additional confounders in risk estimation
báo cáo khoa học: " The role of complex genomic alterations in neuroblastoma risk estimation" pot
... risk estimation strategies An inherent disadvantage of array-CGH analysis is its propensity to disregard low-level copy number losses or gains in samples with a high proportion of contaminating ... gene-expression-based classifiers can distin guish patients with contrasting clinical courses in almost all prognostic subgroups, including those defined by prognostic genomic makers such as ... disease and is characterized by defects in maintaining genomic stability leading to Fischer and Berthold Genome Medicine 2010, 2:31 http://genomemedicine.com/content/2/5/31 segmental chromosome...
Ngày tải lên: 11/08/2014, 12:20
Risk estimation in retrospective studies
... association studies in general, involves not only investigating individual SNP in isolation, and that GWA approach has intrinsic problems such as multiple testing that can result in an unprecedented potential ... Relative risk As discussed in the previous Section, it is usually natural to define risk of developing a disease for an individual belonging to any subclass to be the number of cases in that subclass ... same line (Figure 1.1) This shows that the same odds ratio can arise from different risk parameters In this thesis we argue that estimating risks has the advantage of better interpretability In addition,...
Ngày tải lên: 16/10/2015, 15:38
Additional Titles in Entrepreneur’s Made Easy Series docx
... Long Time Coming: Opening the First Store Gaining, Training, and Retaining Staff Improvements—Roasting and Going Nuts Front Porch Two: A Dream Coming True Tips for Those Starting a Business Conclusion ... everything is working right ̈ Provide training or instructions, including training for new people who might come later, after the customer is using the product We must make sure that this training ... Introduction 11 Getting What You Need Purchasing for Projects Getting Expertise Getting Information Getting Permission Evaluating Vendors Tracking and Saving Money in the Purchasing Process Conclusion:...
Ngày tải lên: 07/03/2014, 02:20
Advances in Risk Management pdf
... Operational risk can be defined as the risk remaining after eliminating market, credit, interest and exchange risks (Allen & Bali, 2007) The Basel Committee on Banking Supervision defines operational risk ... market risks – the two risk categories deemed to be the most important in the industry, gaining most of the attention by risk managers in financial institutions and by regulators The main reasons ... managing, measuring and monitoring operational risks; the Committee has also adopted a common industry definition of operational risk, namely:” the risk of direct or indirect loss resulting from inadequate...
Ngày tải lên: 27/06/2014, 01:20
job descriptions in risk and compliance management docx
... deliver win-win solutions CORE COMPETENCIES • Communication/Influencing • Planning / Organising • Technical Knowledge including o Risk and Compliance • Teamworking • Problem Solving & Decision Making ... range of business as well as technologies Proven experience in building and maintaining exceptional relationships with Clients Willingness to travel In addition, experience in the following would ... Credit risk concepts, capital markets, brokerage, financial services industry • Experience in implementing Risk management systems • Experience in requirements gathering, designing, testing, and...
Ngày tải lên: 27/06/2014, 23:20
NOVEL APPROACHES AND THEIR APPLICATIONS IN RISK ASSESSMENT doc
... Applications in Risk Assessment 3.2.2 Spirolides The toxins of the group of SPXs are characterised by binding to and blocking of AChR receptors in the central- and peripheral nervous system including ... For each toxin, contamination levels were monthly determined in only two species For the other ones, a 3-month preliminary study was conducted to gain insight into the variability of inter-species ... bivalves To take into account the cooking process impact, for each toxin, the ratio between the phycotoxin rates in raw samples and in cooked samples was determined in a preliminary study (for...
Ngày tải lên: 28/06/2014, 10:20
Ecological Modeling in Risk Assessment - Chapter 1 pps
... Environmental Decision-Making Lev R Ginzburg and H Resit Akỗakaya Training and Education Applying Existing Ecological Models Integrating Existing Models Developing New, Case-Specific Models Investment Trade-offs ... 1.8): Interval decline risk the probability of a population declining by as much as a given percentage of its initial value at any time during the period of prediction Interval extinction risk ... and Robert T Paine of the University of Washington for inspiration throughout the journey leading to this work Their scientific insights and unrelenting spirit in seeking understanding of the natural...
Ngày tải lên: 11/08/2014, 09:21
Ecological Modeling in Risk Assessment - Chapter 5 docx
... it Relevance — HIGH — Possible endpoints include expected population size (age- or stage-specific), risk of decline, risk of extinction, and expected crossing time (the time at which the population ... estimating two matrices — one with toxins and one without toxins) Obtaining estimates of all such parameters can often be quite difficult However, model parameters are intuitive and can be interpreted ... to be considered (e.g., by choosing and parameterizing a dose–response function or by estimating two matrices — one with toxins and one without toxins) Obtaining estimates of all such parameters...
Ngày tải lên: 11/08/2014, 09:21
Ecological Modeling in Risk Assessment - Chapter 7 pptx
... results include risk of extinction, risk of decline, time to extinction, time to decline, expected abundance, and expected variation in abundance The model has several parameters (e.g., carrying ... results include risk of extinction, risk of decline, time to extinction, time to decline, metapopulation occupancy, local occupancy duration, expected abundance, and expected variation in abundance ... are increasing or decreasing in time Treatment of Uncertainty — HIGH — The model simulates variability in patch occupancy It has special features for sensitivity analysis to incorporate uncertainties...
Ngày tải lên: 11/08/2014, 09:21
Ecological Modeling in Risk Assessment - Chapter 8 doc
... modeling incorporating the effects of toxic chemicals Software for population and food-web modeling Software for food-web modeling incorporating the effects of toxic chemicals Reference Internet ... Relevance — HIGH — Potential endpoints include the expected population size of any population in the model, risk of decline, risk of extinction, and expected crossing time (the time at which the ... species and trophic interactions are user defined The user can define use of any predator–prey model Treatment of Uncertainty — LOW — No treatment of uncertainty is included in this program Degree...
Ngày tải lên: 11/08/2014, 09:21
Ecological Modeling in Risk Assessment - Chapter 9 pps
... LEEM was initiated by the International Joint Commission to aid in anticipating the effects of declining nutrient loading, invasion of zebra mussels, loading of toxic organic contaminants on ... population submodels run in parallel and linked by informational constraints (Sturtevant and Heath 1995) The model divides Lake Erie into three distinct basins Within each basin, the model simulates ... outputs from EcoWin include those endpoints that are routinely included in ecological risk assessments The model explicitly accounts for toxic chemical effects Flexibility — HIGH — EcoWin was purposely...
Ngày tải lên: 11/08/2014, 09:21