analysis of data from longitudinal clinical trials

... dosing In trials of to weeks, 88% of the doses were 200 mg daily In trials of 12 weeks' duration, 46% of doses were 200 mg and 46% were of 400 mg daily In trials of 24 weeks or longer, 92% of doses ... Paracetamol 4,000 No data No data Rofecoxib 25 No data No data Naproxen 1,000 No data No data Diclofenac 100/150 331 2,325 14.2 (12.8–15.6) 593 2,325 25.5 (23.7–27.3) Ibuprofen 2,400 456 1,985 ... conducted using information from company clinical trial reports, supplied by Pfizer Ltd, of completed randomised, double-blind trials from the celecoxib clinical trials programme The objectives...

Ngày tải lên: 09/08/2014, 06:22

Ngày tải lên: 09/08/2014, 07:20

... Analyses of much of the data generated by these programmes had been undertaken, some of which had been published However, only a limited amount of work has been done to construct time series of the data ... provides a general version of multiple linear regression where explanatory variables take the form of factors and covariates Page xiii Integrated Analysis of Data from MRC Fisheries Monitoring ... range of values The standard deviation of a statistical population, data set, or probability distribution is the square root of its variance.* An estimate of that standard deviation, derived from...

Ngày tải lên: 14/03/2014, 08:47

... 75 percent of the males in our sample are overweight or obese while the corresponding figure for the females is lower at 57 percent As a point of comparison, analysis of clinical data from the ... variance of the estimating equation.f Estimates of offered wage rates provide approximate opportunity cost estimates of the value of time for employed individuals and lower-bound estimates of the ... given height b Page 12 of 14 There are some indications that this upward trend may be tapering off as a recent analysis of obesity trends from 1999 to 2008 found no evidence of increases during...

Ngày tải lên: 14/08/2014, 08:20

... benefits of a combined analysis of data from different granddaughter designs QTL mapping / granddaughter design / combined analysis / QTL confirmation / dairy cattle INTRODUCTION With the aid of genetic ... genotyped only for the sires of the Inra-design so far The comparison of the haplotypes of the sires derived once from the Inradesign data and once from the ADR-design data did not reveal any conflicts ... The potential benefit of a combined analysis of data from different granddaughter designs for QTL analysis was demonstrated It was possible to detect and confirm a number of QTL simultaneously...

Ngày tải lên: 14/08/2014, 13:22

... estimates of the internal construct validity of the scale, the total data set is randomised into two further sets of approximately 50% of cases Final results concerning the validity of the scale ... confirmation of strict unidimensionality, the robustness of the solution (analysis 5) was tested on the two random samples embedded within the data (Analyses & 7) Both subsets of data showed good ... is the probability of person n affirming item i; is the person's level of mental wellbeing, and b is the level of mental well-being expressed by the item The process of Rasch analysis is described...

Ngày tải lên: 18/06/2014, 19:20

... proportion of the interviews, assisted with the planning of the analysis, and prepared the first draft of this article for submission LVS assisted in the design of the study, conducted a proportion of ... Page of 12 (page number not for citation purposes) (page number not for citation purposes) Page of 12 Figure participants from the original nested sample to the final sample Flow of Flow of participants ... (16.2-16.8) 20.8 (20.3-21.2) a US data from Milliken et al (2007) age; percentage for all other variables c UK data weighted to take account of sampling weights d Demographic data are not separately available...

Ngày tải lên: 11/08/2014, 17:20

... glycoforms (Hex6 to Hex8) were of greater abundance in the spectrum of RM6252 than in the one of RM7290 From ESI-MS data it was also evident that PCho was not a major substituent in the LPS of ... 2003 Fig The ESI-MSn analysis of permethylated OS7290-P (A) Product ion spectrum of m/z 2283.6 corresponding to the sodium adduct of the Hex6 glycoform (B) The MS3 spectrum of the fragment ion ... devoid of this gene (data not shown) None of the strains expressed high levels of chain extension from HepI However, ESI-MSn on permethylated and dephosphorylated OS samples indicated minor glycoforms...

Ngày tải lên: 23/03/2014, 21:20

... the gene expression profile of MPD neutrophils differed from that of healthy subject neutrophils and G-CSF-mobilized neutrophils Further analysis found that the expression of 1,006 genes differed ... the expression of miR-216 and miR-217 and the lack of expression of miR-133a were characteristic of pancreatic tissue [36] Page of 17 (page number not for citation purposes) Journal of Translational ... subjects (data not shown) Discussion In order to better characterize the molecular basis of MPDs, we compared gene and miRNA expression profiles of neutrophils from MPD patients with those from healthy...

Ngày tải lên: 18/06/2014, 15:20

... RDQ may have the potential to meet some of the questionnaire needs for GERD clinical trials In this study, the performance of the RDQ was assessed in a clinical treatment trial for patients with ... status as a result of therapy in a large clinical population of patients diagnosed as having GERD The concordance between the RDQ evaluations of symptom severity was compared to those offered by specialty ... treatment of selected RDQ scales; 2) assessment of the concordance between RDQand physician-generated ratings of disease severity; and 3) assessment of the internal consistency reliability of the...

Ngày tải lên: 18/06/2014, 22:20

... [3-6] We hereby describe a retrospective analysis of 58 samples from patients, diagnosed with endemic NPC, who had previously been randomized into a trial of radiotherapy (RT) alone versus concurrent ... characteristics including the treatment received The extent of COX-2 staining was scored from to 3, and the intensity of staining scored from to The scores were then multiplied together and the ... to a dose of 70 Gy in 35 fractions using a modified Ho's technique Patients on the CRT arm received cycles of concurrent cisplatin on weeks 1, and of RT, followed by a further cycles of adjuvant...

Ngày tải lên: 09/08/2014, 10:20

... [20] Another case of AML had a deletion of the long arm of chromosome at the breakpoint of 5q21, a deletion of the short arm of chromosome at breakpoint of 6p21.3, and monosomy Two of the three unspecified ... Table Results of JAK2V617F Tests Sample Types and Diagnosis Number of total samples Number of V617F+ samples Percentage of V617F+ samples Average ages of V617F- samples Average ages of V617F+ samples ... Loss of chromosome Y + Isochromosome of the entire long arm of chromosome - Loss of chromosome Y - Chromosomes and 12 translocation at 9p21 and 12p12 Leukocytosis + Deletion of the long arm of...

Ngày tải lên: 10/08/2014, 21:23

... epidemiology of severe sepsis in different populations [10]; however, most of these studies had a short time frame and were unable to describe changes over time We present data from an analysis of a database ... only four years' data were available, limiting the usefulness of comparisons over time The increasing amount of data from this ongoing audit means that a more complete analysis of time trends is ... associated number of hospital deaths per 100,000 population rising from 23 to 30 Strengths and weaknesses of this study The main strength of this study is the use of a large clinical database with...

Ngày tải lên: 12/08/2014, 23:22

... considered significant at a 95% confidence level Results Clinical data The clinical data from the study subjects are summarised in Table Analysis of the age distribution between the two groups showed ... participated in clinical sample and clinical data collection and contributed to the design of the Page 10 of 12 Rukmangadachar et al Clinical Proteomics 2011, 8:4 http://www.clinicalproteomicsjournal.com/content/8/1/4 ... detected by Western blot Graphical representation of the semi quantitative analysis of Western blot results (mean ± SD of OD of bands) d Relative abundance of C1 inhibitor: control, 33920.4 ± 8991.7,...

Ngày tải lên: 13/08/2014, 13:20

... of understanding of the study or treatment procedures, although a high proportion of parents showed no understanding of the risks and of the research nature of the clinical trials Randomization, ... feasibility of providing information about clinical trials according to informed consent criteria and the understanding of information related to clinical trials The appreciation of children ... Another analysis was done by rating the interviews but these results are reported elsewhere [30] The attitudes of children and adolescents and parents towards health and their concept of clinical trials...

Ngày tải lên: 13/08/2014, 18:21

... registries A data variable dictionary should contain information on the "data point number", "data point name", "descriptive field name", "type of data" , "data point category/value", "definition of data ... reporting of data following a major trauma was published to simplify the comparison of data from different trauma registries [17] We believe that a similar template for the uniform reporting of data ... http://www.sjtrem.com/content/17/1/58 Table 3: Core post-intervention variables Data variable number Data variable name Type of data Data variable categories or values Definition of data variable 16 Post-intervention ventilation...

Ngày tải lên: 13/08/2014, 23:21

... C-G and Data 62 5.5 Logarithm of posterior means of φ for Data plotted against those of Data and Data 3, for C-G 5.6 Scatter plot of logarithm of posterior ... for C-G and Data 5.9 64 Scatter plot of logarithm of posterior means of φ for Data against corresponding values for Data using results from C-IG 5.8 63 66 Logarithm of posterior ... means of φ for Data plotted against those of Data and Data 3, for C-G 107 C.7 Acf plots of α, β, ν and the logarithm of the target distribution for C-G and Data ...

Ngày tải lên: 22/12/2014, 17:20

... efficiency was down, but not too much The profitability ratio analysis of Vinamilk between 2012 to 2014 • The table of profitability ratioes of Vinamilk from 2012 to 2014 Quota 2012 2013 2014 ROA ... 30,7% 24,9% ROE 41,6% 39,6% 32,6% • The chart of profitability ratioes of Vinamilk from 2012 to 2014 Thourgh the table and chart of profitability ratioes analysis, we can see that ROA, ROE was reducing ... activities of Vinamilk in 2012 to 2014 had certain positive effects when the economic situation is having a lot of difficulties Liquidity ratioes analysis of Vinamilk from 2012 to 2014 • The table of...

Ngày tải lên: 15/08/2016, 11:15

... Enghoff need not be identical It is unlikely, however, that this distinction undermines the clinical utility of either surrogate of high V/Q All clinical estimates of the gas exchange function of ... calculated from routine clinical data is an independent predictor of hospital mortality in patients with ALI and ARDS Clinicians at the bedside often calculate PaO2/FiO2 ratio to estimate the degree of ... Siddiki et al.: Bedside quantification of dead-space fraction using routine clinical data in patients with acute lung injury: secondary analysis of two prospective trials Critical Care 2010 14:R141...

Ngày tải lên: 13/08/2014, 21:21

Ngày tải lên: 14/08/2014, 07:21