action and preference part 2
Insulin Action and Its Disturbances in Disease - part 1 ppsx
... Aromatase Sex steroids and body fat Summary Acknowledgement References 20 7 20 7 20 9 21 0 21 0 21 1 21 1 21 2 21 2 21 3 21 4 21 4 21 5 21 6 21 7 21 7 21 8 21 8 21 9 22 0 22 0 22 2 22 4 22 4 22 4 PPARγ and Glucose Homeostasis ... stoichiometry and subcellular location inherent in autophosphorylation-dependent signalling IRS-1 IRS -2 PH p85-SH2 IR-JM Grb2-SH2 pY pY PtdInsP2 pY SHP2-SH2 pY pY PTB IR-JM Grb2-SH2 pY ?? pY Shc p 52/ p46 ... INSULIN RECEPTOR AND DOWNSTREAM SIGNALLING 895 YVNIE 608 YMPMS 628 YMPMS 658 YMMMS Grb2 SHP2 PTPase 122 2 YASIS p85 (PI 3-kinase) 11 72 YIDLD 18 IRS-1 mTOR IKKβ PKB S 6 12 S 6 32 S 6 62 PKC insulin lipids...
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Insulin Action and Its Disturbances in Disease - part 3 pptx
... Increased insulin sensitivity Akt2 −/− Tissue-specific knockout mice MIRKO Reference 8, 11, 12 13 14 15 57 16 18, 17 18, 19 20 20 21 58, 59 60 24 61 25 22 62 26 27 28 30 Bat IRKO Muscle GLUT4 KO ... Chem 26 8, 25 27 7 25 28 4 26 Ashford, A J and Pain, V M (1986) Effect of diabetes on the rates of synthesis and degradation of ribosomes in rat muscle and liver in vivo J Biol Chem 26 1, 4059–4065 27 ... C., Klein, R., Krone, W., Muller-Wieland, D and Kahn, C R (20 00) Role of brain insulin receptor in control of body weight and reproduction Science 28 9, 21 22 21 25 38 Maeda, N., Shimomura, I., Kishida,...
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Insulin Action and Its Disturbances in Disease - part 4 pdf
... risk of diabetes 100 93 .2 80 60 54.0 40.3 40 27 .6 20 15.8 1.0 2. 9 4.3 5.0
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Insulin Action and Its Disturbances in Disease - part 5 pptx
... mouse obese gene and its human homologue Nature 3 72, 425 –4 32 59 Margetic, S., Gazzola, C., Pegg, G G and Hill, R A (20 02) Leptin: a review of its peripheral actions and interactions Int J Obes ... and Unger, R H (20 02) Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity Am J Physiol Endocrinol Metab 28 2 (6), E1334–E1341 22 Ravussin, E and Smith, S R (20 02) ... 117 118 119 120 121 122 123 124 PPARγ AND GLUCOSE HOMEOSTASIS Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice Diabetes 52, 1311–1318...
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Insulin Action and Its Disturbances in Disease - part 6 pps
... 50, 625 –635 22 Rolls, B J., Morris, E L and Roe, L S (20 02) Portion size of food affects energy intake in normal-weight and overweight men and women Am J Clin Nutr 76, 120 7– 121 3 23 Rennie, K and ... and obese individuals with either normal or impaired glucose tolerance.6 The exact mechanism for the link between 20 15 ta t2 22 23 ye ar >24 10 ei >11 5–10
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Insulin Action and Its Disturbances in Disease - part 8 pdf
... CANDIDATE GENES 419 Table 13.4 Genome scans and linkages for metabolic syndrome phenotypes Locus or gene 2p21 (D2S1788) 3q27 17p 12 APO E CEPT 16p13–pter 3q27 8q23 6q 22 q23 ∗ Phenotype(s) ... 97, 12 222 – 12 226 68 Hawkins, M., Barzilai, N., Liu, R., Hu, M., Chen, W and Rossetti, L (1997) Role of the glucosamine pathway in fat-induced insulin resistance J Clin Invest 99, 21 73 21 82 69 ... REFERENCES 118 119 120 121 122 123 124 125 126 127 128 435 Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration...
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Insulin Action and Its Disturbances in Disease - part 9 pot
... resistance and pseudoacromegaly REFERENCES 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 529 A disorder characterized by selective postreceptor insulin resistance J Clin Invest 101, 1111–1 120 Dunaif, ... Circulation 103, 22 25 22 29 Cao, H and Hegele, R A (20 00) Nuclear lamin A/C R482Q mutation in Canadian kindreds with Dunnigan-type familial partial lipodystrophy Hum Mol Genet 9, 109–1 12 Shackleton, ... Connell, J M., Gould, G W and Dominiczak, A F (20 00) Cd36 and molecular mechanisms of insulin resistance in the stroke-prone spontaneously hypertensive rat Diabetes 49, 22 22 22 26 48 Williams, S B.,...
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Insulin Action and Its Disturbances in Disease - part 10 ppt
... homeostasis and PPARγ 23 7–8 cell and rodent models 23 8 adipocytokines 24 5–8 adipose tissue insulin sensitivity 24 2 dietary lipid handling 24 2–5, 24 4 liver 24 9–51, 25 1 pancreatic β-cells 24 9, 25 1 skeletal ... familial partial lipodystrophy (FPL; Dunnigan–Kobberling syndrome) 413, 514, 522 –4, 523 fasting levels of insulin 64 fat distribution 20 7–9, 20 8, 22 4 see also obesity android pattern 20 8, 20 9, 22 2 change ... protein kinase (AMPK) 27 7 future drug therapies 573–4 androgens 22 3–4 android pattern of fat distribution 20 8, 20 9, 22 2 Angelman syndrome 4 12 angiotensinogen (AGT) 21 6, 21 7 Insulin Resistance...
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Insulin Action and Its Disturbances in Disease - part 2 pptx
... and Kobayashi, M (1998) Relative involvement of Shc tyrosine residues 23 9 /24 0 and tyrosine 317 on insulin-induced mitogenic signaling 52 2 12 213 21 4 21 5 21 6 21 7 21 8 21 9 22 0 22 1 22 2 22 3 22 4 22 5 ... adapter in 54 24 3 24 4 24 5 24 6 24 7 24 8 24 9 25 0 25 1 25 2 25 3 25 4 25 5 25 6 25 7 THE INSULIN RECEPTOR AND DOWNSTREAM SIGNALLING platelet-derived growth factor BB-, insulin-like growth factor I- and insulin-mediated ... and Karasik, A (1995) Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1) REFERENCES 194 195 196 197 198 199 20 0 20 1 20 2 20 3 20 4 20 5 20 6 20 7 20 8 20 9 21 0...
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Insulin Action and Its Disturbances in Disease - part 3 ppsx
... Increased insulin sensitivity Akt2 −/− Tissue-specific knockout mice MIRKO Reference 8, 11, 12 13 14 15 57 16 18, 17 18, 19 20 20 21 58, 59 60 24 61 25 22 62 26 27 28 30 Bat IRKO Muscle GLUT4 KO ... Chem 26 8, 25 27 7 25 28 4 26 Ashford, A J and Pain, V M (1986) Effect of diabetes on the rates of synthesis and degradation of ribosomes in rat muscle and liver in vivo J Biol Chem 26 1, 4059–4065 27 ... C., Klein, R., Krone, W., Muller-Wieland, D and Kahn, C R (20 00) Role of brain insulin receptor in control of body weight and reproduction Science 28 9, 21 22 21 25 38 Maeda, N., Shimomura, I., Kishida,...
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Insulin Action and Its Disturbances in Disease - part 4 ppsx
... risk of diabetes 100 93 .2 80 60 54.0 40.3 40 27 .6 20 15.8 1.0 2. 9 4.3 5.0
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Insulin Action and Its Disturbances in Disease - part 5 doc
... mouse obese gene and its human homologue Nature 3 72, 425 –4 32 59 Margetic, S., Gazzola, C., Pegg, G G and Hill, R A (20 02) Leptin: a review of its peripheral actions and interactions Int J Obes ... and Unger, R H (20 02) Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity Am J Physiol Endocrinol Metab 28 2 (6), E1334–E1341 22 Ravussin, E and Smith, S R (20 02) ... 117 118 119 120 121 122 123 124 PPARγ AND GLUCOSE HOMEOSTASIS Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice Diabetes 52, 1311–1318...
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Insulin Action and Its Disturbances in Disease - part 7 pptx
... American youth Type and objective of trial Baseline (m/f): 29 /41 Mean BMI (m/f): 26 .7 /25 .6 Year 1.5 (m/f): 39 /25 Mean BMI (m/f): 24 .2/ 22. 7 Year (m/f): 32/ 33 Mean BMI (m/f): 27 .0 /23 .9 All three groups: ... Imrie, K., Mathers, J C and Alberti, K G (20 01) Randomised controlled trial evaluating the effectiveness of behavioural REFERENCES 195 196 197 198 199 20 0 20 1 20 2 20 3 20 4 20 5 20 6 20 7 399 interventions ... over 12 weeks N (m/f): 0/51 Age: 29 (SD 5), 28 (SD 3), 28 (SD 4) years BMI: 22 (SD 2) Ethnicity: Caucasians N (m/f): 59 /23 Age: 61 .2 ( 12. 2) years BMI: 27 .9 (4.7) Nationality: American Fasting insulin...
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Insulin Action and Its Disturbances in Disease - part 9 docx
... resistance and pseudoacromegaly REFERENCES 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 529 A disorder characterized by selective postreceptor insulin resistance J Clin Invest 101, 1111–1 120 Dunaif, ... Circulation 103, 22 25 22 29 Cao, H and Hegele, R A (20 00) Nuclear lamin A/C R482Q mutation in Canadian kindreds with Dunnigan-type familial partial lipodystrophy Hum Mol Genet 9, 109–1 12 Shackleton, ... Connell, J M., Gould, G W and Dominiczak, A F (20 00) Cd36 and molecular mechanisms of insulin resistance in the stroke-prone spontaneously hypertensive rat Diabetes 49, 22 22 22 26 48 Williams, S B.,...
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NTC's pocket dictionary of words and phrases part 75
... or something (Past tense and past participle: worshiped Present participle: worshiping.) iv to attend a church service (Past tense and past participle: worshiped Present participle: worshiping.) ... a ruined vehicle wrist ["rIst] n the part of the body where the hand joins the lower part of the arm wreak vengeance (up)on someone or something to seek and get revenge on someone or a group ... mouth, as in Q 714 year ["jIr] n 12 months; 365 .25 days; the time it takes for earth to revolve around the sun n a full or partial Q spent doing a certain activity n a particular level of study in...
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Project Planning and Control Part 9
... formally closed 3 52 33 Stages and sequence Summary of project stages and sequence The following pages show the stages and sequences in diagrammatic and tabular format Figure 32. 1 shows the normal ... same Figure 32. 1 354 Stages and sequence Project stage control techniques Figure 32. 2 355 CPM (11) Figure 32. 3 Number in parentheses ( ) indicates chapter number Close out report ( 32) Cash in & ... Close out report ( 32) Cash in & out curves (26 ) Cash flow (26 ) Comparative curves (27 ) Cost/EVA (27 ) Cumulative ‘S’ curve (25 ) Resource histogram (25 ) Milestones/slip chart (16) Gantt chart (16)...
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Interpolation and Extrapolation part 3
... −1 (3 .2. 3) This recurrence generates the rational functions through m + points from the ones through m and (the term R(i+1) (i+m−1) in equation 3 .2. 3) m−1 points It is started with (3 .2. 4) Ri ... started with (3 .2. 4) Ri = yi and with (3 .2. 5) R ≡ [Ri(i+1) (i+m) with m = −1] = Now, exactly as in equations (3.1.4) and (3.1.5) above, we can convert the recurrence (3 .2. 3) to one involving only ... 1-800-8 72- 7 423 (North America only),or send email to trade@cup.cam.ac.uk (outside North America) x−xi x−xi+m 3.3 Cubic Spline Interpolation 113 } CITED REFERENCES AND FURTHER READING: Stoer, J., and...
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