a way of thinking in addition to a way of modeling

... can be obtained, enabling considerably higher concentrations during gel filtration This may explain the appearance of both dimer and tetramer peaks during gel filtration of non-incubated recombinant ... at )80 °C before use for kinetic and molecular mass analyses The activity at saturating conditions was similar before and after dilution, incubation and storage Native molecular size The apparent ... exhibiting hyperbolic kinetics with a Km of 0.7 lm This also indicates slow dissociation of the tetramer form, and may explain why linear progress curves are always obtained with all forms of the...

Ngày tải lên: 18/02/2014, 12:20

... Laboratories, Abbott Park/IL, USA) [22] Statistical analysis Continuous variables are presented as mean ± standard deviation or median (with interquartile range), and categorical variables as ... obtained from all participating patients Clinical evaluation and follow-up Patients underwent an initial clinical assessment including clinical history, physical examination, echocardiogram, pulse ... activate ADM gene transcription [35] and overexpression of ADM leads to a biologic activity similar to that of natriuretic peptides causing vasodilatation, an increase in cardiac output and induction...

Ngày tải lên: 13/08/2014, 18:22

... obscure Various glycoconjugates are detected in a position and stage-speci®c manner during Drosophila development [24] Heparin-like glycosaminoglycans that contain galactose and N-acetylgalactosamine ... & Kawakita, M (1996) Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line de®cient in UDP-galactose translocator ... 5¢-GGCATTCTGGAGCACCAGCA-3¢ 5¢-GGCAGCCTGGACCACCAGCA-3¢ 5¢-TGCTGAGGGTGAGGGAGGC-3¢ 5¢-ACCCCTCTTCTCTGCGAAGAGC-3¢ 5¢-GGCAACATACGCGAGGTTATT-3¢ 5¢-GCTGCAGTGGGCCTCCCTGCTGATGCTCTTCACTGG-3¢ 5¢-TGCCAGGCCTGCCCCAGGGTTCTG-3¢...

Ngày tải lên: 21/02/2014, 15:20

... Long An, Tiền Giang, An -18- Giang, Kiên Giang, Cà Mau, Sóc Trăng, Bạc Liêu, Đồng Tháp, Bến Tre, Hậu Giang, Vónh Long, Trà Vinh thành phố Cần Thơ Vò trí đ a lí Nam Bộ: ph a bắc tây - bắc giáp Cam-pu-chia, ... ngữ Nam Bộ Như vậy, không gian đ a lí tiếng miền Nam, phương ngữ miền Nam hay phương ngữ Nam tác giả xác đònh rộng Không gian đ a lí phương ngữ Nam Bộ xác đònh hẹp Ranh giới PNNB trùng với ranh ... chinh phục vùng đất ph a Nam bàn tay khối óc mình, cần cù, lam lũ: “Họ to n tiên phong vũ trang óc phiêu lưu mạo hiểm, cán b a, lưỡi cày, lưới ” [59; 60] Hoặc “Nam Kì chinh phục gươm vó ngựa...

Ngày tải lên: 17/04/2013, 16:09

... Cells were again washed three times for with NaCl/Pi During the last wash total DNA was stained with bisbenzimide (2 lgÆmL)1 in NaCl/ Pi) Finally PCNA (Alexa FluorÒ 568 stain) and total DNA (bisbenzimide ... the incorporation rate remained relatively low up to h after medium exchange and then gradually increased up to 10 h, when maximal incorporation was attained This was followed by a decrease Under ... had to meet two demands Firstly to find a cell line that can be induced to bear a maximal number of replicons arrested in the ‘hypoxic preinitiation state’ and as few as possible in other states...

Ngày tải lên: 21/02/2014, 00:20

... in response to galactose The GAL genetic switch The GAL regulatory network is composed of three regulatory proteins: a transcriptional activator Gal4p, a negative regulator Gal80p and a signal ... 291 Yano, K & Fukasawa, T (1997) Galactose dependent reversible interaction of Gal3p with Gal80p in the induction pathway of Gal4p activated genes of Saccharomyces cerevisiae Proc Natl Acad Sci ... in cytoplasm Gal3p Activated Gal3p Operator of genes with one binding site for Gal4p Operator of genes with two binding site for Gal4p Molar balance equations The following are the molar balance...

Ngày tải lên: 07/03/2014, 16:20

... tyrosine kinase activates several signalling pathways, including the ERK1 ⁄ pathway, the PKB pathway and the Janus kinase ⁄ signal transducer and activator of transcription (JAK-STAT) pathway, to ... ⁄ inhibitors and PI3K–PKB pathway inhibitors Indeed, rapamycin, an inhibitor of mammalian target of rapamycin (mTOR) downstream of PKB, can synergize with the MEK1 ⁄ inhibitor, PD0325901, to ... mitogen-activated protein kinase ⁄ extracellular signal-regulated kinase kinase ⁄ kinases: mechanism of action in vivo, pharmacokinetic ⁄ pharmacodynamic relationship, and potential for combination in...

Ngày tải lên: 16/03/2014, 00:20

... the R3 pair bound to L1 and L2 Turning a gene into an active state from a state of inactivation often involves binding of a single activator molecule to its site in a repressive chromatin structure ... binding of proteins at singular sites in an array of densely packed and equally spaced nucleosomes can cause substantial decondensation and rearrangements in condensed chromatin regions, working ... lac operator always faces the histone octamer in a manner that allows repressor binding on the outward surface [31] We have previously shown that binding of a transcription factor next to the...

Ngày tải lên: 16/03/2014, 10:20

... stream at Biological assays room temperature The lipid sample was placed in a closed cuvette, and the air above the sample was satur- 12 Stimulation of macrophages ated with water vapour to maintain ... membrane surface and for antagonists a cylindrical shape with a low inclination angle For other effects, however, for which particular binding epitopes are necessary, exchange of charges may largely ... inclination angle of the diglucosamine ring plane with respect to the membrane plane [14] In Table 1, the data are summarized showing high R values for the tetraacyl, corresponding to small inclination...

Ngày tải lên: 23/03/2014, 13:20

... Groups Reading, Mass; Addison Wesley Bales, Robert F and Edgar F Borgatta 1955 "Size of Group as a Factor in the Interaction Profile." In A. P Hare, E F Borgatta and R F Bales, eds., Small Groups: ... ~o be associated with other characteristics of the medium, such as the greater tendency for minorlt¥ opinions to be maintained, rather than a total group consensus emerginK, in a fuller analysis ... of other investigators, since apparently ~he training for coding interpreted many more statements as representing some sort of analysis or opinion than "should" be there, according to the distributions...

Ngày tải lên: 24/03/2014, 01:21

... his/her availability.1 The findings of this study allow us to conclude that parameters such as the family status, the frequency of conduction of clinical / para-clinical exams, as well as the age of ... reported that they preferred a female doctor to take their Pap smear, 48% that they preferred a woman for their breast exam and 36% that they preferred a woman to take a sample of vaginal fluid ... questioned variables The x2 test was used on the qualitative variables and the t-test on the quantitative variables From the total of the examined variables, the ones that presented a significant statistic...

Ngày tải lên: 28/03/2014, 14:20

... equivalent ( D o , Play : ~ - & ) that can be associated in common to a part of the structure of the categories as in Fig.l, and then find appropriate translation equivalents in detail at the ... with associated pairs of verb and its translation equivalent through case relations to enable the appropriate selections of translation equivalents of verbs in MT systems Additional information ... level categories (2) To each verb found in the process of the association, consults ordinary dictionary of translation equivalents and word usage of verbs and obtain the set of all the translation...

Ngày tải lên: 31/03/2014, 17:20

... A DEFENCE OF FREE -THINKING IN MATHEMATICS A Defence of Free -Thinking in Mathematics In answer to a Pamphlet of Philalethes Cantabrigiensis, intituled, Geometry no Friend to Infidelity, or a ... Defence of Sir ISAAC NEWTON, and the BRITISH Mathematicians Also an Appendix concerning Mr WALTON'S Vindication of the Principle of Fluxions against the Objections contained in the ANALYST WHEREIN ... say, can be plainer to any impartial reader than that, by the evanescence of augments in the above-cited passage, Sir Isaac means their being actually reduced to nothing But, to put it out of all...

Ngày tải lên: 18/04/2014, 15:15

... manuscript and read and approved the final manuscript Additional material Additional file Analysis of covariance of each subscale of SF-36 (n = 227) with respect to SOC adjusted for sex, age group, marital ... in a way that is easy for them to understand Professionals could also encourage residents to engage in the kind of everyday activities that are meaningful for them Health care professionals play ... need to invest if they want to maintain a sense of meaningfulness: feelings, interpersonal relationships, employment and existential value Health care professionals could facilitate meaningfulness...

Ngày tải lên: 18/06/2014, 19:20

... GGGACAAGTG AAAATGTCTC TTCAGGGGAT TCAGCTTAGT GACTTGTCCT ATAAGCATGC AATCCTTAAA GAATCACAGT ACACAATCAA GGGACAAGTC AAAATGTCTC TTGAAAGTAT TAGACTCAGT GACTTGGAGT ACAAACATGC AATTCTTGAA GACTCTCAGT ATACAATTAG 90 ... aMPV /A/ UK/3b AGGTAGTGAG GTGCAGGCAG TATTGACCAA GACA TACT CTCTTGG-GA AGGGCAAAAA CAGCAAAGGG GAGGAGTTGC AAATGTTAGA CGGTAGTGAA GTACAGGGTG TTATGACCAA GATTGTTACA CTTTCGGCAG AGGGTTCTGT CAGAAAGCGA GAGGTGCT AAACATTCAC ... CAATGGGAGC AATGG TTA GGGAAAAAGT GCAACTCA 444 443 aMPV/C/US/Co aMPV /A/ UK/3b ACCAATACCA CAAAATCAAA GACCATCATC CCCGGATGCT CCTATCATAC TACTCTGCAT AGGAGCATTA ATCTTCACGA AGCTGGCATC CAA - -AGAATCAAA...

Ngày tải lên: 19/06/2014, 08:20

... time of 6.7 years Age at baseline was 17–30 years The overall annual decline in FEV1 was 11.1 ml Continuing smoking was associated with increased loss in FEV1 and atopy in smokers further increased ... ever-welding Danish metal workers N Welders Mild steel Stainless steel Alloyed steel Aluminum All particulates manual metal arc (MMA) metal active gas (MAG) manual metal arc (MMA) tungsten inert gas ... ventilation, and welding in confined spaces we computed the product of number of years and particulate concentration in each decade and summed over all decades to arrive at a summary measure of total lifelong...

Ngày tải lên: 20/06/2014, 00:20

... Hagberg M, Ekenvall L, Futatsuka M, Harrison J, Nasu Y, Welsh C, Yamada S, Yoshida M: Clinical and laboratory diagnostics of vascular symptoms induced by hand-arm vibration In Proceedings Stockholm ... study, was the examining physician at the baseline and the follow ups, participated and contributed substantial in the analysis and in the interpretation of data Acknowledgements This research was ... an average daily exposure duration of 14 minutes at a value of 3.5 m/s2 and an average total exposure duration of 12 years [7] The value 3.5 m/s2 for 14 minutes corresponds to an A( 8) value of...

Ngày tải lên: 20/06/2014, 00:20

... GGGACAAGTG AAAATGTCTC TTCAGGGGAT TCAGCTTAGT GACTTGTCCT ATAAGCATGC AATCCTTAAA GAATCACAGT ACACAATCAA GGGACAAGTC AAAATGTCTC TTGAAAGTAT TAGACTCAGT GACTTGGAGT ACAAACATGC AATTCTTGAA GACTCTCAGT ATACAATTAG 90 ... aMPV /A/ UK/3b AGGTAGTGAG GTGCAGGCAG TATTGACCAA GACA TACT CTCTTGG-GA AGGGCAAAAA CAGCAAAGGG GAGGAGTTGC AAATGTTAGA CGGTAGTGAA GTACAGGGTG TTATGACCAA GATTGTTACA CTTTCGGCAG AGGGTTCTGT CAGAAAGCGA GAGGTGCT AAACATTCAC ... CAATGGGAGC AATGG TTA GGGAAAAAGT GCAACTCA 444 443 aMPV/C/US/Co aMPV /A/ UK/3b ACCAATACCA CAAAATCAAA GACCATCATC CCCGGATGCT CCTATCATAC TACTCTGCAT AGGAGCATTA ATCTTCACGA AGCTGGCATC CAA - -AGAATCAAA...

Ngày tải lên: 20/06/2014, 04:20

... evidence that the mass media is making the desired impact with regard to information about HIV/AIDS in Nigeria The impact of healthcare providers/institutions in the dissemination of information on ... subjects was generally good This finding is in line with the general trend in other parts of the world.[10,16] A similarly high level of awareness has also been reported in a national HIV/AIDS and ... on background characteristics, sexual behaviors, and condom use Data Analyses The data were analyzed using the Statistical Package for Social Sciences (SPSS), version 10.[15] All statistical tests...

Ngày tải lên: 20/06/2014, 08:20

... participated in the operational research, which was approved by all affiliated institutional review boards We obtained written informed assent from minors aged 13 to 17 years, and read an informational ... Fund, Kinshasa, Democratic Republic of the Congo Acknowledgements We thank Tshimanga Badinga, Nicole Kutumbakana, Odette Daiku, Mamie Ilaka, Jean-Serges Kalengi Kukemfuka and Jose Kayumba Baye for ... experiences among youth and parents and caregivers in non-research settings, as well as culturally appropriate approaches for disclosing an HIV diagnosis to minors as this information could inform our assent...

Ngày tải lên: 20/06/2014, 08:20