... than inactivation of GSK3 [26] In an attempt to establish the importance of GSK3 in the acute regulation of glucose transport in terms of its regulatory control of GS in muscle and fat cells we ... activity To establish the importance of GSK3 inhibition on GS activity we monitored the effects of insulin, Li, SB-415286 and wortmannin (a PI3K inhibitor) on the incorporation of Ó FEBS 2003 GSK-3 and ... elements implicated in the regulation of GSK3 and GS To further understand the effects of Li and SB-415286 on cell signalling events we assessed their effects and that of insulin on p70S6K, PKB,...
... department of Sitaram Bhartia Institute as a preparatory step prior tothe survey These involved asking the mothers to identify the most important positive and negative areas of their lives and to rate ... number of areas identified to six, to keep the scoring points at 10, to allow 12 spending points and to allow the mother and child counselors to administer the index if requested by the subject To ... subject was reviewed and it was decided to adapt the index tothe Indian setting, possibly at the expense of limiting its comparability to other settings In an attempt to keep the index as simple...
... investigations and tothe data analysis and writing ofthe manuscript ACR contributed tothe laboratory investigations and contributed tothe data analysis and writing ofthe manuscript NC contributed tothe ... conceived the study design, undertook the clinical investigations and contributed tothe data analysis and writing ofthe manuscript AMK contributed tothe study design, clinical and laboratory investigations ... study was toexplorethe efficacy of orthotic treatment for mechanically induced 1st MTP joint pain and to investigate whether any change in pain correlated with changes in foot and ankle kinematic...
... ZXL is the leader ofthe study group DL carried out the experiments and wrote the manuscript ZJL and PS carried out the animal tests BXX and YLC propagated the FMDV strain YFF detected all the sera ... strain at the ear-rootneck area after 28 dpv and FMD symptoms were monitored for 10 days The results ofthe antibody response titrations of 14 dpv and 28 dpv of vaccinated pigs by LPB-ELISA and protective ... antibody The kit (bought from WRLforFMD, Britain) was handled according to manufacture’s instruction When the titer is higher than 1.65, it means positive Lower than 0.6 means negative The range...
... establishment of a substitute anti-oxidant mechanism, which would explain its excessive response and the extensive diffusion The anti-oxidant, anti-enzymatic and anti-inflammatory properties of endothelium ... from the degree of oxidative stress, the reduction ofthe hepatic anti-oxidant capacity would aggravate the intensity ofthe inflammatory response [18] It is possible that another organ, like the ... endothelium, associated with the progressive reduction ofthe anti-oxidant capacity ofthe liver in the evolution of cirrhosis, tries to make up for the deficit In this case, the objective of angiogenic...
... occurrence ofthe 13C atoms and the inability to detect the presence of C-O moieties associated with the 12C atoms open up the possibilities ofthe presence ofthe C-O moieties in the carbonaceous ... evidences of expansion ofthe carbon bodies at the end ofthe synthesis Regardless ofthe compression conditions (CF and holding duration), AC synthesized from the thinner pellets (2.5g of HEC) ... dependent on the thickness ofthe pellet due tothe quantity of “quasi” crosslink networks formed in the axial direction The stiffness ofthe pellet is also dependent on the development ofthe “quasi”...
... information tothe public: The benefits of using public transport, including financial savings to households, improved health and lower burden tothe environment, need to be communicated tothepublic ... expect Real-time public transport information in Guangzhou, China Photo: Ko Sakamoto • Make it affordable and provide incentives for the uptake ofpublic transport: Public transport fares should ... for Asia and the Pacific : Fact Sheet - Policy options to improve the quality ofpublic transport Japanese multi-modal station for bus and train in Toyama City (Iwasehama station) Japanese multi-modal...
... the amount of untreated raw sewage deposited in the Ganga The most noteworthy of these is the Ganga Action Plan (GAP) Initiated in 1984 by the Indian Government, and supported by the Netherlands, ... reduction ofthe amount of untreated raw sewage deposited therein through the improvement ofthe capacity and technology ofthe sewage treatment plants (STPs), and (ii) whether thepublic s aggregated ... attributes considered, and the vectors of coefficients to n are attached tothe vector of attributes (Z) The assumptions about the distribution of error terms implicit in the use ofthe CLM impose a...
... different from that of ZHE2 The amount of ZHE2 transcript is considered to be much lower than that of ZHE1 Taken together with the results ofthe northern blot analysis, the ZHE2 gene in developing ... for (lane 2), 10 (lane 3) and 40 (lane 4) Numbers on the right show the molecular masses ofthe major bands 5938 39 kDa band disappeared, and only two bands with the same mobility as the 43 and ... DNA of Teleostei, Osteoglossomorpha first branched off from an ancestor, followed by Elopomorpha, and then branched paraphyletically to Otocephala and Euteleostei [11–14] The cDNA cloning analysis...
... arrangement juxtaposes the basic regions at the N-termini of bZIP domains into close proximity and thereby enables them to insert into the major grooves of DNA at the promoter regions in an optimal ... pair of single-alanine mutants ofthe Jun-Fos heterodimer analyzed alone and in combination with each other with respect to binding to DNA relative tothe wild-type proteins The complete thermodynamic ... DGwt are the respective free energies of binding of TRE duplex tothe mutant and wild-type constructs ofthe Jun-Fos heterodimer (Tables and 2) Note that the numerals on the x-axis refer tothe ID...
... mean) M EAN AND M EDIAN To find the average, or the mean, of a set of numbers, add all the numbers together and divide by the quantity of numbers in the set sum of values Average = ᎏᎏ number of ... ordered pair and tells you how many units to move either tothe left or tothe right If the x-coordinate is positive, move tothe right If the x-coordinate is negative, move tothe left The y-coordinate ... Find the average of 9, 4, 7, 6, and 9+4+7+6+4 ᎏᎏ 30 = ᎏ5ᎏ = The denominator is because there are numbers in the set To find the median of a set of numbers, arrange the numbers in ascending order and...
... went on to further characterize the permissiveness of these cells for viral mRNA transcription by using a recombinant HRSV engineered to express GFP [33] The relevance of these findings tothe natural ... infection in many cell types other than epithelial cells ofthe respiratory tract Although the overall biological significance of such an abortive infection is unclear, biological effects ofthe individual ... unrelated tothe level of HRSV F expressed (see Figure 2B, lanes and 4) Similar levels of expression were observed for the HRSV F protein from the A and B subgroups (Figure 1B, lane compared to lane...
... is devoted tothe derivation ofan exact expression for the BEP ofan M-PAM subject to Nakagami-m fading, while Section deals with the derivation ofan exact expression for the BEP ofthe I × J-QAM ... presents the system model Section addresses the derivation ofthe CDF ofthe additive noise In Section 4, the CDF is used to derive an exact expression for the BEP of M-QAM subject to Nakagami-m ... the fact that a signal received from a fading channel is subject to a multiplicative distortion (MD) and tothe usual additive noise—then, following a compensation ofthe MD, the signal fed to...
... equal and omission of any of them did not alter the a value significantly The calculation of sensitivity (Sn) and specificity (Sp) at various cut-off levels for the two scales is shown in Table The ... conceived the study, gathered and managed the data, performed the genetic analysis, participated in the statistical analysis and wrote the paper KNF conceived the study, carried out the literature ... designing the study, analysing the data and writing the paper GB participated in designing the study, analysing the data and writing the paper All authors read and approved the final manuscript...
... soluble factors, namely hepatocyte growth factor and TGF-β, were also involved The addition of anti-HGF and anti-TGF-β partially restored the proliferation of CD2+ cells in the presence of MSCs ... TGF, transforming growth factor Table Proposed mechanisms of antiproliferative and immunomodulatory effects of MSCs Mechanism Model Reference (year) Soluble factors: TGF-β, HGF Reversible Human in ... expression and tryptophane depletion [37,38] Recently, failure to achieve significant restoration of T-cell proliferation via tryptophane addition was reported and attributed tothe production of T-cell...
... University of Toronto, Toronto, Ont., Canada 13 Department of Radiation Oncology, University of Toronto, Toronto, Ont., Canada 14 Regional Cancer Prevention and Early Detection Network Hamilton, Niagara, ... for the interpretation ofthe data; review ofthe draft versions ofthe manuscript; provision of feedback for important intellectual revisions; and review and final approval ofthe version to ... contributions MB and CD developed the original study concept and protocol MB, CD, and LB were responsible for acquisition and analysis ofthe data; development ofthe initial draft manuscript, and manuscript...