advances in drug delivery to cns neurons

... with drug- containing anti-CD134 liposomes Next, we investigated whether local targeting to CD134+ T cells in the joint-draining PLN would affect the course of actively induced arthritis in the ... for investigating in vitro binding and internalization contained 0.1 mol% Texas red-phosphatidylethanolamine (Molecular Probes Europe) Liposomes used for studying drug delivery in vitro and for ... s.c in the paw (Fig 3a) Drug delivery to CD134+ T cells in vitro using anti-CD134 liposomes containing the dipalmitate-anchored cytostatic agent FUdR The fate of anti-CD134 liposomes after binding...

Ngày tải lên: 09/08/2014, 06:22

... results obtained for the uptake of 99mTc Discussion using a scale ranging from to sections for the total joint inflammation Histological grading of the knee4 using a scale ranging from to (-) indicates ... No Butoescu et al Figure Histology of mouse knee joints days after intra-articular injection Staining is with haematoxylin and eosin unless specified otherwise (a, b) Antiinjection gen-induced ... Prussian blue staining was positive, indicating that the SPIONs were To address the shortcomings related to the intra-articularly administered DXM suspension, we investigated the clinical potential...

Ngày tải lên: 09/08/2014, 14:20

... while interacting with its target, thereby leading to high binding affinity and sensitive detection GNPs in biosensors can also provide a biocompatible microenvironment for biomolecules, greatly increasing ... modified with enzyme into redox polymer hydrogels First, an enzyme was incubated in a single-walled carbon nanotube (SWNT) solution, then cross-linked within a poly[(vinylpyridine)Os(bipyridyl)(2)Cl2+/3+] ... finally formed into composite films The redox polymer films incorporated with glucose oxidase modified SWNTs resulted in a to 10-fold increase in the oxidation and reduction peak currents during...

Ngày tải lên: 28/05/2014, 15:12

... Chromatography IC Intra-cerebral ICV Intracerebroventricular IFN-Ȗ Interferon gamma IL-1ȕ interleukin-1 beta IL-2 interleukin-2 IL-4 interleukin-4 IL-6 interleukin-6 IR infrared XIV iNOS inducible ... cell-penetrating peptide may use this way to penetrate the BBB and bring drug molecules to the brain (Santra et al., 2005; Torchilin et al., 2001) 3.2 Strategies for drug delivery into the brain Clinically, ... challenging task in treatment of various diseases or injuries in the central nervous system (CNS) is to overcome the barrier preventing the drugs moving into the brain parenchyma The blood brain barrier...

Ngày tải lên: 11/09/2015, 09:10

... undergoing surgery must be maintained at a certain anesthetic state (loss of sensation) in order to prevent the awareness of pain and to attenuate the body’s stress response to injury In order to ... FOR AUTOMATIC DRUG DELIVERY TO REGULATE ANESTHESIA DURING SURGERY YELNEEDI SREENIVAS (M.Tech., Indian Institute of Technology Madras, India) (B.Tech., Andhra University Engineering College, India) ... constraints and drug minimization 1.2 Drugs and their Effect during Anesthesia • A well-designed drug administration policy should suppress the inter- and intra-individual variability thus avoiding...

Ngày tải lên: 14/09/2015, 08:25

... equation was integrated in the model [27] to estimate the amount of drug entering the small intestine as a function of time M = D e−Ke(t) where M is the mass of the drug remaining in the stomach, ... established in- house in order to assess the amount of drug absorbed (dA) as a function of time [26,27] In this model, the stomach empting time was taking into consideration A log linear gastro ... rate-limited Within the linear range, an increased surface area (i.e., due to the nanolized drug) will result in a linear increase of oral absorption This model was found to be sufficient to predict...

Ngày tải lên: 21/06/2014, 03:20

... means for monitoring and confirming resistance to lamivudine therapy Indeed, resistance to antivirals is still generally defined clinically by a rise in serum HBV DNA levels during antiviral ... no intermediate high Complexity of Labor Automatability interpretation intensiveness intermediate intermediate low intermediate intermediate high Intermediate high high low low intermediate intermediate ...

Ngày tải lên: 03/11/2012, 09:41

... Cytokines implicated in T cell exhaustion Another potential inducer of CD8+ T cell exhaustion is the anti-inflammatory cytokine IL10 IL-10 has been shown to be a potent inhibitor of inflammatory ... the inhibitory receptors PD-1 and LAG-3 in CD8+ T cells during a chronic LCMV Cl 13 infection Moreover, this conditional knockout resulted in increased cytotoxicity of 32 Recent Advances in Immunology ... T-cell and pro-inflammatory cytokines tended to be correlated with EOTAXIN in women with carcinogenic HPV, while Recent Advances in Immunology to Target Cancer, Inflammation and Infections they were...

Ngày tải lên: 07/03/2014, 20:20

... revealed that, like insulin, FSE also induces tyrosine phosphorylation of a number of proteins including the insulin receptor, insulin receptor substrate and p85 subunit of PI3-K, in both 3T3-L1 adipocytes ... and glucose uptake were inhibited by wortmannin, a phosphatidylinositol 3-kinase (PI3-K) inhibitor, and bisindolylmaleimide 1, a protein kinase C (PKC)-specific inhibitor In vitro phosphorylation ... on intestinal transit and castor oil induced intestinal fluid accumulation (enteropooling) with using standared drug atropine sulphate The reduction in total number of diarrhoeal faeces and total...

Ngày tải lên: 28/05/2014, 15:10

... mechanical, including photocopying, recording or any information storage and retrieval system now known or to be invented, without written permission from the Publisher For photocopying of material in ... Printed in Singapore by Mainland Press Pte Ltd In memoriam Armin Lamprecht This page intentionally left blank Preface Research and development of innovative drug delivery systems are increasing ... entrapped drug) or intracellular drug delivery which is interesting in gene and cancer therapy The nanotechnological approaches in drug delivery include a large variety of forms, mainly systems...

Ngày tải lên: 04/06/2014, 14:31

... mapping has recently pinpointed genetic variation of Nalp1 as a contributor to interstrain differences in the inflammatory response to injured skin [38] It is important to recognize that the involvement ... Pro-inflammatory mRNA increase occurs in cortex within hours following lesioning [26] or ischemia [27,28 ]in vivo Since there were no established foci of inflammation in the tissue prior to sectioning ... involvement in models of neurological disease and injury [16-18] This included pro-inflammatory cytokines, chemokines, CD74, and antisecretory factor CD74 is differentially regulated among inbred strains...

Ngày tải lên: 19/06/2014, 22:20

... additional advantages for tracking and real-time monitoring of drug delivery efficacy in vivo Intracellular drug delivery To study the cellular drug delivery, in vitro experiments have unique ... carriers of recombined ricin A chain protein toxin (RAT) for tumor targeting The complexes of RAT and MWCNT were capable of translocating in the cytoplasm of various cell lines, including L-929, HL7702, ... publications in this interesting field Apart from their uses in the cellular imaging with diagnostic effects in nanomedicine [4,5], CNTs are promising drug carriers in the target drug delivery systems...

Ngày tải lên: 20/06/2014, 22:20

... particles containing no Cu (left) The difference between the amount released at 48 h and that contained in the original loading solution determined Cu loading, resulting in values ranging between ... synthesized including those employing other polymers routinely used in targeted drug delivery, such as PLGA, chitosan, or dextran Thus, the metal/ligand chemistry is readily adaptable to, and independent ... was reduced In vitro toxicity of CuCNPs in HeLa cells The toxicity of CuCNPs to cancer cells was investigated and results demonstrated that the delivery vector itself, particles containing no Cu,...

Ngày tải lên: 21/06/2014, 02:20

Ngày tải lên: 08/08/2014, 18:20

... lymphoid tyrosine phosphatase that affects the threshold for T-cell receptor signaling through binding to a Csk kinase In vitro experiments have shown that the PTPN22 T-allele-encoded protein binds less ... which is ineffective in 66% of patients [54] Subsequently, methotrexate is switched to another disease-modifying antoretroviral drug or a diseasemodifying antoretroviral drug is added to the methotrexate ... consequence of carrying the C5-TRAF1 polymorphism is as yet unknown Cytotoxic T lymphocyte antigen A genetic risk factor that has been investigated frequently in relation to RA, providing inconsistent...

Ngày tải lên: 09/08/2014, 10:23

... toxicity and efficacy of nano -drug delivery system in both in vitro and in vivo (WT mice) systems, and evaluate the efficacy of PLGA-PEG mediated PS-341 lung delivery in controlling inflammatory ... mediated PS-341 drug delivery in controlling Pa-LPS induced lung disease in CF mice We verified that PLGA-PEGPS341 treatment controls PaLPS induced NFB protein levels (Fig 9), indicating towards its ... ability to control Pseudomonas aeruginosa LPS induced CF lung disease in murine model In this study, we determined that our PLGA-PEG drug delivery system can not only provide sustained drug release...

Ngày tải lên: 11/08/2014, 00:22

... hence far more changes in injecting partners [56] Syringe exchange machines were found to be very effective in increasing access to sterile injecting equipment in prisons in Switzerland and Germany ... et al [30], in their vending machine study in Berlin, found that machines users were more likely to report a shorter history of injection The authors explained that early in their injection career ... Australian initiatives to prevent the spread of HIV/AIDS amongst injecting drug users International Journal on Drug Policy 1991, 2(4):13-16 Dodding J Gaughwin M: The Syringe in the machine Australian...

Ngày tải lên: 11/08/2014, 18:20

... factors are involved in initiating and maintaining the dormant state In addition to phagocytosis, macrophages contribute further to the immune response both by inhibiting growth or by killing ... eliciting longer lived immunity by linking interleukin-12-inducing strategies with immunogenic mycobacterial proteins in a vaccine may be efficacious Indeed, several groups are pursing this When interleukin-12 ... cell wall, interleukin-12 production is stimulated in THP-1 cells, a human macrophage-like cell line Interleukin-12 is an important pro-inflammatory cytokine in host responses against tuberculosis,...

Ngày tải lên: 12/08/2014, 18:20

... spending precious time in examining my thesis and providing valuable comments I am thankful to A/Prof Yang Kun-Lin and A/Prof Chen Shing Bor for being the panel examiners in my oral qualifying ... process of drug loading and release, and provide bottom-up guidelines towards the intelligent design of new amphiphilic peptides for drug delivery The main contents of the thesis contain four parts ... feasible to develop better delivery method for existing drugs rather than inventing new drugs Current delivery materials such as surfactants and copolymers have been tested and few of them are in clinical...

Ngày tải lên: 09/09/2015, 08:13

... affects drug transport from the implant through drug loss from interstial tissue across BBB into cerebral spinal fluid (CSF) circulation besides drug diluting effects due to CSF coming into the interstial ... developing controlled releases implants in the form of discs for Paclitaxel to be surgically inserted to remove remaining tumor cells after a debulking surgery (to remove the main tumor bulk) in ... tumor inoculation The cytotoxicity of the microparticles was evident in the analysis by Hematoxylin & Eosin (H & E) staining of the tumor tissue harvested of the groups at the end-points showing...

Ngày tải lên: 05/10/2015, 21:33