active and passive drainage of the pleural cavity

... at the two spatial tips of the molecule, at the N-terminus with Arg1 and in the turn in the presence of Arg7 and Arg9 (see Figs and 4) The shorter analogue, BM-2, was the most flexible of all the ... of the peptide Two hydrophilic regions were located at the two spatial tips of the molecule, at both termini with Arg1 and Arg17, and in the turn in the presence of Arg8 and Arg10 (see Figs and ... on the membrane This may also account for differences in the haemolytic activity of the peptides A better understanding of the mode of action of these peptides is crucial for the development of...

Ngày tải lên: 22/03/2014, 21:20

... in the ÔupÕ position rows and shows that in the presence of the substrate, rotation of Asp142 towards Glu144 lowers the pKa of the latter by 0.8 pH units The calculated effects of the D140N and ... for the position of residue 142 [34] The pKa calculations indicate that the only candidate for a residue determining the basic arm of the pH-activity profile of the D142N mutant is Glu144 The ... simplicity, and in line with the results from the other calculations, the 20.0 to Asp142 b The calculations were performed on the crystal structure of the Dl40N...

Ngày tải lên: 07/03/2014, 14:20

... bound to the s-site only, and inactive mR14b, with d-ATP bound to the s- and a-sites [2] Addition of l-ATP should lead to saturation of the a-site and complete conversion to mR14b, leading to the ... higher than the apparent Km for d-ADP of 91 lm (Fig 6A,B) As above, this probably reflects retention of the base and especially b-phosphate interactions at the active site and loss of the specific ... binds first to the s-site, inducing active R12 formation, and then to the a-site, inducing inactive R14b formation, thus accounting for the biphasic curves observed The changes in the curves in...

Ngày tải lên: 07/03/2014, 17:20

... Stereo figures of the model of the bound substrate in the AD2 E526A mutant (A) and D524A mutant (B) The structures of bound sugars and the side-chains of three acidic residues in the conserved ... conformational changes, but of the removal of negative charge at these residues Conformation of chito-oligosaccharides bound to the active site cleft For the structural determination of the AD2–substrate ... D524A, E526Q and E526A) The D522N and D522A mutants retained about 40% and 20%, respectively, of the wild-type kcat values The D524N mutation increased the Km value slightly, and decreased the kcat...

Ngày tải lên: 15/03/2014, 11:20

... recorded in the spectra were mapped onto the anticipated sequence of subunit C on the basis of their mass value and the specificity of the enzyme, leading to the complete verification of the amino ... trifluoroacetic acid The identification of the flavin cofactor was obtained by comparing the retention time of the eluted peak with that of reference samples of authentic FAD and FMN Characterization of recombinant ... soluble fraction of the induced cell in the case of the expression of pET22b(+)/touBEA and /touC, whereas the product of the expression of pET22b(+)/touF was accumulated in the insoluble fraction,...

Ngày tải lên: 17/03/2014, 10:20

... is the angle between the projection of the tilt of the z axis on the xÂ, y plane (dened direction of tilt of z and the x axis), and j % a + c denes the location of the rhombic (x, y) axes The ... The two structures of WT metHb and rWT metHbH2O, exhibit signicant differences in the interaction of the FG loop with the heme and in the position of the B-helix, with Tyr32(B10) closer to the ... of WT and the other of rWT metHb, exhibit differences that include important portions of the protein that we have characterized above Thus parts of the FG corner move away from the heme and the...

Ngày tải lên: 23/03/2014, 17:22

... in the design of the study and performed the statistical analysis ML treated some of the patients included in the study and participated in the critical discussion of the data AM helped draft the ... to the combined sparing of the contralateral parotid and part of the contralateral submandibular gland Certainly, the salivary function can be further preserved using ipsilateral IMRT because the ... because of the morbidity of radiotherapy The results of the present study demonstrate that the failure rate in the opposite neck is rare in selected cases with well lateralized tumors of the tonsillar...

Ngày tải lên: 09/08/2014, 10:20

... stimuli [11-13] However, in spite of the relevance of these reservoir cells in the control of viral persistence, the mechanisms responsible of apoptosis resistance of persistently-infected cells ... independent of the magnitude of viral replication Apoptosis resistance is independent of the magnitude of viral replication A) Jurkat and J1.1 cells were incubated in the presence or absence of 1000 ... experiments of apoptosis by Hoechst and APOBrDU DOC and GAR were responsible of experiments using Western blot analysis, and contributed to writing of the manuscript MB, RL and MS performed and interpreted...

Ngày tải lên: 13/08/2014, 06:20

... 10 My pocket has been picked (by someone) 11 The enemy has been defeated by our army 12 I shall be obliged to go (by circumstances) Stay on top of your writing! Download our grammar guide from...

Ngày tải lên: 29/08/2016, 16:45

Ngày tải lên: 29/08/2016, 22:29

... mentioned The men, especially the husband and the grandfather, sip alcohol and tell their family members what they see and hear or remind them of right or wrong things in life The others also ... denoting the objects covered by the scope of the notion expressed in the word, and the significative function is the function of expressing the content of the respective notion The function of rendering ... difficult The oldest or the husband of the family sits at the head of the table and others sit in descending order according to age or wherever they like The meal starts when everyone has their own...

Ngày tải lên: 15/04/2013, 15:11

... “Introduction” states the rationale of the study, Semantics can be simply defined as the study of meaning It defines the aims, objectives and the significance, presents the is central to the study of communication ... review of the research Chapter 3: “Methodology and Procedures” mentions the method and procedures of the research Chapter 4: “Findings and Discussions” is the main frame of need to understand semantics ... element of the meaning of a word; a description of the characteristic feature of what the word refers to E.g the sense of “grasshopper” is “an insect which can jump high the study, which describes and...

Ngày tải lên: 26/11/2013, 13:21

... recognition of the field And the findings of semantic aspects often borrow the WDBs for not only conveying the denotative as well as analysis of pragmatic aspects of these kinds of words will ... understand their cases of Secondly, English considers the WDB “owl” as the symbol meaning, it is important to consider them in their collocations From of “wisdom” on the basis of their experience and ... pragmatic features of the WDBs The finding of the pragmatic features of the WDBs leads both teachers and learners of study may be in one way or another beneficial to the language English and Vietnamese...

Ngày tải lên: 26/11/2013, 13:30

Ngày tải lên: 04/12/2013, 06:12

Ngày tải lên: 04/12/2013, 16:11

... disappearance of the heavier inactive peak Furthermore, FPLC analysis of the recombinant wild-type cN-II showed the presence of the tetrameric active form irrespective of the presence of effectors ... addition to the tetramer However, stabilization of the dimeric form had no effect on the catalytic capacity of the enzyme Our results show that the monomer is probably inactive, and the dimer is the ... determine the value of K50 for these compounds Under these experimental conditions, the accumulation of radiolabelled inosine (nucleotidase activity) represents the sum of the phosphatase and the phosphotransferase...

Ngày tải lên: 15/02/2014, 01:20

... II The hood domain is mainly built up by residues from the C-terminus and consists of a two-stranded anti-parallel b-sheet composed of b2 and b9 and an a-helix from the C-terminus (Fig 1A) The ... Lys173 interacts with both O6 and N7 (Fig 1C) The 2¢OH of the ribose is hydrogen bonded to the main chain and the side chain of Asp142 (Fig 1C) Both hydroxyl groups of the ribose are involved in ... Asp142, 2¢ and 3¢OH of the ribose and three water molecules with ˚ coordination distances of approximately 2.4 A The phosphate of the GMP is hydrogen bonded to main chain and side chain atoms of amino...

Ngày tải lên: 15/02/2014, 01:20

... position at the present day The present theories of the transmission of light and sound; of the production of winds, and sun-spots, and of the method of development and dissemination of heat, are ... except in the direction of other spheres These theories throw new light upon the character and extent of the atmosphere of the moon and planets, and the consequent availability of those and other ... intimate and inherent nature of those forces? Do they, or either of them, belong to the domain of the supernatural? Are they the products of some supreme force, or forces, heretofore unappreciated? The...

Ngày tải lên: 17/02/2014, 01:20

... regards as the equivalent of thc npper part of t h e Portland Beds of southern England If, with ARKELL (1946, pp 24-28), we place the Portland Beds in the upper part of the Lower Volgian, they, the ... whorls of Tollia pnyeri Bitween 360 and 370 m, on the same flank of the moontain, the writer found similar doggers and platy-weathering sandstones, which contained occasional exarnples of Surifes and ... but further than this I am not prepared to go The dip of the rocks exposed in the 17all~gsides is often vcry nearly 1v Stratigraphy and Anr~noniteFauna of East Greenland 13 the same as the gradient...

Ngày tải lên: 17/02/2014, 20:20

... cause of offence In these habits we resemble the Aborigines of our country They load their huge pipes with the dried leaves of this plant, and when lighted, they breathe the dark cloud of smoke ... men void of understanding; capable of soothing the sorrows of the afflicted, of healing the wounds of the spirit, and assuaging the anguish of a broken heart But how it fulfils these desirable indications, ... form or other, either to ease the pains of dyspepsia, to allay the horrors of tedium vitæ, or to drown the anguish of a guilty conscience And may not many of these patients say to those of the Faculty,...

Ngày tải lên: 17/02/2014, 22:20