... or
genomic deletion of the CCR1 gene [22], reduces clinical
disease. Taken together, the results of the present study
and from previous ones on the role of CCR1 and its ligand
CCL3 in the pathogenesis ... chemokine receptors CCR1, CCR2 and CCR5 are critical for the recruitment of mononuclear
phagocytes to thecentralnervoussystem (CNS) in multiple sclerosis (MS) and other neuroinflammatory diseases.
Mononuclear ... crucial
for the understanding of therapeutic modulation andthe validation of CCR1, CCR2 and CCR5 as feasible targets for
therapeutic intervention in MS.
Background
Multiple sclerosis (MS) is the most...
... Constitutive NOSs are most
important in the initial generation of NO in the central
nervoussystem (CNS), and therefore NO is important for
intracellular signaling and neurotransmission [1, 11]. Besides
its ... hematoxylin. Magnification
A and B,
ì
66. C and D,
ì
132.
Immunohistochmical study of nitric oxide synthase in thecentralnervoussystem of goat 79
Enhanced expression of nNOS and iNOS in
L
.
mon
oc
ytogenes
-infected ... endothelial NOS (eNOS), and inducible
NOS (iNOS) [13]. In thecentralnervoussystem tissues, all
major NOS isoforms are either constitutively expressed or
induced by the appropriate stimuli...
... wrote the initial draft. WY drew the pictures. WZ revised the draft. SL
described the MRI features. GL provided the pathological diagnosis. TJ was
the surgeon and gave the final approval of the ... of thecentralnervous system: initial and
follow-up MR features. Neuroradiology 2009, 51:651-659.
12. Ay H, Sahin G, Saatci I, Söylemezoğlu F, Saribaş O: Primary Angiitis of the
CentralNervous ... Vasculitis of thenervous system. Curr Opin Neurol 2004,
17:317-336.
16. Calabrese LH, Furlan AJ, Gragg LA, Ropos TJ: Primary angiitis of the central
nervous system: diagnostic criteria and clinical...
... cen-
tral nervoussystem to support the PHM activity and that it predates the
emergence of Plathelminthes in the evolutionary history.
Abbreviations
AsA, ascorbic acid; CNS, centralnervous system; ... the emer-
gence of the Plathelminthes in the evolutionary his-
tory.
The eye of the planarian is one of the most ancestral
and primitive types of visual systems in animals and is
of particular ... of the simplest animal groups with a central nervous
system. Their primitive centralnervoussystem produces large quantities
of a variety of neuropeptides, of which many are amidated at their
C...
... in the
striatum, in the limbic zones of the cerebral cortex, and in other major regions of the limbic system
except the hippocampus (seeHökfelt, et al. , 1976, 1977). At the cellular level, the ... (D
2S
) and D
2
long (D
2L
), the D
3
, andthe D
4
receptors (seeGrandy and Civelli, 1992; Gingrich
and Caron, 1993; Civelli, 1994). The D
1
and D
5
receptors activate adenylyl cyclase. The D
2
... of the anesthetic agent in inspired gas, (2) pulmonary ventilation delivering the
anesthetic to the lungs, (3) transfer of the gas from the alveoli to the blood flowing through the
lungs, and...
... combinations of
chemotherapy and cranial radiation. The excellent
correlation of the in vitro and in vivo results of Noble and
colleagues’ study [1] raises the hope that the technique
used might ... G:
Abnormal CT scans of the brain in asymptomatic children
with acute lymphocytic leukemia after prophylactic treat-
ment of thecentralnervoussystem with radiation and
intrathecal chemotherapy. N Engl ... necessitating either
bone marrow transplantation or peripheral stem cell support
to boost the immune system, and either no craniospinal
radiation or focused radiation to the tumor bed. The
increased...
... there was a 2.5-fold increase in apoptosis in the
subventricular zone (SVZ) and a 4-fold increase in the
dentate gyrus of the hippocampus (DG). The increased cell
death persisted in the SVZ and ... interaural AP +2.5 mm
and AP +1.1 mm. BrdU
+
cells were counted in the area of
the dentate gyrus, including the hilus, subgranular zone
and the granule cell layer and analyzed as for the SVZ.
Quantitative ... 0.001), andthe interaction of treatment and time is very significant (
p
< 0.01);
((bb))
in the CC, both the treatment effect and time effect
are extremely significant (
p
< 0.001), and the...
... also found that the agents caused
increased cell death and decreased cell division in the
subventricular zone, the dentate gyrus of the hippocampus
and the corpus callosum in mice. These effects ... hippocampus andthe corpus callosum),
primarily in progenitor cells and oligodendrocytes. To
determine whether these findings resulted in functional
impairment, they investigated the auditory ... understanding of the mechanisms of
acute and, importantly, progressive and delayed injury to
the brain from clinically relevant short-term exposure to a
widely used chemotherapy agent. Furthermore,...
... system. We study
the effects and interactions of negatively charged gold
nanoparticles (nAuNPs) with the cockroaches CNS
in vivo. The authors refer to thenervoussystem as the
brain andthe nerve cord ... vibration and changes in weather affect the activ-
ity of both g roups. The effects of these variables are
diminished by presenting the activity ratio of the treated
to the untreated group. Although the ... nters the biological system, the response of the
immune system is to block further damage by encapsu-
lating the object. This response has been readily found
and studied in insects [27,28]. The...
... hours,
while the ketamine metabolite half-life is two and a half
hours. Gabapentin is eliminated from the systemic cir-
culation by renal excretion. Ketamine is metabolized in
the liver and excreted by the ... Bejnarowicz and Bruce A Schoneboom
Abstract
Introduction: The drugs gabapentin and ketamine are used frequently in the peri-operative setting. There is poor
documentation whether or not gabapentin and ... Unfortunately, however, there is little
documented evidence to suggest that gabapentin and
ketamine interact to additively or synergistically depress
the centralnervoussystem (CNS) and/ or have respira-
tory-depressant...
... Barnholtz-Sloan, Andrew E. Sloan, and Ann G. Schwartz
Chapter 25
Cancer of the Brain and
Other CentralNervous System
Chapter 25 Cancer of the Brain andNervous System
National Cancer Institute ... in the United
States: a study of the Brain Tumor Section of the AANS andthe
CNS andthe Commission on Cancer of the ACS. Clin Neurosurg
1990;36:347-52.
12. Gurney JG, Smith MA, Bunin GR. Chapter ... IV
Unknown
Figure 25.8: Other CentralNervousSystem Cancer: Relative
Survival Rates by Grade, Ages 20+, 12 SEER Areas, 1988-2001
Table 25.8: Cancer of the Other CentralNervousSystem Cancer: 1-,...