action efficacy and safety of cs 917
Báo cáo y học: "Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review" pdf
... the role of the 5-HT-mediated systems in the mechanism of action of aripiprazole [33] Aripiprazole reaches peak concentration (Cmax) to h after ingestion, and has a bioavailability of 87% and half ... Hypnotics and sedatives were used by 25% of aripiprazole patients and 21% of placebo patients At least adverse event was reported by 142 (76%) of the 186 patients in the placebo group and 154 ... Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D(2L) receptors are modified by co-transfection of D(3) receptors:...
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Báo cáo y học: "A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee" potx
... double-blind and placebo-controlled clinical study, we sought to evaluate the efficacy and safety of 5-Loxin® in treatment of OA of the knee We assessed the effectiveness of 100 mg/day and 250 mg/ ... Haematological and biochemical evaluations For assessment of safety of 5-Loxin®, several parameters were evaluated in serum, urine and whole blood of all patients at each visit of the study duration ... analyses using SAS software to evaluate the efficacy of two doses of 5-Loxin® in comparison with the placebo group in terms of improvement in pain and physical ability scores, and to assess biomolecular...
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Báo cáo y học: " Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold" doc
... Analysis of days of onset of common cold symptoms Shown are the numbers of patients for verum, placebo and total divided into groups with days of onset of common cold symptoms at the point of inclusion ... the principles of the Declaration of Helsinki, local drug law and standard operating procedures of the investigator, sponsor and CRO involved The study protocol and attached documentation (consent ... clear, colourless, odourless and free of particles Verum and placebo nasal sprays were identical in shape, size and colour to allow a double-blind design, and were randomized at the CRO Before...
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Báo cáo y học: " Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease" potx
... inactivation and pharmacological activity of its main metabolites Eur J Pharm Sci 2010, 39:283-290 Jansat JM, Lamarca R, Garcia GE, Ferrer P: Safety and pharmacokinetics of single doses of aclidinium ... in favour of aclidinium for cough and sputum production (Week 1), breathlessness (Week 12), wheezing (Week 28) and use of daily rescue medication (Weeks 12 and 28) (p < 0.05 for all) Safety The ... Pneumology and Thoracic Surgery, Grosshansdorf, Germany 6Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy 7Division of Pulmonary...
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Báo cáo y học: "Efficacy and safety of tiotropium in COPD patients in primary care – the SPiRiva Usual CarE (SPRUCE) study" ppsx
... unacceptable, and (2%) of the curves were too faded to read during the audit Exclusion of unacceptable/unreadable curves did not influence the results of the analysis of this study Demographics and baseline ... (maximum change of 57.0 mm) and 3.5 mm (-1.0, 20.0) with placebo (maximum change of 61.0 mm) Safety Adverse events were reported in 51.0% of patients treated with tiotropium, and 61.5% of patients ... all tiotropium studies [11-14] and supports the clinical relevance of the sustained efficacy of tiotropium and reduction of COPD exacerbations The actual magnitude of the reduction in rescue medication...
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Báo cáo y học: "Efficacy and safety of non-invasive ventilation in the treatment of acute cardiogenic pulmonary edema – a systematic review and meta-analysis" docx
... the methods of implementation and technical characteristics of the ventilation devices (Table 3) and regarding the definition and adequacy of criteria for ETI (Table 3) The analysis of safety issues ... practice and more challenging for clinicians to understand The aim of our study was to systematically review the evidence in order to answer key clinical questions about the efficacy and safety of ... analyze the impact of patients' baseline hypercapnia on the efficacy of CPAP and NPPV and to test a common clinical hypothesis about the advantage of NPPV when using higher levels of pressure support...
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Báo cáo khoa học: "Efficacy and safety of a low-flow veno-venous carbon dioxide removal device: results of an experimental study in adult sheep" pps
... experiments and data acquisition MV conducted experiments, interpretation of data, and manuscript drafting GB performed study conception and design, statistical analysis and interpretation of data, and ... Care Vol 10 No Livigni et al A variety of recent studies have investigated the efficacy and safety of pumpless arterovenous devices to remove CO2 [1417], which offer several advantages over ECMO: ... cannulation, increase of left-to-right shunt (thus excluding patients with cardiac failure), and no direct blood flow control Our study was designed to evaluate the efficacy and safety of a veno-venous...
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Báo cáo y học: "Drug monitoring in child and adolescent psychiatry for improved efficacy and safety of psychopharmacotherapy" pdf
... pharmacology of drugs, a safety system in standard treatment would help to solve the black box of safety and of unknown relationship between the dosage and actions of drugs (e.g effectiveness and side ... effect of human ontogenesis on interactions between psychoactive drugs and biological target structures (i.e the pharmacodynamics) and the consequence of these interactions (i.e efficacy and side ... including both standardized measurements of blood concentrations of psychotropic drugs and the documentation of efficacy and side effects of the medication For practical reasons, the use of an internet...
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Efficacy and safety of pregabalin in the treatment of
... guidelines and the Declaration of Helsinki applicable at the time of the study For all sites, the respective ethics committees granted approval of the protocol, and after an explanation of the risks and ... PRESS INC Efficacy and Safety of Pregabalin in GAD Figure Efficacy of Pregabalin as Measured by Unadjusted Mean HAM-A Total Score by Week and Treatment Group Versus Placebo (analysis of covariance)a,b,c ... efficacy variable of the study) were compared between each dose of pregabalin and placebo, as well as between venlafaxine and placebo and (in post hoc analyses) between each pregabalin dose and...
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Báo cáo khoa học: "Radiosurgery for pituitary adenomas: evaluation of its efficacy and safety" ppsx
... actuarial rate of HC and HN were 62,4% and 37,6%, respectively, and the 5-year actuarial rate were 81,2% and 55,4%, respectively (Figures and 2) Table Distribution of results of radiological ... pre and post-radiosurgical GH and IGF-1 levels were, respectively, 5.8 and 2.9 ng/ml and 688.5 and 361.5 ng/ ml; the median pre- and post-radiosurgircal prolactin levels were, respectively, 55 and ... the effects of Gamma Knife RS on the growth and endocrinological response and its safety in the treatment of pituitary adenomas Materials and methods Patient population Forty-two out of the first...
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Báo cáo y học: "Ablation of atrial fibrillation with the Epicor system: a prospective observational trial to evaluate safety and efficacy and predictors of success" pptx
... suffered in 20% of cases of paroxysmal, in 37% of persistent, and in 41% of cases of long standing persistent AF There was no statistical significant correlation in between type of AF and diagnosis ... without the need of large thermal gradients and without jeopardizing adjacent structures (Figure 1) [6] The purpose of this study was to evaluate the efficacy of left atrial HIFU ablation of AF with ... Two patients each died of mediastinitis and of mesenterial ischemia and retroperitoneal bleeding, respectively Three out of the patients were > 70 years The EuroSCORE of these patients was 19.9...
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Báo cáo y học: " Impact of race on efficacy and safety during treatment with olanzapine in schizophrenia, schizophreniform or schizoaffective disorde" pdf
... olanzapine to compare efficacy and safety characteristics between black and white patients Methods Study Design Data were pooled from similarly designed, randomized, double-blind studies of olanzapine ... all-cause time to discontinuation and PANSS Total score between white, black, and Hispanic subgroups Another study looked at the impact of race on the efficacy and safety of long-acting risperidone ... Ciliberto N, Bossie CA, Urioste R, Lasser RA: Lack of impact of race on the efficacy and safety of long-acting risperidone versus placebo in patients Page 11 of 11 27 28 29 30 31 32 33 34 35 36 37 38...
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Characterization of CMX 13 and evaluation of efficacy and mechanisms of action in animal model of autoimmunity
... Immunosupression of PHA+PBMCs by EtOAc EXT Suppression of PHA+PBMCs by Solvent Extracts Bioassay-guided fractionation of CMX-13’ RP- TLC of CMX-13, CMX-13-5 and CMX-13’ Retention times of RP-HPLC isolates ... bioassay-guided fractionation of CMX-13’ RP-HPLC Chromatogram of CMX-13’ RP-HPLC Chromatogram of CMX-13 Immunosuppression of PHA+PBMCs by subfractions of CMX-13 after RP-HPLC RP-HPLC Chromatogram of CMX-13-1 ... CM and its EX on PBMC IgG production in SLE Patients Drug interactions of CM with CsA and dexamethasone (DEX): Mean effect analysis Comparison of the inhibitory effect of the various extracts of...
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Báo cáo y học: "omparative Efficacy and Tolerability of 5-Loxin® and Aflapin® Against Osteoarthritis of the Knee: A Double Blind, Randomized, Placebo Controlled Clinical Study"
... comparative efficacy and tolerability of 5-Loxin® and Aflapin® in the treatment of OA of the knee Materials and Methods Study materials BE-30 (5-Loxin) is a novel Boswellia serrata extract standardized ... Hematological and biochemical evaluations For assessment of safety of 5-Loxin® and Aflaseveral parameters were evaluated in serum, urine and whole blood of all subjects at each visit of the study ... software to evaluate the efficacy of 5-Loxin® and Aflapin® in comparison with the placebo group in terms of improvement in pain and physical function scores at baseline and on days 7, 30, 60 and...
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QUALITY AND SAFETY OF ORGANIC PRODUCTS pdf
... Comparison of resveratrol content of Swiss wines from organic and integrated viticulture (1997 grape harvest).55 Dossier Quality and Safety of Organic Products Secondary metabolite content of organic and ... variety of direct parameters such as loss of water and substance, accumulation of harmful substances and microorganisms, and physiological parameters such as respiration, and enzymatic, defence and ... biodiversity and landscape, soil, water, climate and air, and also to energy consumption In short, organic is better for people, animals and the environment 22 Quality and Safety of Organic Products...
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báo cáo hóa học:" Poor Efficacy and Tolerability of Stavudine, Didanosine, and Efavirenz-based Regimen in Treatment-Naive Patients in Senegal" potx
... http://www.jiasociety.org/content/9/4/7 Respectively, 47% and 53% of patients were at CDC stages B and C Seven of the patients at CDC stage C had a history of pulmonary tuberculosis, and had a history of extrapulmonary tuberculosis ... 14:1601-1610 Abstract Gerstoft J, Kirk O, Obel N, et al.: Low efficacy and high frequency of adverse events in a randomized trial of the triple nucleoside regimen abacavir, stavudine and didanosine AIDS ... baseline characteristics of most Senegalese patients We observed a high frequency of peripheral neuropathies relative to other studies of the same combination,[6-8] but Gerstof and colleagues[9]...
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báo cáo hóa học:" Effectiveness and Safety of Generic Fixed-Dose Combination of Tenofovir/Emtricitabine/Efavirenz in HIV-1-Infected Patients in Western India" doc
... However, there are no data on the effectiveness and safety of this combination We assessed virologic, immunologic, and clinical benefits and safety of this combination in HIV-infected Indian patients ... developed IRIS on TDF/FTC/EFV (8 cases of tuberculosis, of cytomegalovirus vitreitis, of hepatitis B virus, of Pneumocystis jiroveci pneumonia, of herpes zoster, and of cryptococcal meningitis) One ... Gallant JE, Staszewski S, Pozniak A, et al.: Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral naive patients: a year randomized trial JAMA 2004, 292:191-201...
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Báo cáo hóa học: " The efficacy and value of emergency medicine: a supportive literature review" pdf
... one aspect of EM efficacy Efficacy of EM for critical care and procedures Efficacy of EM for efficiency or cost of care Efficacy of EM for public health and preventive medicine Efficacy of EM for ... accuracy of reading films, etc.) Efficacy of EM for trauma and airway management Efficacy of EM for using ultrasound Efficacy of EM faculty Efficacy of EM residencies Overviews and editorials of EM efficacy ... efficacy or value of EM or aspects of EM delivered care Case reports and case series of successful clinical care in the Emergency Department (ED) were not included (there are of course thousands...
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Báo cáo y học: "Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus" potx
... counts of B cells and plasmacytoid cells were calculated on the basis of white blood cell counts multiplied by the percentage of lymphocytes and the percentage of cells staining for the CD20 and ... depletion and were reversible within months of drug withdrawal The pharmacokinetic profile of one or two doses of belimumab was dose proportional and consistent with a fully human mAb A half-life of ... initiation of phase II studies investigating the safety and clinical activity of belimumab in patients with SLE and rheumatoid arthritis Competing interests JZ, WC, and WF were all employees of Human...
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Báo cáo y học: " Comparative efficacy and acceptability of methylphenidate and atomoxetine in treatment of attention deficit hyperactivity disorder in children and adolescents: a meta-analysis" pdf
... extraction form Title, year of publication, total number of participants, age of participants, design of study (parallel vs crossover), blinding, name and dose of drug, number who dropped out and ... established its efficacy in treatment of ADHD [10] Tricyclic antidepressants and bupropion are other non-stimulants which are effective in treatment of ADHD [11] Efficacy of both methylphenidate and atomoxetine ... inclusion and exclusion criteria and description of therapy and statistics Since all selected studies scored more than 12 on the Detsky quality scale, all were included in the meta-analysis Data extraction...
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