acute vs chronic myelogenous leukemia

... (FDA) for marketing based on trials using the FAB criteria. Acute Myeloid Leukemia Incidence The incidence of acute myeloid leukemia (AML) is ~3.7 per 100,000 people per year, and the age-adjusted ... agent–associated leukemias occur on average 4–6 years after exposure, and affected individuals have aberrations in chromosomes 5 and 7. Topoisomerase II inhibitor–associated leukemias occur ... Radiation Survivors of the atomic bomb explosions in Japan had an increased incidence of myeloid leukemias that peaked 5–7 years after exposure. Therapeutic radiation alone seems to add little...

Ngày tải lên: 07/07/2014, 04:20

... Acute myelomonocytic leukemia Acute monoblastic and monocytic leukemia Acute erythroid leukemia Acute megakaryoblastic leukemia Acute basophilic leukemia Acute panmyelosis ... Minimally differentiated leukemia 5% M1: Myeloblastic leukemia without maturation 20% M2: Myeloblastic leukemia with maturation 30% M3: Hypergranular promyelocytic leukemia 10% AML with 11q23 ... Myelomonocytic leukemia 20% M4Eo: Variant: Increase in abnormal marrow eosinophils M5: Monocytic leukemia 10% M6: Erythroleukemia (DiGuglielmo's disease) 4% M7: Megakaryoblastic leukemia...

Ngày tải lên: 07/07/2014, 04:20

... transducer and Chapter 104. Acute and Chronic Myeloid Leukemia (Part 3) Immunophenotype and Relevance to the WHO Classification The immunophenotype of human leukemia cells can be studied ... promyelocytic leukemia (Pml)/retinoic acid receptor α (Rarα), which is formed by the fusion of the retinoic acid receptor α (RARα) gene from chromosome 17 and the promyelocytic leukemia (PML) ... specific recurrent genetic abnormalities. For example, AML FAB M3 is now designated acute promyelocytic leukemia (APL), based on the presence of either the t(15;17)(q22;q12) cytogenetic rearrangement...

Ngày tải lên: 07/07/2014, 04:20

... by abnormal lobulation and deficient granulation. Figure 104-1 Chapter 104. Acute and Chronic Myeloid Leukemia (Part 4) Clinical Presentation Symptoms Patients with AML most often ... leukocyte dysfunction, or thrombocytopenia. Nearly half have had symptoms for ≤3 months before the leukemia was diagnosed. Half mention fatigue as the first symptom, but most complain of fatigue...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 104. Acute and Chronic Myeloid Leukemia (Part 5) Morphology of AML cells. A. Uniform population of primitive ... (leukemic infiltration, most commo n in monocytic leukemia) Skin infiltration or nodules (leukemia infiltration, most common in monocytic leukemia) Lymphadenopathy, splenomegaly, hepatomegaly ... I V sites (DIC, possible acute promyelocytic leukemia) Fever and tachycardia (signs of infection) Papilledema, retinal infiltrates, cranial nerve abnormalities (CNS leukemia) ...

Ngày tải lên: 07/07/2014, 04:20

... most importantly, achievement of CR. In addition, patients who achieve Chapter 104. Acute and Chronic Myeloid Leukemia (Part 6) Most patients are anemic and thrombocytopenic at presentation. ... the importance of cytogenetic as well as the previously discussed molecular assessment of the leukemia cells at diagnosis and relevance of storing samples for potential later use. A prolonged ... The bone marrow should contain <5% blasts, and Auer rods should be absent. Extramedullary leukemia should not be present. For patients in morphologic CR, reverse transcriptase polymerase...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 104. Acute and Chronic Myeloid Leukemia (Part 7) Acute Myeloid Leukemia: Treatment Treatment of the newly diagnosed patient with ... Figure 104-2 Flow chart for the therapy of newly diagnosed acute myeloid leukemia. For all forms of AML except acute promyelocytic leukemia (APL), standard therapy includes a 7-day continuous ... the CR duration. After induction chemotherapy, the bone marrow is examined to determine if the leukemia has been eliminated. If ≥5% blasts exist with ≥20% cellularity, the patient is usually...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 104. Acute and Chronic Myeloid Leukemia (Part 8) The hematologic toxicity of high-dose cytarabine-based induction...

Ngày tải lên: 07/07/2014, 04:20

... antibodies Yttrium-90-labeled human M195 Chapter 104. Acute and Chronic Myeloid Leukemia (Part 9) Treatment of Promyelocytic Leukemia Tretinoin is an oral drug that induces the differentiation ... autologous SCT. High- dose cytarabine is more effective than standard-dose cytarabine. The Cancer and Leukemia Group B (CALGB), for example, compared the duration of CR in patients randomly assigned...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 104. Acute and Chronic Myeloid Leukemia (Part 11) Chronic Myelogenous Leukemia Incidence The incidence of chronic myelogenous leukemia (CML) is 1.5 per 100,000 ... (named after the abelson murine leukemia virus) gene located on chromosome 9q34. Untreated, the disease is characterized by the inevitable transition from a chronic phase to an accelerated ... compared to 1977–1997. Definition Disease Progression The events associated with transition to the acute phase, a common occurrence in the pre-imatinib era, were extensively studied. Chromosomal...

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... amoxycillin/ clavulanic acid 875 mg b.i.d. with cefuroxime 500 mg b.i.d. in the treatment of chronic and acute exacerbation of chronic sinusitis in adults. J Chemother 2002, 14:508-517. 185. Hashiba M, Baba ... of acute rhinosinusitis (ARS) and chronic rhinosinusitis (CRS) to enable them to better meet the needs of this patient population. These guidelines describe controversies in the management of acute ... fungi and eosinophils in chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 2005, 13:2-8. 174. Van Cauwenberge P, Van Hoecke H, Bachert C: Pathogenesis of chronic rhinosinusitis. Curr...

Ngày tải lên: 19/02/2014, 08:20