acute lymphoblastic leukemia in adolescents and young adults

... hepatitis, and cirrhosis were more frequent in female than in male children, adolescents, and young adults During the past decade, the number of publications on NAFLD and NASH has increased dramatically, ... diagnoses Finally, underdiagnosis among males may be leading to our differential findings by sex Obesity constitutes a serious and challenging health risk for children and adolescents Childhood and ... adipose tissue hormones, such as leptin and adiponectin, earlier leptin activation of the hypothalamic–pituitary axis resulting in initiation and progress of puberty, and the presence of other features...

Ngày tải lên: 14/03/2014, 11:20

... characteristics, adolescents and young adults living in rural places are as likely to become nondependent drug abusers as individuals growing up in urban communities We qualify this null finding as important ... change The underlying rationale is that the association between boredom and drug use in adolescents and young adults might be stronger in rural than in urban communities because living in rural communities ... events, and adjustment in urban elementary-school children J Clin Child Psychol 1994, 23:391-400 Kliewer W: Children's coping with chronic illness In Handbook of Children's Coping: Linking Theory and...

Ngày tải lên: 13/08/2014, 18:21

... must be developed and incorporated into appropriate initial training and continuing education programs to ensure that all providers who work with adolescents and young adults including but not limited ... needed for inclusion in appropriate initial training and continuing education programs to ensure that all providers who work with adolescents and young adults have the requisite understanding of ... and legal independence Young adults in their 20s and 30s are seeking and forming intimate and long-term relationships and are either planning or establishing their careers and families A cancer...

Ngày tải lên: 14/02/2014, 21:20

... nucleus In some cells of hypothalamus, leptin and insulin activate both JAK-STAT and PI3K signaling pathways Additionally, both enzymes terminating leptin and insulin function – SOCS3 and PTP-1B ... levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G > A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia Journal ... may be the reason of leptin resistance The closed-loop leptin/insulin feedback makes the GH/insulin/leptin relations understandable [30,31] According to Link et al leptin might serve as a good...

Ngày tải lên: 10/08/2014, 10:21

... breakpoint to regions downstream of the stop codon of SET and to intron 17/18 of NUP214 in both cell lines AC-3' For the determination of genomic SET and NUP214 breakpoints in cell lines LOUCY and ... expressed in myeloid leukemias [7,8] Conclusion We demonstrated the presence of the SET-NUP214 gene in the T-ALL cell line LOUCY and in the AML cell line MEGAL by genomic sequencing In both cell lines, ... del(9)(q34.11q34.13) in cell lines LOUCY and Deletion del(9)(q34.11q34.13) in cell lines LOUCY and MEGAL Sequencing identified SET exon 7/NUP214 exon 18 fusion mRNA in both cell lines Genomic sequencing located...

Ngày tải lên: 10/08/2014, 22:20

... Guangdong Province, PR China RNA extraction and cDNA synthesis RNA was extracted using the Trizol kit (Invitrogen, Carlsbad, CA, USA) and reverse transcribed into the first-strand cDNA using random hexamer ... probe, and PCR buffer containing 4.5 mM MgCl2 After an initial denaturation at 95°C for min, 50 cycles consisting of 95°C for 15 s and 64°C for were performed Primers and probes for BCL11B and b2M ... GK, Crist WM: Acute lymphoblastic leukemia In Principles and Practice of Hematology Blood Edited by: Handin RI, Stossel TP, Lux SE 1995, 743-759 Uckun FM, Sensel MG, Sun L, Steinherz PG, Trigg...

Ngày tải lên: 10/08/2014, 22:21

... catarrhalis, whereas clindamycin is active against most S pneumoniae including some penicillinintermediate and resistant strains (85% susceptible to CLSI breakpoints) [94] However, clindamycin resistance ... eradication and pharmacodynamic endpoints in the antimicrobial treatment of ABRS, by inserting an indwelling catheter into the maxillary sinus This allowed serial sinus aspirate sampling IDSA Guideline ... oral antihistamines (brompheniramine and phenylpropanolamine in syrup) in combination with nasal oxymetazoline vs placebo (oral syrup and nasal saline) in the treatment of ABRS in children All...

Ngày tải lên: 05/03/2014, 10:20

... participated in its design and coordination DX contributed effort in designing, performing, and analyzing the results and conclusion All authors read and approved the final manuscript Competing interests ... S, Khanin M, Studzinski GP, Danilenko M: Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid, and silibinin on proliferation and apoptosis in acute myeloid leukemia ... cell lines To determine if growth inhibition induced by curcumin was a result of apoptosis, the pro-apoptotic effect was examined using Wright-Giemsa, Hoechst 33342 and Annexin-V/PI staining Both...

Ngày tải lên: 18/06/2014, 19:20

... in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical characteristics on HRQOL Methods Setting Indonesia is a multi-island ... n = 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment); proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive ... determinants: monthly income level of parents and assigned hospital class during the diagnostic process Both determinants are obtained routinely during admission to the clinic and recorded in the...

Ngày tải lên: 18/06/2014, 19:20

... confirm these findings and provide more detailed information on the relationship between sleep and QoL, and on factors affecting sleep in pediatric ALL and in children with cancer in general Abbreviations ... children and allows for two summary scores (physical and psychosocial) Items are scored using a four to six point Likert scale and converted to a to 100 point continuum, with higher scores indicating ... Health-related quality of life during post-induction chemotherapy in children with acute lymphoblastic leukemia in remission: An influence of corticosteroid therapy Int J Oncol 1997, 11(2):333-339...

Ngày tải lên: 20/06/2014, 15:20

... in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical characteristics on HRQOL Methods Setting Indonesia is a multi-island ... n = 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment); proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive ... determinants: monthly income level of parents and assigned hospital class during the diagnostic process Both determinants are obtained routinely during admission to the clinic and recorded in the...

Ngày tải lên: 20/06/2014, 16:20

... China Dose-dependent plasmid-constructed ß-actin, HVR2 and CD standards were used in each run of real-time PCR Of these, both plasmids containing the CD breakpoint and the HVR2 region were kindly ... with minor groove binder (MGB) groups, which is more sensitive and appropriate than nonspecific dsDNA-binding dye PCR methods previously used [16] Besides, we taken the acute lymphoblastic leukemia ... patients undergoging total body irradiation (TBI) precondionting as human beings in vivo irradiation model The advantage of using this model lies in full view of in vivo microenvironment, and without...

Ngày tải lên: 09/08/2014, 09:21

... chromosome in the metaphase and on the interphase nuclei of leukemic cells It was measured in newly diagnosed cases (Table 1) and it was positive in 30/80 (37.5%) determining its frequency in B-lineage ... biologic and clinical significance of TEL-AML1 as MRD in CD 10 positive ALL is needed to determine how to best integrate TEL-AML1 testing into routine patient care Abbreviations ALL: Acute lymphoblastic ... frequency of MRD positivity is high after induction and decreases gradually during consolidation and maintenance phase being in some genes 88% during early induction to 13% at week 52 [19] If MRD...

Ngày tải lên: 10/08/2014, 22:20

... transforming in undifferentiated leukemia [3,5] and one report of Ph negative T-ALL in a patient receiving treatment [6] TMZ is an oral alkylating agent that is now known to be active against a ... methylates guanines in DNA at the O6 position, causing base-pair mismatch Unsuccessful cycles of mismatch repair eventually lead to breaks and permanent nicks in the daughter strand, preventing mitotic ... of myeloid leukemia, but not for lymphoblastic leukemia TMZ is a new alkylating agent; its safety profile and lack of data on any mutagenic potential has led to its incorporation in a large number...

Ngày tải lên: 11/08/2014, 03:21

... transforming in undifferentiated leukemia [3,5] and one report of Ph negative T-ALL in a patient receiving treatment [6] TMZ is an oral alkylating agent that is now known to be active against a ... methylates guanines in DNA at the O6 position, causing base-pair mismatch Unsuccessful cycles of mismatch repair eventually lead to breaks and permanent nicks in the daughter strand, preventing mitotic ... of myeloid leukemia, but not for lymphoblastic leukemia TMZ is a new alkylating agent; its safety profile and lack of data on any mutagenic potential has led to its incorporation in a large number...

Ngày tải lên: 11/08/2014, 07:20

... clinical endpoints are chance findings due to combinatorial multiple testing Thus, in individualized medicine candidate associations limited to certain patient subgroup/marker/outcome combinations ... we face in individualized medicine, and how they can be addressed Childhood acute lymphoblastic leukemia In the industrialized countries cancer is the most common medical cause of death in children ... relapses in the past were insufficiently treated, partly due to variations in drug disposition, rather than reflecting treatment resistance Individualized medicine and childhood acute lymphoblastic leukemia...

Ngày tải lên: 13/08/2014, 13:20

... Liu, Li and Wong 2004), typically involving grouping genes with correlated expressions into bins and then selecting representatives from each bin, have also been used One of the more interesting ... effects of the training data, and result in prediction failures In contrast, unsupervised learning targets on classifying cases in a dataset into several subgroups by evaluating the major variance ... similarity is calculated between two clusters Candidates include single linkage, complete linkage, average linkage, and centroid linkage Single linkage takes the similarity of the nearest samples...

Ngày tải lên: 10/09/2015, 15:50

... guideline in individual hospitals, units and practices, and to monitor compliance This may be done by a variety of means including patient-specific reminders, continuing education and training, and ... confirming diagnosis of IMD 11 Management of invasive meningococcal disease in children and young people 5 Illness severity and outcome 5.1 clinical variables A combination of initial clinical ... protein is a frequently measured acute phase protein and may be useful diagnostically in helping to distinguish bacterial from viral infection, it has poor sensitivity and specificity in predicting...

Ngày tải lên: 14/03/2014, 09:20

... concerning an infectious origin of childhood leukemia ‘Population mixing’ hypothesis by Kinlen In early 1980, an unusual increase in the incidence of childhood leukemia was observed in young people ... people living in the vicinity of nuclear reprocessing plants in Cumbria, England and Dounreay, Scotland It was thought that such increase in leukemias was the result of radio‐ active contamination, ... of the population mixing studies had failed to find an increase in a symptomatic infection in adults or children, paralleling the increase in leuke‐ mia incidence Considering that there are viruses...

Ngày tải lên: 17/03/2014, 12:20