acute vs chronic lymphocytic leukemia

... level, genomic aberrations, and survival in chronic lymphocytic leukemia Blood 2002, 100:1410-1416 Chiorazzi N, Rai KR, Ferrarini M: Chronic Lymphocytic Leukemia N Engl J Med 2005, 352:804-815 Page ... derivation of B cell chronic lymphocytic leukemia Curr Top Microbiol Immunol 2005, 294:31-49 Caligaris-Cappio F, Ghia P: The normal counterpart to the chronic lymphocytic leukemia B cell Best ... B-cell receptor in IgG-positive chronic lymphocytic leukemia Clin Cancer Res 2006, 12:1672-1679 Schroeder HW Jr, Dighiero G: The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody...

Ngày tải lên: 18/06/2014, 15:20

... (>2.2 g/L vs ≤2.2 g/L); modified Rai staging (0-I vs II-III-IV); FISH group (normal/13q- vs +12/11q-/17p-); CD38 (≥ 30% vs

Ngày tải lên: 18/06/2014, 16:20

... of newly diagnosed patients with chronic lymphocytic leukaemia Br J Haematol 2008, 141:607-614 Dearden C: Disease-specific complications of chronic lymphocytic leukemia Hematology Am Soc Hematol ... Messmer B, Damle RN, Allen SL, Rai KR, Ferrarini M, Kipps TJ: Biology and treatment of chronic lymphocytic leukemia Hematology Am Soc Hematol Educ Program 2003, 153-175 Palmer S, Hanson CA, Zent ... U, Ménard S, Balsari A: Thymic function and immunoglobulin mutation genotype in Bcell chronic lymphocytic leukemia patients Int J Cancer 2003, 107:958-961 van Zelm MC, Szczepanski T, van der Burg...

Ngày tải lên: 18/06/2014, 16:20

... genes in chronic lymphocytic leukemia (CLL) Leukemia 19, 1211–1215 [24] Kalachikov S., et al (1997) Cloning and gene mapping of the chromosome 13q14 region deleted in chronic lymphocytic leukemia ... low CD22 surface expression in chronic lymphocytic leukemia Leukemia 20, 877–878 [66] Michel F., et al (1993) Defective calcium response in B -chronic lymphocytic leukemia cells: alteration of ... in chronic lymphocytic leukemia Cancer 107 (5), 925-934 [42] Nilsson, J et al (2000) Thioredoxin prolongs survival of B-type chronic lymphocytic leukemia cells Blood 95 (4), 1420-1426 36 Chronic...

Ngày tải lên: 27/06/2014, 13:20

... Acute Myeloid Leukemia Incidence The incidence of acute myeloid leukemia (AML) is ~3.7 per 100,000 people per year, and the age-adjusted ... Alkylating agent–associated leukemias occur on average 4–6 years after exposure, and affected individuals have aberrations in chromosomes and Topoisomerase II inhibitor–associated leukemias occur 1–3 ... Radiation Survivors of the atomic bomb explosions in Japan had an increased incidence of myeloid leukemias that peaked 5–7 years after exposure Therapeutic radiation alone seems to add little risk...

Ngày tải lên: 07/07/2014, 04:20

... maturation myelodysplastic Acute myelomonocytic leukemia Acute monoblastic and monocytic leukemia Acute erythroid leukemia Acute megakaryoblastic leukemia Acute basophilic leukemia Acute panmyelosis with ... differentiated leukemia 5% M1: Myeloblastic leukemia without maturation 20% M2: Myeloblastic leukemia with maturation 30% M3: Hypergranular promyelocytic leukemia 10% M4: Myelomonocytic leukemia 20% ... Variant: Increase in abnormal marrow eosinophils M5: Monocytic leukemia 10% M6: Erythroleukemia (DiGuglielmo's disease) 4% M7: Megakaryoblastic leukemia 1% a ES Jaffe et al: World Health Organization...

Ngày tải lên: 07/07/2014, 04:20

... of specific recurrent genetic abnormalities For example, AML FAB M3 is now designated acute promyelocytic leukemia (APL), based on the presence of either the t(15;17)(q22;q12) cytogenetic rearrangement ... promyelocytic leukemia (Pml)/retinoic acid receptor α (Rarα), which is formed by the fusion of the retinoic acid receptor α (RARα) gene from chromosome 17 and the promyelocytic leukemia (PML) ... associated with improved treatment outcome In contrast, overexpression of genes such as brain and acute leukemia, cytoplasmic (BAALC) predicts for poor outcome Gene expression profiles to predict outcome...

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

... from IV sites (DIC, possible acute promyelocytic leukemia) Fever and tachycardia (signs of infection) Papilledema, retinal infiltrates, cranial nerve abnormalities (CNS leukemia) Poor dentition, ... hypertrophy (leukemic infiltration, most common in monocytic leukemia) Skin infiltration or nodules (leukemia infiltration, most common in monocytic leukemia) Lymphadenopathy, splenomegaly, hepatomegaly ... infection Table 104-2 Initial Diagnostic Evaluation and Management of Adult Patients with Acute Myeloid Leukemia History Increasing fatigue or decreased exercise tolerance (anemia) Excess bleeding...

Ngày tải lên: 07/07/2014, 04:20

... greater proportion of patients have more resistant disease Chronic and intercurrent diseases impair tolerance to rigorous therapy; acute medical problems at diagnosis reduce the likelihood of ... maturation The bone marrow should contain

Ngày tải lên: 07/07/2014, 04:20

... Figure 104-2 Flow chart for the therapy of newly diagnosed acute myeloid leukemia For all forms of AML except acute promyelocytic leukemia (APL), standard therapy includes a 7-day continuous ... improve the CR duration After induction chemotherapy, the bone marrow is examined to determine if the leukemia has been eliminated If ≥5% blasts exist with ≥20% cellularity, the patient is usually re-treated ... and one-third require two courses About 50% of patients who not achieve CR have a drug-resistant leukemia, and 50% not achieve CR because of fatal complications of bone marrow aplasia or impaired...

Ngày tải lên: 07/07/2014, 04:20

... graft-versus-host disease (GVHD) Cytomegalovirus (CMV)-negative blood products should be used for CMVseronegative patients who are potential candidates for allogeneic SCT Leukodepleted products are...

Ngày tải lên: 07/07/2014, 04:20

... underway to determine whether a critical threshold level of transcripts uniformly predicts for leukemia relapse Postremission Therapy Induction of a durable first CR is critical to long-term ... autologous SCT Highdose cytarabine is more effective than standard-dose cytarabine The Cancer and Leukemia Group B (CALGB), for example, compared the duration of CR in patients randomly assigned...

Ngày tải lên: 07/07/2014, 04:20

... ABL (named after the abelson murine leukemia virus) gene located on chromosome 9q34 Untreated, the disease is characterized by the inevitable transition from a chronic phase to an accelerated phase ... actin microfilaments is enhanced Disease Progression The events associated with transition to the acute phase, a common occurrence in the pre-imatinib era, were extensively studied Chromosomal instability...

Ngày tải lên: 07/07/2014, 04:20

... 20%, blood or marrow basophils ≥20%, or platelet count

Ngày tải lên: 07/07/2014, 04:20

... hematologic, cytogenetic, or molecular remission a Nutritional Comprehensive Cancer Network, Chronic myelogenous leukemia b Denotes that at the indicated milestones, patients should stay on the same...

Ngày tải lên: 07/07/2014, 04:20

... Syngeneic BMT in patients with chronic- phase CML results in 7-year disease-free survival in 55% of patients, with a 30% relapse rate BMT with an HLA-identical sibling in the chronic phase achieves 5-year ... groups, patients receiving BMT from unrelated donors have higher rates of graft failure and acute and chronic GVHD and prolonged convalescence after treatment, compared to those who receive allogeneic ... donors in chronic- phase CML, marrow stem cells led to a higher cumulative incidence of relapse at years, while peripheral blood stem cell recipients had a higher cumulative incidence of chronic...

Ngày tải lên: 07/07/2014, 04:20

... as a treatment goal in CML Specific milestones have been developed for chronicphase CML patients (Table 104-4) For example, chronic- phase CML patients who not achieve any cytogenetic remission...

Ngày tải lên: 07/07/2014, 04:20

... appropriate management of newly diagnosed acute promyelocytic leukemia Blood 105:3019, 2005 [PMID: 15604216] Tallman MS et al: Drug therapy for acute myeloid leukemia Blood 106:1154, 2005 [PMID: 15870183] ... implications J Clin Oncol 23:6285, 2005 [PMID: 16155011] National Comprehensive Cancer Network: Acute myeloid leukemia Clinical Practice Guidelines in Oncology, Version 2006 http://www.nccn.org/professionals/physician_gls/PDF/aml.pdf ... 106:1154, 2005 [PMID: 15870183] CML Cortes J, Kantarjian H: New targeted approaches in chronic myeloid leukemia J Clin Oncol 23:6316, 2005 [PMID: 16155014] Hughes TP et al: Monitoring CML patients...

Ngày tải lên: 07/07/2014, 04:20

... Maddocks KJ, Lin TS: Update in the management of chronic lymphocytic leukemia J Hematol Oncol 2009, 2:29-36 Dighiero G, Hamblin DJ: Chronic lymphocytic leukemia Lancet 2008, 371:1017-1029 Pleyer L, ... AE, Meyer M, Kolb JP: Apoptotic effects on B-cell chronic lymphocytic leukemia (B-CLL) cells of heterocyclic compounds isolated from Guttiferaes Leukemia Res 2008, 32:1914-1926 Lee BW, Gal SW, ... cells Leukemia 2005, 19:223-229 doi:10.1186/1756-8722-3-49 Cite this article as: Loisel et al.: Therapeutic activity of two xanthones in a xenograft murine model of human chronic lymphocytic leukemia...

Ngày tải lên: 10/08/2014, 22:21