Understanding the way that different DNA binding proteins interact with DNA regulatory elements and modulate gene...
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Báo cáo y học: "Transpulmonary thermodilution-derived cardiac function index identifies cardiac dysfunction in acute heart failure and septic patients: an observational study" pptx
... medians (interquartile ranges) Creatinine, norm 70 to 105 μmol/L Troponin T, norm
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Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
... formation of huntingtin-containing inclusion bodies in Huntington’s disease encourages cell survival, whereas monomers and small inclusion bodies of huntingtin, a protein possessing abnormal polyQ ... aB-Crystallin R120 corresponds to aA-crystallin R116 and both are conserved a-crystallin domain arginines R120G aB-crystallin permits intermediate filament self association in vitro, although binding ... aAcrystallin requires this domain [66] Attachment of R116C aA-crystallin to Hsp27 and aB-crystallin increases in comparison to wild type, while binding to cC-crystallin and bB2-crystallin decreases...
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Department of Reproductive Health and Research including the UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP) doc
... worked in reducing maternal mortality include those relating to innovative financing measures; investment in human resources, both in terms of strengthening pre-service education and emphasizing in- service ... NGOs and other institutions Improving maternal and perinatal health working in the field on maternal and infant health Work with Doctors with Africa CUAMM, an NGO operating in Africa since 1955 in ... Hypertension in Pregnancy (ISSHP), in Geneva WHO will be leading and coordinating a number of sessions in both Congresses increasing visibility and repositioning HRP's work and priorities in the global...
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Báo cáo khoa học: Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells potx
... turn recruits other proteins, including paxillin, p130Cas, vinculin and talin in focal adhesions These protein complexes anchor the actin cytoskeleton and provide structural integrity to cells [16] ... either tyrosine kinase inhibitor, genistein, or MAP kinase inhibitor, PD98059 Inhibition of tyrosine kinase by genistein greatly inhibited LPA-induced PAK activation, whereas MAP kinase activity ... endothelial cells [52] and G protein coupled receptor kinase (GRK)-interacting targets (GIT) links PAK and FAK [53], involvement of PIX, Nck and GIT in LPA-induced FAK phosphorylation and cell motility...
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Báo cáo sinh học: "Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells" doc
... Materials and methods Cells and chemicals Human hepatoma Huh7 cells were grown in DMEM containing 10% FBS, 1× penicillin, streptomycin, fungizone, 10mM L-glutamine, and 1× non-essential amino acids ... signaling and increased HCV replication in the presence of IFN Inhibition of Jak-Stat signaling may involve ethanol perturbation of IFN-α induced changes in membrane fluidity, inhibition of IFN binding ... Ras-ERK, and phosphoinositol kinase (PI3K) [36-40] However, p38 kinase activity, which is important in IFN-α and IFN-γ induced transcription, is not involved in IFN induced Stat1 serine phosphorylation...
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báo cáo hóa học:"Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells" potx
... Materials and methods Cells and chemicals Human hepatoma Huh7 cells were grown in DMEM containing 10% FBS, 1× penicillin, streptomycin, fungizone, 10mM L-glutamine, and 1× non-essential amino acids ... signaling and increased HCV replication in the presence of IFN Inhibition of Jak-Stat signaling may involve ethanol perturbation of IFN-α induced changes in membrane fluidity, inhibition of IFN binding ... Ras-ERK, and phosphoinositol kinase (PI3K) [36-40] However, p38 kinase activity, which is important in IFN-α and IFN-γ induced transcription, is not involved in IFN induced Stat1 serine phosphorylation...
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Báo cáo khoa học: "Real time PCR analyses of expression of E-cadherin, alpha-, beta- and gamma-catenin in human breast cancer for predicting clinical outcome" pps
... following invasion and degradation of surrounding matrix, and migration into the vasculature and surrounding tissue, E-cadherin catenin complex is reintroduced and cells adhere to the vasculature and ... for positivity and negativity We determined the expression of E-cadherin, α-, β- and γcatenin in human breast carcinomas using real time quantitative polymerase chain reaction and investigated ... relationship of E-cadherin, α-catenin, β-catenin and γ-catenin in breast tumours to Nottingham Prognostic Index (NPI) (E-cadherin p = 0.094, αcatenin p = 0.144, β-catenin p = 0.378, γ-catenin p = 0.131)...
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Báo cáo khoa học: "Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells" potx
... paraformaldehyde in PBS (pH 7.4) and mounted in Vectashield mounting medium with 1.5 Ag/mL 4V, 6-diamidino-2phenylindole (Vector Laboratories, Inc., Burlingame, CA) The cells were stained by method ... again with PBS and resuspended in PBS containing PI and RNase A The samples were subjected to a FACScaliber flow cytometer and data analysis was done using CellQuest Pro software (Becton Dickinson, ... separated apart and, instead, aggregated in the center of the nucleus in a round cell contour These findings indicated a mitotic arrest at the metaphase was induced by costunolide Signaling molecules...
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Báo cáo y học: " Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells" pdf
... formation and TFIIB binding in vivo The high prevalence for the occurrence of motif combinations in TFIIB-dominated genes in illustrated in Figure 5e In line with the known synergy between INR and ... (black line) and replicate (grey line) relative to aligned TSSs at 10-bp resolution Binding of TBP and the initiating form of RNAPII (phosphorylated at serine in its carboxy-terminal domain) were ... one initial cycle consisting of minutes at 55° (during which polymerase was added), minutes at 72°C and minutes at 94°C, followed by 22 cycles of 0.5 minutes at 94°C, 0.5 minutes at 60°C and minutes...
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báo cáo khoa học: "Population genetics of the metabolically related Adh, Gpdh and Tpi polymorphisms in Drosophila melanogaster : II. Temporal and Spatial Variation in an Orchard Population Karen M. NIELSEN A.A. HOFFMANN S.W. McKECHNIE" potx
... rainfall in Asia that was not apparent in Europe or North America In the Wandin North population, Gpdh-F frequency was independent of rainfall Factors affecting genetic variation patterns within ... Variation Within the Orchard Tpi-F frequency fluctuated seasonally, characterised by an increase in the F in autumn and winter months (fig 2) Total monthly rainfall, mean daily maximum and minimum temperature ... 2,000 in the vicinity of the vineyard buildings) These numbers are more similar to those found in an equivalent area of the orchard In general, Drosophila tend to remain in the , ALLACE vicinity...
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Báo cáo y học: "LMP-420, a small-molecule inhibitor of TNF-alpha, reduces replication of HIV-1 and Mycobacterium tuberculosis in human cell" pps
... TNF inhibited p24 release induced by mycobacteria In a recent review Collins et al [4] postulate that higher viral loads, increased HIV diversity, and changes in cytokine/chemokine levels in HIV-infected ... prepared and RT-PCR performed for 30 cycles using primers for TNF-α and β-actin obtained from R & D Systems Thus, several studies suggest that minimizing TNF levels in both HIV and M Tb-infected ... goes untreated in HIV+ patients, most will die within one year M Tb is the most common opportunistic infection occurring in HIV-infected individuals in resource poor countries and it accelerates...
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Báo cáo y học: "JNK suppression is essential for 17b-Estradiol inhibits prostaglandin E2-Induced uPA and MMP9 expressions and cell migration in human LoVo colon cancer cells" ppsx
... significantly inhibits PGE-induced activation of JNK1/2 within 30 min, and suppressed PGE2-induced expression of uPA and MMP-9 within 24 h in human LoVo colon cancer cells (Figure 4B) 17b-Estradiol Inhibits ... of proteins by immunoblotting assay Phosphorylation of JNK1/2 was significantly induced within 15 in response to PGE2 stimulation, and was maintained up for 24 h (Figure 3B) The findings suggested ... functionally related zinc-containing enzymes that include interstitial collagenases, gelatinases, stromelysin, matrilysin, metalloelastase, and membrane-type MMPs [7,8] Upregulation of MMP-2 and MMP-9 has...
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báo cáo khoa học: "Prognostic significance of STAT3 and phosphorylated STAT3 in human soft tissue tumors - a clinicopathological analysis" ppt
... immnunohistochemistry staining, western blotting and RT-PCR and drafted the manuscript LM, and KB, provided the clinical samples and collected clinical information and MR participated in the coordination of ... streptavidin-biotin method, with a Vecta Elite ABC staining kit (Vector Laboratories) The slides were rinsed in phosphatebuffered saline, exposed to diaminobenzidine, and counterstained with ... circumscription, encapsulation and presence of necrosis with clinical parameters Histopathological parameters were studied using μm thick paraffin sections stained with Hematoxylin and Eosin and the tumors were...
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báo cáo khoa học: "Serum proteomic profiling and haptoglobin polymorphisms in patients with GVHD after allogeneic hematopoietic cell transplantation" pps
... haptoglobin-β haptoglobin-β haptoglobin-β haptoglobin-β haptoglobin-β haptoglobin-α haptoglobin-α haptoglobin-α apolipoprotein A-IV apolipoprotein A-IV apolipoprotein A-IV α-1-antitrypsin α-1-antitrypsin ... reaction After preparing resin disc, binding sample and washing to release albumin-free sample, the albumin-free serum was collected for determination of protein concentration The protein concentration ... phenotype determination of patients by immuoblot Polyclonal antibody against human Hp was used to binding the Hp on the blots Lane is the Hp protein standard containing Hp β, α-1 and α-2 chains Lane...
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báo cáo khoa học: "Dysregulation of miR-15a and miR-214 in human pancreatic cancer" potx
... cultures and clinical samples BxPC-3 human pancreatic cancer cells were maintained in RPMI 1640 medium containing 10% fetal bovine serum (FBS; Gibco BRL) 293T cells were maintained in DMEM containing ... Xiaohua S, Xinyu R, Kai W, Tonghua L: Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines Mol Cancer ... signal induces cell migration and invasion in pancreatic cancer Br J Cancer 2008, 99(2):305-13 27 Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK: The candidate...
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báo cáo khoa học: "Quantum dot-induced cell death involves Fas upregulation and lipid peroxidation in human neuroblastoma cells" pptx
... processes including adenosine triphosphate (ATP) production, intracellular pH regulation and neuronal-glial interactions [25] Many neurodegenerative diseases, including Parkinson's and Alzheimer's ... peroxidation, and the membrane potential is no longer stable, resulting in an uncontrolled release of mitochondrial content [40,41] In addition to causing membrane instability and increasing the vulnerability ... receptors, and is a prototypical "death receptor." In the immune system, it regulates cell numbers by inducing apoptosis, and is involved in T cell-mediated cytotoxicity It can also induce neuronal...
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Báo cáo khoa học: " The role of NH4Cl and cysteine proteases in Human Papillomavirus type 16 infection" ppsx
... cathepsin B or cathepsin L protease, Figure Cathepsin B and L treatment of HPV16 increases binding Cathepsin B and L treatment of HPV16 increases binding Reporter virus binding was compared in 293 ... infectivity by cleaving and removing a highly glycosylated mucin domain in the Ebolavirus glycoprotein and resulted in increased binding suggesting that cathepsins are indeed present on the cell ... at minutes post binding for early endosome staining (with goat anti- EEA1, Fig 2A and 2B, red) and hours post binding for caveolin-1 staining (with goat anti-caveolin 1, Fig 2C and 2D, red) HPV16...
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