acute or chronic myeloid leukemia
Chapter 104. Acute and Chronic Myeloid Leukemia (Part 1) ppsx
... Acute Myeloid Leukemia Incidence The incidence of acute myeloid leukemia (AML) is ~3.7 per 100,000 people per year, and the age-adjusted ... 11q23 Chloramphenicol, phenylbutazone, and, less commonly, chloroquine and methoxypsoralen can result in bone marrow failure that may evolve into AML Classification The World Health Organization ... Alkylating agent–associated leukemias occur on average 4–6 years after exposure, and affected individuals have aberrations in chromosomes and Topoisomerase II inhibitor–associated leukemias occur 1–3...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 2) pot
... Acute monoblastic and monocytic leukemia Acute erythroid leukemia Acute megakaryoblastic leukemia Acute basophilic leukemia Acute panmyelosis with myelofibrosis Myeloid sarcoma French-American-British ... Increase in abnormal marrow eosinophils M5: Monocytic leukemia 10% M6: Erythroleukemia (DiGuglielmo's disease) 4% M7: Megakaryoblastic leukemia 1% a ES Jaffe et al: World Health Organization Classification ... differentiated leukemia 5% M1: Myeloblastic leukemia without maturation 20% M2: Myeloblastic leukemia with maturation 30% M3: Hypergranular promyelocytic leukemia 10% M4: Myelomonocytic leukemia 20%...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 3) pps
... classification to incorporate genetic (chromosomal and molecular) information Indeed, AML is first subclassified based on the presence or absence of specific recurrent genetic abnormalities For example, ... of FLT3 ITD in patients with normal cytogenetics predicts for short remission duration and inferior survival Other molecular prognostic factors in patients with normal karyotype AML include mutations ... recurring cytogenetic abnormalities has revealed genes that may be involved in leukemogenesis; this information is increasingly being incorporated into the WHO classification For instance, the t(15;17)...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 4) pps
... prostate, bone, or other organs The mass lesion represents a tumor of leukemic cells and is called a granulocytic sarcoma, or chloroma Typical AML may occur simultaneously, later, or not at all ... intrapulmonary hemorrhage, or intracranial hemorrhage occur most often in APL Bleeding associated with coagulopathy may also occur in monocytic AML and with extreme degrees of leukocytosis or thrombocytopenia ... characteristic of immature cells Abnormal rod-shaped granules called Auer rods are not uniformly present, but when they are, myeloid lineage is virtually certain (Fig 104-1) Poor neutrophil function may...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 5) docx
... nonfocal neurologic abnormalities (CNS leukemia or bleed) Early satiety (splenomegaly) Family history of AML (Fanconi, Bloom, or Kostmann syndromes or ataxia telangiectasia) History of cancer (exposure ... Patients with Acute Myeloid Leukemia History Increasing fatigue or decreased exercise tolerance (anemia) Excess bleeding or bleeding from unusual sites (DIC, thrombocytopenia) Fevers or recurrent infections ... Social work referral for patient and family psychosocial support Counseling for All Patients Provide patient with information regarding his/her disease, financial counseling, and support group...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 6) pps
... discriminator between patients in CR who or not require additional and /or alternative therapies Age at diagnosis is among the most important risk factors Advancing age is associated with a poorer prognosis, ... successive decade of age, a greater proportion of patients have more resistant disease Chronic and intercurrent diseases impair tolerance to rigorous therapy; acute medical problems at diagnosis ... cytogenetic abnormality have a moderately favorable outcome (approximately 40% cured) Patients with a complex karyotype, t(6;9), inv(3), or have a very poor prognosis This emphasizes the importance...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 7) pot
... Figure 104-2 Flow chart for the therapy of newly diagnosed acute myeloid leukemia For all forms of AML except acute promyelocytic leukemia (APL), standard therapy includes a ... observed with increasing age and in patients with prior hematologic disorders (MDS or myeloproliferative syndromes) or chemotherapy treatment for another malignancy High-dose cytarabine-based regimens ... drug-resistant leukemia, and 50% not achieve CR because of fatal complications of bone marrow aplasia or impaired recovery of normal stem cells Higher induction treatment–related mortality and...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 8) pdf
... rates or shortened hospitalizations In most randomized studies, both G-CSF and GM-CSF have failed to improve the CR rate, disease-free survival, or overall survival Although receptors for both ... therapeutic efficacy is neither enhanced nor inhibited by these agents The use of growth factors as supportive care for AML patients is controversial We favor their use in elderly patients with complicated ... major cause of morbidity and death during induction and postremission chemotherapy for AML Prophylactic administration of antibiotics in the absence of fever is controversial Oral nystatin or...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 9) pptx
... in patients with favorable [t(8;21) and inv(16)] and normal cytogenetics, but it had no significant effect on patients with other abnormal karyotypes For older patients, exploration of attenuated ... 55–65) For younger patients, most studies include intensive chemotherapy and allogeneic or autologous SCT Highdose cytarabine is more effective than standard-dose cytarabine The Cancer and Leukemia ... persistent abnormal gene product have been found who not suffer a relapse Studies are underway to determine whether a critical threshold level of transcripts uniformly predicts for leukemia relapse...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 11) pps
... t(9;22), trisomy 8, or 17p- (p53 loss), is a basic feature of CML Acquisition of these additional genetic and /or molecular abnormalities is critical to the phenotypic transformation Large deletions ... without affecting normal colony formation The mechanism(s) by which p210 BCR/ABL promotes the transition from the benign state to the fully malignant one is still unclear Messenger RNA for BCR/ABL can ... fusion protein of 230 kDa, p230BCR/ABL Bcr/Abl fusion proteins can transform hematopoietic progenitor cells in vitro Furthermore, reconstituting lethally irradiated mice with bone marrow cells infected...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 12) docx
... degrees of anemia unaccounted for by bleeding or therapy; cytogenetic clonal evolution; or blood or marrow blasts between 10 and 20%, blood or marrow basophils ≥20%, or platelet count
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 13) pptx
... cytogenetic remission Any cytogenetic remissionc 12 Minore or no cytogenetic Completeb,f partialc,g remission or cytogenetic remission 18 Partial, minor, or no cytogenetic remission Anytime Complete cytogenetic ... Loss of previously achieved hematologic, cytogenetic, or molecular remission a Nutritional Comprehensive Cancer Network, Chronic myelogenous leukemia b Denotes that at the indicated milestones, ... milestones, for patients on 400 mg/d, one can either continue the same or increase the dose to a maximum of 600–800 mg, as tolerated d Complete hematologic remission, WBC
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 14) pot
... peripheral blood from sibling donors for newly diagnosed chronic- phase CML patients Patients with more advanced stages are offered peripheral blood SCT Umbilical-cord blood may permit mismatched ... HLA-matched unrelated donor in chronic phase
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 15) ppt
... inactive conformation, which leads to inhibition of tyrosine phosphorylation of proteins involved in Bcr/Abl signal transduction It shows specificity for Bcr/Abl, the receptor for platelet-derived ... developed for chronicphase CML patients (Table 104-4) For example, chronic- phase CML patients who not achieve any cytogenetic remission following six months of imatinib are unlikely to achieve major ... approved by the FDA for the treatment of all stages of CML with resistance or intolerance to prior therapy, including imatinib Nilotinib will likely follow suit Both are oral agents given twice...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 16) pptx
... Tallman MS et al: Drug therapy for acute myeloid leukemia Blood 106:1154, 2005 [PMID: 15870183] CML Cortes J, Kantarjian H: New targeted approaches in chronic myeloid leukemia J Clin Oncol 23:6316, ... al: Genetics of myeloid malignancies: Pathogenetic and clinical implications J Clin Oncol 23:6285, 2005 [PMID: 16155011] National Comprehensive Cancer Network: Acute myeloid leukemia Clinical ... conversion factor so that individual laboratories will be able to express BCR/ABL transcript levels on an agreed upon scale Slow reduction of BCR/ABL transcripts following SCT correlates with...
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báo cáo khoa học: "Evolution of T-cell clonality in a patient with Ph-negative acute lymphocytic leukemia occurring after interferon and imatinib therapy for Ph-positive chronic myeloid leukemia" pot
... and interferon therapy for BCR-ABL-positive chronic myeloid leukemia Leukemia 1999, 13:126-129 Ohtsuka E, Kikuchi H, Abe Y, Moriyama K, Ohno E, Hirota K, Tezono K, Nasu M: Acute myeloblastic leukaemia ... PCR for amplification of the TCR Va and Vb subfamilies respectively [23] Subsequently, a runoff PCR was performed with fluorescent primers labelled at 5’ end with the FAM fluorophore (Ca-FAM or ... Garcia-Manero G, Abruzzo LV, Cortes J: Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia Blood 2006, 108:2811-2813 Au WY, Lie AK, Ma SK,...
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báo cáo khoa học: "First-line treatment for chronic myeloid leukemia: dasatinib, nilotinib, or imatinib" ppsx
... M: Nilotinib for the frontline treatment of Ph(+) chronic myeloid leukemia Blood 2009, 114:4933-4938 Saglio G, Baccarani M: First-line therapy for chronic myeloid leukemia: new horizons and an ... a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation Blood 2007, 109:500-502 53 Cortes J, Paquette R, Talpaz ... 66 Aurora Kinase Inhibitor, Induces Clinical Responses in Chronic Myeloid Leukemia Harboring T315I Mutations of BCR-ABL Blood 2007, 110(Suppl) Gontarewicz A, Brummendorf TH: Danusertib (formerly...
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Báo cáo nghiên cứu khoa học: " ỨNG DỤNG KỸ THUẬT PCR (POLYMERASE CHAIN REACTION) ĐỂ PHÁT HIỆN NHIỄM SẮC THỂ PHILADELPHIA TRÊN BỆNH NHÂN UNG THƯ BẠCH CẦU MÃN TÍNH DÒNG HẠT (CHRONIC MYELOID LEUKEMIA )" pptx
... (1987), 156-9 Joanna Gora-Tybor Targeted drugs in Chronic Myeloid Leukemia Current medicinal Chemistry, 15, (2008), 3036-3051 Nowel, PC and D.A Hungerford Chromosome studies on normal and Leukemic ... : from molecular Mechanisms of Leukemia induction to treatment of chronic myelogenous Leukemia. Oncogene 21 (56), (2002), 8547- 59 Sawyers, C.L Chronic myeloid leukemia The New England Journal ... Quantitative bcr-abl Assay for Clinical Laboratory Use Am J Clin Pathol 120, (2003), 42-48 Chomczynski P, Single-step method of RNA isolation by acid guanidinium thiocyanatephenol-chloroform extraction Anal...
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báo cáo khoa học: "The research on the immuno-modulatory defect of Mesenchymal Stem Cell from Chronic Myeloid Leukemia patients" pdf
... chronic myeloid leukemia cells Hematology 2007, 12(6):497-503 Kim JG, Sohn SK, Kim DH, Baek JH, Lee NY, Suh JS: Clinical implications of angiogenic factors in patients with acute or chronic leukemia: ... profiles in chronic myeloid leukemia cells using a cDNA microarray Int J Oncol 2003, 23(3):681-91 11 Bruchova H, Borovanova T, Klamova H, Brdicka R: Gene expression profiling in chronic myeloid leukemia ... the tumor cells, and the transfer and proliferation of tumor cells[36] So, the loose of ECM and secreted cytokines are important for the metastasis of the tumor cells from the primary tumor[37]...
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Báo cáo y học: "A single-tube allele specific-polymerase chain reaction to detect T315I resistant mutation in chronic myeloid leukemia patients" pdf
... Laboratory practice guidelines for detecting and reporting BCR-ABL drug resistance mutations in chronic myelogenous leukemia and acute lymphoblastic leukemia: a report of the Association for ... road to a cure for chronic myeloid leukemia Blood 2007, 110:2242-2249 Cang S, Liu D: P-loop mutations and novel therapeutic approaches for imatinib failures in chronic myeloid leukemia J Hematol ... Cortes J: Chronic myeloid leukemia and secondgeneration tyrosine kinase inhibitors: when, how, and which one? Semin Hematol 47:344-353 23 Wei G, Rafiyath S, Liu D: First-line treatment for chronic...
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