aging changes in pain perception that occur with

báo cáo hóa học: " Identification of symptom domains in ulcerative colitis that occur frequently during flares and are responsive to changes in disease activity" ppt

Ngày tải lên : 18/06/2014, 19:20

... currently being developed in preclinical testing and clinical trials, including molecules targeting interleukin 12, interleukin 17, and endothelial integrins The efficacy of UC therapies in clinical ... bowel movements Abdominal pain Anorexia Erythema nodosum Pyoderma gangrenosum Eye redness /pain Fever Use of anti-diarrheals Incontinence Nausea Cramping Joint pain Symptom Domains Derived from Focus ... error-checking Any discrepancies in ratings for a given symptom domain endpoint were resolved by having J.C.J and T.K re-examine the original questionnaire and re-measure the distance of the VAS rating...

12
382
1

báo cáo hóa học:" Relationships between changes in pain severity and other patient-reported outcomes: an analysis in patients with posttraumatic peripheral neuropathic pain" docx

Ngày tải lên : 20/06/2014, 15:20

... in Sleep Interference (Figure 1) A 2-point decrease in pain was associated with an estimated 1.5-point decrease in pain interference on daily function or PII (Figure 2) A 2point decrease in pain ... Page of Change in mBPI-sf Pain Interference Index –1 –2 –3 –4 –5 –4 –3 –2 –1 Change in pain Figure Predicted relationship between change in pain severity and mean change in pain interference on ... Relationship between change in pain severity and change in pain interference on daily function assessed using the modified Brief Pain Inventory-short form (mBPI-sf) Pain Interference Index Analysis based...

8
288
0

Báo cáo y học: "Changes in multi-segment foot biomechanics with a heat-mouldable semi-custom foot orthotic device" pps

Ngày tải lên : 10/08/2014, 21:24

... applicable to walking and cannot be extrapolated to running Since many chronic injuries, such as plantar fasciitis, occur in response to atypical loading during running, future running-related research ... during shod walking with and without an orthotic device We chose to investigate a semi-custom orthotic device that incorporates a heat-moulding process, to further understand if the moulding ... study indicate that semi-custom orthoses reduce plantar fascia strain compared to walking without an orthoses While we are not aware of another gait study that has calculated strain within the...

8
325
0

Báo cáo y học: "Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including a-actinin " docx

Ngày tải lên : 13/08/2014, 13:21

... actin, a-actinin 4, myosin, and a-tubulin in glomeruli (1) and tubules (2) 1) Although the intensity of immunoreactivity of a-tubulin did not change, that of immunoreactivity of actin, aactinin ... cytoskeletal proteins (actin, a-actinin4, a-tubulin, and myosin) and quantified their signals Signals of O-GlcNAcylated-actin, a-actinin 4, a-tubulin, and myosin were observed in the glomerulus ... of actin may modulate the actin-tropomyosin interaction and be involved in the polymerization of myosin heavy chains [24] High glucose alters protein kinase C-dependent actin assembly in both...

16
271
0

Tài liệu Báo cáo khoa học: Changes in rat liver mitochondria with aging Lon protease-like activity and N e-carboxymethyllysine accumulation in the matrix doc

Ngày tải lên : 20/02/2014, 11:20

... with aging (Eur J Biochem 270) 2299 Western blotting of modified proteins Fig Determination of CML-protein content in liver mitochondrial matrix with aging The CML content in the matrix proteins ... immunological signals increased with aging These findings are consistent with previous reports showing an increase in carbonyl proteins in mitochondria from different tissues of several animals with age, ... emerged in this latter sample Western blotting with mAb 6D12 was used to detect matrix proteins undergoing CML modification with aging Proteins from all molecular masses were immunolabelled in samples...

8
412
0

Báo cáo y học: "Expert agreement confirms that negative changes in hand and foot radiographs are a surrogate for repair in patients with rheumatoid arthritis" pot

Ngày tải lên : 09/08/2014, 10:20

... experts viewing only the joint-of-interest in Exercise I; in the remaining six cases, the two independent readers did not score repair in the joint-of-interest, which was in agreement with the judgement ... Bio-Imaging Technologies (Newtown, NJ, USA) The meeting started with a thorough training session discussing many examples of joints and features showing repair These features were filling -in of ... 74 joints out of 1,292 joints showed repair phenomena [7] The authors also found that, in the group of patients with repair phenomena in single joints, an increase and decrease in the score occurred...

9
373
0

Báo cáo khoa học: "Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]" doc

Ngày tải lên : 12/08/2014, 20:20

... greater in patients with bacterial infections than in the group with infection of unknown etiology (clinical infection but without confirmatory culture) This latter group, compared with patients with ... prothrombin fragment F1.2 (F1.2), thrombin– antithrombin complex (TAT), plasminogen activator inhibitor (PAI)-1, thrombin activatable fibrinolysis inhibitor (TAFI), α2antiplasmin (α2-AP), plasminogen, ... α2-antiplasmin; APTT, activated partial thromboplastin time; AT, antithrombin; CI, confidence interval; F1.2, prothrombin fragment 1.2; IL, interleukin; PAI, plasminogen activator inhibitor; PT,...

9
263
0

Tài liệu Báo cáo khoa học: Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae pdf

Ngày tải lên : 20/02/2014, 01:20

... [6,7] In this study, Nop53p was isolated in a two-hybrid screen as a protein interacting with Nop17p, which is involved in the early steps of prerRNA processing [28] Nop17p and Nop53p interacted in ... revealed that Nop53p also interacts with Nip7p (Fig 1), a protein component of the pre60S complex that is involved in processing of 27S preRNA [6,7,9] The interaction between Nop53p and Nip7p in the ... 9–10, [32P]5.8S incubated with increasing amounts of bovine serum albumin; 11, 20 pmol of bovine serum albumin and 40 pmol of cold 5.8S rRNA; 12, [32P]5.8S, 20 pmol bovine serum albumin and 40 pmol...

14
505
0

Accounting for Changes in Social Support Among Married Older Adults: Insights From the MacArthur Studies of Successful Aging pptx

Ngày tải lên : 06/03/2014, 15:20

... asked to indicate how distressed they were by feelings of hopelessness, lack of interest, worrying, feeling blue, feeling lonely, blaming themselves, feeling trapped, crying easily, having a poor ... support, with closer relationships (e.g., spouse) providing increased emotional support over time The Role of Individual Differences In addition to experiencing changes in network composition that ... resource in the informal support system Research on Aging, 1, 434 – 463 Carstensen, L L (1987) Age-related changes in social activity In L L Carstensen & B A Edelstein (Eds.), Handbook of clinical...

10
449
0

Báo cáo khoa học: Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability docx

Ngày tải lên : 07/03/2014, 00:20

... Nanoparticle-induced metabolic changes The formation of LDs induced by NPs could be partially explained by a reduction in fat oxidation, which occurs in parallel with an increase in LD number ... Treatments with NPs were performed in serum-containing and serum-free medium buffered with 10 mm Hepes (pH 7.4) LD staining and quantiﬁcation LDs were stained with Oil Red O, as described in detail ... compromised by the inhibition of PI3K signaling with LY294002 in a fully supplemented medium and within the tested time period (Fig 3B, D) QDs induce the formation of LDs in PC12 cells in a growth factor-dependent...

14
540
0

Báo cáo khoa học: Esculentin-1b(1–18) – a membrane-active antimicrobial peptide that synergizes with antibiotics and modiﬁes the expression level of a limited number of proteins in Escherichia coli doc

Ngày tải lên : 16/03/2014, 00:20

... synergizes with erythromycin, presumably by increasing the intracellular in ux of this drug, as a result of increased membrane permeability; (c) elicits identical changes in the bacterium’s protein expression ... corresponding MIC of Esc(1–18) resulted in an irregular rod form with a deep wrinkling of the cell surface (within min) However, all of these changes became more pronounced after a longer incubation ... mixed with lm SYTOX Green in NaCl ⁄ Pi for in the dark After addition of peptide, the increase in ﬂuorescence, owing to the binding of the dye to intracellular DNA, was measured at 37 °C in a...

18
494
0

Báo cáo khoa học: Vaccination with prion peptide-displaying papillomavirus-like particles induces autoantibodies to normal prion protein that interfere with pathologic prion protein production in infected cells pptx

Ngày tải lên : 16/03/2014, 11:20

... Immunization with PrP–VLPs induced high-titer Abs to PrP in rabbits and in rats, without causing overt adverse effects Sera speciﬁcally recognized PrPC in its native conformation in mouse brain and ... predominantly spherical structures approximately 50–55 nm in diameter (Fig 1B), indicating selfassembly into VLPs with a morphology similar to that of wild-type L1–VLPs [35] In addition, incompletely ... to allow functional testing in mouse models [31] Our results are in agreement with those obtained with mAb to Helix 1, which has been shown to be effective in inhibiting prion pathogenesis [12,14,29]...

12
322
0

Báo cáo khoa học: Local binding with globally distributed changes in a small protease inhibitor upon enzyme binding ppt

Ngày tải lên : 23/03/2014, 10:21

... mapping of the binding site of a protein proteinase inhibitor: changes in the 1H, 13C and 15N NMR chemical shifts of turkey ovomucoid third domain upon binding to bovine chymotrypsin Aa J Mol Recogn ... protease-binding loop and the N-terminal part of the ﬁrst b strand The alterations furthest from the binding site, in segment Gly7–Lys10, are reﬂected in the changes in the chemical shifts Intriguingly, ... corresponding restraint is violated in the complex structure lending support for the relevance of this conformational change Other violated restraints indicate changes in the protease-binding loop,...

12
396
0

Báo cáo khoa học: "Automatic training of lemmatization rules that handle morphological changes in pre-, in- and suffixes alike" docx

Ngày tải lên : 23/03/2014, 16:21

... replacement since their affixing of words (inflection of words) can include both prefixing, infixing and suffixing Therefore we created a trainable lemmatizer that handles pre- and infixes in addition ... pertains to the training algorithm employing a tree The typical situation during training is that a rule that already has been added to the tree makes lemmatization errors on some of the training ... lemma from the full form The training process terminates when the full forms in all pairs in the training set are transformed to their corresponding lemmas After training, the data structure of rules...

9
372
0

Báo cáo khoa học: Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways docx

Ngày tải lên : 30/03/2014, 01:20

... These findings were confirmed in CCl4-induced experimental hepatic fibrosis Bcl-2, which can rarely be detected in the normal liver, was expressed increasingly in intrahepatic HSCs after CCl4 injury ... C.-J Guo et al Signaling pathways regulated in HSCs by miRNAs Fig Double immunofluorescence staining of Bcl-2, caspase-9 and desmin in liver tissue (· 200) Double staining of desmin (green), Bcl-2, ... in nuclei (blue) was in the liver tissue The arrowheads indicate the expression of Bcl-2 and caspase-9 in HSCs showing red ⁄ green double-stained cytoplasm and blue-stained nuclei incubated with...

14
478
0

Báo cáo hóa học: " Mass spectrometry-based analysis of therapy-related changes in serum proteome patterns of patients with early-stage breast cancer" pot

Ngày tải lên : 18/06/2014, 16:20

... signatures that correlated with increased risk of metastatic relapse (the signature included haptoglobin alpha chain, transferrin, C3a complement fraction, apolipoprotein C1 and apolipoprotein A1), ... neutrofil defensin-3 (DEFA), fibrynogen alfa chain (FGA), haptoglobin (HP), inter-alphatrypsin inhibitor heavy chain H4 (ITIH4), platelet factor (PF4), transthyrein (TTR), neurosecretory protein VGF (VGF) ... correlated with clinical data; two clusters of samples were separated where the component's intensity either increased or decreased between points B and C We found that modality in changes of...

11
391
0

Báo cáo hóa học: "Dynamic changes in cellular infiltrates with repeated cutaneous vaccination: a histologic and immunophenotypic analysis" pot

Ngày tải lên : 18/06/2014, 16:20

... cytokines, antigen formulation, frequencies and dose in human subjects are needed We have found that evaluating the immune responses in the vaccinedraining node can be helpful in increasing the ... optimize vaccine efficacy In the present study, we report observations about the inflammatory infiltrate induced by incomplete Freund’s adjuvant, with or without peptide, in a clinical trial ... the T-cell zone Bar = 100 μm in a-c (d) Double-staining for CD20+ B-cells (brown membranous stain) and CD8 (purple membranous stain) Counter-staining with hematoxylin marks nuclei blue Note the...

13
339
0

báo cáo hóa học: " Indoors illumination and seasonal changes in mood and behavior are associated with the health-related quality of life" pdf

Ngày tải lên : 18/06/2014, 19:20

... Social Insurance Institution of Finland were contacted Interviewers attended training sessions on the specific themes that were to be covered in the computer assisted interviews During the interviews, ... Our findings herein suggest that illumination levels indoors are of importance to mental well-being They may therefore stimulate further research aiming at designing optimal working and living ... Determinants of mental well-being To start with, we found that both the seasonal changes in mood and behavior and the experienced illumination indoors contributed independently to mental well-being,...

8
469
0

Báo cáo hóa học: " Changes in viral load and HBsAg and HBeAg status with age in HBV chronic carriers in The Gambia" pdf

Ngày tải lên : 20/06/2014, 01:20

... of infection is dependent on the host immune response to the virus [20] Important changes are occurring which are impacting on the natural history of HBV infection These changes include vaccination ... machine after the PCR amplification and quantification Linear trend was tested by fitting a generalized estimating equation to allow for multiple responses within subjects using a logistic link with ... Manduar (situated in West Kiang district) in the period before 1986–1990, when the national vaccination programme in The Gambia commenced, have shown that infection was uncommon in infants under...

8
460
1

Báo cáo hóa học: " Changes in the gene expression profile of Arabidopsis thaliana after infection with Tobacco etch virus" potx

Ngày tải lên : 20/06/2014, 01:20

... repeat-binding protein DNA binding domain: a new fold with an additional C-terminal helix J Mol Biol 2006, 356:72-85 Kirik V, Bäumlein H: A novel leaf-specific myb-related protein with a single binding ... plants infected with TEV It has been well established that symptoms in potyvirusinfected plants are associated with the RNA silencing suppressor activity of the HC-Pro protein that interferes with ... binding-leucine rich repeat (NB-LRR) proteins to signal isolate-specific pathogen recognition [22,23] The second gene encodes a protein with isochorismate synthase activity that is involved in...

11
436
0