a target for the treatment of drug resistant ovarian cancer

... However, there are certain locations such as nasal tip, nasal ala, and facial areas near the eye, where a mm margin is not feasible or desirable Therefore, a reduced margin was utilized to account for ... writing, final review, and approval of this manuscript AL was responsible for the recording of treatment planning and treatment data and for the writing and final approval of this manuscript Competing ... source for HDR brachytherapy with surface applicators for the treatment of NMSC All patients received a hypofractionated course of EBT comparable to published treatment schedules for traditional...

Ngày tải lên: 09/08/2014, 09:20

... de-innervation of the joint and removal of the entire end-plate receptors that adhere to the bone and capsular tissue Limitations of the current study include a lack of comparison group and lack of blinding ... 71% of 21 patients at one year follow-up with laser denervation of the dorsal facet capsule Li et al treated patients with RFA of the dorsal rami Three patients had durable response after to 16 ... men; mean age 64, range 22-89) were included Length of follow-up was at least years with a maximum of years Location of facet pain was cervical in 45, thoracic in 15, and lumbar in 114 patients...

Ngày tải lên: 26/10/2012, 09:32

... Modulation of metal availability for treating AD P J Crouch et al research attention as potential therapeutic targets Plaques and NFTs, however, cannot be regarded as ‘upstream’ causative factors ... down-regulated by decreased availability of intracellular Cu [83] and up-regulated by increased availability of Cu [84] Collectively, these data present a strong case for the native role of APP ⁄ Ab ... Furthermore, an increase in extracellular metals can catalyse Ab oligomerization and aggregation, and the amyloid plaques that subsequently form may then exacerbate intracellular metal deficiency...

Ngày tải lên: 07/03/2014, 10:20

... PE38) has undergone several early-phase clinical trials for the treatment of B cell malignancies [35–37] These trials have validated the use of CD22 as a target and highlighted several potential ... of the majority of domain Ia (D1–250) and a portion of domain Ib (D365–380) from native PE Several RITs incorporating a 38 kDa fragment of PE are in preclinical evaluation or have already reached ... cleavage efficiency Additional obstacles exist outside of PE and its intoxication pathway Target selection and the targeting element are at least as important as the toxin portion of RITs The ability...

Ngày tải lên: 22/03/2014, 15:21

... with adjunctive therapy or the actual exercise dosage is the critical factor is unclear The optimal length of treatment and the number of treatment episodes could be useful information for the marketing ... quantity and quality of the educational information about the condition and PFM function The impact of these factors on the outcome of treatment has yet to be evaluated Furthermore, it has been ... Hay-Smith (2002) A A = available in English only as abstract; a = According to Australian National Health and Medical Research Council Hierarchy of Evidence (1998); b = Mean age (SD) unless otherwise...

Ngày tải lên: 28/03/2014, 14:20

... type diabetes subjects Immunogenetics 2010, 62:101-107 36 Kawasaki E, Awata T, Ikegami H, Kobayashi T, Maruyama T, Nakanishi K, Shimada A, Uga M, Kurihara S, Kawabata Y, et al: Genetic association ... and state of activation, may not accurately reflect the status and behavior of their counterparts localized in the target organ In this latter regard, there is experimental evidence that the blood ... Health Center, 1650 Cedar Avenue, Montreal, H3G 1A4 , Qc, Canada Full list of author information is available at the end of the article thymic and peripheral CD4+ T cells in humans and mice, and...

Ngày tải lên: 18/06/2014, 16:20

... parallel 1.8 mm Kirschner wires from the tip of the olecranon and a 18 gauge wire in a figure -of eight fashion Major intraoperative goal was the perforation of the ulnar Mayo Classification for ... Visual Analogue Scale (VAS) patient satisfaction score (b) the intramedullary pin The above hypothesis wasn't confirmed by Paremain et al [22] as the results of their biomechanical study indicated ... olecranon fracture Mayo Type IIA fracture of the left olecranon after a fall in a 52-year-old woman (A) Lateral (B) and anteroposterior radiographs (C) at years postoperatively showed signs of...

Ngày tải lên: 20/06/2014, 01:20

... circulating in the population for many years without pandemic potential and leaving the population at least partially immune The implications for avian influenza H5N1 remain uncertain Oseltamivir ... the time point for the importation of the resistant strain is shifted towards the initial phase of the epidemic, the resistant strain increasingly replaces the sensitive strain (Figure 1c) Early ... ME and MS formulated and programmed the model in Java and delivered the simulation results HPD participated in the design of the study, performed the statistical analysis, produced the figure and...

Ngày tải lên: 20/06/2014, 01:20

... is a chance of intra-articular pin placement, causing septic arthritis and a risk of damaging the growth plate An external fixator is also used for the treatment of paediatric supracondylar fractures ... this article as: Lam et al.: The use of tibial Less Invasive Stabilization System (LISS) plate [AO-ASIF] for the treatment of paediatric supracondylar fracture of femur: a case report Journal of ... the site, the pattern of the fracture and its associated injury When treating the displaced supracondylar fracture, the traditional method of traction may fail due to the unbalanced pull of the...

Ngày tải lên: 20/06/2014, 04:20

... Page of 100 points indicating a normal foot This includes a maximum score of 30 points for amount of pain; of 20 points each for level of activity and patient satisfaction; and of 10 points each ... permits and consists of gentle manipulation of the foot and the serial application of long leg plaster casts at weekly interval without the use of anesthesia, as described by Ponseti [4] In all patients, ... of the treatment Out of patients resistant to Ponseti serial cast manipulation were from the 13-24 weeks of the age group while beginning of the treatment, while was from the 25-36 weeks of the...

Ngày tải lên: 20/06/2014, 04:20

... Page of 100 points indicating a normal foot This includes a maximum score of 30 points for amount of pain; of 20 points each for level of activity and patient satisfaction; and of 10 points each ... permits and consists of gentle manipulation of the foot and the serial application of long leg plaster casts at weekly interval without the use of anesthesia, as described by Ponseti [4] In all patients, ... of the treatment Out of patients resistant to Ponseti serial cast manipulation were from the 13-24 weeks of the age group while beginning of the treatment, while was from the 25-36 weeks of the...

Ngày tải lên: 20/06/2014, 07:20

... study Additional studies appear warranted for the use of Apatone as a co–adjuvant, or for emerging salvage chemotherapy in the treatment of late stage prostate cancer Acknowledgements This research ... fit analysis was used to measure and compare PSA values before, during and after therapy.12 Prostate cancer patients who had failed standard therapy were enrolled at William Beaumont, Royal Oak, ... of prior chemotherapy regimens was two Table Patient Characteristics N = 17 Age: median (range) AUA Symptom Score: median (range) Race: Caucasian African American Prior therapies (1 or more treatments):...

Ngày tải lên: 08/08/2014, 17:20

... patient, a Caucasian woman aged 28 years with a DSM-IV diagnosis of unipolar depression, was enrolled in the acute and long-term phases of the pilot study of VNS therapy for TRD At acute-phase study ... Date of Assessment The patient's score on the CGI-S scale also indicated a substantial improvement after the initiation of VNS therapy Figure The patient's score on the CGI-S scale also indicated ... scales [24] After a year of follow-up, adjunctive VNS therapy was associated with sustained symptomatic benefit and sustained or enhanced functional status [25] Because pregnancy was a contraindication...

Ngày tải lên: 08/08/2014, 21:20

... SANS and amelioration of auditory hallucinations Loo et al [19] noted that examinations of individual-controlled trials reveal that a substantial proportion of rTMS studies for the treatment of ... Ya’akov Mental Health Center and is paid by the research fund of the Beer Ya’akov Mental Health Center KM serves as the director of the Beer Ya’akov Mental Health Center ZA works at the Department ... Department of Neurobiology of the Weizmann Institute of Science and also serves as a research consultant for Brainsway DP is head of the research department of Beer Ya’akov Mental Health Center and head...

Ngày tải lên: 09/08/2014, 01:21

... shortened radiation treatment time (86%) and delivery of radiation to a smaller area of the body (77%) Twelve of the patients (27%) indicated that having a local treatment facility was a factor in their ... for treatment Factors affecting the success of implanting the balloon applicator and administering the prescribed radiation therapy were analyzed Patients answered a questionnaire after implantation ... applicable regulations The patient selection criteria were based on the Page of 10 American Society of Breast Surgeons Consensus Statement for Accelerated Partial Breast Irradiation and the American...

Ngày tải lên: 09/08/2014, 01:24

... The mainstay of surgical therapy in primary or metastatic disease is to achieve a complete resection with negative margins [7] Conventional chemotherapy and radiation therapy may have minor adjunctive ... Kubota K, Makuuchi M, Kusaka K, Kobayashi T, Miki K, Hasegawa K, Harihara Y, Takayama T: Measurement of liver volume and hepatic functional reserve as a guide to decision-making in resectional ... colorectal liver metastases Am J Surg 2003, 185:221-229 Kawasaki S, Makuuchi M, Kakazu T, Miyagawa S, Takayama T, Kosuge T, Sugihara K, Moriya Y: Resection for multiple metastatic liver tumors after...

Ngày tải lên: 09/08/2014, 07:21

... N2-3/T4 group Arm A, blue; arm B, brown; arm C, yellow; arm D, green Discussion Concurrent chemoradiation is the established standard of care for locally advanced carcinoma of the anal canal Attempts ... Impact of overall treatment time on local control of anal cancer treated with radiochemotherapy Oncology 2003, 65:14-22 Hughes LL, Rich TA, Delclos L, Ajani JA, Martin RG: Radiotherapy for anal ... Radiation Oncology 2007, 2:41 http://www.ro-journal.com/content/2/1/41 Background The standard of care for the curative treatment of anal canal carcinoma has evolved over the past three decades,...

Ngày tải lên: 09/08/2014, 10:21

... on the National Cancer Institute Common Toxicity Criteria (version 2), clinical laboratory evaluations, and physical examinations OS was calculated from the date of FCR treatment to the date of ... statistical analysis Author details Department of Hematology Regina Elena National Cancer Institute, Via Elio Chianesi, 53 00128 Rome, Italy 2Department of Nuclear Medicine Regina Elena National Cancer ... survival; tMDS: treatment related myelodisplastic syndrome Acknowledgements The authors thank Dr Diana Giannarelli of the Department of Oncology Regina Elena National Cancer Institute for statistical...

Ngày tải lên: 10/08/2014, 10:21

... Data source The databases of PubMed, Wanfang Data, as well as American Society of Hematology (ASH) and American Society of Clinical Oncology (ASCO) annual meeting abstracts were searched for articles ... 35 Saito K, Furusawa S, Yamada K, Waga K, Aoyagi A, Koike T, Arimura H, Noguchi M, Yamato H, Sakuma H et al: Comparison of low-dose cytosine arabinoside and aclarubicin in combination with granulocyte ... Saito K, Nakamura Y, Aoyagi M, Waga K, Yamamoto K, Aoyagi A, Inoue F, Arai Y, Tadokoro J, Handa T et al: Low-dose cytarabine and aclarubicin in combination with granulocyte 18 colony-stimulating...

Ngày tải lên: 10/08/2014, 21:23

... Characteristics of the patients Characteristics of the patients at the time of diagnosis are listed in Table The median age of these patients was 70 (60–84) years Seven patients had history of ... Coso D, Bardou VJ, Stoppa AM, Braud AC, Bouabdallah R, Sainty D, Mozziconacci MJ, Lafage M, Damaj G, Blaise D, Gastaut JA, Maraninchi D: The benefit of induction chemotherapy in patients age > or ... in patients JW designed the research, supervised the research, analyzed the data, wrote and revised the paper SL analyzed the data and wrote the paper; JY, XS, LC, CH, JH, WZ treated part of the...

Ngày tải lên: 10/08/2014, 22:20