adjustment of drug dosage in patients with renal insufficiency

... (12 of 17) of the formalin-fixed samples, and 38% (10 of 26) of the Bouin's fixed tissues Thus, the VHL gene was entirely sequenced (ie 100% of the coding sequence analysed) for a total of 26 ... ppm.years with peaks) other chlorinated solvents, cutting oils, lead, ionizing radiations, asbestos and welding fumes 20 pack-years < 25 of missense mutations is different in the two groups with 68% of ... support the hypothesis of the involvement of environmental factors in the aetiology of sporadic RCC [17-19] Brüning et al studied the RCC incidence in individuals with former prolonged and high-level...

Ngày tải lên: 20/06/2014, 00:20

... confirmed in a larger cohort of patients in independent clinical settings [14,15] Conversion of sputum smear from positive to negative is a main indicator of the efficacy of anti-TB intervention ... Our findings support two earlier clinical trials of V5 demonstrating favorable outcome in TB patients [7,8] These studies reported a range of beneficial effects including better quality of life, ... after AFB staining of sputum smears One month later 78.3% of V5 patients who had positive sputum smear at baseline had negative findings, while none of patients cleared bacteria in the placebo...

Ngày tải lên: 11/08/2014, 08:21

... difference in the minimum value of haemoglobin during DrotAA and in the post-DrotAA period (Table 4) A larger proportion of patients required platelet transfusion during DrotAA infusion compared with ... analysis in a small number of patients; however, this is an area of practice that is clinically important and in which it is difficult for individual clinicians working in smaller centres to gain sufficient ... Additional anticoagulation in patients receiving RRT during DrotAA infusion is not routinely necessary and does not improve FST The use of DrotAA in patients with severe sepsis requiring RRT is safe and...

Ngày tải lên: 13/08/2014, 11:23

... mortality in a community based cohort with mild renal insufficiency Kidney Int 1999; 56: 2214-19 Shilpak MG, Fried LF, Crump C et al Cardiovascular disease risk status in elderly persons with renal insufficiency ... electrocardiogram in the prediction of cardiac death in dialysis patients Arch Intern Med 1988; 148: 2381-2385 20 Aronow Ws Usefulness of serum creatinine as a marker for coronary events in elderly patients with ... majority of patients (79%) had HTN and 27% had DM CVD was prevalent in 35% of patients A total of 62% were on angiotensin converting enzyme inhibitors (ACE-i), 30% on beta blockers and 53% on statins...

Ngày tải lên: 03/11/2012, 11:52

... extrapulmonary involvement in the elderly could result from the small number of patients older than 60 yr (61 patients, 19.1%) in this study In this setting, a small change in the number of patients with ... analysis for predicting combined extra-pulmonary involvement in patients with pulmonary TB EPTB, pulmonary TB with extra-pulmonary involvement; sAlbumin, serum level of albumin regarded as a marker ... presence of cavitary lesions, absence of bilateral lung involvement, and lower albumin levels were associated with extrapulmonary involvement in patients with pulmonary TB Patients with bilateral...

Ngày tải lên: 15/03/2014, 03:20

... defined as neuroserpin decrease All determinations were carried out in a laboratory blind to the clinical outcome and neuroimaging findings Endpoints The primary endpoint was the decrease of ... http://www.translational-medicine.com/content/9/1/58 our group obtained after investigating neuroserpin effects using an in vitro model of brain ischemia [40] The information reported here regarding biomarkers ... of cerebral ischemia [3-5] by inhibiting extravascular deleterious effects of tPA in the brain parenchyma Due to the fact that patients treated with tPA were excluded in our study, neuroserpin...

Ngày tải lên: 18/06/2014, 19:20

... defined as neuroserpin decrease All determinations were carried out in a laboratory blind to the clinical outcome and neuroimaging findings Endpoints The primary endpoint was the decrease of ... http://www.translational-medicine.com/content/9/1/58 our group obtained after investigating neuroserpin effects using an in vitro model of brain ischemia [40] The information reported here regarding biomarkers ... of cerebral ischemia [3-5] by inhibiting extravascular deleterious effects of tPA in the brain parenchyma Due to the fact that patients treated with tPA were excluded in our study, neuroserpin...

Ngày tải lên: 20/06/2014, 03:20

... improve in those patients who attain a sustained viral response, similar to naïve patients undergoing treatment In this study, 25 of the 152 patients (17%) initiated on the study achieved a sustained ... differently in terms of the HRQOL domain scores when re-treated with a combination of interferon alpha-2b and ribavirin Compared to the baseline, the responders sustained a significant decrease in the ... utilization of peginterferon alpha 2a vs the combination of interferon alpha 2b plus ribavirin as initial treatment in patients with chronic hepatitis C J Viral Hepat 2004, 11:157-165 Publish with Bio...

Ngày tải lên: 20/06/2014, 15:20

... [13,14] In a clinical trial, the knowledge of instrument’s responsiveness helps in the selection of measures, in setting the correct sample size and assists in prioritising the number of outcomes ... J: Interpreting the significance of changes in health-related quality -of- life scores J Clin Oncol 1998, 16:139-144 18 Jaeschke R, Singer J, Guyatt GH: Measurement of health status Ascertaining ... suggest a lack of sensitivity of these QoL questionnaires compared to the patient’s overall assessment of his/her change in state of health These results of responsiveness in patients receiving chemotherapy...

Ngày tải lên: 20/06/2014, 15:20

... study replicates the findings of numerous studies that demonstrated the presence of neurocognitive deficits in patients with schizophrenia on most domains tested, including attention, vigilance, ... illness; a history of stroke or head trauma in the past; a history of alcohol or drug misuse; a mini mental state examination (MMSE) score of less than 28; a history of receiving electro-convulsive ... an anticholinergic medication 32% of the patients took a benzodiazepine Neurocognitive function Results are reported according to the domains of cognition tested (Table 2) Patients with schizophrenia...

Ngày tải lên: 08/08/2014, 23:20

... epithelial cells, no staining for IL-18 was found in acinar cells (Fig 3a,3d) In a minority of patients with chronic R452 Of the 32 periductal inflammatory foci identified in the samples studied, ... prime candidate also in the pathogenesis of SS Increased serum levels and salivary gland expression of IL18 in patients with SS is in keeping with an active role for this cytokine in the tissue pathogenesis ... Valesini G: Role of anti-cyclic citrullinated peptide antibodies in discriminating patients with rheumatoid arthritis from patients with chronic hepatitis C infection-associated polyarticular involvement...

Ngày tải lên: 09/08/2014, 01:23

... performance of an in- house enzyme-linked immunosorbent assay (ELISA), designed with in vitro citrullinated bovine myelin basic protein (MBP) MBP and vimentin have similarly high proportions of arginine ... described in the serum of patients with RA [19] These include antibodies targeting cyclic citrullinated peptide (CCP) [20] and antibodies targeting in vivo citrullinated proteins, such as anti-keratin ... translate into genuine consequent associations with outcomes Antibodies present in sera from RA patients recognize citrullinated peptidic residues in the context of adjoining amino acid residues and of...

Ngày tải lên: 09/08/2014, 06:22

... found for inflammation of the joint capsule of the left SI joint, which was present in only three patients Table summarizes the concordant findings of both readers with respect to inflammation ... assessment of patients with early inflammatory back pain It is the amount of variation in the outcome of interest (inflammation and/or structural changes) rather than the number of patients under ... Abnormality Number of patients with involvement of sacroiliac joints Only the left sacroiliac joint Only the right sacroiliac joint Both sacroiliac joints One or two sacroiliac joints Inflammation...

Ngày tải lên: 09/08/2014, 07:20

... prediction of risk by combining the Framingham risk score with coronary calcium score, and this combination appears of value to estimate risk in the general population [23,24] In RA patients with coronary ... Framingham risk scores were correlated with Agatston scores (ρ = 0.44, P < 0.001), and an increase in one unit of the Framingham risk score was associated with a 20% increase in the odds of higher ... subjects, independent of Framingham risk scores (odds ratio = 2.46, 95% confidence interval 1.20 to 5.05) Discussion The two primary findings in this report are that patients with long-standing RA...

Ngày tải lên: 09/08/2014, 08:23

... degradation were inhibited by blocking IL-1β but not IL-1α In RA patients, IL-1β is overexpressed in inflamed synovial tissue, in particular in the lining layer and in sublining cells [9], and ... destruction of the joint within to 10 days, controlateral joints or joints receiving control 3T3 cells not exhibit signs of inflammation Application of ACZ885 intraperitoneally hours before injecting ... Scoring was performed on decoded slides by two separate observers, using the following parameters In the haematoxylin/eosin stained slides the amount of cells infiltrating the synovial lining...

Ngày tải lên: 09/08/2014, 10:23

... scores, both indicating impact on physical functioning and well-being for up to three years These effects were also clinically meaningful The remaining HRQOL outcomes, including the remaining SF-36 ... 3.0point change in summary scores is considered clinically meaningful for patients with rheumatoid arthritis [41] Previous studies in patients with AS have used three or more points to determine ... AS patients have experienced improvements in the signs and symptoms of their disease In clinical trials of TNF antagonists, improvements in clinical symptoms of AS have been sustained, lasting...

Ngày tải lên: 09/08/2014, 14:22

... predominant drug of choice, and was given as monotherapy in 64 (16.7%) patients Biological agents were given to 13 patients, all in combination with methotrexate Sulphasalazine was prescribed in ... diagnosis within the first year of follow-up Evidence of confounding between the serologic markers was found as removal of RF resulted in an increase in the regression coefficient of ACPA exceeding ... region with approximately 1.7 million inhabitants The cohort includes patients (age 18 to 75 years) presenting with at least one clinically swollen joint of 16 weeks' duration or less, and patients...

Ngày tải lên: 09/08/2014, 14:22

... to difficulty with walking in about 75% of people with RA, and is the main or only cause of walking difficulty in 25% [1] In the foot, joint pain and stiffness is the most common initial presentation, ... of mobility 42% of RA patients are registered disabled within yrs of diagnosis [2] 80% are moderately to severely disabled within 20 yrs At diagnosis, 16% of RA patients may have foot joint involvement ... should be in place whereby everyone with a diagnosis of inflammatory arthritis receives a foot examination within three months of diagnosis [16] Patients with RA should be provided with information...

Ngày tải lên: 10/08/2014, 21:23

... because of its high content of proteins with essential amino acids, carotenoids, B-vitamin complex, minerals and γ-linolenic, ω-3 and ω-6 fatty acids [10] In previous studies with rats using an intraperitoneal ... side-effects were observed Table 1: Initial and final plasma values seen in patients Case Case Case Parameters Initial Final Δ% Initial Final Δ% Initial Final Δ% ALT (U/L) 46.3 21.5 -54 35.6 ... observed among patients with NAFLD In another issue, oxidative stress plays a fundamental role in the pathogenesis of fatty liver as observed in patients with NAFLD who have increased levels of malonic...

Ngày tải lên: 11/08/2014, 12:20

... error of 3% Assuming that approximately 50% of patients would drop out within year [35,36], enrollment of 600 patients was planned Analysis included evaluation of baseline demographics, clinical ... ongoing multinational, observational registry study, has been evaluating outcomes in patients with schizophrenia After 24 months of follow-up in eSTAR in Spain, RLAT use was associated with increased ... acquisition of data, analysis and interpretation of data, and drafting of the manuscript and its critical revision for important intellectual content WM was involved in the interpretation of data and in...

Ngày tải lên: 11/08/2014, 16:20