amp their receptors in non small cell lung cancer detection

... now being exploited in cancer, attempting to modulate their expression, reintroducing microRNAs lost in cancer, or inhibiting oncogenic microRNAs by using anti-micro oligonucleotides [38] In a ... Al-Saad S, Al-Shibli K, et al: Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer Clin Cancer Res 2007, 13:6649-57 World ... lymphocyte infiltration in non- small cell lung cancer Clin Cancer Res 2008, 14:5220-7 Andersen S, Eilertsen M, Donnem T, et al: Diverging prognostic impacts of hypoxic markers according to NSCLC...

Ngày tải lên: 18/06/2014, 16:20

... Jeremic B: Report from the international atomic energy agency (IAEA) consultants' meeting on elective nodal irradiation in lung cancer: non- small cell lung cancer (NSCLC) Int J Radiat Oncol Biol ... Yin Y: A randomized study of involved field irradiation versus elective nodal irradiation in combination with concurrent chemotherapy for inperable stage III nonsmall cell lung cancer AM J Clin ... irradiation be omittd in Stage III non- small cell lung cancer? An analysis of recurrences in a phase II study of induction chemotherapy and involved-field radiotherapy Int J Radiat Oncol Biol...

Ngày tải lên: 09/08/2014, 09:22

... mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non- small cell lung cancer cells in an epidermal growth factor receptor-independent manner Cancer Res 2005, 65(14):6275-81 ... Clinical Cancer Research 2011, 30:6 http://www.jeccr.com/content/30/1/6 Figure Cell viability (MTT assay) for determination of EC50 of COX-2 stimulation in non- small cell lung cancer cell lines ... Sun X, Roman J, Han S: Prostaglandin E2 stimulates human lung carcinoma cell growth through induction of integrin-linked kinase: the involvement of EP4 and Sp1 Cancer Res 2009, 69(3):896-904 Mayoral...

Ngày tải lên: 10/08/2014, 10:20

... chemokines ena-78/cxc ligand (cxcl) and interleukin-8/cxcl8 in human non- small cell lung cancer Cancer Res 2004, 64:1850-1860 Choe MS, Zhang X, Shin HJC, Shin DM, Chen Z: Interaction between epidermal ... gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), and celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, in patients with platinum refractory non- small cell lung cancer ... phase II study of celecoxib in combination with paclitaxel, carboplatin, and radiotherapy for patients with inoperable stage IIIA/B non- small cell lung cancer Clin Cancer Res 2009, 15(6):2158-2165...

Ngày tải lên: 10/08/2014, 10:21

... 90 Paracancerous tissue 14.3 P < 0.05 Reference Li Feng, Liu Yongmei, Chen Huijiao, Liao Dianying, Shen Yali, Xu Feng, Wang Jin: EGFR and COX-2 protein expression in non- small cell lung cancer ... Correction: EGFR and COX-2 protein expression in non- small cell lung cancer and the correlation with clinical features Journal of Experimental & Clinical Cancer Research 2011 30:32 ... clinical features Journal of Experimental & Clinical Cancer Research 2011, 30:27 doi:10.1186/1756-9966-30-32 Cite this article as: Li et al.: Correction: EGFR and COX-2 protein expression in non- small...

Ngày tải lên: 10/08/2014, 10:21

... squamous cell carcinoma in 24 patients, adenocarcinoma in 15 patients, large cell carcinoma in patients and non- small cell lung cancer of unspecified type in patients Based on the TNM staging system: ... biomarkers in non- small cell lung cancer: a review Clin Cancer Res 2005, 11:3974-3986 16 Zhu CQ, Shih W, Ling CH, Tsao MS: Immunohistochemical markers of prognosis in non- small cell lung cancer: ... lectins in stage II nonsmall cell lung cancers In examinated group of 94 patients they showed poorer prognosis for the galectin-1 and galectin-3-expressing tumor in the univariate survival examination...

Ngày tải lên: 10/08/2014, 10:21

... cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone as first-line therapy in EGFRexpressing advanced non- small- cell lung cancer Ann Oncol 2008 in press Pirker R, Szczesna ... Perez-Soler R: Phase II clinical trial data with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (OSI-774) in non small- cell lung cancer Clin Lung Cancer 2004, 6(Suppl 1):S20-S23 ... apoptosis in the EGFRL858R non- small- cell lung cancer cell line H3255 Cancer Res 2004, 64:7241-7244 Shepherd FA: Molecular selection of patients for first-line treatment of advanced non- small- cell lung...

Ngày tải lên: 10/08/2014, 22:20

... al.: Phase III Study of Erlotinib in Combination With Cisplatin and Gemcitabine in Advanced Non- Small- Cell Lung Cancer: The Tarceva Lung Cancer Investigation Trial J Clin Oncol 2007, 25(12):1545-1552 ... erlotinib in advanced non- small cell lung cancer (NSCLC) patients (p) with mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) J Clin Oncol (Meeting Abstracts) ... first-line study of gefitinib (G) versus carboplatin/paclitaxel (C/P) in clinically selected patients (pts) with advanced non- small cell lung cancer (NSCLC) in Asia (IPASS) J Clin Oncol (Meeting...

Ngày tải lên: 10/08/2014, 22:21

... lung cancer harbouring mutations in the EGFR kinase domain Clin Transl Oncol 2010, 12:75-80 Gazdar AF: Activating and resistance mutations of EGFR in non- small- cell lung cancer: role in clinical ... receptor tyrosine kinases, which also includes HER2/neu, HER3, and HER4 [15] Activating mutations in the tyrosine kinase domain, involving mainly exons 19 and 21, play an important role in lung oncogenesis ... counterstained with hematoxylin IHC expression of mAbs against EGFR was evaluated using the following scoring, as previously described [14]: = negative or faint staining in

Ngày tải lên: 18/06/2014, 16:20

... versus vinorelbine or ifosfamide in patients with advanced non- small- cell lung cancer previously treated with platinum-containing chemotherapy regimens The TAX 320 Non- Small Cell Lung Cancer Study ... copies per cell in ≥10% cells ≤2 copies in >90% of cells ≤2 copies in ≥40% of cells, copies in 10%–40% of the cells, ≥4 copies in 90% of cells ≤2 copies in ≥40% of cells, copies in 10%–40% of the cells, ≥4 copies in

Ngày tải lên: 08/08/2014, 17:20

... Docetaxel versus docetaxel/cisplatin in patients with advanced non- small- cell lung cancer: preliminary analysis of a multicenter, randomized phase III study Clin Lung Cancer 2003, 4:288-93 Lilenbaum ... Saville W, Chahinian P, Weeks JC, Holland JC, Green MR: Single-agent versus combination chemotherapy in advanced non- small- cell lung cancer: the cancer and leukemia group B (study 9730) J Clin Oncol ... response induced by first-line chemotherapy with single agent docetaxel in a patient with advanced non small cell lung cancer World Journal of Surgical Oncology 2010 8:8 Conflict of interests...

Ngày tải lên: 09/08/2014, 03:21

... versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non- small- cell lung cancer J Clin Oncol 1999, 17:2692-2699 Komaki R, Seiferheld ... radiochemotherapy with vinorelbine plus cisplatin or carboplatin in patients with locally advanced non- small- cell lung cancer (NSCLC) and an increased risk of treatment complications: Preliminary results ... chemotherapy and IMRT [21] More clinical evidence on using IMRT in treating lung cancer is needed We started using IMRT to treat lung cancer in 2005, and we evaluated clinical and dosimetric factors...

Ngày tải lên: 09/08/2014, 08:23

... Metastases in Non- Small- Cell Lung Cancer: A Systematic Review and Pooled Analysis J Clin Oncol 2008, 26:1142-1147 15 Pfannschmidt J, Dienemann H: Surgical Treatment of Oligometastatic Non- Small Cell Lung ... NSCLC to any organ(s), including brain, bone, liver, or lung were included in this study Only patients with biopsy-proven NSCLC were included Those with prior curative-intent treatment of metastatic ... factors for survival in Stage III non- small- cell- lung cancer treated with definitive radiation therapy: impact of tumor volume IJROBP 2006, 64:449-454 30 Nishio W, Sakamoto T, Uchino K, Yuki T, Nakagawa...

Ngày tải lên: 09/08/2014, 09:20

... stage I non- small cell lung cancer Radiother Oncol 2007, 85:429-434 Sinha B, McGarry RC: Stereotactic body radiotherapy for bilateral primary lung cancers: the Indiana university experience Int J ... performed in 22 stage IA and stage 1B non- small cell lung cancer patients in order to develop and evaluate the planning guidelines differentiated according to type of dose calculation algorithm ... Japan clinical oncology group trial for stereotactic body radiation therapy of non- small cell lung cancer J Thorac Oncol 2007, 2:S115-S117 Schuring D, Hurkmans CW: Developing and evaluating stereotactic...

Ngày tải lên: 09/08/2014, 09:22

... thoracic radiotherapy in combination with mito- 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 mycin, vindesine, and cisplatin in unresectable stage III nonsmall -cell lung cancer J Clin Oncol 1999, 17:2692-2699 ... Methods Worldwide and in Europe lung cancer is the most common cause of cancer related-death with an increasing incidence each year The majority of patients has Non- Small Cell Lung Cancer (NSCLC) and ... stage I Nonsmall cell lung carcinoma Cancer 2004, 101:1623-1631 Belderbos J, Heemsbergen W, Hoogeman M, Pengel K, Rossi M, Lebesque J: Acute esophageal toxicity in non- small cell lung cancer patients...

Ngày tải lên: 09/08/2014, 10:21

... clinical trials for locally advanced non- small cell lung cancer in Japan Int J Clin Oncol 2008, 13:112-6 Farray D, Mirkovic N, Albain KS: Multimodality therapy for stage III nonsmall -cell lung ... cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non- small- cell lung cancer: Four-Arm Cooperative Study in Japan ... Miyaoka E: The Japanese Joint Committee of Lung Cancer Registry Prognosis of 6644 resected non- small cell lung cancers in Japan: a Japanese lung cancer registry study Lung Cancer 2005, 50:227-34...

Ngày tải lên: 10/08/2014, 09:22

... entered into the database Patients with non- small cell lung cancer comprise the majority of cases annotated within the database Other cancers contained in the database include small cell lung cancer, ... of indicates faint staining, indicates medium intensity staining, and indicates dark staining Furthermore, the pathologist is also able to visually assess the localization of predominant protein ... IRB: Institutional Review Board; NAACCR: North American Association of Central Cancer Registries; NCI: National Cancer Institute; Non- RTK: Non- Receptor Tyrosine Kinase; NSCLC: Non- Small Cell Lung...

Ngày tải lên: 10/08/2014, 09:22

... immature autologous dendritic cells Lung Cancer 2007, 57:365-372 12 Hirschowitz EA: Autologous Dendritic Cell Vaccines for Non- Small- Cell Lung Cancer Journal of Clinical Oncology 2004, 22:2808-2815 ... Burlingame, CA, USA) The labeling was carried out at room temperature for 30 minutes in PBS For the intracellular labeling (IL-10 and IL-12p70), cells were permeabilized and fixed using the Fix-Cells ... Estadual Sumaré UNICAMP for support in carrying out the imaging methods Author details Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil 2Hemocentro,...

Ngày tải lên: 10/08/2014, 10:21

... UCH-L1 expression is higher in NSCLC cell lines than in normal lung cells A Fold change of UCH-L1 mRNA in lung cancer cell lines compared to the normal lung cell line BEAS-2B (n = 3) B Densitometry ... evident Methods Cell Culture All cell lines were maintained in RPMI 1640 medium containing 10% fetal bovine serum (PAA, Pasching, Austria), 100 U/ml penicillin and 100 μg/ml streptomycin (Invitrogen, ... UCH-L1 expression increases apoptotic resistance in the adenocarcinoma cell line (H838) and promotes cell migration in the H157 squamous cell carcinoma cell line Also, in NSCLC tumor samples we showed...

Ngày tải lên: 10/08/2014, 10:21

... B, González G, Lage A: Combining an EGF based cancer vaccine with chemotherapy in advanced non small cell lung cancer J Immunotherapy 2009, 32(1):92-9 14 García B, Neninger E, de la Torre A, Leonard ... guidelines for the treatment of non- small- cell lung cancer: an updated edition Clin Transl Oncol 2010, 11:735-41 Gridelli C, De Marinis F, Di Maio M, Cortinovis D, Cappuzzo F, Mok T: Gefitinib ... Safety, immunogenicity and preliminary efficacy of multiple-site vaccination with an Epidermal Growth Factor (EGF) based cancer vaccine in advanced non small cell lung cancer (NSCLC) patients Journal...

Ngày tải lên: 11/08/2014, 08:21