aberrant signaling pathways in cancer modulation by the dietary flavonoid quercetin
Báo cáo khoa học: Oligosaccharide synthesis in Fibrobacter succinogenes S85 and its modulation by the substrate potx
Ngày tải lên :
07/03/2014, 17:20
... are used internally rather than released into the medium The present work provides further details regarding the metabolism of MDs in F succinogenes These 2423 Cellulose metabolism in Fibrobacter ... confirmed the presence of spot and spot in these incubations with cellulose (data not shown) Synthesis of cellodextrins The synthesis of cellodextrins was monitored by 1H NMR spectra after incubation ... was not present in either the supernatant or in the cell extracts of resting cells incubated with or without glucose, and (ii) maltotriose was the minimum MD ‘building block’ allowing bacterial...
- 12
- 406
- 0
Báo cáo khoa học: Role of Ca2+/calmodulin regulated signaling pathways in chemoattractant induced neutrophil effector functions Comparison with the role of phosphotidylinositol-3 kinase ppt
Ngày tải lên :
08/03/2014, 10:20
... counteracts the calcineurin induced affinity switch of a5b1 integrin in CHO cells, suggesting also a role for Ca2+/calmodulin-dependent molecules in regulating the affinity state of integrins on neutrophils ... effector calmodulin in G-protein-coupled receptor regulated signaling pathways in human neutrophils was investigated Additionally, the role of calmodulin and PtdIns3K in chemoattractant induced neutrophil ... calmodulin, the major downstream effector of Ca2+, in the regulation of intracellular signaling was analyzed by using the inhibitor W7 This inhibitor was found highly specific for calmodulin [34],...
- 10
- 537
- 0
Trends in Cell Signaling Pathways in Neuronal Fate Decision Edited by Sabine Wislet-Gendebien potx
Ngày tải lên :
16/03/2014, 20:21
... excitotoxic injury to the hippocampus, ablating activin signaling by infusion of the activin inhibitor follistatin potently inhibits post-injury neurogenesis and exacerbates the inflammatory ... neurogenesis in the SVZ and DG whereas the BMP inhibitor noggin promotes it [96] In contrast, inhibition of BMP signaling by upre‐ gulation of the BMP inhibitor chordin after lysolecithin-induced demyelination ... activin signaling in the SVZ may be the predominant Smad3-utilizing cytokine in defining basal levels of neurogenesis In the DG pSmad2 is normally absent from Sox2-positive type and primary NSCs in...
- 366
- 413
- 0
Báo cáo khoa học: Suppression of nuclear factor-jB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles pot
Ngày tải lên :
23/03/2014, 04:20
... to the liver in CMR in the postprandial phase In this study, we investigated the effects of CMR on NF-jB activation in macrophages and determined whether these are modulated by the fatty acid ... and incubations continued in fetal bovine serum-free culture medium for 24 h in the presence of ApoA-I ⁄ phosphatidylcholine (100 lgÆmL)1) At the times indicated in the text, aliquots of the ... enriched in n-6 or n-3 PUFA [30] These findings provide strong evidence that induction of macrophage foam cell formation is in uenced by dietary fatty acids during their transport from the gut to the...
- 14
- 328
- 0
Báo cáo sinh học: " The involvement of survival signaling pathways in rubella-virus induced apoptosis" ppt
Ngày tải lên :
18/06/2014, 22:20
... Ras-RafMEK-ERK signaling during RV infection in RK13 cells The PI3K inhibitor LY294002 and the MEK inhibitor U0126 were used to investigate PI3K-Akt and Ras-Raf-MEK-ERK signaling respectively during RV ... results in an increase in the speed and magnitude of RV-induced apoptosis To evaluate the role of PI3K-dependent signaling during RV infection, the effects of PI3K inhibitor LY294002 on the development ... inositol lipids at the 3' position of the inositol ring These 3'phosphoinsoitides recruit proteins such as Akt and phosphoinositide dependent kinases and (PDK1/2) to the plasma membrane via their...
- 12
- 357
- 0
Báo cáo y học: "Participation of the PI-3K/Akt-NF-κB signaling pathways in hypoxia-induced mitogenic factor-stimulated Flk-1 " pot
Ngày tải lên :
12/08/2014, 16:20
... while TGF-β inhibits Flk-1/KDR expression through a mechanism that involves reduced binding of GATA-2 to a palindromic GATA site in the 5'-UTR [30] These findings indicate that the binding of specific ... serines 19 and 23 facilitate their ubiquitination on neighboring lysine residues, thereby targeting these proteins for rapid degradation by the proteosome [32] Dissociation from IκBs unmasks the ... PI-3K/Akt-NF-κB signaling pathway In addition, our recent studies indicated that VEGF expression in lung epithelial cells can be induced by HIMF via the same signaling pathway [17], suggesting that...
- 14
- 221
- 0
The study of interactions of transmembrane receptors and intracellular signaling proteins in live cells by fluorescence correlation and cross correlation spectroscopy
Ngày tải lên :
14/09/2015, 14:25
... C-terminus domain, to expose binding sites for Src-homology-2 (SH2) domain-containing proteins and phosphotyrosine-binding (PTB) domain-containing proteins Adaptor proteins with a SH2-binding domain ... epitope tag heparin-binding epidermal growth factor protein kinase C-related kinase homology region IQ motif containing GTPase activating protein infrared insulin receptor tyrosine kinase substrate ... for promoting axon regeneration In summary, this thesis will examine the interactions of two sets of signaling proteins, one from the receptor tyrosine kinase family and the other from the Rho...
- 173
- 360
- 0
Tài liệu Báo cáo Y học: The Fc receptor c-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin ppt
Ngày tải lên :
22/02/2014, 07:20
... revealed the importance of the arginine residue in the transmembrane domain of the immunoglobulin receptor However, the cytoplasmic domain of these FcRs is not essential for binding to the FcR c-chain ... activated with the GPVIspecific ligand convulxin, resulting in phosphorylation of the protein kinase Syk, therefore reproducing the proximal events of GPVI signalling in platelets The FcR c-chain is We ... suggesting that it may associate with GPVI in the absence of the FcR c-chain Convulxin also induced an increase in calcium in GPVI-expressing Jurkat cells (Fig 10D) In contrast, however, neither...
- 10
- 506
- 0
Báo cáo khoa học: Distinguishing between different pathways of bilayer disruption by the related antimicrobial peptides cecropin B, B1 and B3 pptx
Ngày tải lên :
08/03/2014, 08:20
... and there was a short lag in CB3-induced liposome disruption Initially the peptide appeared to bind to the liposome, as indicated by the short period of mass increase, and binding was followed by ... characterized using solid-state NMR [47–49] In addition, experiments using synthetic enantio analogues of a variety of defence peptides, including cecropins, magainins and melittin or melittin-cecropin chimaeras, ... with ethanolamine The maximum avidin loading was achieved by optimizing the flow rate used (1 lLÆmin)1) Anionic liposomes (1 mgÆmL)1) were then immobilized on the surface of the chip using various...
- 10
- 443
- 0
The study: An analysis of common errors on verb tenses and word choices in VietnameseEnglish translation by the secondyear English majors at Dong Thap University
Ngày tải lên :
03/07/2014, 14:17
... meaning – the additional meanings, which a word has in other contexts with other words in certain orders In English, we can say The boy runs.” with the meaning The boy moves fast”, but in the ... and greatly diminish the idiom‟s impact By substituting a similar Vietnamese idiom, then, the flow and the impact of the original text are retained in the translation Translating by paraphrase ... obvious that these units link together to create a larger unit of meaning in a given text to be translated The linking meaning itself does not exist in separate word units but in the link of the units...
- 81
- 1.8K
- 1
Báo cáo khoa học: "Ultrasound-guided central venous catheterization in cancer patients improves the success rate of cannulation and reduces mechanical complications: A prospective observational study of 1,978 consecutive catheterizations" pps
Ngày tải lên :
09/08/2014, 03:22
... access is essential in patients with cancer, and the need for intravenous access devices for the administration of cancer therapy has increased proportionally with the increasing number of patients ... disagreed with the recommendation that ultrasound imaging should be the preferred method for insertion of a central venous catheter in the internal jugular vein [19] In addition, a report in the United ... which determines an increase of the diameter of the veins Under ultrasoundguide in real time, a 16-gauge needle is introduced into the last portion of internal jugular vein This vein was reached...
- 7
- 422
- 0
Báo cáo lâm nghiệp: " The role of glutamine synthetase, glutamate synthase and glutamate dehydrogenase in ammonia assimilation by the mycorrhizal fungus Pisolithus tinctorius" ppt
Ngày tải lên :
09/08/2014, 04:20
... marked increase in the and glutamine pools after h in the fresh medium (Fig 3a) Glutamate levels remained constant after h but the glutamine concentration continued to increase up to h indicating ... small increase in glutamine concentration was probably due to a lag in GS inhibition by MSX The increase in the glutamate pool appeared to indicate assimilation of ammonia into glutamate by GDH ... extracts were found to contain significant amounts of arginine, which is thought to play a major role in nitrogen storage Arginine was the most abundant amino acid in the nitrogen-starved mycelia...
- 5
- 360
- 0
Báo cáo y học: "Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo" ppsx
Ngày tải lên :
14/08/2014, 21:20
... regulated genes are linearly combined into principal components, thereby reducing the dimensionality of the feature space Binary regression on the principal components is then applied to an unknown ... result from the collaboration between multiple signaling pathways, the ability to detect the activation status of individual pathways within a complex network of other pathways in the cell is ... activation These results indicate that Ras activation in the mammary gland results in gene expression changes similar to those induced by TGFβ in mammary epithelial cells in vitro This, in turn,...
- 11
- 262
- 0
Colloquial language used in speaking classes by the English major sudents of Foreign Language Faculty - Thai Nguyen University= Ngôn ngữ thông tục được sử dụng
Ngày tải lên :
28/03/2015, 09:36
... competence of using colloquial English in their speaking classes Then, the study focuses on investigating the factors influencing the use of colloquial English in the classroom setting so that teachers ... with the topics they are learning in the official learning hours During the semester, the teachers should highlight the significance of colloquial English speech as well as the main goal of these ... activities mainly focused on the authenticity of the materials and the learning situations, the notion of appropriateness in English communications and the teaching of social parameters in the speaking...
- 59
- 608
- 1
The common errors in using some skinds of nouns in english made by the eleventh grade student at nguyen trai hight school, thai binh
Ngày tải lên :
16/07/2015, 08:06
... made the incorrect answer with “two son- in- laws” The students not remember the ways of adding “s” when changing the singular to the plural forms II.2.3 Errors in using singular nouns There ... Pluralize the principle word The vast majority of compound nouns form their plurals by adding “s” to the principle word E.g I have two mothers -in- law (plural of mother -in- law) Daughters- in- law ... nouns in singular and plural forms Some nouns have the different meaning when changing the singular form to the plural form It is based on each word When choosing the meaning of the underlined...
- 57
- 473
- 0
AN INVESTIGATION INTO THE PRONUNCIATION ERRORS IN ENGLISH EXPERIENCED BY THE LAOTIAN STUDENTS AT
Ngày tải lên :
02/11/2015, 16:03
... consonants in initial and final position in the syllable The results were intended to detect the students’ knowledge about the presence of the consonants in the syllable with their influence on the ... recording the results, presenting the data in frequency and percentage distribution tables, and analyzing and interpreting the data in the light of the research objectives The first part of the ... students, the words in questions were not familiar and quite new, which 28 caused their failure in pronouncing the vowels correctly Instead, the degree of their failure in pronouncing the consonants in...
- 71
- 1.5K
- 7
Common errors in the use of past tense and aspects in active voice by the 11th grade students thanh ba high school
Ngày tải lên :
30/11/2015, 09:12
... our return, the story can continue in the simple past) The burglar got in through the kitchen window He had no difficulty in forcing it open, then he went into the living – room… 1.2.4 The past ... agree/agreeing, see/seeing For example: Come/coming Have/having Ride/riding Use/using Make/making Exceptions: age/ageing, singe/singeing, dye/dyeing Run/running For a verb ends with a single vowel ... used It involves such activities as choosing the correct answer, giving the correct tense form of the verbs in the brackets, giving the form of the irregular verbs, or writing the correct “- ing”...
- 85
- 482
- 0