activation of innate immune defenses against infection
báo cáo hóa học: " Apolipoprotein E isoform-dependent dendritic recovery of hippocampal neurons following activation of innate immunity" pot
Ngày tải lên :
19/06/2014, 22:20
... mice show apoE isoform-dependent innate immune activation following stimulation of CD14/TLR4 co-receptors with LPS [39,40] Specifically, our experiments have shown greater innate immune response ... others have used a model of selective innate immune activation, intracerebroventricular (ICV) injection of lipopolysaccharide (LPS) [3-10] LPS specifically activates cluster of differentiation (CD) ... clear interpretation of the contribution of innate immune activation to neurodegeneration in human diseases and their corresponding animal models is the simultaneous occurrence of multiple pathogenic...
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báo cáo hóa học: " Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis" docx
Ngày tải lên :
19/06/2014, 22:20
... the local innate immune response with the production of innate components of the complement system while preventing secondary tissue damage Of note, the increased expression of CRegs by brain ... evading the host innate immune defense mechanisms [29,39-41] A better understanding of the cellular and molecular innate immune responses in the CNS and deciphering the Page of (page number not ... some of the intrinsic pathways expressed by reactive brain epithelial cells to control bystander cytotoxic properties of the local innate immune response Our data indicate that the integrity of...
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Báo cáo y học: "Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish" pdf
Ngày tải lên :
14/08/2014, 08:20
... Phylogenetic trees of the innate immune signaling adaptors and diagrams of their protein structures Phylogenetic trees of the innate immune signaling adaptors and diagrams of their protein structures ... Figure 15 Structure of the amino-termini of the new zebrafish NLR proteins Structure of the amino-termini of the new zebrafish NLR proteins ClustalW alignment of the set of 70 predicted NLR proteins ... Whether IL-24 is the product of a second local duplication or of an older duplication of a larger segment of the genome is not clear, but it shows a higher degree of similarity to the class II...
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Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt
Ngày tải lên :
06/03/2014, 09:22
... prominent feature of the innate immune systems of insects is the activation of serine proteinase cascade pathways in hemolymph, which function to activate plasma proteins that perform immune functions ... functions This mechanism leads to activation of phenoloxidase, which oxidizes catechols, leading to the formation of toxic quinones and melanin [1,2], and to the activation of cytokines that stimulate ... Easter [31] Injection of either of these M sexta proteinases into larvae stimulated the expression of antimicrobial peptide genes, suggesting that they might function in activation of a Toll pathway...
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báo cáo hóa học: " Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo" doc
Ngày tải lên :
19/06/2014, 22:20
... A2, each of which are potent activators of a large family of G protein-coupled receptors [5] The combination of these initial and secondary signaling cascades produces a robust innate immune response ... by apoptotic cells [9] also activate CD14-dependent innate immune response in macrophages While none of these data point to CD14 or innate immune response as etiological in neurodegenerative ... proximate contributor to dendritic degeneration in the context of innate immune activation One obvious, commonly voiced criticism of the model described here is that it produces an acute stress...
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Báo cáo y học: "Minocycline fails to modulate cerebrospinal fluid HIV infection or immune activation in chronic untreated HIV-1 infection: results of a pilot stud" doc
Ngày tải lên :
10/08/2014, 05:22
... Monocyte Activation (percent CD16+) infection, particularly for attenuating the CNS components of immunoactivation and infection It aimed to provide a preliminary view of the biological effects of ... J, et al: Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load Blood 2004, 104(4):942-947 61 Hunt PW: Role of immune activation ... Minocycline might attenuate both types of infection by its effects on T cell and monocyte-macrophage activation In the case of transitory infection, T cell activation is critical to support HIV...
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Control of Innate and Adaptive Immune Responses during Infectious Diseases ppt
Ngày tải lên :
05/03/2014, 23:20
... this infection If reactivation occurs in the CNS, it is often lethal During the early years of the AIDS epidemic, encephalitis due to reactivation of chronic T gondii infection was one of the ... of Mtb, Ag85The activation of naive T cells has been had been used The published data show a significant up-regulation of an early marker of T cell activation (CD69) as well as proliferation of ... Control of Innate and Adaptive Immune Responses during Infectious Diseases Julio Aliberti Editor Control of Innate and Adaptive Immune Responses during Infectious Diseases...
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Báo cáo khóa học: Collectins Players of the innate immune system docx
Ngày tải lên :
07/03/2014, 15:20
... Enhancement of IAV-induced respiratory burst of neutrophils Protection against neutrophil inactivation by IAV Aggregation of E coli Stimulation of phagocytosis of E coli Inhibition of phagocytosis of ... Collectins – players of the innate immune system (Eur J Biochem 271) 1233 groups at the 1– and 2– position of the sugar ring [28] This mode of binding excludes the possibility of binding to galactose ... degree of oligomerization of the collectin [66], on the other Clustering of glycoproteins or glycolipids on the surface of microorganisms allows for the simultaneous binding of multiple CRDs of one...
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Báo cáo sinh học: " Dengue virus serotype infection specifies the activation of the unfolded protein respon" pot
Ngày tải lên :
18/06/2014, 18:20
... of this nuclear form of ATF6 as a marker of its activation during infection by Dengue virus To this end, GFP tagged ATF6 was transfected into A549 cells which then were infected with 10 moi of ... determinant for the physiological consequences of infection Since the activation of the UPR is on the one hand essential for cell survival during viral infection and on the other hand detrimental ... time points post -infection (Fig 2) Cell lysates were first analyzed by immunoblot using an antibody against phospho-eIF2α In both cases of Dengue infection, phosphorylated forms of eIF2α were detected...
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Báo cáo hóa học: " Dengue virus serotype infection specifies the activation of the unfolded protein response" pdf
Ngày tải lên :
20/06/2014, 01:20
... of this nuclear form of ATF6 as a marker of its activation during infection by Dengue virus To this end, GFP tagged ATF6 was transfected into A549 cells which then were infected with 10 moi of ... determinant for the physiological consequences of infection Since the activation of the UPR is on the one hand essential for cell survival during viral infection and on the other hand detrimental ... time points post -infection (Fig 2) Cell lysates were first analyzed by immunoblot using an antibody against phospho-eIF2α In both cases of Dengue infection, phosphorylated forms of eIF2α were detected...
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Báo cáo y học: "CD14 mediates the innate immune responses to arthritopathogenic peptidoglycan–polysaccharide complexes of Gram-positive bacterial cell walls" docx
Ngày tải lên :
09/08/2014, 01:23
... secretion of inflammatory cytokines The activation of macrophages by PG-PS represents an example of innate immune response, a defensive reaction based on recognition of conserved pathogen-associated ... that culminate in the activation of transcription of defensive genes Individual TLRs produce overlapping but distinct patterns of gene expression, permitting tailoring of host responses to different ... are not well defined Recognition of lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria, is the best studied model of innate immunity [9] In serum, LPS...
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Báo cáo y học: "Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis" pps
Ngày tải lên :
09/08/2014, 10:23
... expression of osteoclastogenic genes is switched on by a cascade of transcription factors that include NF-κB, NFATc1, c-Fos [150,151] and osterix [152] T cell-mediated activation of the innate immune ... interests The Scientific Basis of Rheumatology: A Decade of Progress This article is part of a special collection of reviews, The Scientific Basis of Rheumatology: A Decade of Progress, published to ... and leads to the induction of interferon regulatory factors (IRFs) and a late activation of NF-κB Signalling through TLR4 results in phosphoprylation and activation of protein tyrosine kinases...
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báo cáo khoa học: "Use of silver nanoparticles increased inhibition of cell-associated HIV-1 infection by neutralizing antibodies developed against HIV-1 envelope proteins" potx
Ngày tải lên :
11/08/2014, 00:23
... complex level of antigenic diversity of HIV-1, the shielding of key epitopes within the three dimensional structure of the native Env trimer, and the failure of newer versions of Env proteins ... inhibition of cell free HIV-1IIIB virus infection When NABs and AgNPs were used together, we recorded no additive effect of inhibition of cell free HIV-1IIIB Virus infection Inhibition of cell -associated ... cream not only acts against infections, but also against inflammation and enhance the healing of the tissue The many attempts to find a better remedy for the topical treatment of burns than silver...
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Báo cáo y học: "Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV" pps
Ngày tải lên :
11/08/2014, 08:21
... pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV Journal of Immune Based Therapies and Vaccines 2011 9:2 Page of Submit your next manuscript ... Published: 18 January 2011 References Belyakov IM, Berzofsky JA: Immunobiology of mucosal HIV infection and the basis for development of a new generation of mucosal AIDS vaccines Immunity 2004, 20:247-253 ... complication of Lm infection To assess Whitney et al Journal of Immune Based Therapies and Vaccines 2011, 9:2 http://www.jibtherapies.com/content/9/1/2 A RMh-8 RSg-8 RUg-8 Group1 250 200 Page of B RAm-9...
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Báo cáo y học: "hytol-based novel adjuvants in vaccine formulation: 2. assessment of efficacy in the induction of protective immune responses to lethal bacterial infections in mice" ppsx
Ngày tải lên :
11/08/2014, 10:23
... detection of each isotype Results are expressed as mean ± SEM A Isotypic profiles of anti-E coli antibodies B Relative levels of IgG1 and IgG2a anti-E coli antibodies C Isotypic profiles of anti-S ... that interact with both components of the immune system have the ability to induce effective prophylaxis against a variety of infectious diseases In bacterial infection, antibody response is crucial ... vaccine formulated in different adjuvants immunized Isotypic with of humoral immune responses in mice Isotypic profiles of humoral immune responses in mice immunized with bacterial vaccine formulated...
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Báo cáo y học: " A novel trifunctional IgG-like bispecific antibody to inhibit HIV-1 infection and enhance lysis of HIV by targeting activation of complement" ppsx
Ngày tải lên :
12/08/2014, 04:20
... as a first line of defense against pathogenic microorganisms and a mediator between the innate and adaptive immune responses, the complement system is a particular focus of these immune- evasion ... the absence of HIV-specific antibodies [7] After seroconversion, the presence of HIV-specific antibodies triggers further activation of the classical complement pathway [11] Complement activation ... amounts of C3-fragments are deposited on the surface of HIV Also, binding of C3-fragments to gp120 reduces the accessibility of the viral envelope protein [9] Current therapies for HIV infection...
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Báo cáo y học: " Differential epithelial expression of the putative innate immune molecule SPLUNC1 in Cystic Fibrosis" pptx
Ngày tải lên :
12/08/2014, 15:21
... of the PLUNC family of putative innate immune molecules, and is highly expressed in the epithelium of the upper respiratory tract, nasopharynx and submucosal glands [1] The mouse orthologue of ... defensive capability of the innate immune shield One of the major limitations of this study is that we have only been able to obtain tissue from patients with severe CF at the time of lung transplantation ... "normal" human airways (A) and a lack of staining in the epithelium of smaller airways (B, C, an enlarged inset of B) Expression of SPLUNC1 is increased in cases of CF (D-H) where staining was predominantly...
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Báo cáo y học: " Characterization of the innate immune response to chronic aspiration in a novel rodent model" ppsx
Ngày tải lên :
12/08/2014, 15:21
... activation of TH1 immune pathways and the generation of a cytotoxic response has been associated with rejection in a number of lung allograft models [27,28] A principal promoter of T cell activation ... aspiration of gastric T-cell infiltrates as a result of chronic aspiration of gastric fluid Relative T cell quantities in bronchoalveolar lavage (BAL) specimens following aspiration of either ... majority of BAL specimens, was detected in of specimens from rats undergoing weeks of gastric fluid aspiration (Figure 9, p < 0.0001 based on chi-square analysis) Figure 6gastric fluid ration of in...
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Báo cáo y học: "spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response" doc
Ngày tải lên :
12/08/2014, 17:21
... cells + 1.21% of CD4+ T cells + 0.57% of CD4+ T cells + 0.69% of CD4+ T cells 0.0% of CD4 T cells 0.0% of CD4 T cells 0.0% of CD4 T cells 0.0% of CD4 T cells 0.0% of CD4 T cells a PMA = phorbol 12-myristate ... overestimated as the source of IL-17 in these chronic inflammatory diseases and that an innate immune response in the context of IL-17 might be of relevance Interestingly, a high frequency of IL-17+ mast ... of soluble IL-17 is more important than modulation of a T-cell response Interestingly, a similar discussion of the effect of TNF blockers, mainly neutralisation of soluble TNF or modulation of...
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Báo cáo y học: "Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis" ppsx
Ngày tải lên :
12/08/2014, 19:21
... related to the innate immune response, and its activation and regulation is dependent on local and systemic immune responses The simultaneous activation of clotting and the innate immune response ... of the innate immune system function in a manner that is remarkably similar to that of contact factors of the intrinsic clotting system The pattern recognition molecules of the innate immune ... sections, elements of the coagulation system feed back and rapidly upregulate innate immune responses Many of the coagulation molecules and inflammatory molecules of the human innate immune system...
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