a soluble apyrase for acute lung injury

... of APC to the distal airspaces might in fact be appealing, because it could allow for attenuation of lung injury without significant systemic effects Finally, plasma and bronchoalveolar lavage ... Critical Care Vol 13 No Liu et al in bleeding complications associated with administration of intravenous APC, the administration by the inhaled route is a novel approach that may allow for safer ... of acute lung injury N Engl J Med 2005, 353:1685-1693 Network TARDS: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory...

Ngày tải lên: 13/08/2014, 16:20

... timelines and outcomes A diagnosis of ALI/ARDS was made after a median of day (interquartile range to days) from the day of clinical insult in all patients (Figure 3a) , and was not statistically different ... risk factor identification and diagnosis of acute lung injury /acute respiratory disdiagram tress syndrome (ALI/ARDS) are displayed along with hospital outcomes for each group ICU, intensive care ... design and interpretation of the data FFV, FG, TH, OP, AA, GG, AA, and IR participated in the acquisition of the data NDF performed the data analysis and wrote the first draft of the manuscript,...

Ngày tải lên: 13/08/2014, 08:20

... pneumology ward days after admission Conclusion Mean airways pressure limitation is now a largely accepted strategy in adult acute lung injury; however, there is debate about the exact level of mean airways ... echocardiography, pulmonary systolic arterial pressure daily in all mechanically ventilated newborns as an indirect indicator of alveolar overdistension [5] We have realized that the application ... pulmonary capillaries, as intra-alveolar vessels, are collapsed by alveolar pressure This can lead to a progressive right ventricular dysfunction which may affect the patient's outcome For this reason...

Ngày tải lên: 11/08/2014, 21:22

... equation Statistical analysis The results are presented as mean ± standard deviation values Statistical analysis was performed using GraphPad Prism version 4.0 (GraphPad Software, San Diego, CA, ... Figure Arterial partial pressure of carbon dioxide (PaCO2)) in animals with normal and lavaged lungs B, baseline; N-, normal lung, one arterial cannula open, dioxide (PaCO2 in animals with normal and ... normal and lavaged lungs B, baseline; N-, normal lung, one arterial cannula open, no gas flow; N+, norlungs mal lung, one arterial cannula open, gas flow of lO2/minute; N++, normal lung, two arterial...

Ngày tải lên: 12/08/2014, 23:23

... in acute respiratory failure Am J Respir Crit Care Med 2001, 163:283-291 Esteban A, Frutos-Vivar F, Ferguson ND, Arabi Y, Apezteguia C, Gonzalez M, Epstein SK, Hill NS, Nava S, Soares MA, et al.: ... 344:481487 Rana S, Jenard H, Gay PC, Buck CF, Hubmayr RD, Gajic O: Failure of non-invasive ventilation in patients with acute lung injury: observational cohort study Crit Care 2006, 10:R79 Antonelli ... positive-pressure ventilation? Ann Intern Med 2003, 138:861-870 Masip J, Roque M, Sanchez B, Fernandez R, Subirana M, Exposito JA: Noninvasive ventilation in acute cardiogenic pulmonary edema JAMA 2005, 294:3124-3130...

Ngày tải lên: 12/08/2014, 23:24

... in acute respiratory failure Am J Respir Crit Care Med 2001, 163:283-291 Esteban A, Frutos-Vivar F, Ferguson ND, Arabi Y, Apezteguia C, Gonzalez M, Epstein SK, Hill NS, Nava S, Soares MA, et al.: ... 344:481487 Rana S, Jenard H, Gay PC, Buck CF, Hubmayr RD, Gajic O: Failure of non-invasive ventilation in patients with acute lung injury: observational cohort study Crit Care 2006, 10:R79 Antonelli ... positive-pressure ventilation? Ann Intern Med 2003, 138:861-870 Masip J, Roque M, Sanchez B, Fernandez R, Subirana M, Exposito JA: Noninvasive ventilation in acute cardiogenic pulmonary edema JAMA 2005, 294:3124-3130...

Ngày tải lên: 12/08/2014, 23:24

... patients with acute lung injury: a randomized controlled trial JAMA 2004, 291:1603-1609 The ARDS Network: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute ... outcomes, and clinical trial coordination Am J Respir Crit Care Med 1994, 149:818-824 Page of (page number not for citation purposes) Critical Care 2007, 11: 314 Khan, Milbrandt, and Venkataraman Mangialardi ... three trials, it seems reasonable to conclude that the exact approach to fluid management in ALI depends on timing Early on in the acute resuscitative phase, additional fluid may be beneficial Yet,...

Ngày tải lên: 13/08/2014, 08:20

... as having ALI/ARDS had hydrostatic pulmonary edema or pulmonary infection and that patients identified as not having ALI/ARDS actually had ALI/ARDS This may have happened in cardiac-arrest patients, ... regression analysis of risk factors associated with development of acute lung injury Lung injury (n = 12) No lung injury (n = 138) P value univariate analysis P value multivariate analysis Age (years) ... analysis Data are presented as mean with standard deviation for parametric data or as medians with interquartile range (IQR) for nonparametric data Baseline comparisons between groups were made with...

Ngày tải lên: 13/08/2014, 20:21

... K, Bayer O, Brunkhorst F, et al Markers of endothelial damage in organ dysfunction and sepsis Crit Care Med 2002; 30: S302-12 Okajima K, Harada N, Sakurai G, et al Rapid assay for plasma soluble ... AJ, Hemingway I, Pigott R, et al Soluble forms of vascular adhesion molecules, e-selectin, ICAM-1, and VCAM-1: Pathological significance Ann N Y Acad Sci 1992; 667: 324-31 Kayal S, Jais JP, Aguini ... was made by at least two pulmonary physicians and a cardiologist, according to these criteria All pneumonia patients received immediate antibiotic therapy The etiology of pneumonia was aspiration...

Ngày tải lên: 08/08/2014, 18:21

... instillate was adjusted by adding 5% BSA as an established method to quantify liquid clearance of lung epithelial barriers as an index of lung edema [24] The bacteria were added just before airspace ... monoclonal anti-PcrV antibody Mab166 and its Fab fragments protected rats infected with Pseudomonas aeruginosa from acute lung injury Mab166 and its Fab fragments are potential useful adjuvant therapies ... was used for comparisons of data Significance was accepted at P value of < 0.05 Results Coinstillation of Mab166 with P aeruginosa decreased induced acute lung injury First, to evaluate the maximal...

Ngày tải lên: 11/08/2014, 10:23

... day 1, day 6, and the change in value between day and Stata 9.0 (StataCorp, College Station, Texas) computer software was used for statistical analysis All interval data in tables and text are ... http://respiratory-research.com/content/12/1/52 Page of Table Bivariate analysis of respiratory variables for 93 patients with acute lung injury who were ventilated for more than days Variable Day Day ... independently associated with mortality In addition, odds ratios for the change between day and day of mechanical ventilation were calculated for each variable (Table 3) The only variable associated with...

Ngày tải lên: 12/08/2014, 13:22

... of 0.5 mL/kg to a maximum of mL/kg Haemodynamics, airway pressures, arterial and venous Statistical Analysis Data were analysed by repeated measures analysis of variance (ANOVA) as previously described ... BT, Schoenfeld D, Anzueto A, Matthay MA: Airway pressures and early barotrauma in patients with acute lung injury and acute respiratory distress syndrome Am J Respir Crit Care Med 2002, 165:978-982 ... pressure in acute lung injury and the lowest VT and plateau pressure compatible with acceptable gas exchange should be a goal If this is borne out, then application of a variable ventilator pattern,...

Ngày tải lên: 12/08/2014, 18:21

... typical histopathologic changes of acute lung injury a, no hyaline membrane formation; b, mild hyaline membrane formed; c, moderate hyaline membrane appeared; d, severe hyaline membrane formed; ... Schibler A, Numa A, Nuthall G, Yung M, Pascoe E, Wilkins B: Acute lung injury in pediatric intensive care in Australia and New Zealand: a prospective, multicenter, observational study Pediatr Crit Care ... "two-hit", we established a hemodynamically stable ALI model by infusing oleic acid Page of (page number not for citation purposes) Acta Veterinaria Scandinavica 2009, 51:17 http://www.actavetscand.com/content/51/1/17...

Ngày tải lên: 12/08/2014, 18:22

... properties that are protective against inflammatory lung injury [27] and vascular leakage [28,29], and therefore the S1P regulating enzyme became a very attractive ALI-related candidate Moreover, ... vascular endothelial cell growth factor and protects against hyperoxic acute lung injury J Clin Invest 2000, 106:783-791 34 Bhattacharya S, Patel R, Sen N, Quadri S, Parthasarathi K, Bhattacharya ... 160:1165-1170 Enkhbaatar P, Murakami K, Shimoda K, Chandra A, Traber L, Hawkins H, Herndon D, Traber D: Ketorolac, a nonsteroidal anti-inflammatory agent prevents burn/smoke-induced acute lung injury in...

Ngày tải lên: 12/08/2014, 20:20

... Changes in the average alveolar–arterial N HCl artery lavages (PAP), and cardiac output of 2.5 ml/kg of pulthree separatepressure and intratracheal oxygen (A- a O2 gradient,0.1 monary(fractional ... mean pulmonary artery pressure (PAP) A femoral artery was cannulated for continuous monitoring of the mean arterial pressure (MAP; Datascope 2001; Datascope Co., Paramus, NJ, USA) as well as ... MAP the AV-ECMO animals could not maintain an AV shunt of over 5% of baseline CO Statistical analyses All values are expressed as mean ± standard deviation Differences in specific variables after...

Ngày tải lên: 12/08/2014, 20:20

... 0.001) and 3.4 (2.64–4.29, P < 0.001) After adjustment for covariates, acute kidney injury was still associated with an almost twofold increased hazard for hospital mortality (Table 5, panel A) Maximum ... performed automated and manual data verification The patient data included demographic, administrative, physiologic, laboratory and hospital outcome information Ethnicity, reported as white, black ... of acute kidney injury was associated with an increasing length of ICU stay and hospital stay, and higher mortality (Table and Figure 2) Patients with maximum RIFLE class R, class I and class...

Ngày tải lên: 12/08/2014, 23:23

... Cheatham and Safcsak [21] Statistical analysis Data are shown as means ± SD All data were analyzed with SAS software (version 8.2; SAS Institute, Cary, NC, USA) The study design included a baseline ... was actioned until airway, esophageal, and gastric pressures decreased from their maximum value to an apparent plateau Similarly, Page of (page number not for citation purposes) Critical Care ... pulmonary disease, heart failure or severe head trauma Their main clinical characteristics are summarized in Table After completing the study and analyzing the data we realized the possible importance...

Ngày tải lên: 12/08/2014, 23:23

... not for citation purposes) Critical Care Vol 10 No David et al Table Ventilatory parameters, hemodynamics, and blood gas analysis before and after induction of lung injury Healthy animal Plateau ... trachea was intubated and the lung was mechanically ventilated via an endotracheal tube (inner diameter, 8.0 mm) in constant-volume mode (AVEA Ventilator; VIASYS Healthcare, Palm Springs, CA, ... minutes) An equal distribution for all data was analyzed by the Kolmogorov-Smirnov test Differences for hemodynamics and blood gases before lung lavage and after lung lavage before HFOV and PCV...

Ngày tải lên: 12/08/2014, 23:24

... not for citation purposes) Critical Care Vol 10 No David et al Table Ventilatory parameters, hemodynamics, and blood gas analysis before and after induction of lung injury Healthy animal Plateau ... trachea was intubated and the lung was mechanically ventilated via an endotracheal tube (inner diameter, 8.0 mm) in constant-volume mode (AVEA Ventilator; VIASYS Healthcare, Palm Springs, CA, ... minutes) An equal distribution for all data was analyzed by the Kolmogorov-Smirnov test Differences for hemodynamics and blood gases before lung lavage and after lung lavage before HFOV and PCV...

Ngày tải lên: 12/08/2014, 23:24

... conditions for acute lung injury in the intensive care unit and hospital ward: a prospective observational study Crit Care 2007, 11:R96 Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K: The American-European ... Critical Care Vol 11 No Finney and Evans managed clinically on the general wards is difficult because of uncontrollable variables such as the numbers and availability of ICU beds, referral practice ... respiratory evaluation with chest radiography and arterial gas analysis is more likely in those with pneumonia as opposed to say, non pulmonary sepsis, is unclear What is the take home message from this...

Ngày tải lên: 13/08/2014, 08:20