... illustrates redundancy in the
chemokine system. Although some ofthe data on the role
of CCR5 in the pathogenesis of MS and EAE appears to be
conflicting, the weight of evidence identifies CCR5 ... purposes)
macrophages and resident microglia to sites of CNS inflammation. Detailed knowledge of expression patterns is crucial
for the understanding of therapeutic modulation andthe validation of CCR1, CCR2 and ... immu-
noneutralization of CCL3 [44], DNA vaccination [45], or
genomic deletion ofthe CCR1 gene [22], reduces clinical
disease. Taken together, the results ofthe present study
and from previous ones on the role of...
... various combinations of
chemotherapy and cranial radiation. The excellent
correlation ofthe in vitro and in vivo results of Noble and
colleagues’ study [1] raises the hope that the technique
used ... G:
Abnormal CT scans ofthe brain in asymptomatic children
with acute lymphocytic leukemia after prophylactic treat-
ment ofthecentralnervoussystem with radiation and
intrathecal chemotherapy. N Engl ... this very
young, and hence vulnerable, population of patients.
Chemotherapy-induced cognitive decline in
the absence of radiation
The best data on the cognitive effects of chemotherapy alone
have...
... markedly
decreased levels of MBP in the CC and in the white-matter
tracts ofthe striatum of treated animals (Figure 10). In
agreement with the majority ofthe cell bodies in the mature
CC belonging ... that
should prove of great value in the discovery and evaluation
of therapies that either allow selective killing of cancer cells
or offer selective protection to the normal cells ofthe body.
MMaatteerriiaallss ... oligodendrocytes
and extensive myelin pathology. Functional analysis also provided the first demonstration of
delayed effects of chemotherapy on the latency of impulse conduction in the auditory system,
offering...
... cover of only 48 examples out of
the 92 variants in the corpus. The active corpus treated
separately requires 38 examples out of 46 andthe passive
corpus requires 28 out of 46. Treating the ... for inducing the language. Though
the minimal number
of examples is of course unique, the set
of particular strings in the covering sample is not necesm~rily
Imique.
INFERENCE OFTHE ENGLISH ... overgeneralizes the full corpus
as well as the active and passive corpora treated as separate
languages. For the active corpus, zero-reversible inference
groups the forms of
do
with the other modals. The...
... the emer-
gence ofthe Plathelminthes in the evolutionary his-
tory.
The eye ofthe planarian is one ofthe most ancestral
and primitive types of visual systems in animals and is
of particular ... one ofthe simplest animal groups with a central nervous
system. Their primitive centralnervoussystem produces large quantities
of a variety of neuropeptides, of which many are amidated at their
C ... in the planarian cen-
tral nervoussystem to support the PHM activity and that it predates the
emergence of Plathelminthes in the evolutionary history.
Abbreviations
AsA, ascorbic acid; CNS, central...
... amounts of norepinephrine within the hypothalamus and in certain zones
of the limbic system, such as thecentral nucleus ofthe amygdala andthe dentate gyrus ofthe
hippocampus. However, this ... Management ofthe
anesthetic interplays constantly with the general physiologyofthe patient. Historically, and
continuing to the present, the great majority of cases involves the administration of ... loss ofthe agent from the arterial blood to all the tissues ofthe body. Obviously, the
concentration in neural tissues is of greatest importance. The details ofthe uptake and distribution
of...
... also found that the agents caused
increased cell death and decreased cell division in the
subventricular zone, the dentate gyrus ofthe hippocampus
and the corpus callosum in mice. These effects ... understanding ofthe mechanisms of
acute and, importantly, progressive and delayed injury to
the brain from clinically relevant short-term exposure to a
widely used chemotherapy agent. Furthermore, ... whereas they found enhanced
long-term potentiation in slices obtained 8 and 53 weeks
after treatment [11]. Thus, some ofthe variability of the
results in these studies may be related to the time...
... Barnholtz-Sloan, Andrew E. Sloan, and Ann G. Schwartz
Chapter 25
Cancer ofthe Brain and
Other CentralNervous System
Chapter 25 Cancer ofthe Brain andNervous System
National Cancer Institute ... patterns of care of brain tumor patients in the United
States: a study ofthe Brain Tumor Section ofthe AANS andthe
CNS andthe Commission on Cancer ofthe ACS. Clin Neurosurg
1990;36:347-52.
12. ...
Chapter 25 Cancer ofthe Brain andNervous System
other. For all race specific analyses, only white and black
patients are used because the other category is made up
of a mix of racial groups....