analysis of bioequivalence clinical trials

... Enghoff need not be identical It is unlikely, however, that this distinction undermines the clinical utility of either surrogate of high V/Q All clinical estimates of the gas exchange function of ... predictive of mortality during both early and intermediate phase of ARDS [31] Traditionally, the Enghoff modification of the Bohr equation is used to calculate Vd/Vt and requires a measurement of expired ... Siddiki et al.: Bedside quantification of dead-space fraction using routine clinical data in patients with acute lung injury: secondary analysis of two prospective trials Critical Care 2010 14:R141...

Ngày tải lên: 13/08/2014, 21:21

Ngày tải lên: 14/08/2014, 07:21

... patient data of five clinical trials studying atomoxetine in children and adolescents with ADHD Methods Study design and procedures Individual patient-level data from five clinical trials (four ... sub-domain (item 1: ‘‘How often does your child have a lot of fun?’’ and item 4: ‘‘How often does your child feel happy?’’) The items of the SPS sub-domain Psychometric properties of the CHIP-CE composed ... sub-domains of the CHIP-CE versus ADHD-RS total score were low (\0.4) (e.g., CHIP-CE The objective of this combined analysis was to evaluate the psychometric properties of the CHIP-CE in a sample of children...

Ngày tải lên: 12/02/2014, 19:20

... implication of our findings of high rates of loss to follow up is on the interpretation of outcomes, such as toxicity, rates of virological suppression, adherence and mortality, reported from clinical ... Gerver et al.: High rate of loss to clinical follow up among African HIV-infected patients attending a London clinic: a retrospective analysis of a clinical cohort Journal of the International AIDS ... and 12 of these (3.5%) had died In total, 375 (51.9% of 722 LFU patients, or 20.2% of the 1859 eligible clinic population) were defined as UKLFU because there was no record of any further clinical...

Ngày tải lên: 20/06/2014, 08:20

... al Annals of Intensive Care 2011, 1:38 http://www.annalsofintensivecare.com/content/1/1/38 Page of 12 Table Summary of cohort glycemic performance results STAR pilot trials SPRINT clinical data ... et al Annals of Intensive Care 2011, 1:38 http://www.annalsofintensivecare.com/content/1/1/38 Page of 12 Number of patients with cTIB cutoff >= 0.80 Num patients 2 Days on STAR % of patients with ... doi:10.1186/2110-5820-1-38 Cite this article as: Evans et al.: Pilot proof of concept clinical trials of Stochastic Targeted (STAR) glycemic control Annals of Intensive Care 2011 1:38 Submit your manuscript to...

Ngày tải lên: 20/06/2014, 23:20

... of internodes/stem No of internodes that have pods Mean of 10 samples 79.5 65.6 9.8 2.0 13.9 12.5 Profitability of sunflower production in Viet Nam March 2006 Table Yield and ancillary data of ... 2005 Observations Mean of 10 sample No of pods/plant 30.5 No of pods that have 1seed/plant 4.5 No of pods that have seeds/plant 19.3 No of pods that have seeds/plant 6.8 Total of seeds/plant 63.3 ... Profitability of sunflower production in Viet Nam March 2006 PROJECT COMPLETION REPOT AN ASSESSMENT OF THE PROFITABILITY OF SUNFLOWER PRODUCTION IN THE MEKONG...

Ngày tải lên: 22/06/2014, 13:20

... management trials have been planted in the summer rainfall region of South Africa Being vegetation management trials all had a weedy (no vegetation control) and weedfree (repeated removal of all ... occur MATERIALS AND METHODS 2.1 Description of trial sites and data For each of the 33 eucalypt trials, data on climate, physiography, presence/absence of several vegetation types (grasses, sedges, ... selection was not employed to simplify models because of the well documented limitations of stepwise regression, most important of which is that it often fails to identify the best model [34] Instead,...

Ngày tải lên: 07/08/2014, 16:21

... terms of efficacy and prediction of outcome This leaded to criticize the clinical trial method [1,2] The difference is mainly due to the fact that in the clinical practice a much higher number of ... limited number of predictive variables [20] We therefore propose a very preliminary strategy of comprehensive assessment in line with the evidence of the complex pattern of determinants of depressive ... number of traits of Dependent Personality Disorder (like difficulties to express disagreement, difficulty to things autonomously, fear of being alone and need of support) and several traits of Obsessive-Compulsive...

Ngày tải lên: 08/08/2014, 21:20

... design of the analysis, execution of the statistical analysis, interpretation of the data, and final approval of the manuscript RD contributed to the design of the analysis, interpretation of the ... writing/editing of the text, and final approval of the manuscript LM contributed to design of the analysis, execution of the statistical analysis, interpretation of the data, and final approval of the ... extensions of the 6-week, double-blind, pivotal trials of paliperidone ER conducted in men and women 18 years of age or older with a diagnosis of schizophrenia These Kozma et al Annals of General...

Ngày tải lên: 08/08/2014, 23:21

... lung disease, randomized controlled trials, observational studies, multicenter studies, clinical trials phase II, clinical trials phase III, and clinical trials phase IV Diffuse alveolar damage ... pooled analysis of the treatment arms of the randomized clinical trials and of the observational studies suggested that both the FVC and DLCO predicted values improved after 12 months of therapy, ... was limited by the small number of eligible studies and a lack of variability in quality across studies Results of the meta -analysis In the randomized clinical trials, the FVC mean difference...

Ngày tải lên: 09/08/2014, 13:22

... reliability determined the adequacy of randomisation, concealment of allocation, blinding of outcome assessors and adequacy Page of 14 of data analysis (was intention-to-treat -analysis performed?) (internal ... validity) of the randomised controlled trials' analysis Author, year Adequate randomisation Adequate allocation concealment Blinding of assessor Intention-to-treat analysis Inclusion of patients ... Table 3: Effect sizes of head-to-head comparisons of different types of aerobic exercise on selected outcome variables Outcome title post treatment Number of studies Number of patients Effect sizea...

Ngày tải lên: 12/08/2014, 12:20

... complex treatment or concomitant use of other therapies (n = 89) Five randomized controlled trials (RCTs) [5-9] and two controlled clinical trials (CCTs) [10,11] Page of fulfilled the inclusion criteria ... between 60 and 240 Assessment of risk of bias All of the included studies (five RCTs and two CCTs) had risks of performance bias, attrition bias and detection bias None of these studies reported ... included trials failed to report details of statistical analysis; thus, it is difficult to interpret the results Although three studies reported favorable effects of Guasha [8,10,11], our re-analysis...

Ngày tải lên: 13/08/2014, 15:21

... I, Rennie D, Stroup DF: Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement Quality of Reporting of Meta-analyses Lancet 1999, 354:1896-1900 ... McQuay HJ: Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996, 17:1-12 Greenland S, Robins JM: Estimation of a common effect parameter ... quality assessment score was less than three [26] Two trials Figure Flowchart of randomised controlled trials selected for the meta -analysis meta -analysis ARDS = acute respiratory distress syndrome...

Ngày tải lên: 13/08/2014, 16:20

... recent meta -analysis of the effects of prone positioning on intensive care unit (ICU) mortality Along with a global meta -analysis, a subgroup meta -analysis is performed on the group of studies that ... used a short duration of prone positioning Page of Figure Flow diagram of the meta -analysis (

Ngày tải lên: 14/08/2014, 07:21

... number of weeks available), and for the final on-therapy (FOT) visit HAM-D17, MADRS, CGI-S, and CGI-I Table 1: Summary of 22 placebo-controlled clinical trials of venlafaxine for treatment of major ... sensitivity of the Montgomery-sberg Depression Rating Scale, the Hamilton Depression Rating Scale and the Clinical Global Impressions Rating Scale in antidepressant clinical trials: a replication analysis ... correlation coefficient (r), a measure of the tendency of two variables to increase or decrease together, was used to measure the correlation of a pair of two efficacy variables measured on the...

Ngày tải lên: 08/08/2014, 23:21

... dosing In trials of to weeks, 88% of the doses were 200 mg daily In trials of 12 weeks' duration, 46% of doses were 200 mg and 46% were of 400 mg daily In trials of 24 weeks or longer, 92% of doses ... expected in clinical practice, where the population may be sicker, or take more medications, than in clinical trials Using company clinical trial reports removes some of the problems of selective ... to 150 mg, and loxoprofen 180 mg daily Details of the included trials are in Table Trial inclusion and exclusion criteria Patients were adults who had a clinical diagnosis of osteoarthritis or...

Ngày tải lên: 09/08/2014, 06:22

Ngày tải lên: 09/08/2014, 07:20

... number of RCTs, trials were not excluded because of trial quality (design) or insufficient number of patients A trial quality score was assigned (scale of 1-5) according to the method of Jadad ... blinding: author, location of study site, journal, year of publication, study design, number of patients, demographic characteristics, clinical outcomes, and follow-up period In all of the included articles, ... C, Reynolds DJ, Gavaghan DJ, et al Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17(1):1-12 23 Stammberger U, Klepetko W, Stamatis...

Ngày tải lên: 10/08/2014, 09:22

... loss of who had where loss of response was defined as a ≥ Meier (KM) Analysis of 1–7 Kaplan Meier (KM) Analysis of olanzapine versus risperidone for days to loss of response, where loss of response ... loss of who had where loss of response was defined as a ≥ Meier (KM) Analysis of 1–7 Kaplan Meier (KM) Analysis of olanzapine versus ziprasidone for days to loss of response, where loss of response ... loss of who had where loss of response was defined as a ≥ Meier (KM) Analysis of 1–7 Kaplan Meier (KM) Analysis of olanzapine versus ziprasidone for days to loss of response, where loss of response...

Ngày tải lên: 11/08/2014, 16:23

... combination of comparable studies is necessary For example, meta -analysis of several studies has been used to support the use of antibiotics in acute exacerbations of COPD [22] In clinical medicine, ... from of the subjects Volume correction of CT Scans The level of inspiration during scan acquisition is recognised to influence lung density and reduce the Figure Measurement of progression of emphysema ... combined analysis of the Danish-Dutch and EXACTLE trials confirms that AAT augmentation therapy has a beneficial effect on the decline in lung density, which is a measure of the progression of emphysema...

Ngày tải lên: 12/08/2014, 11:22