a sniffer for ventilator induced lung injury

... Tachykinins and tachykinin receptors in human uterus Br J Pharmacol 2003, 139:523-532 Nakayama K, Okugawa S, Yanagimoto S, Kitazawa T, Tsukada K, Kawada M, Kimura S, Hirai K, Takagaki Y, Ota ... digital camera at ×400 magnification Statistical analysis Statistical analysis was performed with the Fisher exact test and paired and unpaired Student t-tests, as appropriate Comparisons that involved ... regulator of the TLR pathways and a master regulator of NF-B and inflammation [13,14] Several known pathways can lead to NF-B activation The classical (canonical) pathway involves the activation...

Ngày tải lên: 12/08/2014, 11:20

... inhaled APC can prevent or minimize primary or secondary lung damage when low tidal volumes are used for mechanical ventilation Abbreviations APC, activated protein C; ERK, extracellular-regulated ... endotoxin -induced lung injury in anaesthetised sheep Crit Care 2009, 13:R51 Kotanidou A, Loutrari H, Papadomichelakis E, Glynos C, Magkou C, Armaganidis A, Papapetropoulos A, Roussos C, Orfanos SE: ... ventilator- induced lung injury Crit Care 2010, 14:R70 doi:10.1186/cc8977 Cite this article as: Abraham E: Inhaled activated protein C: a new therapy for the prevention of ventilator- induced lung injury? ...

Ngày tải lên: 13/08/2014, 20:21

... the mitogen-activated protein kinase cascade Proc Natl Acad Sci USA 1995, 92:7686-7689 23 Sammons MJ, Raval P, Davey PT, Rogers D, Parsons AA: Carrageenan -induced thermal hyperalgesia in the mouse: ... pathology, are fertile, are of normal size, and have normal lung parenchyma and airways [20] This study was performed in accordance with animal experimental guidelines of the National Institutes of Health ... incubated at 37°C overnight The supernatant was separated by centrifugation at 5,000 g for 30 minutes, and the amount was recorded EBD in the plasma and lung tissue was quantitated by dualwavelength...

Ngày tải lên: 13/08/2014, 03:20

... Critical Care Vol 12 No Liu et al reverse primer, 5'-TCA CAG AGC AAT GAC TCC AAA G-3'; and GAPDH (internal control) forward primer, 5'-AAT GCA TCC TGC ACC ACC AA-3' and reverse primer, 5'-GTA GCC ATA ... connected to a Harvard apparatus ventilator (model 55-7058; Harvard Apparatus, Holliston, MA, USA) The rats were then ventilated Page of 11 (page number not for citation purposes) with a tidal volume ... Pro-inflammatory activity of contaminating DNA in hyaluronic acid preparations J Pharm Pharmacol 2001, 53:551-561 37 Altemeier WA, Matute-Bello G, Frevert CW, Kawata Y, Kajikawa O, Martin TR,...

Ngày tải lên: 13/08/2014, 11:22

... was approved by the local animal ethics committee Page of Animal preparation Anesthesia was induced by tiletamine mg.kg-1, zolazepam mg.kg -1 , xylazine 2.2 mg.kg-1 intramuscularly, and maintained ... MAP: mean arterial pressure; MPAP: mean pulmonary arterial pressure; PaCO2: partial pressure of arterial carbon dioxide; PaO2: partial pressure of arterial oxygen; pCO2: partial pressure of carbon ... in all alveoli and septa The evaluation scores for these markers were averaged to obtain a cumulative histopathology score for each animal Lung mechanics The estimation of total respiratory system...

Ngày tải lên: 14/08/2014, 08:21

... Ventilation -induced lung injury is associated with an increase in gut permeability Shock 2003, 19:559-563 89 Imai Y, Kawano T, Iwamoto S, Nakagawa S, Takata M, Miyasaka K: Intratracheal anti-tumor ... 21 Veldhuizen RA, Tremblay LN, Govindarajan A, van Rozendaal BA, Haagsman HP, Slutsky AS: Pulmonary surfactant is altered during mechanical ventilation of isolated rat lung Crit Care Med 2000, ... because any increase in the driving force will have a dramatic effect on edema formation in the face of an altered microvascular permeability [27] Mechanical determinants of ventilator- induced lung...

Ngày tải lên: 21/06/2014, 01:20

... 5'-TGA-GCT-GCG-CTG-TCA-GTG-CCT-3' (sense) and 5'-AGA-AGC-CAG-CGT-TCA-CCA-GA-3' (antisense) for CXCL1 (259 bp) and 5'-GCT-GGC-CAC-CAA-CCACCA-GG-3' (sense) and 5'-AGC-GAG-GCA-CAT-CAGGTA-CG-3' (antisense) ... extravasation technique, as previously described [30,42] Extravasation of Evans blue (Sigma-Aldrich) into the extravascular compartment was used as a quantitative measure of lung injury and changes ... was added to vol of deionized formamide and incubated at 60C for 12 h The supernatant was separated by centrifugation at 2000 × G for 30 Evans blue in the plasma and lung tissue was quantitated...

Ngày tải lên: 11/08/2014, 08:21

... lung injury in mice Am J Respir Crit Care Med 2001, 163(3 Pt 1):762-769 Ueno H, Matsuda T, Hashimoto S, Amaya F, Kitamura Y, Tanaka M, Kobayashi A, Maruyama I, Yamada S, Hasegawa N, et al.: Contributions ... of acute lung injury by mechanical ventilation is known as "VILI, and also as "ventilatorassociated" lung injury VILI is characterized by an increased alveolar permeability, pulmonary edema, ... Crit Care Med 2007, 173 :A8 39 Kitamura Y, Hashimoto S, Mizuta N, Kobayashi A, Kooguchi K, Fujiwara I, Nakajima H: Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide -induced lung...

Ngày tải lên: 12/08/2014, 14:20

... Amato MB, Barbas CS, Medeiros DM, Magaldi RB, Schettino GP, Lorenzi-Filho G, Kairalla RA, Deheinzelin D, Munoz C, Oliveira R, Takagaki TY, Carvalho CR: Effect of a protective-ventilation strategy ... in ARDS The transition of physiologic concepts derived from basic science research into management strategies has already significantly impacted on the care of patients with ARDS Standard of care ... organ failure: is mechanical ventilation a contributing factor? Am J Respir Crit Care Med 1998, 157:1733-1743 Laffey JG, Tanaka M, Engelberts D, Luo X, Yuan S, Tanswell AK, Post M, Lindsay T, Kavanagh...

Ngày tải lên: 12/08/2014, 19:22

... vascular pressure to ventilator- induced lung injury Just as with inflammation, mechanical forces that tear the delicate alveolar–capillary membrane can originate on either side of the boundary ... excellent reason to believe that regional transmural vascular forces may be dramatically different when mechanically heterogeneous lungs are ventilated with adverse ventilatory patterns Experimental evidence ... threshold for edema forma- Available online http://ccforum.com/content/7/6/435 What disrupts the blood–gas barrier during ventilator- induced lung injury? Clinicians have long been aware that certain...

Ngày tải lên: 12/08/2014, 20:20

... P, Doulis A, Kitsakos A, Karachaliou A, Lekka ME, et al.: Lung and ‘end organ’ injury due to mechanical ventilation in animals: comparison between the prone and supine positions Crit Care 2006, ... Whitehead T, Evans T, Griffiths M: Ventilator- associated lung injury Lancet 2003, 361:332-340 Ranieri M, Giunta F, Suter PM, Slutsky A: Mechanical ventilation as a mediator of multisystem organ failure ... studied by Nakos and colleagues Competing interests The author declares that they have no competing interests References Nakos G, Batistatou A, Galiatsou E, Konstanti E, Koulouras V, Kanavaros P,...

Ngày tải lên: 12/08/2014, 23:23

... the transient activation of these pathways could be beneficial Last but not the least, awareness of the significance and limitation of experimental data are crucial for our knowledge translation ... to reveal the potential of a biological stimulus on a particular biological process This strategy has also been adapted to animal studies On the other hand, this may also explain why many experimental ... (if at all) used clinically Are these experimental data really useful? This is really a good question First of all, as experimental biologists, we always try to create a condition that can give...

Ngày tải lên: 13/08/2014, 08:20

... Chicago, IL, USA) was used for statistical analyses Means of numerical variables in LVT, HVT and HVT+dopamine groups were compared using analysis of variance Tukey's test was applied when variances ... 0.21, and then (at T30 or T60) AWP and BP were measured and arterial blood gases analyzed Materials and methods Animals We studied 132 male Wistar-Kyoto rats weighing 250 to 300 g A total of 60 rats ... in a rat model of ventilator- induced lung injury improves clearance of pulmonary oedema, and this greater clearance is associated with improved survival Key messages • The increased clearance...

Ngày tải lên: 13/08/2014, 08:21

... Factor Assay Kit; Active Motif) [22,23] Statistical analysis All data are expressed as mean ± standard error of the mean Statistical analysis was performed using SPSS for Windows® (Release 11.0.1; ... pentobarbital sodium and intubated via tracheostomy MV was performed with a rodent ventilator (Harvard Apparatus, Holliston, MA, USA) The mice in the LPV group were ventilated with a peak inspiratory ... showed typical findings of lung injury, scores such as intra-alveolar exudates, hyaline membrane formation, inflammatory cell infiltration, intra-alveolar hemorrhage, and interstitial edema These...

Ngày tải lên: 13/08/2014, 11:22

... Matthay MA: Pathogenetic significance of biological markers of ventilator- associated lung injury in experimental and clinical studies Chest 2006, 130:19061914 Page of (page number not for citation ... roles of poly (ADP-ribose) polymerase in ventilator- induced lung injury Crit Care 2008, 12:R108 Vaneker M, Halbertsma FJ, van Egmond J, Netea MG, Dijkman HB, Snijdelaar DG, Joosten LA, van der Hoeven ... Critical Care Vol 12 No Vaneker et al diseased lungs, normal lungs are relatively insusceptible to the detrimental effects of mechanical ventilation [3] To investigate newer pathogenetic mechanisms...

Ngày tải lên: 13/08/2014, 11:23

... elucidate the mechanisms of response and nonresponse to INO in an endotoxin -induced animal lung injury model Materials and methods Animals After approval of the local Animal Research Ethical committee, ... in acute lung injury, which was awarded The Alain Harf Award on Applied Respiratoy Physiology ESICM ECCRN Awards 2006 The assistance of Marie Ekberg-Richter, Lena Almgren, Annie Bjurebäck, Ann-Christine ... pulmonary vascular resistance, whereas the cardiac output remained unaltered There was a mean decrease in the mean arterial pressure The systemic vascular resistance fell as well, but the decrease was...

Ngày tải lên: 13/08/2014, 11:23

... Nakagawa H, Tsunooka N, Yamamoto Y, Yoshida M, Nakata T, Kawachi K: Pitavastatin prevents intestinal ischemia/reperfusion -induced bacterial translocation and lung injury in atherosclerotic rats ... L1026-L1032 Naidu BV, Woolley SM, Farivar AS, Thomas R, Fraga C, Mulligan MS: Simvastatin ameliorates injury in an experimental model of lung ischemia-reperfusion Journal of Thoracic and Cardiovascular ... Hoetzel A, Dolinay T, Vallbracht S, Zhang Y, Kim HP, Ifedigbo E, Alber S, Kaynar AM, Schmidt R, Ryter SW, Choi AM: Carbon monoxide protects against ventilator- induced lung injury via PPAR-gamma and...

Ngày tải lên: 13/08/2014, 21:21

Ngày tải lên: 13/08/2014, 21:21

... Nutr 2009, 44:1-13 11 Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S: Hydrogen acts as a therapeutic antioxidant by selectively reducing ... polymicrobial sepsis via reducing oxidative stress and HMGB1 release Shock 2010, 34:90-97 30 Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo J, Katayama T, Kawamura A, Kohsaka S, Makino ... Imanaka H, Shimaoka M, Matsuura N, Nishimura M, Ohta N, Kiyono H: Ventilator- induced lung injury is associated with neutrophil infiltration, macrophage activation, and TGF-beta mRNA upregulation...

Ngày tải lên: 14/08/2014, 07:21

... Ventilator Induced Lung Injury • Barotrauma • Volutrauma • Stretch Injury • Biochemical Injury VIASYS Healthcare, Inc Ventilator Induced Lung Injury • Barotrauma • Air leaking into pleural ... Activation of alveolar macrophages and pro-inflammatory cytokines play a pivotal role in Ventilator Induced Lung Injury Takata M, AJRCCM 1997; 156:272 VIASYS Healthcare, Inc Risk Factors for ARDS • ... VIASYS Healthcare, Inc Alveolar Edema and Hyaline Membrane VIASYS Healthcare, Inc Hemorrhage and Edema VIASYS Healthcare, Inc Adult ARDS • HFOV - Caring for the Baby in Adults • Baby Lung Sitting...

Ngày tải lên: 12/05/2016, 16:31