aches arthritis muscles and bone
Báo cáo y học: "Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3 alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456]" ppsx
... markers of bone and cartilage turnover, the correlations between the markers and bone mass and joint damage, and the associations between changes in biochemical markers and changes in BMD and joint ... Radiographs of the hands, wrists, and distal part of the feet were obtained at baseline and after 12 and 24 months Forty joints in the hands and feet were scored (in the hands, proximal interphalangeal ... Christiansen C: The effect on bone mass and bone markers of different doses of ibandronate: a new bisphosphonate for prevention and treatment of postmenopausal osteoporosis: a 1-year, randomized, doubleblind,...
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Báo cáo y học: "Nurse-like cells reside in the synovial tissue and bone marrow in rheumatoid arthritis" doc
... synovial fluid and bone marrow of patients with inflammatory and degenerative arthritis were reported to be negative for CD45 and to be positive for D7-FIB, CD13, CD105, CD55, and CD10 [13]; ... synovial membranes of patients with rheumatoid arthritis and osteoarthritis Ann Rheum Dis 1993, 52:870-875 36 Nagata S, Suda T: Fas and Fas ligand: lpr and gld mutations Immunol Today 1995, 16:39-43 ... colonystimulating factor, GM-CSF, and the levels of IgM were increased, and IL-1β and TNF were detected Direct contact with the B-cell clone was required for RA-NLCs to produce IL-1β and TNF and higher levels...
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Báo cáo y học: "Inflammatory cells and bone loss in rheumatoid arthritis" doc
... NFkappa B ligand in the serum and synovial fluid A comparison Available online http:/ /arthritis- research.com/content/9/3/104 of patients with longstanding rheumatoid arthritis and osteoarthritis ... factor kappaB ligand system in cartilage Arthritis Rheum 2001, 44:2768-2776 Collin-Osdoby P, Rothe L, Anderson F, Nelson M, Maloney W, κ Osdoby P: Receptor activator of NF-κB and osteoprotegerin ... (RANKL) expression in synovial tissue from rheumatoid arthritis, spondyloarthropathy, osteoarthritis and normal patients: semi-quantitative and quantitative analysis Ann Rheum Dis 2002, 61:1047-1054...
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Báo cáo y học: "Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: depletion of memory B cells correlates with clinical response" potx
... number not for citation purposes) Arthritis Research & Therapy Vol 11 No Nakou et al Figure Effect of rituximab on B cells in rheumatoid arthritis peripheral blood and bone marrow Rituximab preferentially ... preferentially depletes B cells in peripheral blood marrow (PB) and reduces activated B cells in the PB and the bone marrow (BM) of rheumatoid arthritis (RA) patients (a) The percentage of PB (n = 11) ... rheumatoid arthritis patients (a) No effect of anti-TNF treatment on peripheral blood (PB) in rheumatoid arthritis patients CD19+ cells, CD19+HLA-DR+ cells, and CD19+CD27+ cells in rheumatoid arthritis...
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Báo cáo y học: "Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model" pptx
... antigen-induced arthritis and collagen-induced arthritis models [10,11], and a similar incidence and severity of arthritis was displayed by Mmp3-deficient and control mice in both arthritis models ... or KO with arthritis −[Ct target − Ct -actin ]WT or KO controls For wildtype and Mmp8-deficient samples without arthritis, ΔΔCt = and 20 = For wildtype and knockout samples with arthritis, ... inflammation and bone erosion in Mmp8deficient mice To quantify joint involvement, we assessed synovial inflammation and bone erosion in hematoxylin and eosin stained sections of ankle joints, and cartilage...
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KDIGO Clinical Practice Guideline for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) pdf
... density and bone quality, together with risk for falling and trauma Bone biopsies provide measurements of bone turnover, mineralization, and volume These help to assess bone quality and the underlying ... replacement? Evaluation of bone What is the association between additional biomarkers of bone turnover, and (a) morbidity and mortality, (b) bone abnormalities, and (c) vascular and valvular calcification? ... Outcomes: mortality, bone outcomes, CVD outcomes How bone biopsy and DXA, and other bone imaging tests, including plain radiographs, qCT, and quantitative US predict (a) clinical outcomes and (b) surrogate...
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Báo cáo Y học: Dietary bisphenol A prevents ovarian degeneration and bone loss in female mice lacking the aromatase gene (Cyp19 ) pptx
... maintenance of bone mass in rodents and humans We reported that ArKO mice exhibit marked bone loss due to increased bone resorption, and that the treatment with E2 restored the bone mass in ArKO ... female reproductive tract and bone by using ArKO mice MATERIALS AND METHODS Materials A standard rodent chow (NMF) was obtained from Oriental Yeast (Tokyo, Japan) BPA and E2 were from Sigma-Aldrich ... distinct trabecular bone could be detected visually, seen as red and yellow, in wild-type mice, but the trabeculae disappeared and the area was occupied by bone marrow, seen as gray and black, in ArKO...
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báo cáo hóa học:" Loss of correction in unstable comminuted distal radius fractures with external fixation and bone grafting -a long term followup study" pdf
... not expand crushed cancellous bone and cannot work without soft tissue hinges [3] Skeletal traction maintained by a half frame external fixator between the radius and second metacarpal bone appears ... [6] Bone grafting was carried out either primarily or secondarily and also on the acceptability of patients for bone grafting Bone grafting improved the anatomical alignment of the fragments and ... radius and 20 percent by the triangular fibrocartilage and the distal end of the ulna[1] The limitation of external fixation to achieve articular Table Grading of Radiocarpal arthritis Grade Arthritis...
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báo cáo hóa học:" Loss of correction in unstable comminuted distal radius fractures with external fixation and bone grafting -a long term followup study" potx
... not expand crushed cancellous bone and cannot work without soft tissue hinges [3] Skeletal traction maintained by a half frame external fixator between the radius and second metacarpal bone appears ... [6] Bone grafting was carried out either primarily or secondarily and also on the acceptability of patients for bone grafting Bone grafting improved the anatomical alignment of the fragments and ... radius and 20 percent by the triangular fibrocartilage and the distal end of the ulna[1] The limitation of external fixation to achieve articular Table Grading of Radiocarpal arthritis Grade Arthritis...
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Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 1) pot
... the tumor-suppressor gene p53 and an increased incidence of soft tissue sarcomas and other malignancies, including breast cancer, osteosarcoma, brain tumor, leukemia, and adrenal carcinoma (Chap ... Chemical carcinogens such as polycyclic hydrocarbons, asbestos, and dioxin may be involved in the pathogenesis Iatrogenic Factors Sarcomas in bone or soft tissues occur in patients who are treated with ... Soft tissues include muscles, tendons, fat, fibrous tissue, synovial tissue, vessels, and nerves Approximately 60% of soft tissue sarcomas arise in the...
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Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 2) pps
... best with plain radiographs and MRI for tumors of the extremities or head and neck and by CT for tumors of the chest, abdomen, or retroperitoneal cavity A radiograph and CT scan of the chest are ... as the retroperitoneum, mediastinum, and subcutaneous tissue Rhabdomyosarcomas, Ewing's sarcoma, and other small-cell sarcomas tend to be more aggressive and are more responsive to chemotherapy ... of malignant GISTs have activating mutations of the c-kit gene that result in ligand-independent phosphorylation and activation of the KIT receptor tyrosine kinase, leading to tumorigenesis Diagnosis...
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Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 3) ppsx
... angiosarcomas, and vincristine, etoposide, and irinotecan are effective in rhadomyosarcomas and Ewing's sarcomas Imatinib mesylate targets the KIT tyrosine kinase activity and is standard therapy ... time-consuming, and less expensive Adjuvant Chemotherapy Chemotherapy is the mainstay of treatment for Ewing's primitive neuroectodermal tumors (PNET) and rhabdomyosarcomas Meta-analysis of 14 randomized ... incorporating the biopsy site, is the standard surgical procedure for local disease The adjuvant use of radiation therapy and/ or chemotherapy improves the local control rate and permits the use of limb-sparing...
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Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 4) ppsx
... common benign bone tumors include enchondroma, osteochondroma, chondroblastoma, and chondromyxoid fibroma, of cartilage origin; osteoid osteoma and osteoblastoma, of bone origin; fibroma and desmoplastic ... origin; and giant cell tumor, of unknown origin Malignant Tumors The most common malignant tumors of bone are plasma cell tumors (Chap 106) The four most common malignant nonhematopoietic bone tumors ... Ewing's sarcoma, and malignant fibrous histiocytoma Rare malignant tumors include chordoma (of notochordal origin), malignant giant cell tumor and adamantinoma (of unknown origin), and hemangioendothelioma...
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Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 5) pps
... all bone sarcomas, is a spindle cell neoplasm that produces osteoid (unmineralized bone) or bone About 60% of all osteosarcomas occur in children and adolescents in the second decade of life, and ... appearance), and a cuff of periosteal new bone formation at the margin of the soft tissue mass (Codman's triangle) A CT scan of the primary tumor is best for defining bone destruction and the pattern ... defining intramedullary and soft tissue extension A chest radiograph and CT scan are used to detect lung metastases Metastases to the bony skeleton should be imaged by a bone scan Almost all osteosarcomas...
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Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 6) ppt
... Metastatic to Bone Bone is a common site of metastasis for carcinomas of the prostate, breast, lung, kidney, bladder, and thyroid and for lymphomas and sarcomas Prostate, breast, and lung primaries ... fli-1 gene on chromosome 11 and ews on 22 This disease is very aggressive, and it is therefore considered a systemic disease Common sites of metastases are lung, bones, and bone marrow Systemic chemotherapy ... and lung primaries account for 80% of all bone metastases Metastatic tumors of bone are more common than primary bone tumors Tumors usually spread to bone hematogenously, but local invasion from...
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Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 7) ppsx
... may relieve pain and inhibit bone resorption, thereby maintaining bone mineral density and reducing risk of fractures in patients with osteolytic metastases from breast cancer and multiple myeloma ... inhibition (antiandrogens for prostate cancer, antiestrogens for breast cancer) Strontium 89 and samarium 153 are bone- seeking radionuclides that can exert antitumor effects and relieve symptoms ... osteoporosis, the cortical bone may be preserved, whereas cortical bone destruction is usually noted with metastatic cancer Metastatic Bone Disease: Treatment Treatment of metastatic bone disease depends...
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Báo cáo khoa học: "Lesions in the thymus and bone marrow in chicks with experimentally induced chicken infectious anemia disease" pot
... Animal Science and Health (ID-DLO; Netherlands), and was used for the streptavidin-biotin peroxidase technique The antibody was intended for use at Table Sacrifice and sampling dates and number of ... seventh and seventeenth days, and in bone marrow sections obtained between the thirteenth and seventeenth days These results are supported by the reports of parallel studies [13,15,18,25] and also ... 18 Burak Kuscu et al Table ELISA test results and scoring of histopathologic lesions and immunoperoxidase results in the bone marrow and thymus Days Bird No ELISA test results C1 C2 C3...
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Báo cáo y học: "Vastus medialis cross-sectional area is positively associated with patella cartilage and bone volumes in a pain-free community-based population" pdf
... cartilage and bone structure, participated in the analysis and interpretation of data, and reviewed the manuscript PAB and AJT performed the statistical analysis and interpretation of data and drafted ... medialis and lateralis cross-sectional areas and patella structures The association between vastus medialis and lateralis crosssectional areas and patella structures, including cartilage and bone ... contributions FMC and AEW participated in the design of the study and in the analysis and interpretation of data and reviewed the manuscript DRE and GGG participated in the acquisition of data and in the...
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Báo cáo y học: "Dissection of a locus on mouse chromosome 5 reveals arthritis promoting and inhibitory genes" ppsx
... in arthritis models have been mapped to this region: CIA (Cia13, Cia14 and Cia27) [15,16], proteoglycan-induced arthritis (Pgia16) [17] and Borrelia burgdorferi-associated arthritis (Bbaa3 and ... of rheumatoid arthritis and the need for animal models to find and understand the underlying genes Arthritis Res 2001, 3:87-97 Karlsson J, Zhao X, Lonskaya I, Neptin M, Holmdahl R, Andersson A: ... linked to disease in arthritis models have been identified on this chromosome: Cia13, Cia14 and Cia27 for CIA [15,16], Pgia16 for proteoglycan-induced arthritis [17], and Bbaa3 and Bbaa2 for Borrelia...
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Báo cáo y học: "Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus" pptx
... mutation had rheumatoid arthritis [23] Deficiency in RUNX2 (also called AML3) leads to bone malformation and boneless mice; RUNX2 is therefore of Available online http:/ /arthritis- research.com/content/6/4/169 ... important in bone regeneration, bone formation and repair, and it is of particular interest when considering the susceptibility to response to treatment of patients with rheumatoid arthritis or ... and in osteoblast and chondrocyte development [25,26], although recent evidence shows that RUNX1 might also be involved in skeletal development [27] and has been found expressed in the skin and...
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