ago piwi protein family comprises two sub families

... homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein Brain Res Mol Brain Res 30, 381–384 ... Structure of the carboxypeptidase Y inhibitor IC in complex with the cognate proteinase reveals a novel mode of the proteinase protein inhibitor interaction J Mol Biol 346, 1323–1334 Mima J, Hayashida ... phosphatidylethanolamine-binding protein is the prototype of a novel family of serine protease inhibitors J Biol Chem 276, 535–540 20 Lorenz K, Lohse MJ & Quitterer U (2003) Protein kinase C switches...

Ngày tải lên: 19/02/2014, 05:20

... ceratoplatanin family The identified proteins were aligned and subjected to neighbor-joining analysis using mega3.1 (Fig 4) 4352 Bootstrap support for most branches was low, which indicates that these proteins ... orthologous protein of H virens form a basal clade in the analysis, which also exhibits the highest genetic distance to the proteins from all other fungi Nevertheless, sequence analysis of these two proteins ... Interestingly, the major protein found is a member of the recently identified cerato-platanin protein family, which contains proteins from plant pathogenic fungi that have been demonstrated to act as elicitors...

Ngày tải lên: 07/03/2014, 12:20

... in the same subfamily (scope: subfamily), between sequences in the same family, but not the same subfamily (scope: family) or between sequences in the same class, but not the same family (scope: ... observed hits between N- and C-terminal halves within the same subfamily (scope: subfamily) differed significantly for the different subfamilies in ST3 ranging from 0% for [st303]AIT5 to 76% for [st315]AITE ... position of the central hydrophilic loop that for many subfamilies is easily recognized in the average hydropathy profile of the subfamily Subfamilies for which the position of the central loop was...

Ngày tải lên: 07/03/2014, 17:20

... different The presence of two homologous units in the same protein resembles the structure of PDI; in fact, the PDI molecule possesses two thioredoxin-like domains with two active sites Interestingly, ... Thermoanaerobacter tengcongensis not encode a protein related to bacterial DsbA and no DsbA-like protein in Archaea were found, suggesting that PfPDO-like proteins represent a new family characteristic of extremophiles ... from P furiosus) [54] This protein is the first glutaredoxin-homolog protein that directly mediates electron transfer from a thioredoxin reductase-like flavoprotein to protein disulfide in archaea...

Ngày tải lên: 16/03/2014, 16:20

... proteins not contain any of the two identified peroxisome signal signatures [38], but several experimentally verified peroxisomal proteins have yet unidentified means of targeting The putative protein ... TTR-related protein from the Gram-negative bacterium E coli The construct including the signal sequence generates two protein products and MS confirms that one corresponds to the mature protein starting ... of a complex of two plasma proteins: transthyretin and retinol-binding protein Science 268, 1039–1041 Naylor, H.M & Newcomer, M.E (1999) The structure of human retinol-binding protein (RBP) with...

Ngày tải lên: 17/03/2014, 09:20

... and used to display a family in overlapped subfamilies based on distances in the tree Documentation consists of links to the protein sequence databases and to other protein family databases (PROSITE, ... cross-referencing most of the European protein family databases and provides a single entry point into them Ideally, in a protein family database each family s function would be fully documented ... Clustered Protein Family Databases Several efforts have been made since 1990 to overcome the effort required to maintain curated protein family databases by automatically clustering the protein sequence...

Ngày tải lên: 23/03/2014, 12:20

... arranged into 11 protein clans and subdivided into 27 protein families, according to the nomenclature of Barrett et al [44] Our own BLAST searches in WormBase, using protein family consensus ... EGF-like domain is missing In subgroup IV (two genes) a SXC domain and in subgroup V (six genes) a TSP-1 domain is added to EGF and CUB domains, Ó FEBS 2003 Astacin protein family in C elegans (Eur ... further segments are attached (subgroup III), or a SXC domain (subgroup IV) or a TSP-1 domain (subgroup V) might follow The second cluster comprises the NAS-1 to NAS-15 proteins, characterized by...

Ngày tải lên: 23/03/2014, 15:21

... is a novel ion selection site in the ZIP family of proteins Results Subcellular localization of TjZNT1 and TjZNT2 in yeast Initially, differences in subcellular localization between TjZNT1 and ... of interest by use of a series of TjZNT1 and TjZNT2 chimeric proteins, and found that differences in Zn2+ selectivity between the two proteins were associated with differences in the extracellular ... characterization of the ZIP family of metal ion transport proteins J Membr Biol 166, 1–7 19 Nishida S, Mizuno T & Obata H (2008) Involvement of histidine-rich domain of ZIP family transporter TjZNT1...

Ngày tải lên: 29/03/2014, 00:20

... thus aligned the red algal 20-kDa protein sequence with the PsbQ-like protein from two cyanobacteria, Synechocystis sp PCC 6803 and Anabaena sp PCC7120, the PsbQ protein from green algae and higher ... that the 20-kDa protein among red algae, and the PsbQ protein within the same category of organisms are rather conserved The resulting phylogenic tree indicated that the PsbQ protein family could ... 20-kDa protein For reconstitution experiments, the 20-kDa protein of Cy caldarium was successfully expressed as a fusion protein with a His-tag using the pET expression system The expressed protein...

Ngày tải lên: 31/03/2014, 07:20

... disjoint k and l element subsets If k + l ≤ n, but, say, l > n , then any two l-element subsets meet each other For any fixed k-element subset there are n−k l-element subsets disjoint from this ... is also known, that starting from any family of sets, performing finitely many shift operation, one can obtain a so-called left-shifted family, that is a family for which τi,j (F ) = F for all ... large sets into our family when considering the k and n − − k-element complementing pairs 3.4 So we will be done, if we can prove Lemma 3.5 For any intersecting and co-intersecting family F , there...

Ngày tải lên: 07/08/2014, 08:22

... number of signaling proteins, including eNOS, ␤-adrenergic receptors, protein kinase C isoforms, G proteins, Src -family kinases, and multiple components of the dystrophin-glycoprotein complex [34,76-79] ... of this family of proteins are poorly defined, but information gleaned from the protein sequence has enabled some predictions of structure and Generally speaking, caveolins are small proteins ... lipidanchored signaling molecules, such as GPI-anchored proteins, H-Ras, Src- family tyrosine kinases, eNOS, and Gprotein alpha-, beta-, and gamma- subunits Methods Mol Biol 1999, 116:51-60 A description...

Ngày tải lên: 09/08/2014, 20:20

... annexin B family, found in both protostome and deuterostome invertebrates, have also undergone many lineage-specific duplications, leading to more than 20 subfamilies whose gene organization, protein ... protein (Figure 4a) A more complicated problem in the study of large protein families is the determination of which structural differences are responsible for functional specificity in each subfamily ... distinct evolutionary clades of the Afamily annexins, reveal patterns of structural divergence between subfamilies that localize principally to sites exposed on the protein surface that are most likely...

Ngày tải lên: 09/08/2014, 20:20

... netrin family of proteins (a) Netrins are members of the laminin superfamily A phylogenetic tree based on human protein sequences illustrates the relationship between netrin and laminin family ... Frizzled-related proteins that are involved in axon guidance, in the type I procollagen C-proteinase enhancer proteins (PCOLCE), which are metalloproteinase inhibitors, and in tissue inhibitors of metalloproteinases ... actin and microtubule networks [34] The first netrin receptors to be identified belong to the DCC subfamily of proteins, which in vertebrates includes DCC and neogenin, a protein with approximately...

Ngày tải lên: 09/08/2014, 20:20

... snRNP, thus establishing a network of protein- protein and protein- RNA interactions The establishment of such a network would then permit the stable association of SR proteins with many different ... of SR proteins SR proteins may have two exon-independent functions SR proteins facilitate splice-site pairing by simultaneously interacting with U1 snRNP and U2AF across the intron SR proteins ... 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase RNA 1997, 3:344-355 Makarova OV, Makarov EM, Luhrmann R: The 65 and 110 kDa SR-related proteins...

Ngày tải lên: 09/08/2014, 20:20

... AtWOX1 AtWOX2 AtWOX3 HD HD HD AtWOX4 AtWOX5 HD HD AtWOX6 AtWOX7 HD AtWOX8 HD AtWOX9 HD AtWOX10 AtWOX11 AtWOX12 HD HD HD AtWOX13 HD AtWOX14 HD Figure Schematic domain structure of WOX family proteins ... continued Phylogenetic relationships of WOX family proteins (a) Relationship of the WOX family to the other members of the HB transcription factor superfamily Proteins matching the PFAM Homeodomain ... Amoebozoa) Families indicated in black consist of members from both plants and opisthokonts or contain significant amounts of protist (algal, protozoan) sequences (b) The WOX protein family Proteins...

Ngày tải lên: 09/08/2014, 20:21

... major PIN gene subfamily encodes proteins with the central hydrophilic loop virtually absent (‘short’ PINs) and comprises AtPIN5 and AtPIN8 Sequence diversification within the subfamily of short ... retained in short PINs Two motifs important for intracellular trafficking of PIN proteins can be predicted One comprises two diacidic motifs presumably important for trafficking of proteins from the ... plant development by acting on PIN proteins PIN protein activity can be regulated at many levels, including regulation of transcription, protein degradation, subcellular trafficking (endocytic...

Ngày tải lên: 09/08/2014, 20:21

... matrix proteins and proteinases of enamel have been associated with the different phenotypes of AI The main structural proteins in forming enamel are amelogenin, ameloblastin, and enamelin These proteins ... methods Family and phenotype analyses This study was carried out with the approval of the FOP/ UNICAMP Ethics Committee (protocol 127/03) and informed consent was obtained from all subjects Two families ... degraded or reabsorbed by ameloblasts [9] Different proteinases such as matrix metalloproteinase-20 and kallikrein-4, regulate the enamel matrix protein processing that ultimately defines the structure...

Ngày tải lên: 11/08/2014, 23:22

... Tonoplast intrinsic protein isoforms as markers for vacuolar functions Plant Cell 1999, 11:1867-1882 Gillespie J, Rogers SW, Deery M, Dupree P, Rogers JC: A unique family of proteins associated ... elongation zone The image shows two adjacent z-stacks of the same root, separated by a black line B and C: xz projections of the image stack in panel a, revealing two cross-sections of the root ... genomic sequences allowed us to investigate both the tissue specificity and the subcellular localisation of these proteins In general, our fluorescent reporter - TIP localisation data correlate...

Ngày tải lên: 12/08/2014, 03:21

... find other similar proteins based on their 1d-structure (sequence) to NLP protein results in other NLP proteins In this article, we propose a 3d-structure for this protein family based on: (1) ... decarboxylase, auxin-binding protein, globulins, etc Many proteins on this superfamily have functions and chemical properties related to the NLPs: Auxin-Binding Proteins (ABPs) are hormone receptors ... germin-like proteins, apoplastic, glycoproteins are remarkably proteaseresistant because of their cupin fold Results and Discussion According to Dunwell et al [8,9] the cupin domain comprises two conserved...

Ngày tải lên: 12/08/2014, 05:20

... X-associated protein, XAP) have been found only in animals Several other subfamilies are specific for fungi (subfamilies E and F) and plants (subfamilies G and H) Besides the large number of RBR protein ... some RBR protein subfamilies are found only in specific taxonomic groups (Additional data file 1); for example, subfamilies C (such as RING finger protein 144), I (IBR domain-containing protein ... RBR proteins are assigned to 15 subfamilies (A-I, P, S, T, U, X, Z; Figure 1) There are also some 10 orphan sequences that could be considered as their own groups Subfamily A (Ariadne-like proteins)...

Ngày tải lên: 14/08/2014, 18:20