alpha mmp 9 and cyclind1

... China (3 097 2 694 , 810721 59) and Tianjin Municipal Education Commission(20 090 133, 20 090 217), P R China Author details Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, ... regulatory cells Blood 2007, 1 09: 2871-7 13 Mellor AL, Munn DH: Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation? Immunol Today 199 9, 20:4 69- 73 14 Grohmann U, Orabona C, ... tryptophan catabolism Science 199 8, 281:1 191 -3 Munn DH, Mellor AL: Indoleamine 2,3-dioxygenase and tumor-induced tolerance J Clin Invest 2007, 117:1147-54 Astigiano S, Morandi B, Costa R, et al: Eosinophil...

Ngày tải lên: 10/08/2014, 10:21

... 55 .9 ± 11.3 30.8 ± 10.7 34.2 ± 9. 9 28 ± 12.8 14 .9 ± 8.3 18.2 + Normal Healthy Individuals % (mean ± s.d) 76.2 ± 5.7 44.1 ± 5.4 33.1 ± 7.5 9. 9 ± 5.6 13 ± 11 + 2.5 P value 0.0000 0.0000* 0.7 190 ... reported in several studies (Beck et al., 198 5; Onwubalili et al., 198 7; Singhal et al., 198 9; Jones et al., 199 7) In this study decreased CD4 + counts and percentage were observed in patients ... host event in defense against MTB (Stenger and Modlin, 199 9), as decreased synthesis of IFNγ has been associated with active tuberculosis (Zhang et al., 199 5) A Almogren - - + subset of NK cells...

Ngày tải lên: 29/03/2014, 03:20

... catabolism and T-cell tolerance: immunosuppression by starvation? Immunol Today 199 9, 20:4 69- 473 Hubert P, Jacobs N, Caberg JH, Boniver J, Delvenne P: The crosstalk between dendritic and regulatory ... antiCD4 PerCP and CD25 allophycocyanin mAbs (Pharmingen, BD) and were sorted using the Vantage FACSorter (BD Bioscience, San Diego, CA) The purity of the sorted cells was 95 % to 99 % as evaluated ... experimental work, and advised on the study S-HP, and J-KM are the senior researchers, and they supervised the experimental work and advised on the study All authors read and approved the final...

Ngày tải lên: 09/08/2014, 10:22

... Regul 2, 96 5 97 8 Blenis J ( 199 3) Signal transduction via the MAP kinases: proceed at your own RSK Proc Natl Acad Sci USA 90 , 58 89 5 892 Das R & Vonderhaar BK ( 199 6) Activation of raf-1, MEK, and MAP ... production and signaling pathways J Immunol 1 69, 290 7– 291 4 Marrack P & Kappler J ( 199 0) The staphylococcal enterotoxins and their relatives Science 248, 705–711 Cole B & Wells J ( 199 0) Immunosuppressive ... SB-203580 MK 591 MK886 Curcumin SP600125 PD980 59 500 178.4 212.5 173.5 168 74.2 337 p38kinase ± ± ± ± ± ± ± 29. 5 18.6 78.5 19. 5 22 2.5 25 MAPK 250 34 76 55 43 337 225 2 79 38.5 71.5 52.5 39. 8 199 31.0...

Ngày tải lên: 30/03/2014, 04:20

... Allergy, Asthma and Immunology Ann Allergy Asthma Immunol 199 8;81:401–5 13 Durham SR, Walker SM, Varga EM, et al Long-term clinical efficacy of grass pollen immunotherapy N Engl J Med 199 9;341: 468–75 ... Science 199 4;265:1237–40 36 Akdis CA, Blesken T, Akdis M, et al Role of interleukin 10 in specific immunotherapy J Clin Invest 199 8;102 :98 –106 37 Jutel M, Akdis M, Budak F, et al IL-10 and TGF-beta ... Invest 199 3 ;92 :644–51 24 Durham SR, Ying S, Varney VA, et al Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases...

Ngày tải lên: 08/08/2014, 21:20

... Exp Med 199 7, 186:1407-1418 10 Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A: Two subsets of memory T lymphocytes with distinct homing potentials and effector functions Nature 199 9, 401:708-712 ... erythematosus (SLE), and healthy control individuals (a) Representative flow cytometry showing naïve and memory subpopulations of CD4+ and CD8+ T cells from one RA patient and a sex- and age-matched ... of Microbiology and Immunology, Drexel University College of Medicine, Drexel University, 290 0 Queen Lane, Philadelphia, PA 191 29, USA E-mail: katsikis@drexel.edu References R96 Morita Y, Yamamura...

Ngày tải lên: 09/08/2014, 01:21

... cell sorting) of C57BL/6 (B6), TLR-2-/- and TLR-4def anti-BALB/c CTL lines (third stimulation, day 4): Thy1.2+, 99 .0 99 .5%; CD8+, 93 95 %, CD4+, 0.7–2%; CD 19+ (B cells), F4/80+ (macrophages), NK1.1+ ... laboratory mouse Am J Pathol 199 3, 143 :95 9 -97 1 Whitmire WM, Garon CF: Specific and nonspecific responses of murine B cells to membrane blebs of Borrelia burgdorferi Infect Immun 199 3, 61:1460-1467 Steere ... arthritis with HLA-DR4 and HLA-DR2 alleles N Engl J Med 199 0, 323:2 19- 223 Steere AC: Clinical definitions and differential diagnosis of Lyme arthritis Scand J Infect Dis Suppl 199 1, 77:51-54 Barthold...

Ngày tải lên: 09/08/2014, 01:23

... anergy J Immunol 199 1, 147:2155-2163 Melamed D, Friedman A: Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin Eur J Immunol 199 3, 23 :93 5 -94 2 Miller A, Lider ... 3 :94 7 -95 4 Levings MK, Bacchetta R, Schulz U, Roncarolo MG: The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells Int Arch Allergy Immunol 2002, 1 29: 263276 ... AI487 79 and AI54610, and by grants from the American Diabetes Association and Juvenile Diabetes Research Foundation International to SFZ 25 References 220 Sprent J, Kishimoto H: The thymus and...

Ngày tải lên: 09/08/2014, 01:24

... and TNF-α while Tc2 cells predominantly secrete IL-4 and IL-5 (Croft et al., 199 4; Noble et al., 199 5; Sad and Mosmann, 199 5) 22 Chapter 1: Introduction Despite the similarities between CD4 and ... 2007) and type I interferons (Brinkmann et al., 199 3; Parronchi et al., 199 2) also contribute to Th1 polarization Th2 polarization is mediated by IL-4 (Le Gros and Erard, 199 4; Swain et al., 199 0), ... IL-12p70 (Gately et al., 199 6; Gillessen et al., 199 5; Mattner et al., 199 3) It also activates T-cells, acts as a chemokine that attracts macrophages (Ha et al., 199 9) and induces DC migration...

Ngày tải lên: 09/09/2015, 18:58

... ,A ihsokanuF ,N arumiK 41 106- 395 ,41 ,99 91 seR reniM enoB J noitprosbalam muiclac lasuaponemtsop fo ledom enirum dezimotceiravO C ,nehC ,ND ulaK 31 191 -571 ,51 , 199 1 seR reniM enoB ssol enob lasuaponemtsop ... yhotiS ,M yhlaS-lE 91 4-314 ,242 , 799 1 deM nretnI J esaesid lewob yrotammalfni ni sllec enircodne cinoloC L suilemirG ,R gnilnetS ,A nossleinaD ,M yhlaS-lE 5701 -96 01 ,31 , 899 1 lohtapotsiH lotsiH ... ihcugaT ,N ihsigamaY ,N arumatiK ,HR onotraheoS 92 84 -93 ,801 ,99 91 veD gniegA hceM munedoud namuh fo sllec enircodne dna gniegA M yhlaS-lE ,O mortsdnaS 82 95 2-742 ,242 ,2002 pmyS dnuoF sitravoN sisoropoetso...

Ngày tải lên: 07/08/2014, 18:21

... Neutrophils (CD16+) 0 .9 (± 0.6) 1.1 (± 0.7) 1 .9 (± 0.6) 0 .9 (± 1.5) 0 .9 (± 0.4) 0.4 (± 0.7) Macrophages (CD14+) 1.7 (± 0 .9) 1.3 (± 0.7) 0 .9 (± 1.6) Results are expressed as mean with standard deviation ... (0.04-0.51) 0 .90 (0.28-1.44) COPD vs Smokers p < 0.05 COPD vs HNS p < 0.001 0.0 09 (0.001-0.023) 0.022 (0.002-0.056) 0.122 (0.0 19- 0.203) Neutrophils, % 35.3 ( 29. 8-41 .9) 55.5 (38.1-67.2) 74.2 ( 59. 4-82.7) ... bronchitis (Yes/No) (0) 35 ( 19- 51) 10/0 51 (27-77) 5/6 4/6 7/4 112 (88-124) 78 (72-86) 100 ( 89- 122) 74 (73-82) 59 (37-73) 54 ( 39- 69) 2.2 (1.1-3.5) 1.6 (1.1-2.7) 3 .9 (3.6-4.3) FEV1 (% pred) FEV1/FVC...

Ngày tải lên: 12/08/2014, 11:22

... the data and draft of the manuscript HT helped collection and acquisition of the data and draft of the manuscript TA and TK was involved in the interpretation and design of the study, and also ... synthase Cell 199 7, 90 :1085-1 095 11 Kochi Y, Suzuki A, Yamada R, Yamamoto K: Ethnogenetic heterogeneity of rheumatoid arthritis-implications for pathogenesis Nat Rev Rheumatol 2010, 6: 290 - 295 12 Tobon ... and prostaglandin E2 from cord blood mononuclear cells J Immunol 199 6, 157:343-350 23 Szekanecz Z, Koch AE: Macrophages and their products in rheumatoid arthritis Curr Opin Rheumatol 2007, 19: 2 89- 295 ...

Ngày tải lên: 12/08/2014, 18:20

... Spleen 16 678 (± 032) 20 7 89 (± 552) 399 (± 386) 048 (± 627) 164 (± 39) 198 (± 70) 6.80 (± 0.6) 9. 59 (± 2.0) RM Spleen 20 276(± 877) 694 (± 494 ) 206 (± 49) 7.78 (± 2.0) RM Submandibular LN 31 340 (± ... LW9, Gag QI9, Gag LF8, Pol LV10, Pol QV9, Pol SV9, Env CL9, Env ST10, Env TL9, Tat SL8, or VIF QA9, or FLP peptides Few cells (< 0.01%) were positive for Gag LW9, Gag QI9, Gag LF8, or Pol SV9 ... cell depletion in simian immunodeficiency virus-infected macaques J Exp Med 199 9, 1 89: 991 -99 8 Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, Borkowsky W, Farthing C, Ho DD: Temporal association...

Ngày tải lên: 12/08/2014, 23:23

... ( 199 2) of the through(see The model calculated remarkably con- ing the summers in 199 1 and 199 2 Values -1 peaked at 0.8 and 1.0 mm d in the wet months August 199 1 and August 199 2 (figures4 and ... 12.5 mm (for plots under beeches in 199 2, see table IV) and 32.2 mm (for plots under oaks in 199 1), root water uptake (88 and 89 mm in the summers 199 1 and 199 2, respectively) was very high This ... de la couche organique assurait 27 % (en été 199 1), ou 14 % (en été 199 2) de la réserve en eau totale du sol, et 37 % (été 199 1),ou 28 %( été 199 2) de la consommation en eau du peuplement Le...

Ngày tải lên: 09/08/2014, 04:20

... placebo-controlled trial Arthritis Rheum 199 8, 41: 290 - 297 Strobel S, Mowat AM: Immune responses to dietary antigens: oral tolerance Immunol Today 199 8, 19: 173-181 Fishman-Lobell J, Freidman A, ... and erythema limited to the foot and/ or ankle; = slight oedema and erythema from the ankle to the tarsal bone; = moderate oedema and erythema from the ankle to the tarsal bone; and = oedema and ... York: Wiley; 199 6:15.5.1-15.5. 19 Seetharaman R, Mora AL, Nabozny G, Boothby M, Chen J: Essential role of T-cell NF-kappa B activation in collageninduced arthritis J Immunol 199 9, 163:1577-1583...

Ngày tải lên: 09/08/2014, 01:23

... encephalomyelitis J Immunol 199 9, 162:4 490 -4 495 31 Viola A, Lanzavecchia A: T cell activation determined by T cell receptor number and tunable thresholds Science 199 6, 273:104-106 32 Kane LP, ... (Anguilla anguilla) Scand J Immunol 199 2, 36: 89- 97 14 Buzás E, Mikecz K, Brennan FR, Glant TT: Mediators of autopathogenic effector cells in proteoglycan- induced arthritic and clinically asymptomatic ... Immunol 199 4, 158: 292 -304 15 Banerjee S, Webber C, Poole AR: The induction of arthritis in mice by the cartilage proteoglycan aggrecan: roles of CD4+ and CD8+ T cells Cell Immunol 199 2, 144:347-357...

Ngày tải lên: 09/08/2014, 01:21

... intestinal inflammation J Exp Med 199 9, 190 : 99 5-1004 51 Berg DJ, Davidson N, Kuhn R, Muller W, Menon S, Holland G, Thompson-Snipes L, Leach MW, Rennick D: Enterocolitis and colon cancer in interleukin-10-deficient ... transforming β growth factor-β1 gene results in multifocal inflammatory disease Nature 199 2, 3 59: 693 - 699 33 Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, ... by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state Int Immunol 199 8, 10: 196 9- 198 0 38 Thornton AM, Shevach EM:...

Ngày tải lên: 09/08/2014, 01:23

... 2003, 197 :111-1 19 Suvas S, Kumaraguru U, Pack CD, Lee S, Rouse BT: CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses J Exp Med 2003, 198 :8 89- 901 Almeida AR, Legrand ... Autoimmun 199 6, 9: 6 29- 635 Bräuer R, Kittlick PD, Thoss K, Henzgen S: Different immunological mechanisms contribute to cartilage destruction in antigeninduced arthritis Exp Toxicol Pathol 199 4, 46:383-388 ... RB supervised the project and participated together with AS and AR in the design of the study and its coordination, and helped to draft the manuscript All authors read and approved the final manuscript...

Ngày tải lên: 09/08/2014, 06:22

... COPD 19 (9. 6-22) 27 (20-42) P < 0.05 COPD ex-s vs COPD s 0.2 (0.045-0.31) 0. 49 (0.23-1.1) 0. 19 (0.06-0 .93 ) NS 0.36 (0.04-1.07) 0. 19 (0.07-5.2) NS Lymphocytes 1.7 (1.1-2.2) 2.3 (1.5-3 .9) 1.5 (0 .90 -2.8) ... Eur Respir J 20 09, 34(1): 89- 94 doi:10.1186/1465 -99 21-12-74 Cite this article as: Roos-Engstrand et al.: Expansion of CD4+CD25+ helper T cells without regulatory function in smoking and COPD Respiratory ... regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression Clinical immunology (Orlando, Fla 20 09, 131(1):1 09- 118 14 Liu W, Putnam AL,...

Ngày tải lên: 12/08/2014, 13:22